Protein Alignment ItgaPS4 and Itga11

DIOPT Version :10

• Sequence 1: NP_611025.2
• Gene: ItgaPS4 / 36693
• FlyBaseID: FBgn0034005
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: NP_001400722.1
• Gene: Itga11 / 315744
• RGDID: 1311711
• Length: 1188
• Species: Rattus norvegicus
• Alignment Length: 1304
• Identity: 263/1304 - (20%)
• Similarity: 459/1304 - (35%)
• Gaps: 444/1304 - (34%)

  Fly    18 AYNISPYPNSVLNF------PELEGNRRSSYFGFSL----VIREKSIMVAAPRANSSLEAQRNIS 72
            |:.:|.:|.....|      |.:.....:::||:::    :..:|.::|.||     ||...: .
  Rat    10 AWTLSLWPGFTDTFNMDTRNPRVIAGPSAAFFGYTVQQHDISGKKWLVVGAP-----LETNGH-Q 68

  Fly    73 EPGVIFRCYFESGNNCSPYNIDTKGNYKGMPNDGLLTAKN----KDFRWLGGAMDGGTRDSDKFL 133
            :.|.:::|....| ||:..|:            |.:|..|    ||...||.::....:|| .||
  Rat    69 KTGDVYKCPVTQG-NCTKLNL------------GRVTLSNVSERKDNMRLGLSLATNPKDS-SFL 119

  Fly   134 VCAPRFYSINNENDYNNGMC--------------------------------------------- 153
            .|:|.:......:.|..|||
  Rat   120 ACSPLWSHECGSSYYTTGMCSRVNSNFRFSKTVAPALQRCQTYMDIVIVLDGSNSIYPWVEVQHF 184

  Fly   154 -----------------------------YWLSDTPKNIDSTEV--------------------- 168
                                         :.|:|.....|..|.
  Rat   185 LIEILTKFYIGPGQIQVGIVQYGEDAVHEFHLNDYKSVKDVVEAASHIEQRGGTETRTAFGIEFA 249

  Fly   169 ------------------------------MEKWPLRIEKKQVLKLADTNLIPYYS--------- 194
                                          :||...:.||..|.:.| ..::.||:
  Rat   250 RSEAFQKGGRKGAKKVMIVITDGESHDSPDLEKVIRQSEKDNVTRYA-VAVLGYYNRRGINPETF 313

  Fly   195 ----------------------------------------------------MGELGLSAHVSDD 207
                                                                |.:.|.|:||.:|
  Rat   314 LNEIKYIASDPDDKHFFNVTDEAALKDIVDALGDRIFSLEGTNKNETSFGLEMSQTGFSSHVVED 378

  Fly   208 NSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGMNTNRKCNECNPEPKNFGQEEFSYFGYA 272
            .  :|:||.|...|.|:| ||:      ||:|:......:..|  |...|.||..    :|.||.
  Rat   379 G--VLLGAVGAYDWNGAV-LKE------TSAGKVIPLRESYLK--EFPEELKNHA----AYLGYT 428

  Fly   273 VSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYEDSIYKYHE-FRGNHFGEYFGYSVLAEDL 336
            |:|  ..||....| |||.|||.|:. |:..:|.|:.:.....|: .||...|.|||..:.:.|:
  Rat   429 VTS--VVSSKQGRV-YVAGAPRFNHT-GKVILFSIHTNRSLTIHQALRGEQIGSYFGSEITSVDI 489

  Fly   337 NGDGKTDV-IISAPLYALRNSYDDGAIYVF-INKGSFTFEERIIRSPAGSGGRFGTTLSRIGDIN 399
            |.|..||| ::.||:| .....:.|.:||: :.:..|.|...:..|.:....|||:.::.:.|:|
  Rat   490 NNDRVTDVLLVGAPMY-FSEGRERGKVYVYNLRQNRFVFNGTLKDSHSYQNARFGSCIASVQDLN 553

  Fly   400 KDGYNDVAVGAPF--AGNGSVFIYLGSENGLRDPPSQCLDAPSQQPSKYGSYMFGHGLSRGSDID 462
            :|.||||.||||.  :..|:::|:.|.:..:...|.|.:.|....|   |...||..:....|::
  Rat   554 QDSYNDVVVGAPLEDSHRGAIYIFHGFQTNILKKPVQRISASELAP---GLQHFGCSIHGQLDLN 615

  Fly   463 GNGFNDFAIGAPNAEAVYLYRAYPVVKIHAIIKPKLQNVNPEEERVNI----------------- 510
            .:|..|.|:|| ...||.|: |.|||:|:|       :::.|..::||
  Rat   616 EDGLVDLAVGA-LGNAVVLW-ARPVVQINA-------SLHFEPSKINIFHKDCKRNGRDATCLAA 671

  Fly   511 ----------------TVCYRLSSKSDSKAKALMEQELVIRIDIDT-----KSKIKLAVFDEEHG 554
                            ||..|.::..|       |:..:.|..:|.     .::..|....:||.
  Rat   672 FLCFGPIFLAPHFHTATVGIRYNATMD-------ERRYMPRAHLDEGADQFTNRAVLLSSGQEHC 729

  Fly   555 SQMSFKAKAFHEEICSEFQIEMDKRAKFTPIALEMQYELSKKIPNSGDFCEDCAVVDPAEPKFVT 619
            .:::|..              :|......|:|..::|.|..  |:.|      .::|...|..:.
  Rat   730 QRINFHV--------------LDTADYVKPVAFSVEYSLED--PDHG------PMLDNGWPTTLR 772

  Fly   620 EYITFNTGCATDV-CVADLKISCIN--------------------ASSTLVLGTTAVL------R 657
            ..:.|..||..|. ||.||.:...:                    :|.||...||..:      |
  Rat   773 VSVPFWNGCNEDEHCVPDLVLDARSDLPTAMEYCQQVLRRPAQDCSSYTLSFDTTVFIIESTRRR 837

  Fly   658 LTYNIT--NNGEFAYHPKFSVTNSAGLSLAQV--------PGNCKVNEA----VMVCDLNHGQRM 708
            :....|  |.||.||....:::.|..|..|.:        ...| |||.    ..||::::....
  Rat   838 VAVEATLENRGENAYSAVLNISQSENLQFASLIQKDDSDNSIEC-VNEERRLHKKVCNVSYPFFR 901

  Fly   709 AKGDTDSLTISFDVRQ---LRGRSLEIQAEVLSARDESNPENNKLTNVLSLREKADIYVSGVQTN 770
            ||... :..:.|:..:   |....:.:.|...|...:|..::|.......|:.:||:..:...:.
  Rat   902 AKAKV-AFRLDFEFSKSVFLHHLQIHLGAGSDSHEQDSTADDNTALLRFHLKYEADVLFTRSSSL 965

  Fly   771 DHVVLKES-----------PYTAEVVNYYEIKSHGPSTLENLTVSLYIPVAYKTPDSTNVKHIVT 824
            .|..:|.:           |:..    .:::::.|...:..:.:.:.:|:|
  Rat   966 SHFEVKANSSLESYDGIGPPFNC----VFKVQNLGFFPIHGVMMKITVPIA-------------- 1012

  Fly   825 SSPKIQSKYAHKIMPIN--FIDQNNALANNFAIDHDQSTLLFSATPQHENVGNLSGIVEQNPSIS 887
                  ::..::::.:.  |.||.|...|.:.     ::..:.:||..|   :||...::|.|
  Rat  1013 ------TRGGNRLLMLKDFFTDQVNTSCNIWG-----NSTEYRSTPTEE---DLSHAPQRNHS-- 1061

  Fly   888 LLNEDLP--VNNTLVLNCQDTNVTLCVPVEIRLENGLQLKPEELMNMTVSFTVNLKDADDIWEYF 950
              |.|:.  :.|..:...|:|:..|...:.:     :.||..:..:|.:  |||..........|
  Rat  1062 --NSDVVSIICNVRLAPNQETSFYLVGNLWL-----MSLKALKYRSMKI--TVNAALQRQFHSPF 1117

  Fly   951 VIQTDLKVHKIGDPTLS-SFTIEKKIESNVICKHAEIAIWKIIVSVIVGILVFSAATYALYKRGF 1014
            :.:.:       ||:.. :|.|.|:       :..::.||.|:.|.:.|:|:.:....||:|.||
  Rat  1118 IFREE-------DPSRQVTFEISKQ-------EDWQVPIWIIVGSSLGGLLLLALLVLALWKLGF 1168

  Fly  1015 FKRA 1018
            ||.|
  Rat  1169 FKSA 1172

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	FG-GAP_3	335..408	CDD:433275	25/74 (34%)
		Int_alpha	384..434	CDD:214549	18/51 (35%)
		Int_alpha	447..>492	CDD:214549	17/44 (39%)
		Integrin_alpha2	486..808	CDD:462478	72/414 (17%)
Itga11	NP_001400722.1	Int_alpha	37..86	CDD:214549	13/55 (24%)
		vWA_integrins_alpha_subunit	163..341	CDD:238746	12/178 (7%)
		Int_alpha	476..523	CDD:214549	16/47 (34%)
		Int_alpha	538..592	CDD:214549	19/53 (36%)
		Integrin_alpha2	636..1064	CDD:462478	87/501 (17%)