DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS4 and Itga10

DIOPT Version :9

Sequence 1:	NP_611025.2	Gene:	ItgaPS4 / 36693	FlyBaseID:	FBgn0034005	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	NP_001101169.2	Gene:	Itga10 / 310683	RGDID:	1305152	Length:	1167	Species:	Rattus norvegicus

Alignment Length:	934	Identity:	216/934 - (23%)
Similarity:	360/934 - (38%)	Gaps:	236/934 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 MGELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGMNTNRKCNECNPEPK 259
            |.|:|.|.|...|.  :|.|..|...|.|||...:|        ||:.....|..: :|..|..:
  Rat   372 MSEIGFSIHRLQDG--ILFGMVGAYDWGGSVLWLEE--------GRRLFPPRTALE-DEFPPALQ 425

  Fly   260 NFGQEEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYEDSIYKY-HEFRGNHF 323
            |..    :|.||:|||........   |:::.|||..:: |:...|.:.:|.:.|. ...:|:..
  Rat   426 NHA----AYLGYSVSSMLLPGGRR---LFLSGAPRFRHR-GKVIAFQLKKDGVVKVTQSLQGDQI 482

  Fly   324 GEYFGYSVLAEDLNGDGKTDV-IISAPLYALRNSYDDGAIYVF-INKGSFTFEERIIRSPAGSGG 386
            |.|||..:...|.:.||.|:: :::||::....:.:.|.|||: :.:.:....:..::.......
  Rat   483 GSYFGSELCPLDTDMDGITNILLVAAPMFLGPQNKETGRIYVYVVGQQNLLMLQGTLQPDRSQDS 547

  Fly   387 RFGTTLSRIGDINKDGYNDVAVGAPF--AGNGSVFIYLGSENGLRDPPSQCLDAPSQ-QPSKYGS 448
            |||..::.:.|:|.||::|||||||.  ...|::::|.|::.|:|..|:|.:.|.|. |..:|
  Rat   548 RFGFAMAALPDLNHDGFSDVAVGAPLEDGHQGALYLYHGTQTGIRPHPTQRIAAGSMPQALRY-- 610

  Fly   449 YMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHAI-----IKPKLQNVNPEEER- 507
              ||..:....|:||:...|.|:||..  |..|:.:.|:  ||.|     :.|.:..|..:.:|
  Rat   611 --FGRSVDGRLDLDGDDLVDVAVGAHG--AAILFSSQPI--IHLIPTLDVMPPHISVVQKDCKRR 669

  Fly   508 ------VNITVCYRLSSKSDSKAKALMEQELVIRI--DIDTKSKIKLAVFDEEHGSQMSFKAKAF 564
                  :..::|:::.|::..:    .::...||.  .:|..:....|.||   ||.........
  Rat   670 GQEAACLTASLCFQVKSQTPGR----WDRRFHIRFSASLDEWTAGARAAFD---GSGQRLSPGQL 727

  Fly   565 HEEI----CSEFQIE-MDKRAKFTPIALEMQYELS------------------KKIPNSGDFCED 606
            ...:    |.:.... :|......|:||.:.:.|.                  |.||    |.:|
  Rat   728 RLSVGNVTCEQLHFHALDTSDYLRPVALTVTFALDNTTKPGPVLAEGSSTSIRKLIP----FSKD 788

  Fly   607 CAVVDPAEPKFVTEYITFNTGCATD-VCVADLKISCINASSTLVLGTTAVLRLTYNITNNGEFAY 670
            |..               :..|.|| |..||:.|.....|..:|.|....:.::..:.|..|.||
  Rat   789 CGP---------------DNECITDLVLQADMDIRGSRKSPFVVQGGRQKVLVSVTLENKKENAY 838

  Fly   671 HPKFSVTNSAGLSLA----QVPGNCKVNEAV-----MVCDLNHGQRMAKGDTDSLTISFDVRQLR 726
            :...|::.|..|.||    |...:.||..||     .:|.:.|....| |...|..:.|   :..
  Rat   839 NTSLSLSFSRNLHLASLTPQRAKSVKVECAVPSPHARLCIVGHPVFQA-GAKVSFLLEF---EFS 899

  Fly   727 GRSLEIQAEVLSARDESNPENNKLTNVLSLREKADIYVSGVQTNDHVVLKESPYTAEVVNYYEIK 791
            ...|..|..|......|:.|.|:.                :|.|          ||:...|...:
  Rat   900 CTFLLSQVSVRLTASSSSLERNET----------------LQDN----------TAQTSAYIRYE 938

  Fly   792 SH----GPSTLENLTVSLY--IPVA----YKTPDSTNVKHIVTSSPKIQSKYAHKIMPINFIDQN 846
            .|    ..|||....|..|  :||.    :||            :.::|:...|.:
  Rat   939 PHLMFSSESTLHRYEVHPYRALPVGPGPEFKT------------TLRVQNLGCHVV--------- 982

  Fly   847 NALANNFAIDHDQSTLLFSA-TPQHENVGN----LSGIVEQNPSISLLN-EDLP--------VNN 897
                         |.|:.|| .|...:.||    ||.::..|.|.::.| .|.|        :.:
  Rat   983 -------------SGLVVSALLPAVAHGGNYFLSLSQVISGNASCTVQNLTDPPGFPVHPEELQH 1034

  Fly   898 TLVLNCQDTNVTLCVPVEIRLENGLQLKPEELMNMTVSFTVNLKDADDIWEYF---------VIQ 953
            |..||..:|.   |..|...|  ||..|..|:....:....|        |:|         |:.
  Rat  1035 TSRLNGSNTR---CQAVRCHL--GLLPKGTEISVGLLRLVHN--------EFFRRAKFKSVTVVS 1086

  Fly   954 TDLKVHKIGDPTLSSFTIEKKIESNVICKHAE--------IAIWKIIVSVIVGILVFSAATYALY 1010
            |    .|:|....|...:.:..:...  .|.|        |::|.::.||:.|:|:.:...:.|:
  Rat  1087 T----FKLGTEKGSVLLLNEASQWRE--SHLEVIQTLPTLISLWILVGSVLGGLLLLALLVFCLW 1145

  Fly  1011 KRGFFKRAIKDDLKQLIRDSFEDG 1034
            |.|||.|      |::.::...:|
  Rat  1146 KLGFFTR------KKIPKEEQSEG 1163

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	19/74 (26%)
		Int_alpha	384..434	CDD:214549	20/51 (39%)
		Int_alpha	447..>492	CDD:214549	13/44 (30%)
		Integrin_alpha2	484..808	CDD:285619	76/376 (20%)
Itga10	NP_001101169.2	Int_alpha	41..81	CDD:214549
		vWA_integrins_alpha_subunit	166..346	CDD:238746
		Int_alpha	482..>525	CDD:214549	13/42 (31%)
		Int_alpha	545..599	CDD:214549	21/53 (40%)
		Integrin_alpha2	642..1050	CDD:285619	102/502 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335700
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840