Protein Alignment ItgaPS4 and Itgal

DIOPT Version :10

• Sequence 1: NP_611025.2
• Gene: ItgaPS4 / 36693
• FlyBaseID: FBgn0034005
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: XP_006230331.1
• Gene: Itgal / 308995
• RGDID: 631424
• Length: 1161
• Species: Rattus norvegicus
• Alignment Length: 1314
• Identity: 267/1314 - (20%)
• Similarity: 446/1314 - (33%)
• Gaps: 455/1314 - (34%)

  Fly     7 IVLLALQSEINA--YNI-SPYPNSVLNFPELEGNRRSSYFGFSLVIREKSIMVAAPRANSSLEAQ 68
            ::||.||..:||  ||: :.:..|.|       .:...:||:.::.....::|.||...:|
  Rat    10 LLLLGLQLFVNAWSYNLDTRHAQSFL-------TQAGRHFGYQVLQFGDGVVVGAPGEGNS---- 63

  Fly    69 RNISEPGVIFRCYFESGNNCSPYNIDTKGNYKGMPNDGLLTAKNKDFRWLGGAMDGGTRDSDK-- 131
                 .|.::.|:..|| :|.|.::                ..|...::||..|   ..|:.|
  Rat    64 -----TGSLYHCHPSSG-SCQPVHL----------------GSNHTSKYLGMTM---VTDAAKGS 103

  Fly   132 FLVCAPRFYSINNENDYNNGMCYWLSD-------------------------------------- 158
            .|.|.|......::|.|.:|:||..|.
  Rat   104 LLACDPGLSRTCDQNPYLSGLCYLFSQSLGKPILQNRPAYQECMKGNVDLVFLFDGSQSLDKKDF 168

  Fly   159 -----------------------------------------------------TPK--------- 161
                                                                 ||.
  Rat   169 EKIVDFMKDVMRKLSNTSYQFAAVQFSTECKTEFTFLDYIKLNKNPDVLLGNVTPMFLLTNTFRA 233

  Fly   162 -----------------------------------NIDSTEVMEKWPLRIEK------------- 178
                                               |||:.:.:.::.:.|.|
  Rat   234 INYVVTHVFKEESGARPDATKVLVIITDGEASDNGNIDAAQDITRYIIGIGKHFSTTQKQEKLHI 298

  Fly   179 ------KQVLKLADT------------------------NLIPY-YSMGELGLSAHVSDDNSKLL 212
                  ::.:|:.||                        :|..: ..:...|:||.:|..::  :
  Rat   299 FASKPVEEFVKILDTFEKLKDLFTDLQRKIYAIEGTSKQDLASFNMELSSSGISADLSKGHA--V 361

  Fly   213 MGAPGIDQWKGS-VHLKQEVPSIKTSSGRQRRGMNTNRKCNECNPEPKNFGQEEFSYFGYAVSSG 276
            :||.|...|.|. :.|.:::.. .|..|:                ||.. ..|...|.||.|:
  Rat   362 VGAVGAKDWAGGFLDLHEDLEG-ATFVGQ----------------EPLT-SDERGGYLGYTVA-- 406

  Fly   277 YFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYEDSIY--KYHEFRGNHFGEYFGYSVLAEDLNGD 339
             :.:|..|..|..|.||| ....|:..:|...|...:  :..:..|...|.|||..:.:.||:.|
  Rat   407 -WLTSRSSRPLLAAGAPR-YQHVGQVLLFQAPEAGGHWNQTQKIEGTQIGSYFGGELCSVDLHQD 469

  Fly   340 GKTD-VIISAPLYALRNSYDD---GAIYVFINKGS-FTFEERIIRSPAGSGGRFGTTLSRIGDIN 399
            |:|| ::|.|||:     |.:   |.:.|:..:.| |.....:...|....||||..:|.:.|||
  Rat   470 GETDLLLIGAPLF-----YGEQRGGRVSVYQRRRSLFEMVSELQGDPGYPLGRFGAAISALTDIN 529

  Fly   400 KDGYNDVAVGAPFAGNGSVFIYLGSENGLRDPPSQCLDAPSQQPSKYGSYMFGHGLSRGSDIDGN 464
            .||..|||||||....|:|:|:.|...|.....||.:......|   |...||..:....|:.|:
  Rat   530 GDGLTDVAVGAPLEEQGAVYIFNGKPGGFSSQSSQRIPGTQVSP---GVRWFGRSIHGVKDLGGD 591

  Fly   465 GFNDFAIGAPNAEAVYLYRAYPVVKIHAIIKPKLQNVNPEE-----------------ERVNITV 512
            ...|..:||..  .|.:..:.|||.|...:     :.:|:|                 |.|.:.|
  Rat   592 RLADVVVGAEG--QVIVLSSRPVVDIVTEL-----SFSPDEIPVHEVECSYSASQEQKEGVKLKV 649

  Fly   513 CYRLSS-KSDSKAKALMEQELVIRID-IDTKSKIKLAVFDEEHG---------SQMSFKAKAFHE 566
            |:::.. .|..:.:.|......:::| ..|:|:........|.|         |.|.|.   ||.
  Rat   650 CFQIRPLTSQFQGRLLANLSYTLQLDGHRTRSRGLFPGGSRELGGNTSVTPDKSCMDFH---FHF 711

  Fly   567 EICSEFQIEMDKRAKFTPIALEMQYELSKK--IPNSGDFCEDCAVVDPAEPKFVTEYITFNTGCA 629
            .||.:..|        :||.:.:.:.|.::  .|.......|...:.......||:.|.|...|.
  Rat   712 PICIQDLI--------SPINVSLNFSLLEEEGSPRDQKGGRDMQPILRPSIHAVTKEIPFEKNCG 768

  Fly   630 TD-VCVADLKISCINASSTLVLGTTAVLRLTYNITNNGEFAYHPKFSVTNSAGLSL--------- 684
            .| .|.|||.:|....|..|.|.::|.|.:.:.:.|.||.||..:..:....|||.
  Rat   769 EDKKCEADLALSPPARSGVLRLMSSASLAVEWTLRNLGEDAYWVRLDLDFPRGLSFRKVEMLQPH 833

  Fly   685 AQVPGNCK--VNEAVMV-----CDLNH-----GQRMAKGDTDSLTISFD--VRQLRGRSLEIQAE 735
            :|:|.:|:  ..|:.::     |:::.     |::|      :|.:.|:  :....|..:|:...
  Rat   834 SQIPVSCEELTEESSLLTKTLKCNVSSPIFKAGKQM------TLQVMFNTLLNSSWGDFVELNGT 892

  Fly   736 VLSARDESN--PENNKLTNVLSLREKADIYVSGVQTNDHVVLKESPYTAEVVNYYEIKSHGPSTL 798
            |....:.|:  .:|:..|.:..|      |...:.|.|.
  Rat   893 VHCENENSSLGKDNSATTRIPVL------YPVNILTEDQ-------------------------- 925

  Fly   799 ENLTVSLYIPVAYKTPDSTNVKHIVTSSPKIQSKYAHKIMPINFIDQNNALANNFAIDHDQSTL- 862
            ||.|  |||....|.|.:..|:||          |..:|.|             .|.||:...|
  Rat   926 ENST--LYISFTPKGPKTQQVQHI----------YKVRIQP-------------SAYDHNMPALE 965

  Fly   863 LFSATPQHENVGNL--SGIVEQNPSISLLNEDL---------PVNNTLVLNC-----QDTNVTLC 911
            .....||..:.|.:  :..|..:|.::...|||         |....:...|     |:|.:.:.
  Rat   966 ALVEVPQPHSEGPIAHTWTVHTDPLVTCHREDLKKPTREAEQPCLPGVQFRCPIVFRQETFIRVA 1030

  Fly   912 VPVEIRLENGLQLKPEELMNMTVSFTVNLKDADDIWEYFVIQTDLKVHKIGDPTLSSFTIEKKIE 976
            ..||:    ..::|....:::..|.:|:...:    ::|        |..|         .|..:
  Rat  1031 GTVEL----SEKIKASSTLSLCSSLSVSFNSS----KHF--------HLYG---------SKASK 1070

  Fly   977 SNVICK----HAEIAIWKIIVSVIVGILVFSAATYALYKRGFFKRAIKDDLKQLIRDSFEDGIIR 1037
            :.|:.|    :.:..:...::|.|.|:|:.|....||||.|||||.:|:.::       .||.:
  Rat  1071 AQVLMKVDMIYEKEMLHLYVLSGIGGLLLLSLIFLALYKVGFFKRKLKEKME-------ADGGV- 1127

  Fly  1038 TEMEENAQSQGDAD 1051
                .|.....|||
  Rat  1128 ----PNGSPGEDAD 1137

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	FG-GAP_3	335..408	CDD:433275	28/77 (36%)
		Int_alpha	384..434	CDD:214549	22/49 (45%)
		Int_alpha	447..>492	CDD:214549	13/44 (30%)
		Integrin_alpha2	486..808	CDD:462478	78/377 (21%)
Itgal	XP_006230331.1	Int_alpha	38..81	CDD:214549	12/52 (23%)
		vWFA	151..320	CDD:469594	10/168 (6%)
		Int_alpha	398..448	CDD:214549	14/53 (26%)
		Int_alpha	453..499	CDD:214549	17/50 (34%)
		Int_alpha	514..566	CDD:214549	24/51 (47%)
		Int_alpha	577..621	CDD:214549	12/50 (24%)
		Integrin_alpha2	610..978	CDD:462478	93/446 (21%)
		Integrin_alpha	1109..1123	CDD:459778	7/20 (35%)