DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ItgaPS4 and GPLD1

DIOPT Version :9

Sequence 1:	NP_611025.2	Gene:	ItgaPS4 / 36693	FlyBaseID:	FBgn0034005	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	XP_016866242.1	Gene:	GPLD1 / 2822	HGNCID:	4459	Length:	850	Species:	Homo sapiens

Alignment Length:	354	Identity:	89/354 - (25%)
Similarity:	139/354 - (39%)	Gaps:	100/354 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 LADTNLIPYYSMGELGLSAHVSDDNSKLLMGAPGIDQ---WKGSVHLKQEVPSIKTSSGRQRRGM 245
            ||.:.|.|.||.    .|..:.:...:..:|  |:|.   |..:::   .:.|....:|
Human   233 LAVSKLYPTYST----KSPFLVEQFQEYFLG--GLDDMAFWSTNIY---HLTSFMLENG------ 282

  Fly   246 NTNRKCNECN-PEPKNF----GQEEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIF 305
                 .::|| ||...|    ||:..:. |..:....| ..||:|.| ..:..|..|.......|
Human   283 -----TSDCNLPENPLFIACGGQQNHTQ-GSKMQKNDF-HRNLTTSL-TESVDRNINYTERGVFF 339

  Fly   306 DIYE---DS---IYKYHE------FRG----------NHFGEYF--------GYSVLAEDLNGDG 340
            .:..   ||   |||..|      |.|          :....||        |:::.:.|||.||
Human   340 SVNSWTPDSMSFIYKALERNIRTMFIGGSQLSQKHVSSPLASYFLSFPYARLGWAMTSADLNQDG 404

  Fly   341 KTDVIISAPLYALRNSYDDGAIYVF-------------INKGSFTFEERIIRSPAGSGGRFGTTL 392
            ..|:::.||.|:.......|.:|:.             ::|.:    .||:.....| ||||:.|
Human   405 HGDLVVGAPGYSRPGHIHIGRVYLIYGNDLGLPPVDLDLDKEA----HRILEGFQPS-GRFGSAL 464

  Fly   393 SRIGDINKDGYNDVAVGAPFAGN------GSVFIYLGS-ENGLRDPPS---QCLDAPSQQPSKYG 447
            : :.|.|.||..|:|||||..|:      |:|::|.|| :.|:...|:   .|.|....
Human   465 A-VLDFNVDGVPDLAVGAPSVGSEQLTYKGAVYVYFGSKQGGMSSSPNITISCQDIYCN------ 522

  Fly   448 SYMFGHGLSRGSDIDGNGFNDFAIGAPNA 476
               .|..| ..:|::|:...|..||:|.|
Human   523 ---LGWTL-LAADVNGDSEPDLVIGSPFA 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	25/85 (29%)
		Int_alpha	384..434	CDD:214549	24/59 (41%)
		Int_alpha	447..>492	CDD:214549	9/30 (30%)
		Integrin_alpha2	484..808	CDD:285619
GPLD1	XP_016866242.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7104
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.850