DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS4 and Itga1

DIOPT Version :9

Sequence 1:	NP_611025.2	Gene:	ItgaPS4 / 36693	FlyBaseID:	FBgn0034005	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	NP_112256.1	Gene:	Itga1 / 25118	RGDID:	2923	Length:	1180	Species:	Rattus norvegicus

Alignment Length:	1058	Identity:	247/1058 - (23%)
Similarity:	421/1058 - (39%)	Gaps:	242/1058 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 IDTKGNYKGMPNDGLLTAKNKDFRWLGGA-----------MDGGTRDSDKFLV----CAP---RF 139
            |..:|..:.|...|:.||:.:.|....||           .||.:.|:.:...    |..   :.
  Rat   240 IGRQGGLQTMTALGIDTARKEAFTEARGARRGVKKVMVIVTDGESHDNYRLKQVIQDCEDENIQR 304

  Fly   140 YSINNENDYNNGMCYWLSDTPKNID-----STEVMEKWPLRIEKKQVL---------------KL 184
            :||.....||.|..    .|.|.::     ::|..||....:..:..|               ..
  Rat   305 FSIAILGHYNRGNL----STEKFVEEIKSIASEPTEKHFFNVSDELALVTIVKALGERIFALEAT 365

  Fly   185 ADTNLIPY-YSMGELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQE----VPSIKTSSGRQRRG 244
            ||.:...: ..|.:.|.|||.|.|  .:::||.|...|.|:|.:::.    :|.
  Rat   366 ADQSAASFEMEMSQTGFSAHYSQD--WVMLGAVGAYDWNGTVVMQKANQMVIPH----------- 417

  Fly   245 MNTNRKCNECNPEPKNFGQEEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYE 309
             ||.     ...||....:...||.||.|:|......    |||:|..||.|:. |:..|:.:.:
  Rat   418 -NTT-----FQTEPAKMNEPLASYLGYTVNSATIPGD----VLYIAGQPRYNHT-GQVVIYKMED 471

  Fly   310 DSIYKYHEFRGNHFGEYFGYSVLAEDLNGDGKTD-VIISAPLYALRNSYDDGAIYVF-INKGSFT 372
            .:|.......|...|.|||..:...|::.|..|| :::.||:|......:.|.:||: :|:..|.
  Rat   472 GNINILQTLGGEQIGSYFGSVLTTIDIDKDSYTDLLLVGAPMYMGTEKEEQGKVYVYAVNQTRFE 536

  Fly   373 FEERI--IRSPAGS----------------GGRFGTTLSRIGDINKDGYNDVAVGAPFAGN--GS 417
            ::..:  ||....|                |.||||.::.:.|:|.||:|||.:|||...:  |:
  Rat   537 YQMSLEPIRQTCCSSLKDNSCTKENKNEPCGARFGTAIAAVKDLNVDGFNDVVIGAPLEDDHAGA 601

  Fly   418 VFIYLGSENGLRDPPSQCLDAPSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLY 482
            |:||.||...:|:..:|.:  ||....|...: ||..:....|::|:|..|..||.....|::..
  Rat   602 VYIYHGSGKTIREAYAQRI--PSGGDGKTLKF-FGQSIHGEMDLNGDGLTDVTIGGLGGAALFWA 663

  Fly   483 RAYPVVKIHAIIKPKLQNVNPEEERV--------NITVCY--RLSSKSDSKAKALMEQELVIRID 537
            |...|||:....:|...|:..:..||        |.|:|:  :|.||.||    :.|.:|..|:.
  Rat   664 RDVAVVKVTMNFEPNKVNIQKKNCRVEGKETVCINATMCFHVKLKSKEDS----IYEADLQYRVT 724

  Fly   538 IDTKSKIKLAVFD--EEHGSQMSFKAKAFHEEICSEFQIEM-DKRAKFTPIALEMQYELSKKIPN 599
            :|:..:|..:.|.  :|...|.:...:   |..|......| ||......:.:.:.:.|:.  |.
  Rat   725 LDSLRQISRSFFSGTQERKIQRNITVR---ESECIRHSFYMLDKHDFQDSVRVTLDFNLTD--PE 784

  Fly   600 SGDFCEDCAVVDPAEPKFVTEYITFNTGCAT-DVCVAD--LKISCINASSTLVLGTTAVLRLTYN 661
            :|      .|:|.|.|..|.|:|.|...|.. :.|::|  |.:|....|..:|........::..
  Rat   785 NG------PVLDDALPNSVHEHIPFAKDCGNKERCISDLTLNVSTTEKSLLIVKSQHDKFNVSLT 843

  Fly   662 ITNNGEFAYHPKFSVTNSAGLSLAQV----PGNCKVNEAVMVCDLNHGQRMAKGDTDSLTISFDV 722
            :.|.|:.||:.:..|.:|..|..:.:    ..:|:.|:.: .|.:.: ..:..|:|.:..|.|
  Rat   844 VKNKGDSAYNTRTVVQHSPNLIFSGIEEIQKDSCESNQNI-TCRVGY-PFLRAGETVTFKIIF-- 904

  Fly   723 RQLRGRSLEIQAEV-LSARDESNPE----NNKLTNVLSLREKADIYVSGVQ-----TNDHVVLKE 777
             |.....|...|.: |||..:|...    |:...|: |:..|   |..|:|     :..|:.:..
  Rat   905 -QFNTSHLSENAIIHLSATSDSEEPLESLNDNEVNI-SIPVK---YEVGLQFYSSASEHHISVAA 964

  Fly   778 SPYTAEVVN-----------YYEIKSHGPSTLENLTVSLYIPVAYKTPDSTNVKHIVTSSPKIQS 831
            :....|.:|           :|.|:..|...:..|.:|:..|  ..|.|...|
  Rat   965 NETIPEFINSTEDIGNEINVFYTIRKRGHFPMPELQLSISFP--NLTADGYPV------------ 1015

  Fly   832 KYAHKIMPINFIDQNN------ALANNFAIDH------DQSTLLFSATPQHENVGNLSGIVEQNP 884
                 :.||.:...:|      :|.:.|.|:.      .:|.:|...|.|  :..:..|:.  ..
  Rat  1016 -----LYPIGWSSSDNVNCRPRSLEDPFGINSGKKMTISKSEVLKRGTIQ--DCSSTCGVA--TI 1071

  Fly   885 SISLLNEDL-PVNNTLVL------NCQDTNVTLCVPVEIRLENGLQLKPEELMNMTVSFTVNLKD 942
            :.|||..|| .||.:|:|      ....:::.|.:..|::.||.         ::|:| :.|.|.
  Rat  1072 TCSLLPSDLSQVNVSLLLWKPTFIRAHFSSLNLTLRGELKSENS---------SLTLS-SSNRKR 1126

  Fly   943 ADDIWEYFVIQTDLKVHKIGDPTLSSFTIEKKIESNVICKHAEIAIWKIIVSVIVGILVFSAATY 1007
                      :..:::.|.|.|                   ..:.:|.|::|...|:|:......
  Rat  1127 ----------ELAIQISKDGLP-------------------GRVPLWVILLSAFAGLLLLMLLIL 1162

  Fly  1008 ALYKRGFFKRAIKDDLKQ 1025
            ||:|.|||||.:|..:::
  Rat  1163 ALWKIGFFKRPLKKKMEK 1180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	27/92 (29%)
		Int_alpha	384..434	CDD:214549	23/67 (34%)
		Int_alpha	447..>492	CDD:214549	13/44 (30%)
		Integrin_alpha2	484..808	CDD:285619	82/364 (23%)
Itga1	NP_112256.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	30..91
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	101..160
		vWA_integrins_alpha_subunit	171..351	CDD:238746	24/114 (21%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	365..417		15/53 (28%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	422..474		17/56 (30%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	475..537		17/61 (28%)
		Int_alpha	485..>528	CDD:214549	13/42 (31%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	556..614		21/57 (37%)
		Int_alpha	567..620	CDD:214549	23/52 (44%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	618..678		17/62 (27%)
		Integrin_alpha2	663..1073	CDD:285619	98/456 (21%)
		GFFKR motif	1168..1172		3/3 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335727
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940