Protein Alignment ItgaPS4 and Itga8

DIOPT Version :10

• Sequence 1: NP_611025.2
• Gene: ItgaPS4 / 36693
• FlyBaseID: FBgn0034005
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: NP_001395029.1
• Gene: Itga8 / 241226
• MGIID: 109442
• Length: 1079
• Species: Mus musculus
• Alignment Length: 1149
• Identity: 291/1149 - (25%)
• Similarity: 477/1149 - (41%)
• Gaps: 248/1149 - (21%)

  Fly    18 AYNISPYPNSVLNFPELEGNRRSSYFGFSLVI-----REKSIMVAAPRANSSLEAQRNISEPGVI 77
            |:|:.....:|.:.||      .||||:||..     |..|::|.||:||:|   |.:|.|.|.:
Mouse    37 AFNLDVDKLTVYSGPE------GSYFGYSLDFYIPDARTASVLVGAPKANTS---QPDIVEGGAV 92

  Fly    78 FRCYF--ESGNNCSPYNIDTKGNYKGMPNDGLLTAKNKDFRWLGGAMDGGTRDSDKFLVCAPRFY 140
            :.|.:  |....|.....||..|.|...|......:.|..:|.|..:   .....|.:.|||.::
Mouse    93 YYCPWPSERSAQCKQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATV---RAHKGKVVACAPLYH 154

  Fly   141 ----SINNENDYNNGMCYWLSDTPKNIDSTEVMEKWPLRIEKKQVLKLADTNLIPY---YSMGEL 198
                ..|...| ..|.||....     :.:...|..|.|          ::|..|.   |.....
Mouse   155 WRTLKPNPAKD-PVGTCYVAIQ-----NFSAYAEHSPCR----------NSNADPEGQGYCQAGF 203

  Fly   199 GLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGMNTNRKCNECNPEPKNFGQ 263
            .|..:   .|..|::|.||...|:|.|........|...|.:.........|..:..|     ..
Mouse   204 SLDFY---KNGDLIVGGPGSFYWQGQVITVSIADIIANYSFKDILRKLAAEKQTDVAP-----AS 260

  Fly   264 EEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYEDSIYKYHEFRGNHFGEYFG 328
            .:.||.||:|::|.|...:...:  ||..|||...||  |:..|....:.....|.|.....|||
Mouse   261 YDDSYLGYSVAAGEFTGDSQQEL--VAGIPRGAQNFG--YVSIINSTDMTFIQNFTGEQMASYFG 321

  Fly   329 YSVLAEDLNGDGKTDVIISAPLYALR----NSYDDGAIYVFINKGSFTFEERIIRSPAGSGGRFG 389
            |:|:..|:|.||..|:::.|||:..|    |..:.|.:|:::...:..|::..:.:...:.||||
Mouse   322 YTVVVSDVNNDGMDDILVGAPLFMEREFESNPREVGQVYLYLQASALLFQDPQVLTGTETFGRFG 386

  Fly   390 TTLSRIGDINKDGYNDVAVGAPFAG---NGSVFIYLGSENGLRDPPSQCLDAPSQQPSKYGSYM- 450
            ::::.:||:|:|||||:|:|.||||   .|.|.||.|:..||...|||.|.      ..:||..
Mouse   387 SSVAHLGDLNQDGYNDIAIGVPFAGKDQRGKVLIYNGNPRGLHSKPSQVLQ------GIWGSQTI 445

  Fly   451 ---FGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHA--IIKPKLQNVNPEEERV-- 508
               ||..|...:|||.|.:.|..:||.....|.:|||.|||.:.|  ::.|.:.|:..:..::
Mouse   446 PSGFGFSLRGDADIDKNDYPDLLVGAFGKGKVAVYRARPVVTVDAQLLLHPMIINLENKTCQIPE 510

  Fly   509 --------NITVCYRLSSKSDSKAKALMEQELVIRID-IDTKSKIKLAVFDEEHGSQMSF----- 559
                    ::.||..::.:|.|...||:.:   :::| :..|..||..:|...|.|..:|
Mouse   511 FPTPVACFSVRVCASIAGQSISNTIALLAE---VQLDFLKQKGAIKRTLFLHNHQSHFTFPFVMK 572

  Fly   560 KAKAFHEEICSEFQI----EMDKRAKFTPIALEMQYELSKKIPNSGDFCEDCAVVDPAEPK---- 616
            :.|:.|   |.:|.:    |.:.|.|.:||.:.:.|.|           :|....|..|.|
Mouse   573 QQKSLH---CQDFMVYLRDETEFRDKLSPINISLNYSL-----------DDSTFKDSLEVKPILN 623

  Fly   617 -----FVTEYITFNTGCATD-VCVADLKISCINASSTLVLGTTAVLRLTYNITNNGEFAYHPKFS 675
                 .|||.......|..| :||.|||:|.......:::|....|.|..|..|.||.||..:..
Mouse   624 HYRDNVVTEQAHILVDCGEDNLCVPDLKLSARPDKHQIIIGDENHLMLIINARNEGEGAYEAELF 688

  Fly   676 V------------TNSAGLSLAQVPGNCKVN----EAVMVCDLNHGQRMAKGDTDSLTISFDVRQ 724
            |            .|:.||.    |.:|:..    ..::||||  |..|..|...||.:.|.|.:
Mouse   689 VIIPEEADYVGIERNNKGLR----PLSCEYKMENVTRMVVCDL--GNPMVTGTNFSLGLRFAVPR 747

  Fly   725 LRGRSLEIQAEV-LSARDESNPENNKLTNVLSLREKADIYVSGVQTNDHVVL-------KESPYT 781
            |...::.|..:: :.:.::.||::|.....:::...|.:.:.||.....:||       ::.|:.
Mouse   748 LEKTNMSINFDLQIRSSNKDNPDSNFERVQINITAIAQVEIRGVSHPPQIVLPIHNWEPEKKPHK 812

  Fly   782 AE-----VVNYYEIKSHGPSTLENLTVSLYIPVAYKTPDSTNVKHIVTSSPKIQSKYAHKIMPIN 841
            .|     |.:.||:.:.||||:.:..:.:..|.:.:......:.|:.|..| :|.:...:|.|
Mouse   813 EEEVGPLVEHIYELHNIGPSTISDSILDVGWPFSARDEFLLYIFHLQTLGP-LQCQTNPEINP-- 874

  Fly   842 FIDQNNALANNFAIDHDQSTLLFSATPQHENVGNLSGIVEQNPSISLL--NEDLPV------NNT 898
                              ..:..:|:|  |:...||..: :|.:|..|  ..|:||      :..
Mouse   875 ------------------QDIKPAASP--EDTPELSAFL-RNATIPHLVRKRDVPVVQLHRQSPA 918

  Fly   899 LVLNCQDTNVTLCVPVEI---RLENGLQLKPEELMNMTVSFTVNLKDADDIWEYFVIQTDLKVHK 960
            .:|||  ||:. |:.:..   ||..|     |..:         ||....:|.:..:: ::.|.:
Mouse   919 RILNC--TNID-CLQISCAVGRLGGG-----ESAV---------LKVRSRLWAHTFLK-EISVEE 965

  Fly   961 IGD----------------PTLSSFTIEK---------------KIESNVICKHAEIA----IWK 990
            ...                .:|.||.::|               .::::||.....::    :|.
Mouse   966 TSQEQLVKTLKRKNDHYALASLVSFEVKKMPYKEQPAKLPAGSTAVKTSVIWATPNVSFSIPLWV 1030

  Fly   991 IIVSVIVGILVFSAATYALYKRGFFKRA-----IKDDLKQLIRD 1029
            ||:::::|:||.:..|.||:|.|||.||     ...|.:||..|
Mouse  1031 IILAILLGLLVLAILTLALWKCGFFDRARPPQDEMTDREQLTSD 1074

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	FG-GAP_3	335..408	CDD:433275	25/76 (33%)
		Int_alpha	384..434	CDD:214549	26/52 (50%)
		Int_alpha	447..>492	CDD:214549	19/48 (40%)
		Integrin_alpha2	486..808	CDD:462478	91/382 (24%)
Itga8	NP_001395029.1	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	41..104		23/71 (32%)
		Int_alpha	53..111	CDD:214549	21/60 (35%)
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	121..182		13/69 (19%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	187..239		14/64 (22%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	252..305		18/61 (30%)
		FG-GAP	267..300	CDD:460357	13/36 (36%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	306..371		19/64 (30%)
		Int_alpha	316..>364	CDD:214549	17/47 (36%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	372..430		25/57 (44%)
		Int_alpha	382..436	CDD:214549	28/53 (53%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	434..497		22/68 (32%)
		Int_alpha	447..491	CDD:214549	17/43 (40%)
		Cell attachment site. /evidence=ECO:0000255	454..456		0/1 (0%)
		Integrin_alpha2	483..933	CDD:462478	115/499 (23%)
		Integrin_alpha	1051..1065	CDD:459778	6/13 (46%)