DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS4 and ITGA11

DIOPT Version :9

Sequence 1:	NP_611025.2	Gene:	ItgaPS4 / 36693	FlyBaseID:	FBgn0034005	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	NP_001004439.1	Gene:	ITGA11 / 22801	HGNCID:	6136	Length:	1188	Species:	Homo sapiens

Alignment Length:	1283	Identity:	262/1283 - (20%)
Similarity:	468/1283 - (36%)	Gaps:	402/1283 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AYNISPYPNSVLNF------PELEGNRRSSYFGFSL----VIREKSIMVAAPRANSSLEAQRNIS 72
            |:.:|.:|.....|      |.:....|:::||:::    :...|.::|.||...:..:
Human    10 AWALSLWPGFTDTFNMDTRKPRVIPGSRTAFFGYTVQQHDISGNKWLVVGAPLETNGYQ------ 68

  Fly    73 EPGVIFRCYFESGNNCSPYNIDTKGNYKGMPNDGLLTAKN----KDFRWLGGAMDGGTRDSDKFL 133
            :.|.:::|....| ||:..|:            |.:|..|    ||...||.::....:| :.||
Human    69 KTGDVYKCPVIHG-NCTKLNL------------GRVTLSNVSERKDNMRLGLSLATNPKD-NSFL 119

  Fly   134 VCAPRFYSINNENDYNNGMC--------------------------------------------- 153
            .|:|.:......:.|..|||
Human   120 ACSPLWSHECGSSYYTTGMCSRVNSNFRFSKTVAPALQRCQTYMDIVIVLDGSNSIYPWVEVQHF 184

  Fly   154 -----------------------------YWLSD-----------------------TPKNID-- 164
                                         :.|:|                       |...|:
Human   185 LINILKKFYIGPGQIQVGVVQYGEDVVHEFHLNDYRSVKDVVEAASHIEQRGGTETRTAFGIEFA 249

  Fly   165 STEVMEKWPLRIEKKQVLKLAD-------------------------TNLIPYYS---------- 194
            .:|..:|...:..||.::.:.|                         ..::.||:
Human   250 RSEAFQKGGRKGAKKVMIVITDGESHDSPDLEKVIQQSERDNVTRYAVAVLGYYNRRGINPETFL 314

  Fly   195 ---------------------------------------------------MGELGLSAHVSDDN 208
                                                               |.:.|.|:||.:|.
Human   315 NEIKYIASDPDDKHFFNVTDEAALKDIVDALGDRIFSLEGTNKNETSFGLEMSQTGFSSHVVEDG 379

  Fly   209 SKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGMNTNRKCNECNPEPKNFGQEEFSYFGYAV 273
              :|:||.|...|.|:| ||:      ||:|:......:..|  |...|.||.|    :|.||.|
Human   380 --VLLGAVGAYDWNGAV-LKE------TSAGKVIPLRESYLK--EFPEELKNHG----AYLGYTV 429

  Fly   274 SSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYEDSIYKYHE-FRGNHFGEYFGYSVLAEDLN 337
            :|  ..||....| |||.|||.|:. |:..:|.::.:.....|: .||...|.|||..:.:.|::
Human   430 TS--VVSSRQGRV-YVAGAPRFNHT-GKVILFTMHNNRSLTIHQAMRGQQIGSYFGSEITSVDID 490

  Fly   338 GDGKTDV-IISAPLYALRNSYDDGAIYVF-INKGSFTFEERIIRSPAGSGGRFGTTLSRIGDINK 400
            |||.||| ::.||:| .....:.|.:||: :.:..|.:...:..|.:....|||::::.:.|:|:
Human   491 GDGVTDVLLVGAPMY-FNEGRERGKVYVYELRQNLFVYNGTLKDSHSYQNARFGSSIASVRDLNQ 554

  Fly   401 DGYNDVAVGAPFAGN--GSVFIYLGSENGLRDPPSQCLDAPSQQPSKYGSYMFGHGLSRGSDIDG 463
            |.||||.||||...|  |:::|:.|....:...|.|.:.|.....   |...||..:....|::.
Human   555 DSYNDVVVGAPLEDNHAGAIYIFHGFRGSILKTPKQRITASELAT---GLQYFGCSIHGQLDLNE 616

  Fly   464 NGFNDFAIGAPNAEAVYLYRAYPVVKIHAIIKPKLQNVNPEEERVNI--TVCYRLSSKSDSKAKA 526
            :|..|.|:|| ...||.|: :.|||:|:|       :::.|..::||  ..|.|....:...|..
Human   617 DGLIDLAVGA-LGNAVILW-SRPVVQINA-------SLHFEPSKINIFHRDCKRSGRDATCLAAF 672

  Fly   527 LMEQELVIRIDIDTKS-KIKL-AVFDE----------EHGSQMSFKAKAFH--EEICSEFQIEMD 577
            |....:.:.....|.: .|:. |..||          |.|.:.:.:|....  :|:|......:.
Human   673 LCFTPIFLAPHFQTTTVGIRYNATMDERRYTPRAHLDEGGDRFTNRAVLLSSGQELCERINFHVL 737

  Fly   578 KRAKFT-PIALEMQYELSKKIPNSGDFCEDCAVVDPAEPKFVTEYITFNTGCATDV-CVADLKIS 640
            ..|.:. |:...::|.|..  |:.|      .::|...|..:...:.|..||..|. ||.||.:.
Human   738 DTADYVKPVTFSVEYSLED--PDHG------PMLDDGWPTTLRVSVPFWNGCNEDEHCVPDLVLD 794

  Fly   641 CINASSTLVLGTTAVLR----------LTYNIT------------------NNGEFAYHPKFSVT 677
            ..:...|.:.....|||          |:::.|                  |.||.||....:::
Human   795 ARSDLPTAMEYCQRVLRKPAQDCSAYTLSFDTTVFIIESTRQRVAVEATLENRGENAYSTVLNIS 859

  Fly   678 NSAGLSLAQV------PGNCK-VNE----AVMVCDLNHGQRMAKGDTDSLTISFDVRQLRGRSL- 730
            .||.|..|.:      .|:.: |||    ...||::::....||... :..:.|:.    .:|:
Human   860 QSANLQFASLIQKEDSDGSIECVNEERRLQKQVCNVSYPFFRAKAKV-AFRLDFEF----SKSIF 919

  Fly   731 --EIQAEVLSARDESNPENNKLTNVLSLR----EKADIYVSGVQTNDHVVLKES----------- 778
              .::.|:.:..|.:..::.|..||..||    .:||:..:...:..|..:|.:
Human   920 LHHLEIELAAGSDSNERDSTKEDNVAPLRFHLKYEADVLFTRSSSLSHYEVKPNSSLERYDGIGP 984

  Fly   779 PYTAEVVNYYEIKSHGPSTLENLTVSLYIPVAYKTPDSTNVKHIVTSSPKIQSKYAHKIMPI-NF 842
            |::.    .:.|::.|...:..:.:.:.||:|                    ::..::::.: :|
Human   985 PFSC----IFRIQNLGLFPIHGMMMKITIPIA--------------------TRSGNRLLKLRDF 1025

  Fly   843 I-DQNNALANNFAIDHDQSTLLFSATPQHENVGNLSGIVEQNPSISLLNEDLPVNNTLVLNCQDT 906
            : |:.|...|.:.     ::..:..||..|::.....:...|..:..:|    .|..||.| |:.
Human  1026 LTDEANTSCNIWG-----NSTEYRPTPVEEDLRRAPQLNHSNSDVVSIN----CNIRLVPN-QEI 1080

  Fly   907 NVTLCVPVEIRLENGLQLKPEELMNMTVSFTVNLKDADDIWEYFVIQTDLKVHKIGDPTLS-SFT 970
            |..|...:.:|....|:.|..::|       ||..........|:.:.:       ||:.. .|.
Human  1081 NFHLLGNLWLRSLKALKYKSMKIM-------VNAALQRQFHSPFIFREE-------DPSRQIVFE 1131

  Fly   971 IEKKIESNVICKHAEIAIWKIIVSVIVGILVFSAATYALYKRGFFKRA 1018
            |.|:       :..::.||.|:.|.:.|:|:.:....||:|.|||:.|
Human  1132 ISKQ-------EDWQVPIWIIVGSTLGGLLLLALLVLALWKLGFFRSA 1172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	25/74 (34%)
		Int_alpha	384..434	CDD:214549	19/51 (37%)
		Int_alpha	447..>492	CDD:214549	16/44 (36%)
		Integrin_alpha2	484..808	CDD:285619	77/398 (19%)
ITGA11	NP_001004439.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	24..85		13/67 (19%)
		Int_alpha	39..>78	CDD:214549	8/44 (18%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	91..151		15/60 (25%)
		vWA_integrins_alpha_subunit	163..341	CDD:238746	11/177 (6%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	355..406		18/59 (31%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	411..461		23/59 (39%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	462..527		21/65 (32%)
		Int_alpha	476..>518	CDD:214549	16/42 (38%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	528..586		19/57 (33%)
		Int_alpha	538..592	CDD:214549	20/53 (38%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	590..650		20/71 (28%)
		Integrin_alpha2	635..1034	CDD:285619	83/442 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142002
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840