DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ItgaPS4 and Itga10

DIOPT Version :9

Sequence 1:	NP_611025.2	Gene:	ItgaPS4 / 36693	FlyBaseID:	FBgn0034005	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	NP_001289400.1	Gene:	Itga10 / 213119	MGIID:	2153482	Length:	1166	Species:	Mus musculus

Alignment Length:	921	Identity:	207/921 - (22%)
Similarity:	356/921 - (38%)	Gaps:	239/921 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 MGELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGMNTNRKCNECNPEPK 259
            |.|:|.|.|...|.  :|.|..|...|.|||...:|        ||:..             .|:
Mouse   372 MSEIGFSIHRLQDG--ILFGMVGAYDWGGSVLWLEE--------GRRLF-------------PPQ 413

  Fly   260 NFGQEEF--------SYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYEDSIYKY- 315
            ...::||        :|.||:|||........   |:::.|||..:: |:...|.:.:|.:.:.
Mouse   414 AALEDEFPPALQNHAAYLGYSVSSMLLPGGRR---LFLSGAPRFRHR-GKVIAFQLKKDGVVRVA 474

  Fly   316 HEFRGNHFGEYFGYSVLAEDLNGDGKTDV-IISAPLYALRNSYDDGAIYVF-INKGSFTFEERII 378
            ...:|:..|.|||..:...|.:.||.|:: :::||::....:.:.|.:||: :.:.:....:..:
Mouse   475 QSLQGDQIGSYFGSELCPLDTDKDGITNILLVAAPMFLGPQNKETGRVYVYMVGQQNLLMLQGTL 539

  Fly   379 RSPAGSGGRFGTTLSRIGDINKDGYNDVAVGAPF--AGNGSVFIYLGSENGLRDPPSQCLDAPSQ 441
            :.......|||..::.:.|:|.||:.|||||||.  ...|::::|.|::.|:|..|:|.:.|.|.
Mouse   540 QPDRSQDSRFGFAMAALPDLNHDGFTDVAVGAPLEDGHRGALYLYHGTQTGIRPHPTQRIAAVSM 604

  Fly   442 -QPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHAI-----IKPKLQN 500
             |..:|    ||..:....|:||:...|.|:||..  |..|:.:.|:  ||.|     :.|.:..
Mouse   605 PQALRY----FGRSVDGRLDLDGDDLVDVAVGAHG--AAVLFSSQPI--IHLIPTLDVMPPHISV 661

  Fly   501 VNPEEER-------VNITVCYRLSSKSDSKAKALMEQELVIRI--DIDTKSKIKLAVFDEEHGSQ 556
            |..:.:|       :...:|:::.|::..:    .::...||.  .:|..:....||||   ||.
Mouse   662 VQKDCKRRGQEAACLTAALCFQVVSQTPGR----WDRRFYIRFSASLDEWTAGARAVFD---GSG 719

  Fly   557 MSFKAKAFHEEI----CSEFQIE-MDKRAKFTPIALEMQYELS------------------KKIP 598
            .....:.....:    |.:.... :|......|:||.:.:.|.                  |.||
Mouse   720 QRLSPRQLQLSVGNVTCEQLHFHALDTSDYLRPVALTVTFALDNTTKPGPVLAEGSSTTIRKLIP 784

  Fly   599 NSGDFCEDCAVVDPAEPKFVTEYITFNTGCATD-VCVADLKISCINASSTLVLGTTAVLRLTYNI 662
                |.:||..               :..|.|| |..||:.|.....|..:|.|....:.::..:
Mouse   785 ----FSKDCGP---------------DNECVTDLVLQADMDIRGSRKSPFVVQGGRQKVLVSATL 830

  Fly   663 TNNGEFAYHPKFSVTNSAGLSLAQV---PGNCKVNEAV-----MVCDLNHG--QRMAKGDTDSLT 717
            .|..|.||:...|::.|..|.||.:   ..:.||..||     .:|.:.|.  |..||
Mouse   831 ENKKENAYNTSLSLSFSRNLHLASLTPQAKSVKVECAVPSPHTRLCTVGHPVFQTGAK------- 888

  Fly   718 ISFDVRQLRGRSLEIQAEVLSARDESNPENNKLTNVLSLREKADIYVSGVQTNDHVVLKES--PY 780
            :||        .||.:.              ..|.:||     .::|....::..:.:.|:  ..
Mouse   889 VSF--------LLEFEF--------------SCTFLLS-----QVFVRLTASSSSLEMNETLQDN 926

  Fly   781 TAEVVNYYEIKSH----GPSTLENLTVSLY--IPVA----YKTPDSTNVKHIVTSSPKIQSKYAH 835
            ||:...|...:.|    ..|||....|..|  :|:.    :||            :.::|:...|
Mouse   927 TAQTSAYIRYEPHLVFSSESTLHRYEVHPYRTLPMGPGPEFKT------------TLRVQNLGCH 979

  Fly   836 KIMPINFIDQNNALANNFAIDHDQSTLLFSA-TPQHENVGN----LSGIVEQNPSISLLN----E 891
            .:                      |.|:.|| .|...:.||    ||.::..|.|.::.|    .
Mouse   980 VV----------------------SGLVISALLPAVAHGGNYFLSLSQVISGNASCTVQNLTEPP 1022

  Fly   892 DLPVNNTLVLNCQDTNVTLCVPVEIRLENGLQLKPEELMNMTVSFTVNLKDADDIWEYF------ 950
            ..||:...:.:....|.:......:|...||..|..|:....:....|        |:|
Mouse  1023 GFPVHPEELQHASRLNGSNSRCQVVRCHLGLLAKGTEISVRLLRLVHN--------EFFRRAKFK 1079

  Fly   951 ---VIQTDLKVHKIGDPTLSSFTIEKKIESN-----VICKHAE-IAIWKIIVSVIVGILVFSAAT 1006
               |:.|    .|:|....|...:.:...|:     ||..|.. |::|.::.||:.|:|:.:...
Mouse  1080 SVTVVST----FKLGTEEGSVLLLNEASRSSESHLEVIQTHPTLISLWILVGSVLGGLLLLALLV 1140

  Fly  1007 YALYKRGFFKR 1017
            :.|:|.|||.|
Mouse  1141 FCLWKLGFFTR 1151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	18/74 (24%)
		Int_alpha	384..434	CDD:214549	20/51 (39%)
		Int_alpha	447..>492	CDD:214549	13/44 (30%)
		Integrin_alpha2	484..808	CDD:285619	76/379 (20%)
Itga10	NP_001289400.1	Int_alpha	41..81	CDD:214549
		vWA_integrins_alpha_subunit	166..346	CDD:238746
		Int_alpha	482..532	CDD:214549	13/49 (27%)
		Int_alpha	545..599	CDD:214549	21/53 (40%)
		Integrin_alpha2	642..1049	CDD:285619	96/502 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832023
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940