DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS4 and ina-1

DIOPT Version :9

Sequence 1:	NP_611025.2	Gene:	ItgaPS4 / 36693	FlyBaseID:	FBgn0034005	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	NP_499032.1	Gene:	ina-1 / 176296	WormBaseID:	WBGene00002081	Length:	1139	Species:	Caenorhabditis elegans

Alignment Length:	1235	Identity:	288/1235 - (23%)
Similarity:	474/1235 - (38%)	Gaps:	292/1235 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CLLVIVLLALQSEINAYNISPYPNSVLNFPELEGNRRSSYFGFSLVIREKS----IMVAAPRANS 63
            |::...||...|.:.::|:.      :|.|........:.||:|:....|.    :::.|||..|
Worm     4 CIISWTLLLCLSCVKSFNLD------VNAPIYRYGPSGTNFGYSVAEHFKGDKPVMLIGAPRGES 62

  Fly    64 SLEAQRNISEPGVIFRC----YFESGNN--CSP--YNIDTKGNYKGMPNDGLLTAKNKDFRWLG- 119
               .|......|.::.|    ::..|:|  |..  :..:...:|...||:    .:.:....||
Worm    63 ---GQTGTERAGAMYACDINTFYNGGSNHWCEQVRFEYENVEDYAKRPNE----TRGRTVHPLGK 120

  Fly   120 -------GAMDGGTRDSDKFLVCAP--RFYSINNENDYNNGMCYWLSD-----------TPKNID 164
                   ..:..||::... |||||  |::   ....|..|.||.|..           ..||:.
Worm   121 NDQLLASTIVSKGTKNGSA-LVCAPLIRYH---QTAAYPQGACYELESNLRLQSTYATCAQKNLP 181

  Fly   165 STEVMEKWPLRIEKKQVLKLADTNLIPYYSMGELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQ 229
            :|:...::...:|                     |.||.::.|.  ::.|..|..:|.|.|..|:
Worm   182 TTDRHNEYGGCME---------------------GFSAAITQDT--IVTGLIGAVKWTGGVFAKK 223

  Fly   230 EVPSIKTSSGRQRRGMNTNRKCNECNPEPKNFGQEEFSYFGYAVSSG-----YFDSSNLSTVLYV 289
            ...:|..|       :......|:.|.:..........|.||:|..|     |.|...::.|
Worm   224 SSANIFDS-------VVEKYTMNQPNGDMIRTRLVAHDYLGYSVDIGRFGFWYEDGKPITVV--- 278

  Fly   290 ATAPRGNNQFGE--AYIF-DIYEDSIYK--YHE----FRGNHFGEYFGYSVLAEDLNGDGKTDVI 345
                .|..::||  |.|| ...:||..|  .:|    ..|...|..||||:...||||||..|:|
Worm   279 ----SGATRYGEHGAVIFLPFIQDSSSKLTLNEDKFIINGTAMGSAFGYSIEVVDLNGDGFDDLI 339

  Fly   346 ISAPLYALRNSYD---DGAIYVFINKG--------SFTFE-ERIIRSPAGSGGRFGTTLSRIGDI 398
            :.|| :..|:..|   .|.:||:.::|        ...|. .:|:::| ....:||.:::::|::
Worm   340 VGAP-FEHRSGIDGNFGGIVYVYFSQGVQRKQHESHLVFHPPKILKNP-DFYSQFGLSITKLGNV 402

  Fly   399 --NKDGYNDVAVGAPFA--GNGSVFIYLGSEN--GLRDPPSQCL---DAPSQQPSKYGSYMFGHG 454
              :|...||.|||||||  |.|:|:||||::|  ..|..|:|.:   |.|:..|.  |...||..
Worm   403 DGDKSKLNDFAVGAPFAFDGAGAVYIYLGTKNIEKFRKKPAQVIKGNDLPNLPPG--GMRSFGFS 465

  Fly   455 LSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHAIIKPKLQNVNPEEERVNI---TVCYRL 516
            ||.|||:|.||:.|..||:|:...|.|.|:.||:.|..  |.|:     |:..|:|   ..|.|
Worm   466 LSGGSDMDENGYPDLLIGSPSKNFVALLRSRPVISIET--KHKM-----EKRMVDIDKGVNCPR- 522

  Fly   517 SSKSDSKAKALMEQELVIRIDIDTKSKIKLAVFDEE--------------------------H-- 553
                  .||.....::||.:|.:||...:|..|..:                          |
Worm   523 ------GAKTCFPLDMVIYVDEETKRGAELVDFSSDVFMCNLEAIPFRADTTARGFIEGSHSHNY 581

  Fly   554 ----GSQMSFKAKAFHEEICSEFQIEMDKRAKFTPI----ALEMQYELSKKIPNSGDFCEDCAVV 610
                ||....:.:.:.:.|....|   :.:...||:    .:.::.|.....|..|.     .:|
Worm   582 SWPCGSNSHVQKRTYRQLIYLPVQ---ESKDWITPLKFRFTVSIRNEKKPVQPPQGS-----QLV 638

  Fly   611 D----PAEPKFVTEY---ITFNTGCATD-VCVADLKISCINASSTLV-------LGTTAVLRLTY 660
            |    |...|:...|   :.|||.|..| .|..||.:........|.       :|....|.||:
Worm   639 DLKHYPVLNKYGASYEFDVPFNTLCGEDHTCQTDLSLKAAFKDIPLTSNGYVSNVGEKDYLDLTF 703

  Fly   661 NITNNGEFAYHPKFSVT-NSAGLSLAQVPGNCKVNEAVMVCDLNH---GQRMAKGDTDSLTISFD 721
            .:.|..|.||...|.:. |...|.|.||.|:.::....:..::.|   |..|........||.|.
Worm   704 TVENKKEKAYQANFYLEYNEEELELPQVQGSKRMIAETIGKNIVHLPLGNPMNGASKHQFTIQFK 768

  Fly   722 VRQLR----GRSLEIQAEVLSARDESNPE--NNKLTNVLSLREKADIYVSGVQTNDHVVL----- 775
            :.:.|    |::|:..|.|.|...|:..|  :||....:.:.:||::.:.|:...|.|..
Worm   769 LTRGRTEGIGKALKFMAHVNSTSQETEEELKDNKWEAEVQIIKKAELEIYGISDPDRVFFGGKAR 833

  Fly   776 KESPYTAE------VVNYYEIKSHGPSTLENLTVSLYIPVAYKT--PDSTNVKHIVTSSPKIQSK 832
            .||....|      |.:.|.|.:|||.|:.|:...:..|...::  ....|..::: ..|.|.::
Worm   834 AESELELEEDIGTMVRHNYTIINHGPWTVRNVEAHISWPYQLRSRFGRGKNALYLL-DVPTITTE 897

  Fly   833 YAHKIMPIN--FIDQNNALAN--NFAIDHDQSTLLFSATPQHENVGNLSGIV-----EQNPSISL 888
            :......:.  ||.|.....|  ...::...||   ..|..|.....:...:     ||:..:..
Worm   898 FTDGTSEVRKCFIKQQYEYVNPAEIKLNTKYST---QETAPHRVEHRMKREIDEDEEEQSDDLGA 959

  Fly   889 LNEDLPVNNTL-------------------VLNCQDTNVTLCVPVEIRLE----NGLQLKPEELM 930
            :.|::|..:|.                   .|:||| |...|..|....:    |..
Worm   960 VEENIPWFSTANFWNLFAIKGGDGRPREVKHLSCQD-NTANCFTVICHFDFIDANSA-------- 1015

  Fly   931 NMTVSFTVNLKDADDIWEYFVIQTDLKVHKIG------------DPTLSSFTIEKKIESN--VIC 981
             :.:.....|.:|..|.:|..::: :|:...|            ||..::..:|...:.:  .|.
Worm  1016 -VVIDLRARLWNATFIEDYSDVES-VKIRSFGKLQLDESQGIDDDPNNNAAFVETSADPDRPTIG 1078

  Fly   982 KHAEIAIWKIIVSVIVGILVFSAATYALYKRGFFKRAIKDDLKQLIRDSFEDGIIRTEMEENAQS 1046
            ....|..|..:::.::|:|:.|.....|.|.|||||      .:|.:.|.....::.|.||.|.:
Worm  1079 DSRPIPWWIYVIAAVIGVLILSLIIICLSKCGFFKR------NRLDQPSLYTAQLKHEREEWADT 1137

Fly 1047 1046
Worm 1138 1137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	25/86 (29%)
		Int_alpha	384..434	CDD:214549	23/55 (42%)
		Int_alpha	447..>492	CDD:214549	21/44 (48%)
		Integrin_alpha2	484..808	CDD:285619	90/398 (23%)
ina-1	NP_499032.1	Int_alpha	34..>79	CDD:214549	11/47 (23%)
		Int_alpha	317..>362	CDD:214549	20/45 (44%)
		Int_alpha	388..434	CDD:214549	20/45 (44%)
		Int_alpha	462..>502	CDD:214549	19/39 (49%)
		Integrin_alpha2	495..1005	CDD:285619	114/536 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I7058
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810