DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS4 and Itgav

DIOPT Version :9

Sequence 1:	NP_611025.2	Gene:	ItgaPS4 / 36693	FlyBaseID:	FBgn0034005	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	NP_032428.2	Gene:	Itgav / 16410	MGIID:	96608	Length:	1044	Species:	Mus musculus

Alignment Length:	1157	Identity:	281/1157 - (24%)
Similarity:	471/1157 - (40%)	Gaps:	251/1157 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFCLLVIVLLALQSEINAYNISPYPNSVLNFPELEGNRRSSYFGFSLVIREKS------IMVAAP 59
            :..||..:||.|   .:|:|:.      :..|........|||||::...|.|      ::|.||
Mouse    16 LLLLLPGLLLPL---ADAFNLD------VESPAEYAGPEGSYFGFAVDFFEPSTSSRMFLLVGAP 71

  Fly    60 RANSSLEAQRNISEPGVIFRCYFESGNNCSPYNIDTKGNYKGMPNDGLLTAKNKDFRWLGGAMDG 124
            :||::   |..|.|.|.:.:|...|...|.|...|:.||.....:|.|   :.|..:|.|.::
Mouse    72 KANTT---QPGIVEGGQVLKCECSSSRRCQPIEFDSTGNRDYAKDDPL---EFKSHQWFGASV-- 128

  Fly   125 GTRDSDKFLVCAPRFY---SINNENDYNNGMCYWLSDTPKNIDSTEVMEKWPLRIEKKQVLKLAD 186
             ....||.|.|||.::   .:..|.: ..|.|:..       |.|:.:|..|.|.:...    ||
Mouse   129 -RSKQDKILACAPLYHWRTEMKQERE-PVGTCFLQ-------DGTKTVEYAPCRSKNID----AD 180

  Fly   187 TNLIPYYSMGELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGMNTNRKC 251
            ..   .:..|...:....:|   ::|:|.||...|:|.: :..:|..|.:........:..|
Mouse   181 GQ---GFCQGGFSIDFTKAD---RVLLGGPGSFYWQGQL-ISDQVAEIISKYDPNVYSIKYN--- 235

  Fly   252 NECNPEPKNFGQEEF--SYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYEDSIYK 314
               |.......|..|  ||.||:|:.|.|:...:..  :|:..||.....|..||:|  ..::..
Mouse   236 ---NQLATRTAQAIFDDSYLGYSVAVGDFNGDGIED--FVSGVPRAARTLGMVYIYD--GKNMSS 293

  Fly   315 YHEFRGNHFGEYFGYSVLAEDLNGDGKTDVIISAPLYALRNS----YDDGAIYVFINKGSFTFEE 375
            .|.|.|.....|||:||.|.|:|||...||.|.|||:..|.|    .:.|.:.|.:.:....|:.
Mouse   294 LHNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRAVGDFQT 358

  Fly   376 RIIRSPAGSG----GRFGTTLSRIGDINKDGYNDVAVGAPFAG---NGSVFIYLGSENGLRDPPS 433
            ..:     :|    .|||:.::.:||:::||:||:|:.||:.|   .|.|:|:.|...||...||
Mouse   359 TKL-----NGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGLVYIFNGRSTGLNSVPS 418

  Fly   434 QCLD----APSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHAII 494
            |.|:    |.|..||      ||:.:...:|:|.||:.|..:||...:...||||.|||.::|.:
Mouse   419 QILEGQWAAQSMPPS------FGYSMKGATDVDRNGYPDLVVGAFGVDRAVLYRARPVVTVNAGL 477

  Fly   495 K--PKLQNVNPEEERV-------------NITVCYRLSSKSDSKAKALMEQELVIRIDIDTKSKI 544
            :  |.:.|   ::.::             |:..|.:...|.....|...:.||::. .:..|..|
Mouse   478 EVYPSILN---QDNKICPLPGTALKVSCFNVRFCLKADGKGTLPRKLHFQVELLLD-KLKQKGAI 538

  Fly   545 KLAVF----DEEHGSQMS-FKAKAFH-EEICSEFQIEMDKRAKFTPIALEMQYELSKKIPNSGDF 603
            :.|:|    ...|...|: |:..... ||:.:..:.|.:.|.|.|||.:.|:|.|.::  .:.|.
Mouse   539 RRALFLHNRSPVHSKTMTVFRGGQMQCEELVAYLRDESEFRDKLTPITIFMEYRLDQR--TAADA 601

  Fly   604 CEDCAVVDPAEPKFVTEYITFNTGCATD-VCVADLKISCINASSTLVLGTTAVLRLTYNITNNGE 667
            .....:::...|..|:........|..| ||...|::|..:....:.:|....|.||....|.||
Mouse   602 TGLQPILNQFTPANVSRQAHILLDCGEDNVCKPKLEVSVNSDQKKIYIGDDNPLTLTVKAQNQGE 666

  Fly   668 FAYHPKFSVTNSAGLSLAQVP------GNCKVNEAV---------------MVCDLNH----GQR 707
            .||..:..|:         :|      |..:.|||:               :||||.:    |.:
Mouse   667 GAYEAELIVS---------IPPQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQ 722

  Fly   708 MAKG-----------DTDSLTISFDVRQLRGRSLEIQAEVLSARDESNPENNKLTNVLSLREKAD 761
            :..|           ||   ::.||::.....|.:..:.|:|.:             :.|...|.
Mouse   723 LLAGLRFSVHQQSEMDT---SVKFDLKIQSSNSFDNVSPVVSYK-------------VDLAVLAA 771

  Fly   762 IYVSGVQTNDHVVL-------KESPYTAE-----VVNYYEIKSHGPSTLENLTVSLYIPVAYKTP 814
            :.:.||.:.||:.|       ||:|.|.|     |.:.||::::|||:.....::|..|..|...
Mouse   772 VEIRGVSSPDHIFLPIPNWEYKENPETEEDVGPIVQHIYELRNNGPSSFSKAILNLQWPYKYNNN 836

  Fly   815 DSTNVKHIVTSSPKIQSKYAHKIMPINFIDQNNALANNFAIDHDQSTLLFSATPQHENVGNLSGI 879
            ....:.|.....|.                       |...|.:.:.|... ||: :|....:|.
Mouse   837 TLLYILHYDIDGPM-----------------------NCTADTEINPLRIK-TPE-KNDTAAAGQ 876

  Fly   880 VEQNPSISLLNEDLPVNNTLVLNCQDTNVTLCVPVEI---RLENG----LQLK----PEELM--- 930
            .|:|..|:..:..|...:...|.|   .:..|:.:..   ||:.|    |.:|    .|..|
Mouse   877 GERNHLITKRDLTLREGDVHTLGC---GIAKCLQITCQVGRLDRGKSAILYVKSLLWTETFMNKE 938

  Fly   931 NMTVSFTVNLKDADDIWEYFVIQTDLKVHKIGDPTLSSFTIEKKIESNVICKHAEIAIWKIIVSV 995
            |...|:::....:.:|.|:  ...:|.:..:.:.||.:..|...|:...:    .:.:|.||::|
Mouse   939 NQNHSYSLKSSASFNIIEF--PYKNLPIEDLFNSTLVTTNITWGIQPAPM----PVPVWVIILAV 997

  Fly   996 IVGILVFSAATYALYKRGFFKRAIKDDLKQLIRDSFEDGIIRTEMEENAQSQ 1047
            :.|:|:.:...:.:|:.|||||                  :|...||..:.|
Mouse   998 LAGLLLLAVLVFVMYRMGFFKR------------------VRPPQEEQEREQ 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	25/80 (31%)
		Int_alpha	384..434	CDD:214549	21/56 (38%)
		Int_alpha	447..>492	CDD:214549	16/44 (36%)
		Integrin_alpha2	484..808	CDD:285619	87/393 (22%)
Itgav	NP_032428.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	32..98		20/74 (27%)
		Int_alpha	46..103	CDD:214549	20/59 (34%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	109..170		17/74 (23%)
		WD40 repeat	126..183	CDD:293791	16/74 (22%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	173..225		13/62 (21%)
		WD40 repeat	188..248	CDD:293791	12/69 (17%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	237..291		16/57 (28%)
		Int_alpha	248..>288	CDD:214549	14/43 (33%)
		WD40 repeat	254..298	CDD:293791	12/47 (26%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	292..357		23/64 (36%)
		Int_alpha	302..355	CDD:214549	20/52 (38%)
		WD40 repeat	307..362	CDD:293791	19/59 (32%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	358..415		20/61 (33%)
		Int_alpha	367..421	CDD:214549	22/53 (42%)
		WD40 repeat	371..422	CDD:293791	20/50 (40%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	419..482		23/68 (34%)
		Int_alpha	434..476	CDD:214549	16/41 (39%)
		Integrin_alpha2	467..910	CDD:285619	105/501 (21%)
		GFFKR motif	1015..1019		3/3 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1023..1044		3/9 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832018
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740