DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS4 and Itgam

DIOPT Version :9

Sequence 1:	NP_611025.2	Gene:	ItgaPS4 / 36693	FlyBaseID:	FBgn0034005	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	NP_001076429.1	Gene:	Itgam / 16409	MGIID:	96607	Length:	1154	Species:	Mus musculus

Alignment Length:	1297	Identity:	275/1297 - (21%)
Similarity:	462/1297 - (35%)	Gaps:	433/1297 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LVIVLLALQSEINAYNI-SPYPNSVLNFPELEGNRRSSYFGFSLV-IREKSIMVAAPRANSSLEA 67
            |::..|||   .:.:|: :.:|   :.|.|     .:..||.|:| :...|::||||:     ||
Mouse     6 LLVTALAL---CHGFNLDTEHP---MTFQE-----NAKGFGQSVVQLGGTSVVVAAPQ-----EA 54

  Fly    68 QRNISEPGVIFRCYFESGNNCSPYNIDTKGNYKGMPNDGLLTAKNKDFRWLGGAMDGGTRDSDKF 132
             :.:::.|.:::|.: |.:.|.|..:........|.              ||.::...| ...:.
Mouse    55 -KAVNQTGALYQCDY-STSRCHPIPLQVPPEAVNMS--------------LGLSLAVST-VPQQL 102

  Fly   133 LVCAPRFYSINNENDYNNGMCYW---------------LSDTPK----------------NID-- 164
            |.|.|..:....||.|.||:||.               |.:.|:                |||
Mouse   103 LACGPTVHQNCKENTYVNGLCYLFGSNLLRPPQQFPEALRECPQQESDIVFLIDGSGSINNIDFQ 167

  Fly   165 ------STEVMEKW------------------------------------PLR------------ 175
                  || |||::                                    |::
Mouse   168 KMKEFVST-VMEQFKKSKTLFSLMQYSDEFRIHFTFNDFKRNPSPRSHVSPIKQLNGRTKTASGI 231

  Fly   176 ----------------------------------IEKKQVLKLAD-TNLIPY------------- 192
                                              ::.|.|:..|| ..:|.|
Mouse   232 RKVVRELFHKTNGARENAAKILVVITDGEKFGDPLDYKDVIPEADRAGVIRYVIGVGNAFNKPQS 296

  Fly   193 ---------------------------------------------------YSMGELGLSAHVSD 206
                                                               :.|.:.|.||.::.
Mouse   297 RRELDTIASKPAGEHVFQVDNFEALNTIQNQLQEKIFAIEGTQTGSTSSFEHEMSQEGFSASITS 361

  Fly   207 DNSKLLMGAPGIDQWKGSVHL---KQEVPSIKTSSGRQRRGMNTNRKCNECNPEPKNFGQEEFSY 268
            :..  |:|:.|...|.|...|   |.:|..|           ||.|..::.|.          :|
Mouse   362 NGP--LLGSVGSFDWAGGAFLYTSKDKVTFI-----------NTTRVDSDMND----------AY 403

  Fly   269 FGYAVSSGYFDSSNLSTVL-------YVATAPRGNNQFGEAYIFDIYEDSIYKYHEFRGNHFGEY 326
            .|||           |.|:       .|..||| ....|...:|.....:...:...:|:..|.|
Mouse   404 LGYA-----------SAVILRNRVQSLVLGAPR-YQHIGLVVMFRENFGTWEPHTSIKGSQIGSY 456

  Fly   327 FGYSVLAEDLNGDGKTD-VIISAPLYALRNSYD---DGAIYVF-INKGS---FTFEERIIRSPAG 383
            ||.|:.:.|::.||.|: ::|.||.|     |:   .|.:.|. :.:|.   :..|..:......
Mouse   457 FGASLCSVDMDADGNTNLILIGAPHY-----YEKTRGGQVSVCPLPRGQRARWQCEALLHGDQGH 516

  Fly   384 SGGRFGTTLSRIGDINKDGYNDVAVGAP--FAGNGSVFIYLG-SENGLRDPPSQCLDAPSQQPSK 445
            ..||||..|:.:||:|.|...|||:|||  ....|:|:|:.| |...|....||.:......|
Mouse   517 PWGRFGAALTVLGDVNGDKLTDVAIGAPGEQENQGAVYIFYGASIASLSASHSQRIIGAHFSP-- 579

  Fly   446 YGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHAIIK--PK--LQNVNPEEE 506
             |...||..||.|.|:..:|..|.|:||..  .:.|.||.||:::.|.::  ||  .::|...:|
Mouse   580 -GLQYFGQSLSGGKDLTMDGLMDLAVGAQG--HLLLLRAQPVLRLEATMEFSPKKVARSVFACQE 641

  Fly   507 RV-------NITVCYRLSSKSDSKAKALMEQELVIRIDIDT-----KSKIKLAVFDEEHGSQMSF 559
            :|       .:.||.|:...:..:   |.|.::...:..|.     :|:|: |.|||...:...
Mouse   642 QVLKNKDAGEVRVCLRVRKNTKDR---LREGDIQSTVTYDLALDPGRSRIR-AFFDETKNNTRR- 701

  Fly   560 KAKAFH-EEICSEFQIEMDKRA--KFTPIALEMQYELSKKIPNSGDFCEDCAVVDPAEPKFVTEY 621
            :.:.|. .:.|...::.:....  ..:||.|.:.|.|..:...|.........:|  ..:|.|..
Mouse   702 RTQVFGLMQKCETLKLILPDCVDDSVSPIILRLNYTLVGEPLRSFGNLRPVLAMD--AQRFFTAM 764

  Fly   622 ITFNTGCATD-VCVADLKISCINAS--STLVLGTTAVLRLTYNITNNGEFAYHPKFSVTNSAGLS 683
            ..|...|..| :|..||.|: ::|.  .|||:|......::..:.|:||.:|..:.:|...:|||
Mouse   765 FPFEKNCGNDSICQDDLSIT-MSAMGLDTLVVGGPQDFNMSVTLRNDGEDSYGTQVTVYYPSGLS 828

  Fly   684 ----------LAQVPGNCKVNEA-----------VMVCDLNHGQRMAKGD-TDSLTISFDVRQLR 726
                      |.:.|...|..|:           ....::||....|..: |.::|...|.....
Mouse   829 YRKDSASQNPLTKKPWFVKPAESSSSSEGHGALKSTTWNINHPIFPANSEVTFNVTFDVDSHASF 893

  Fly   727 GRSLEIQAEVLSARDESNPENNKLTNVLSLREKADIYVSGVQTNDHVVLK-----ESPYTAEVVN 786
            |..|.::|.|.|..:.|.....|..  |.|..|..||:  :.|:|...::     .|..|::|:.
Mouse   894 GNKLLLKAIVASENNMSRTHKTKFQ--LELPVKYAIYM--IVTSDESSIRYLNFTASEMTSKVIQ 954

  Fly   787 Y-YEIKSHGPSTLENLTVSLYIPVAYKTPDSTNVKHIVTSSPKIQSKYAHKIMPINFIDQNNALA 850
            : |:..:.|..:|. ::|..:|||.                                       .
Mouse   955 HQYQFNNLGQRSLP-VSVVFWIPVQ---------------------------------------I 979

  Fly   851 NNFAI-DHDQSTLLFSATPQHENVGNLSGIVEQNPSISLLNEDLPVNNTLVLNCQDTNVTLCVPV 914
            ||..: ||.|  ::||     :|:.:.....:::|..|...:.|  ..|.||||   :|.:|..:
Mouse   980 NNVTVWDHPQ--VIFS-----QNLSSACHTEQKSPPHSNFRDQL--ERTPVLNC---SVAVCKRI 1032

  Fly   915 EIRLENGLQLKPEELMNMT----VSFTVNLKDADDIWEYFVIQTDLKVHKIGDPTLSSFTI---- 971
            :..|.:   ...:|:.|:|    :||...:|.:.. ....|..|::..:.      |:|.:
Mouse  1033 QCDLPS---FNTQEIFNVTLKGNLSFDWYIKTSHG-HLLLVSSTEILFND------SAFALLPGQ 1087

  Fly   972 --------EKKIESNVICKHAEIAIWKIIVSVIVGILVFSAATYALYKRGFFKRAIKDDLKQ 1025
                    |.|:|...:  |..:.:  |:.|.|.|:::.:..|..|||.|||||..||.:.:
Mouse  1088 ESYVRSKTETKVEPYEV--HNPVPL--IVGSSIGGLVLLALITAGLYKLGFFKRQYKDMMNE 1145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	24/80 (30%)
		Int_alpha	384..434	CDD:214549	21/52 (40%)
		Int_alpha	447..>492	CDD:214549	17/44 (39%)
		Integrin_alpha2	484..808	CDD:285619	83/373 (22%)
Itgam	NP_001076429.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	18..75		19/71 (27%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	76..135		14/73 (19%)
		vWA_integrins_alpha_subunit	149..324	CDD:238746	15/175 (9%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	339..390		12/52 (23%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	391..442		16/72 (22%)
		Int_alpha	453..>495	CDD:214549	16/46 (35%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	507..565		21/57 (37%)
		Int_alpha	517..>558	CDD:214549	18/40 (45%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	570..630		20/64 (31%)
		Int_alpha	582..>620	CDD:214549	16/39 (41%)
		Integrin_alpha2	615..1034	CDD:285619	104/482 (22%)
		Integrin_alpha	1131..1143	CDD:278771	8/11 (73%)
		GFFKR motif	1133..1137		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832069
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840