DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS4 and Itgal

DIOPT Version :9

Sequence 1:	NP_611025.2	Gene:	ItgaPS4 / 36693	FlyBaseID:	FBgn0034005	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	NP_001240801.1	Gene:	Itgal / 16408	MGIID:	96606	Length:	1162	Species:	Mus musculus

Alignment Length:	1263	Identity:	258/1263 - (20%)
Similarity:	426/1263 - (33%)	Gaps:	394/1263 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IVLLALQ--SEINAYNISPYPNSVLNFPELEGNRRSSYFGFSLVIREKSIMVAAPRANSSLEAQR 69
            ::||.||  ::..:||:...|..  :|....|.    :||:.::..|..::|.||....:
Mouse    10 LLLLGLQLFAKAWSYNLDTRPTQ--SFLAQAGR----HFGYQVLQIEDGVVVGAPGEGDN----- 63

  Fly    70 NISEPGVIFRCYFESGNNCSPYNIDTKGNYKGMPNDGLLTAKNKDFRWLGGAMDGGTRDSDK--F 132
                .|.::.|. .|...|.|.:               |...|...::||..:   ..|:.|  .
Mouse    64 ----TGGLYHCR-TSSEFCQPVS---------------LHGSNHTSKYLGMTL---ATDAAKGSL 105

  Fly   133 LVCAPRFYSINNENDYNNGMCY----------------------------WLSDTPKNIDSTEVM 169
            |.|.|......::|.|.:|:||                            :|.|..:::|..: .
Mouse   106 LACDPGLSRTCDQNTYLSGLCYLFPQSLEGPMLQNRPAYQECMKGKVDLVFLFDGSQSLDRKD-F 169

  Fly   170 EKWPLRIEKKQVLKLADTN-----------------LIPYYSMGE-----LG------------- 199
            || .|...|..:.||::|:                 .:.|....:     ||
Mouse   170 EK-ILEFMKDVMRKLSNTSYQFAAVQFSTDCRTEFTFLDYVKQNKNPDVLLGSVQPMFLLTNTFR 233

  Fly   200 ----LSAHV--------SDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGR------------ 240
                :.|||        .|....|::...|....||::....::.......|:
Mouse   234 AINYVVAHVFKEESGARPDATKVLVIITDGEASDKGNISAAHDITRYIIGIGKHFVSVQKQKTLH 298

  Fly   241 ---------------------------QRRGM---NTNRK-CNECNPEPKN-------------- 260
                                       |||..   .|||: ....|.|..:
Mouse   299 IFASEPVEEFVKILDTFEKLKDLFTDLQRRIYAIEGTNRQDLTSFNMELSSSGISADLSKGHAVV 363

  Fly   261 ------------------------FGQEEFS------YFGYAVSSGYFDSSNLSTVLYVATAPRG 295
                                    .|||..:      |.||.|:   :.:|..|..|..|.|||
Mouse   364 GAVGAKDWAGGFLDLREDLQGATFVGQEPLTSDVRGGYLGYTVA---WMTSRSSRPLLAAGAPR- 424

  Fly   296 NNQFGEAYIFDIYE--DSIYKYHEFRGNHFGEYFGYSVLAEDLNGDGKTD-VIISAPLYALRNSY 357
            ....|:..:|...|  ....:..:..|...|.|||..:.:.||:.||:.: ::|.|||:.  ...
Mouse   425 YQHVGQVLLFQAPEAGGRWNQTQKIEGTQIGSYFGGELCSVDLDQDGEAELLLIGAPLFF--GEQ 487

  Fly   358 DDGAIYVFINKGS-FTFEERIIRSPAGSGGRFGTTLSRIGDINKDGYNDVAVGAPFAGNGSVFIY 421
            ..|.::.:..:.| |.....:...|....||||..::.:.|||.|...|||||||....|:|:|:
Mouse   488 RGGRVFTYQRRQSLFEMVSELQGDPGYPLGRFGAAITALTDINGDRLTDVAVGAPLEEQGAVYIF 552

  Fly   422 LGSENGLRDPPSQCLDAPSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYP 486
            .|...||...|||.:......|   |...||..:....|:.|:...|..:||.....|...|  |
Mouse   553 NGKPGGLSPQPSQRIQGAQVFP---GIRWFGRSIHGVKDLGGDRLADVVVGAEGRVVVLSSR--P 612

  Fly   487 VVKIHAIIKPKLQNVNPEE-----------------ERVNITVCYRLSSKSDSKAKALMEQELVI 534
            ||.:...:     :.:|||                 ..|.:..|:|:...:......|: ..|..
Mouse   613 VVDVVTEL-----SFSPEEIPVHEVECSYSAREEQKHGVKLKACFRIKPLTPQFQGRLL-ANLSY 671

  Fly   535 RIDIDTKSKIKLAVF-DEEH---GSQMSFKAKA-----FHEEICSEFQIEMDKRAKFTPIALEMQ 590
            .:.:|........:| |..|   |:......|:     ||..||.:..|        :||.:.:.
Mouse   672 TLQLDGHRMRSRGLFPDGSHELSGNTSITPDKSCLDFHFHFPICIQDLI--------SPINVSLN 728

  Fly   591 YELSKKIPNSGDFCEDCAVVDPAEPKF--VTEYITFNTGCATD-VCVADLKISCINASSTLVLGT 652
            :.|.::.....|.....|:.....|..  ||:.|.|...|..| .|.|:|.:|....|..|.|.:
Mouse   729 FSLLEEEGTPRDQKVGRAMQPILRPSIHTVTKEIPFEKNCGEDKKCEANLTLSSPARSGPLRLMS 793

  Fly   653 TAVLRLTYNITNNGEFAYHPKFSVTNSAGLSLAQV---------PGNCKVNEAVMVCDLNHGQRM 708
            :|.|.:.:.::|:||.||..:..:....|||..:|         |.:|
Mouse   794 SASLAVEWTLSNSGEDAYWVRLDLDFPRGLSFRKVEMLQPHSRMPVSC----------------- 841

  Fly   709 AKGDTDSLTISFDVRQLRGRSLEIQAEVLSARDESNPENNKLTNVLSLREKADIYVSGVQTNDHV 773
                 :.||        .|.||                   ||..|.....:.|:.:|.:.:..|
Mouse   842 -----EELT--------EGSSL-------------------LTKTLKCNVSSPIFKAGQEVSLQV 874

  Fly   774 V---LKESPYT--AEVVNYYEIKSHGPSTLENLTVSLYIPVAYK----TPDSTNVKHIVTSSPK- 828
            :   |..|.:.  .|:......::...|..|:.:.:.:|||.|.    |.:..|....::.:||
Mouse   875 MFNTLLNSSWEDFVELNGTVHCENENSSLQEDNSAATHIPVLYPVNILTKEQENSTLYISFTPKG 939

  Fly   829 -----IQSKYAHKIMPINFIDQNNALANNFAIDHDQST---LLFSATPQHENVGNLSGIVEQNPS 885
                 :|..|..:|.|             .|.||:..|   |:....|..|:....:..|:.:|.
Mouse   940 PKTQQVQHVYQVRIQP-------------SAYDHNMPTLEALVGVPWPHSEDPITYTWSVQTDPL 991

  Fly   886 ISLLNEDL---------PVNNTLVLNCQDTNVTLCVPVEIRLE------NGLQLKPEELMNMTVS 935
            ::..:|||         |....:...|         |:..|.|      ..::|..|...:.|:|
Mouse   992 VTCHSEDLKRPSSEAEQPCLPGVQFRC---------PIVFRREILIQVTGTVELSKEIKASSTLS 1047

  Fly   936 FTVNLKDADDIWEYFVIQTDLKVHKIGDPTLSSFTIEKKIESNVICK----HAEIAIWKIIVSVI 996
            ...:|..:.:..::|        |..|         .|..|:.|:.|    |.:..:...::|.|
Mouse  1048 LCSSLSVSFNSSKHF--------HLYG---------SKASEAQVLVKVDLIHEKEMLHVYVLSGI 1095

  Fly   997 VGILVFSAATYALYKRGFFKRAIKDDLK 1024
            .|:::......||||.|||||.:|:.::
Mouse  1096 GGLVLLFLIFLALYKVGFFKRNLKEKME 1123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	22/74 (30%)
		Int_alpha	384..434	CDD:214549	22/49 (45%)
		Int_alpha	447..>492	CDD:214549	13/44 (30%)
		Integrin_alpha2	484..808	CDD:285619	70/366 (19%)
Itgal	NP_001240801.1	FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	444..504		16/61 (26%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	505..561		22/55 (40%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	565..625		15/69 (22%)
		GFFKR motif	1112..1116		3/3 (100%)
		FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	28..79		13/66 (20%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	80..138		14/75 (19%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	336..387		4/50 (8%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	390..443		16/56 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832047
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840