DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS4 and Itga7

DIOPT Version :9

Sequence 1:	NP_611025.2	Gene:	ItgaPS4 / 36693	FlyBaseID:	FBgn0034005	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	XP_030100775.1	Gene:	Itga7 / 16404	MGIID:	102700	Length:	1180	Species:	Mus musculus

Alignment Length:	1261	Identity:	294/1261 - (23%)
Similarity:	477/1261 - (37%)	Gaps:	369/1261 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AYNISPYPNSVLNFPELEGNRRSSYFGFSLVI------REKS-IMVAAPRANSSLEAQRNISEPG 75
            |:|:     .|:.....|| ...|.||||:.:      |.:| ::|.||:|.:....|.|  ..|
Mouse    33 AFNL-----DVMGAIRKEG-EPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQAN--RTG 89

  Fly    76 VIFRCYFE-SGNNCSPYNIDTKGNYKGMPNDGLLTAKNKDFRWLGGAM----DGGTRDSDKFLVC 135
            .:|.|... ...:|...:||...|         :..::|:.:|||.::    .||     |.:.|
Mouse    90 GLFACPLSLEETDCYRVDIDRGAN---------VQKESKENQWLGVSVRSQGPGG-----KIVTC 140

  Fly   136 APRFYS---INNENDYNN--GMCYWLSDTPKNIDSTEVMEKWPLRIEKKQVLKLADTNLIPYYSM 195
            |.|:.|   ::...:..:  |.|:.||......|..:..| |          |..:.....:...
Mouse   141 AHRYESRQRVDQALETRDVIGRCFVLSQDLAIRDELDGGE-W----------KFCEGRPQGHEQF 194

  Fly   196 G--ELGLSAHVSDDNSKLLMGAPGIDQWKGS-------------VHL----------KQEVPSIK 235
            |  :.|.:|..|.|:..|:.||||...|||:             .||          |::.|.:.
Mouse   195 GFCQQGTAATFSPDSHYLVFGAPGTYNWKGTARVELCAQGSPDLAHLDDGPYEAGGEKEQDPRLI 259

  Fly   236 TSSGRQRRGMNTNRKCNECNPEP---KNFGQEE-----------FSYFGYAVSS--GYFDSSNLS 284
            ........|:......:..:|:.   |.....:           .||.|:::.|  |...|..||
Mouse   260 PVPANSYLGLLFVTNIDSSDPDQLVYKTLDPADRLTGPAGDLTLNSYLGFSIDSGKGLMRSEELS 324

  Fly   285 TVLYVATAPRGNNQFGEAYIFDIYEDSIYKYHE---FRGNHFGEYFGYSVLAEDLNGDGKTDVII 346
               :||.|||.|:: |...|  :.:||..:...   ..|......||||:...|||.||..|:|:
Mouse   325 ---FVAGAPRANHK-GAVVI--LRKDSASRLIPEVVLSGERLTSGFGYSLAVTDLNNDGWADLIV 383

  Fly   347 SAPLYALRNSYDDGAIYVFINKGSFTFEERIIRSPAGSGGRFGTTLSRIGDINKDGYNDVAVGAP 411
            .||.:..|.....||:||::|:|....:...:|........||.:|:.:||:|:||:.|:|||||
Mouse   384 GAPYFFERQEELGGAVYVYMNQGGHWADISPLRICGSPDSMFGISLAVLGDLNQDGFPDIAVGAP 448

  Fly   412 FAGNGSVFIYLGSENGLRDPPSQCLDAPSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNA 476
            |.|:|.||||.||..|:...|||.|:..:     .|...||:.||.|.|:|||.:.|..:|: .|
Mouse   449 FDGDGKVFIYHGSSLGVVVKPSQVLEGEA-----VGIKSFGYSLSGGLDVDGNHYPDLLVGS-LA 507

  Fly   477 EAVYLYRAYPVVKI--HAIIKPK---LQNVNPEEER---VNITVCYRL----SSKSDSKAKALME 529
            :...|:||.||:.:  ...|.|:   |:..|..:.|   |:|.:|:..    ||.|.|.|...|
Mouse   508 DTAALFRARPVLHVSQEIFIDPRAIDLEQPNCADGRLVCVDIKICFSYVAVPSSYSPSVALDYM- 571

  Fly   530 QELVIRIDIDTKSKIK----------LAVFDEEHGSQMSFKAKAFHEEICSE--FQIEMDKRAKF 582
                  :|.||..:::          ..:.|..|.|..:...|..|:.:|.:  ||::.:.:.|.
Mouse   572 ------LDGDTDRRLRGQVPRVTFLSRGLDDLRHQSSGTVWLKHQHDRVCGDTVFQLQENVKDKL 630

  Fly   583 TPIALEMQY-----ELSKKIPNSGDFCEDCAVVDPA----EPKFV-TEYITFNTGCATD-VCVAD 636
            ..|.:.:.|     .|.::.|.     ::...|.|.    :|... ||......||..| :|.::
Mouse   631 RAIVVTLSYGLRTPPLGRQAPG-----QELPTVAPILNAHQPSTQRTEIHFLKQGCGEDKICQSN 690

  Fly   637 LKIS----CINASST----LVL---GTTAVLRLT--------YNITN----------NGEFAYHP 672
            |::.    |...|.|    |.:   |.||:..|:        ..:||          :|:.|:..
Mouse   691 LQLERYQFCSRISDTEFQALPMDLDGRTALFALSGQPFIGLELTVTNLPSDPARPQADGDDAHEA 755

  Fly   673 KFSVTNSAGLSLAQVPG-------NCKVNEAVMVCDLNHGQRMAKG---------DTDSLTISFD 721
            :..||..|.|..:.|..       .|..|::....:...|..|.:|         .|..:||
Mouse   756 QLLVTLPASLRYSGVRALDSVEKPLCLSNDSASHVECELGNPMKRGAQVTFYLILSTSGITI--- 817

  Fly   722 VRQLRGRSLEIQAEVLSA---RDESNPENNKLTNVLSLREKADIYVSGVQTNDHVVLKESPYTAE 783
                  .:.|::.::|.|   ..|.:|.:.:....:.|    .:.:|||.|...:.     ::.|
Mouse   818 ------ETTELEVKLLLATISEQELDPVSVRAHVFIEL----PLSISGVATPQQLF-----FSGE 867

  Fly   784 VVNYYEIKSHGPSTLENLTVSLYIPVAYKTPDSTNVKHIVTSSPKIQSKYAHKIMPINFIDQNNA 848
            |        .|.|.:.:           :....:.||:.||.|.:.||.              |.
Mouse   868 V--------KGESAMRS-----------ERDVGSKVKYEVTVSNQGQSL--------------NT 899

  Fly   849 LAN---NFAIDHDQST---LLFSATPQHENVG---NLSGIVEQNPSISLLNED------------ 892
            |.:   |....|:.:.   ||:....:.|. |   ...||....|:|..|:.|
Mouse   900 LGSAFLNIMWPHEIANGKWLLYPMRVELEG-GQGPGKRGICSPRPNILQLDVDSRDRRRRELGQP 963

  Fly   893 ---------------LPVNNTLVLNCQDTNVTL--------CV----PV---------------- 914
                           .||:     :.:..||||        ||    |:
Mouse   964 EPQEPPEKVEPSTSWWPVS-----SAEKRNVTLDCAQGTAKCVVFSCPLYSFDRAAVLHVWGRLW 1023

  Fly   915 -EIRLENGLQLKPEELM---NMTVSFTVN---LKDADDIWEYFVIQTDLKVHKIGDPTLSSFTIE 972
             ...||..:.:|..|::   |:||..::.   |:||..:....|....:.|...|.|.
Mouse  1024 NSTFLEEYMAVKSLEVIVRANITVKSSIKNLLLRDASTVIPVMVYLDPMAVVVEGVPW------- 1081

  Fly   973 KKIESNVICKHAEIAIWKIIVSVIVGILVFSAATYALYKRGFFKRA---------------IKDD 1022
                            |.|:::|:.|:||.:.....|:|.||||||               .::|
Mouse  1082 ----------------WVILLAVLAGLLVLALLVLLLWKLGFFKRAKHPEATVPQYHAVKIPRED 1130

  Fly  1023 LKQLIRDSFEDGIIRTEMEENAQSQG 1048
            .:|...:  :.|.|:.....|:|.:|
Mouse  1131 RQQFKEE--KTGTIQRSNWGNSQWEG 1154

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	26/72 (36%)
		Int_alpha	384..434	CDD:214549	25/49 (51%)
		Int_alpha	447..>492	CDD:214549	18/46 (39%)
		Integrin_alpha2	484..808	CDD:285619	82/406 (20%)
Itga7	XP_030100775.1	Int_alpha	48..109	CDD:214549	17/62 (27%)
		Int_alpha	304..355	CDD:214549	18/56 (32%)
		Int_alpha	362..415	CDD:214549	20/52 (38%)
		Int_alpha	421..473	CDD:214549	27/51 (53%)
		Int_alpha	483..>523	CDD:214549	17/40 (43%)
		Integrin_alpha2	515..1005	CDD:369878	111/558 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832042
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740