Protein Alignment ItgaPS4 and Itga5

DIOPT Version :10

• Sequence 1: NP_611025.2
• Gene: ItgaPS4 / 36693
• FlyBaseID: FBgn0034005
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: NP_034707.5
• Gene: Itga5 / 16402
• MGIID: 96604
• Length: 1053
• Species: Mus musculus
• Alignment Length: 1139
• Identity: 281/1139 - (24%)
• Similarity: 466/1139 - (40%)
• Gaps: 259/1139 - (22%)

  Fly     5 LVIVLLALQSEINAYNISPYPNSVLNFPELEGNRRSSYFGFSLVIREK-----SIMVAAPRANSS 64
            |:::|.....::..:|:.....:||:.|.      .|.||||:.....     |::|.||:||:|
Mouse    31 LLLLLWPPPLQVGGFNLDAEAPAVLSGPP------GSLFGFSVEFYRPGRDGVSVLVGAPKANTS 89

  Fly    65 LEAQRNISEPGVIFRC-YFESGNNCSPYNIDTKGNYKGMPNDGLLTAKN------KDFRWLGGAM 122
               |..:.:.|.::.| :..|...|:....|:||:  .:....|.:||.      |..:|.|..:
Mouse    90 ---QPGVLQGGAVYVCPWGTSPIQCTTIQFDSKGS--RILESSLYSAKGEEPVEYKSLQWFGATV 149

  Fly   123 DGGTRDSDKFLVCAPRFYSINNENDYNN---GMCYWLSDTPKNIDSTEVMEKWPLRIEKKQVLKL 184
               .......|.||| .||...|.|..|   |.||..::     :.|.::|..|.|.:.......
Mouse   150 ---RAHGSSILACAP-LYSWRTEKDPQNDPVGTCYLSTE-----NFTRILEYAPCRSDFGSAAGQ 205

  Fly   185 ADTNLIPYYSMGELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQR-----RG 244
            .       |..|  |.||..: ...::::|.||...|:|.: |......|..|...:.     :|
Mouse   206 G-------YCQG--GFSAEFT-KTGRVVLGGPGSYFWQGQI-LSATQEQISESYYPEYLINPVQG 259

  Fly   245 MNTNRKCNECNPEPKNFGQEEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYE 309
            ....|:.:....:         ||.||:|:.|.|...:  |..:||..|:||..:|  |:..:..
Mouse   260 QLQTRQASSVYDD---------SYLGYSVAVGEFSGDD--TEDFVAGVPKGNLTYG--YVTVLNG 311

  Fly   310 DSIYKYHEFRGNHFGEYFGYSVLAEDLNGDGKTDVIISAPLYALRNS----YDDGAIYVFINKGS 370
            ..|:..:...|.....||||:|.|.|.||||..|:::.|||...|.:    .:.|.:|:::.:
Mouse   312 SDIHSLYNVSGEQMASYFGYAVAATDTNGDGLDDLLVGAPLLMERTADGRPQEVGRVYIYLQR-- 374

  Fly   371 FTFEERIIRSPAG---------SG----GRFGTTLSRIGDINKDGYNDVAVGAPFAG---NGSVF 419
                      |||         :|    .|||::|:.:||:::|||||||:||||.|   .|.||
Mouse   375 ----------PAGIDPTPTLTLTGQDEFSRFGSSLTPLGDLDQDGYNDVAIGAPFGGEAQQGVVF 429

  Fly   420 IYLGSENGLRDPPSQCLD---APSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYL 481
            |:.|...||...|||.|.   |..:.|..:||.:.|     |.|:||||:.|..:|:...:...:
Mouse   430 IFPGGPGGLSTKPSQVLQPLWAAGRTPDFFGSALRG-----GRDLDGNGYPDLIVGSFGVDKALV 489

  Fly   482 YRAYPVVKIHAIIKPKLQNVNPEEER----------VNITVCYRLSSKSDSKAKALMEQELVIRI 536
            ||..|::...|.:.......||||..          :|::.|...|.|....:...   |:.:::
Mouse   490 YRGRPIISASASLTIFPSMFNPEERSCSLEGNPVSCINLSFCLNASGKHVPNSIGF---EVELQL 551

  Fly   537 DID-TKSKIKLAVF--DEEHGSQMSFKAKAFHEEICSEFQI----EMDKRAKFTPIALEMQYELS 594
            |.. .|..::.|:|  .::.....:...:....|.|.|.:|    |.:.|.|.:||.:.:.:.|.
Mouse   552 DWQKQKGGVRRALFLTSKQATLTQTLLIQNGAREDCREMKIYLRNESEFRDKLSPIHIALNFSLD 616

  Fly   595 KKIP------------NSGDFCEDCA--VVDPAEPKFVTEYITFNTGCATD-VCVADLKISCINA 644
            .|.|            .|....||.|  ::|                |..| :||.||::.....
Mouse   617 PKAPMDSHGLRPVLHYQSKSRIEDKAQILLD----------------CGEDNICVPDLQLDVYGE 665

  Fly   645 SSTLVLGTTAVLRLTYNITNNGE-FAYHPKFSVT---NSAGLSLAQVPGN-----C---KVNEA- 696
            ...:.||....|.||::..|.|| .||..:..||   .:....|.:.|||     |   .||::
Mouse   666 KKHVYLGDKNALNLTFHAQNLGEGGAYEAELRVTAPLEAEYSGLVRHPGNFSSLSCDYFAVNQSR 730

  Fly   697 VMVCDLNHGQRMAKGDTDSLTISFDVRQLRG--RSLEIQAEVLSARDESNPENNKLTNVLSLREK 759
            .:||||  |..|..|.:....:.|.|..|:.  ::::...::|| ::.:|.::|.::..||:..:
Mouse   731 QLVCDL--GNPMKAGTSLWGGLRFTVPHLQDTKKTIQFDFQILS-KNLNNSQSNVVSFPLSVEAQ 792

  Fly   760 ADIYVSGVQTNDHVVL------------KESPYTAEVVNYYEIKSHGPSTLENLTVSLYIPVAYK 812
            |.:.::||...:.|:.            ||......|.:.||:.:.|||::....:.|..|.|.:
Mouse   793 AQVSLNGVSKPEAVIFPVSDWNPQDQPQKEEDLGPAVHHVYELINQGPSSISQGVLELSCPQALE 857

  Fly   813 TPDSTNVKHIVTSSPKIQSKYAHKIMPINFIDQNNALANNFAIDHDQSTLLFSATPQHENVGNLS 877
            ..               |..|..|:..::.. .:|...|:..::.|..|     :|.|
Mouse   858 GQ---------------QLLYVTKVTGLSNC-TSNYTPNSQGLELDPET-----SPHH------- 894

  Fly   878 GIVEQNPSISLLNEDLP-----VNNTLVLNCQDTNVTLCVPVEIRLENGLQLKPEELMNMTVSFT 937
                      |...:.|     .:.|.||.|.:..   |  ..:|.|.| .|..:|..::.:.|.
Mouse   895 ----------LQKREAPGRSSTASGTQVLKCPEAK---C--FRLRCEFG-PLHRQESRSLQLHFR 943

  Fly   938 VNLK------------DADDIWE-----YFVIQTDLKVHKIGDPTLSSFTIEKKIESNVICKHAE 985
            |..|            ..:.::|     |.::...|...|:...|...:|  |...||      .
Mouse   944 VWAKTFLQREYQPFSLQCEAVYEALKMPYQILPRQLPQKKLQVATAVQWT--KAEGSN------G 1000

  Fly   986 IAIWKIIVSVIVGILVFSAATYALYKRGFFKRAI 1019
            :.:|.||::::.|:|:.....|.|||.|||||::
Mouse  1001 VPLWIIILAILFGLLLLGLLIYVLYKLGFFKRSL 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	FG-GAP_3	335..408	CDD:433275	28/89 (31%)
		Int_alpha	384..434	CDD:214549	27/56 (48%)
		Int_alpha	447..>492	CDD:214549	14/44 (32%)
		Integrin_alpha2	486..808	CDD:462478	86/380 (23%)
Itga5	NP_034707.5	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	46..111		20/73 (27%)
		Int_alpha	59..117	CDD:214549	17/66 (26%)
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	131..191		18/68 (26%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	196..248		13/62 (21%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	262..314		16/64 (25%)
		Int_alpha	271..>313	CDD:214549	15/54 (28%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	315..380		22/76 (29%)
		Int_alpha	325..382	CDD:214549	21/68 (31%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	381..440		26/58 (45%)
		Int_alpha	392..446	CDD:214549	28/53 (53%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	444..507		19/67 (28%)
		Int_alpha	458..510	CDD:214549	15/56 (27%)
		Integrin_alpha2	493..925	CDD:462478	104/496 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	879..910		7/52 (13%)
		GFFKR motif. /evidence=ECO:0000305	1024..1028		3/3 (100%)
		Interaction with HPS5. /evidence=ECO:0000250|UniProtKB:P08648	1025..1032		5/6 (83%)