Protein Alignment ItgaPS4 and Itga4

DIOPT Version :9

• Sequence 1: NP_611025.2
• Gene: ItgaPS4 / 36693
• FlyBaseID: FBgn0034005
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: NP_034706.3
• Gene: Itga4 / 16401
• MGIID: 96603
• Length: 1032
• Species: Mus musculus
• Alignment Length: 1127
• Identity: 275/1127 - (24%)
• Similarity: 473/1127 - (41%)
• Gaps: 261/1127 - (23%)

  Fly    17 NAYNISPYPNSVLNFPELEGNRRSSYFGFSLVIR----EKSIMVAAPRANSSLEAQRNISEPGVI 77
            ::||:.| .|::|    .:| ...:.||:|:|:.    ::.::|.||.|  |..:..::..||.|
Mouse    32 HSYNLDP-ENALL----YQG-PSGTLFGYSVVLHSHGSKRWLIVGAPTA--SWLSNASVVNPGAI 88

  Fly    78 FRCYFESGNN--CSPYNIDTKGNYKGMPNDGLLTAKNKDFRWLGGAMDGGTRDSDKFLVCAPRFY 140
            :||......|  |....:   |:..|.| .|....:.:|.:|||..:.....::...:.|..|:.
Mouse    89 YRCGIRKNPNQTCEQLQL---GSPSGEP-CGKTCLEERDNQWLGVTLSRQPGENGSIVTCGHRWK 149

  Fly   141 SI---NNENDYNNGMCYWLSDTPKNIDSTEVMEKWPLRIEKKQVLKLADTNLIPYY-----SMGE 197
            :|   .::|....|:||.:   |.:: .||:.::                 :.|.|     ..||
Mouse   150 NIFYMKSDNKLPTGICYVM---PSDL-RTELSKR-----------------MAPCYKDYTRKFGE 193

  Fly   198 ------LGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSS-----GRQRRGMNTNRKC 251
                  .|:|:..:.|  .::|||||...|.|:|.    |.:|.|:.     .||.:
Mouse   194 NFASCQAGISSFYTQD--LIVMGAPGSSYWTGTVF----VYNITTNQYKAFVDRQNQ-------- 244

  Fly   252 NECNPEPKNFGQEEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYEDSIYKYH 316
                   ..||    ||.||:|.:|:|.|.:.:.|  |..||: :.|.|:||||.|.|:.:...:
Mouse   245 -------VKFG----SYLGYSVGAGHFRSPHTTEV--VGGAPQ-HEQIGKAYIFSIDENELNIVY 295

  Fly   317 EFRGNHFGEYFGYSVLAEDLNGDGKTDVIISAPLYA-LRNSYDDGAIYVFINKGS---FTFEERI 377
            |.:|...|.|||.||.|.|||.||.:|:::.||:.: :|   ::|.::|:||.|.   ....||:
Mouse   296 EMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIR---EEGRVFVYINSGMGAVMVEMERV 357

  Fly   378 IRSPAGSGGRFGTTLSRIGDINKDGYNDVAVGAPFAGN--GSVFIYLGSENGLRDPPSQCLDAPS 440
            :........|||.:::.:|||:.||:.|:|:|||...:  |:|:||.|..:|:....||.::  .
Mouse   358 LVGSDKYAARFGESIANLGDIDNDGFEDIAIGAPQEDDLRGAVYIYNGRVDGISSTYSQRIE--G 420

  Fly   441 QQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHAIIKPKLQNVNPEE 505
            ||.|| ...|||..:|...|.|.||:.|.|:||..:::..|.|..|||.:.|.:.      :||.
Mouse   421 QQISK-SLRMFGQSISGQIDADNNGYVDVAVGAFQSDSAVLLRTRPVVIVEASLS------HPES 478

  Fly   506 ERVNIT-----------VCYRLSSKSDSKAKALMEQELV---IRIDIDTKSKIKLAVFDEEHGSQ 556
              ||.|           ||..|:.....|.|.:....::   :.:|:..|::.....:...:|:.
Mouse   479 --VNRTKFDCTENGLPSVCMHLTLCFSYKGKEVPGYIVLFYNVSLDVHRKAESPSRFYFFSNGTS 541

  Fly   557 ----MSFKAKAFHEEICSEFQIEM--DKRAKFTPIALEMQYELSKKI---PNSGDFCEDCAVVDP 612
                .|.:..:..|: |...|..|  |.|...|||.:|..|.|...:   .|:.:|       .|
Mouse   542 DVITGSIRVSSSGEK-CRTHQAFMRKDVRDILTPIHVEATYHLGHHVITKRNTEEF-------PP 598

  Fly   613 AEP--------KFVTEYITFNTGCATDVCVADLKISC-------INASSTLVLGTTAVLRLTYNI 662
            .:|        ..:.:.|.|...||.:.|.|||::|.       ....:.|.:|:...:.|..::
Mouse   599 LQPILQQKKEKDVIRKMINFARFCAYENCSADLQVSAKVGFLKPYENKTYLAVGSMKTIMLNVSL 663

  Fly   663 TNNGEFAYHPKFSVTNSAG------LSLAQVPGNCKVNEA----VMVCDLN--HGQRMAKGDTDS 715
            .|.|:.||....:|....|      |.|.:...||:|.|:    .:.|.|.  :..|:::.|
Mouse   664 FNAGDDAYETTLNVQLPTGLYFIKILDLEEKQINCEVTESSGIVKLACSLGYIYVDRLSRID--- 725

  Fly   716 LTISF--DVRQL----RGRSLEIQAEVLSARDESNPENNKLTNVLSLREKADIYVSGVQTNDHVV 774
              |||  ||..|    ...|:.:.|...:..:.....:|::|..:.||.:..:.|.|:......|
Mouse   726 --ISFLLDVSSLSRAHEDLSISVHASCENEGELDQVRDNRVTLTIPLRYEVMLTVHGLVNPTSFV 788

  Fly   775 LKES----PYT--AEVVNY-YEIKSHGPSTLENLTVSLYIPVAYKTPDST--NVKHIVTSSPKIQ 830
            ...|    |.|  ||.:|. :.:.:.|.|...|::|.:.:|.::...|..  ||..:.|::.  |
Mouse   789 YGSSEENEPETCMAEKLNLTFHVINTGISMAPNVSVKIMVPNSFLPQDDKLFNVLDVQTTTG--Q 851

  Fly   831 SKYAHKIMPINFIDQNNALANNFAIDHDQSTLLFSATPQHENVGNLSGIVEQNPSISLLNEDLPV 895
            ..:.|......|..|...                        .|.|:.||:
Mouse   852 CHFKHYGRECTFAQQKGI------------------------AGTLTDIVK-------------- 878

  Fly   896 NNTLVLNCQDTNVTLCVPVEI----------RLENGLQLKPEELMNMTVSFTVNLKDADDIWEYF 950
                .|:..|..:..|:..:.          ::|:|    .|..:::.:....::.:.|   |..
Mouse   879 ----FLSKTDKRLLYCMKADQHCLDFLCNFGKMESG----KEASVHIQLEGRPSILEMD---ETS 932

  Fly   951 VIQTDLKVHKIGDPTLSSFTIEKKIESNVI------------CKHAEIAIWKIIVSVIVGILVFS 1003
            .::.::|.....:|  ....||...:.||.            .:|..|.|  |.:|:::|::|..
Mouse   933 SLKFEIKATAFPEP--HPKVIELNKDENVAHVFLEGLHHQRPKRHFTIII--ITISLLLGLIVLL 993

  Fly  1004 AATYALYKRGFFKRAIKDDLKQ 1025
            ..:..::|.|||||..|..|::
Mouse   994 LISCVMWKAGFFKRQYKSILQE 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	25/76 (33%)
		Int_alpha	384..434	CDD:214549	19/51 (37%)
		Int_alpha	447..>492	CDD:214549	17/44 (39%)
		Integrin_alpha2	484..808	CDD:285619	87/386 (23%)
Itga4	NP_034706.3	Int_alpha	48..105	CDD:214549	16/58 (28%)
		Int_alpha	303..351	CDD:214549	21/50 (42%)
		Int_alpha	366..418	CDD:214549	21/51 (41%)
		Int_alpha	429..479	CDD:214549	20/57 (35%)
		Integrin_alpha2	463..902	CDD:285619	103/503 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832079
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.800