DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS4 and Itga2b

DIOPT Version :9

Sequence 1:	NP_611025.2	Gene:	ItgaPS4 / 36693	FlyBaseID:	FBgn0034005	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	NP_034705.2	Gene:	Itga2b / 16399	MGIID:	96601	Length:	1033	Species:	Mus musculus

Alignment Length:	1117	Identity:	280/1117 - (25%)
Similarity:	463/1117 - (41%)	Gaps:	236/1117 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ALQSEINAYNISPYPNSVLNFPELEGNRRSSYFGFSLVIREK-----SIMVAAPRA-NSSLEAQR 69
            ||..:...:::...||             .|:||||:...:.     ||:|.|||| |:|.|
Mouse    31 ALNLDSEKFSVYAGPN-------------GSHFGFSVDFHKDKHGSVSIVVGAPRALNASQE--- 79

  Fly    70 NISEPGVIFRCYFE-SGNNCSPYNIDTKGNYKGMPNDGLLTAKNKDFRWLGGAMDGGTRDSDKFL 133
               |.|.:|.|.:: :|..|:|...|.:...:.:......|.|..  :.||.::   ...:|..:
Mouse    80 ---ETGAVFLCPWKANGGKCNPLLFDLRDETRNLGFQIFQTFKTG--QGLGASV---VSWNDVIV 136

  Fly   134 VCAP-RFYSINNENDYNN----GMCYW----------LSDTPKNIDSTEVMEKWPLRIEKKQVLK 183
            .||| :.:::..:.|...    |.|:.          .|....|..|:...|.:  |.:|:..
Mouse   137 ACAPWQHWNVLEKRDEAEKTPVGGCFLAQLQSGGRAEYSPCRANTMSSVYAESF--RGDKRYC-- 197

  Fly   184 LADTNLIPYYSMGELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGM--- 245
                         |.|.|..|: ...:|::||||...:.|   |...|| |:......|.|.
Mouse   198 -------------EAGFSLAVT-QAGELVLGAPGGYFFLG---LLARVP-IENIISSYRPGTLLW 244

  Fly   246 -NTNRKCNECNPEPKNFGQEEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYE 309
             .:|::....|..|..|.    .|.||:|:.|.|| .:.||..||:.||..:...|...|.|.|.
Mouse   245 HVSNQRFTYDNSNPVFFD----GYRGYSVAVGEFD-GDPSTTEYVSGAPTWSWTLGAVEILDSYY 304

  Fly   310 DSIYKYHEFRGNHFGEYFGYSVLAEDLNGDGKTDVIISAPLY----ALRNSYDDGAIYVFIN-KG 369
            ..:::.|   |.....|||:||...|:||||:.|:::.||||    |.|...:.|.:|:|:. ||
Mouse   305 QPLHRLH---GEQMASYFGHSVAVTDVNGDGRHDLLVGAPLYMESRADRKLAEVGRVYLFLQPKG 366

  Fly   370 SFTFEERIIRSP----AGSG--GRFGTTLSRIGDINKDGYNDVAVGAPF---AGNGSVFIYLGSE 425
                 .:.:.:|    .|:.  ||||:.::.:||:|:|||||:||.||:   :|.|.|.|:||..
Mouse   367 -----PQALSTPTLLLTGTQLYGRFGSAIAPLGDLNRDGYNDIAVAAPYGGPSGQGQVLIFLGQS 426

  Fly   426 NGLRDPPSQCLDAPSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVV-- 488
            .||...|||.||:|.  |:..|   ||..|....|||.||:.|..:||..|..|.:|||.|||
Mouse   427 EGLSPRPSQVLDSPF--PTGSG---FGFSLRGAVDIDDNGYPDLIVGAYGASKVAVYRAQPVVMA 486

  Fly   489 ----KIHAIIKPKLQNVNPEEERV-----NITVC-----YRLSSKSDSKAKALMEQELVIRIDID 539
                .:...:.|.|:|...::.:.     ||.:|     :.:..|...||      ||.:.:...
Mouse   487 TVQLMVQDSLNPTLKNCVLDQTKTPVSCFNIQMCVGATGHNIPQKLHLKA------ELQLDLQKP 545

  Fly   540 TKSKIKLAVFDEEHGSQMSFKAKAFHEEIC----SEFQIEMDKRAKFTPIALEMQYELSKKIPNS 600
            .:.:..|.:..::....:|.......:.||    :..:.|.|.|.|.:||.|.:...|..:....
Mouse   546 RQGRRVLLLASQQASLTLSLDLGGRDKPICHTTGAFLRDEADFRDKLSPIVLSLNVSLPPEETGG 610

  Fly   601 GDFCEDCAVVDPAEPKFVTEYITFNTGCA-TDVCVADLKISCINASSTLVLGTTAVLRLTYNITN 664
            ..     |||...| ..|.|.......|. .|:||..|:::.....|.|::|...||.|.....|
Mouse   611 AP-----AVVLHGE-THVQEQTRIILDCGEDDLCVPQLRLTATAGDSPLLIGADNVLELKIEAAN 669

  Fly   665 NGEFAYHPKFSVTNSAGL----SLAQVPG-------NCKVNEA-VMVCDLNHGQRMAKGDTDSLT 717
            :||.||..:.:|....|.    :|:.:.|       ..|.||: |.:|:|  |..|.|.....:|
Mouse   670 DGEGAYEAELAVHLPPGAHYMRALSNIEGFERLVCTQKKENESRVALCEL--GNPMKKDTRIGIT 732

  Fly   718 ISFDVRQLR--GRSLEIQAEVLSARDESNPENNKLTNVLSLREKADIYVSG----------VQTN 770
            :...|..|.  |.|:..|.:|.| ::..||.:..:...::::.:|.:.:.|          .:..
Mouse   733 MLVSVENLEEAGESVSFQLQVRS-KNSQNPNSKVVMLPVAIQAEATVELRGNSFPASLVVAAEEG 796

  Fly   771 DHVVLKESPYTAEVVNYYEIKSHGPSTLENLTVSLYIPVAYKTPDSTNVKHIVTSSPKIQSKYAH 835
            |........:.:.:.:.||:.:.||.|:..|.:.::||...:..|   :.:|:...|
Mouse   797 DREQEDLDRWVSRLEHTYELHNIGPGTVNGLRLLIHIPGQSQPSD---LLYILDVQP-------- 850

  Fly   836 KIMPINFIDQNNALANNFAIDHDQSTLLFSATPQHENVGNLSGIVEQNPSISLLNEDLPVN---- 896
                                   |..||.|..|..:....||     .||.|.:.   ||:
Mouse   851 -----------------------QGGLLCSTQPSPKVDWKLS-----TPSPSSIR---PVHHQRE 884

  Fly   897 --------------NTLVLNCQDTNVTLCVPVEIRLENGLQLKPEELMNMTVSFTVNLKD-ADDI 946
                          :.::::|..:  ..|..||..|..  .::.:..| :||...:.|.. ....
Mouse   885 RRQAFLQGPKPGQQDPVLVSCDGS--ASCTVVECELRE--MVRGQRAM-VTVQVMLGLSSLRQRP 944

  Fly   947 WEYFVIQT----DLKVHKIGDPTLSSFTIEKKIESNVI--CKHAEIAIWKIIVSVIVGILVFSAA 1005
            .|.||:|:    ::.......|.:|..:.:.::::.::  .:...|.:|.::|.|:.|:|:.:..
Mouse   945 QEQFVLQSHAWFNVSSLPYSVPVVSLPSGQARVQTQLLRALEERAIPVWWVLVGVLGGLLLLTLL 1009

  Fly  1006 TYALYKRGFFKR 1017
            ..|::|.|||||
Mouse  1010 VLAMWKAGFFKR 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	31/83 (37%)
		Int_alpha	384..434	CDD:214549	25/54 (46%)
		Int_alpha	447..>492	CDD:214549	20/50 (40%)
		Integrin_alpha2	484..808	CDD:285619	81/368 (22%)
Itga2b	NP_034705.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	35..96		22/79 (28%)
		Int_alpha	46..102	CDD:214549	23/74 (31%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	109..173		11/68 (16%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	184..237		17/74 (23%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	252..304		19/56 (34%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	305..370		24/72 (33%)
		Int_alpha	315..366	CDD:214549	20/50 (40%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	372..431		26/58 (45%)
		Int_alpha	383..437	CDD:214549	27/53 (51%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	434..495		26/65 (40%)
		Int_alpha	444..>484	CDD:214549	18/42 (43%)
		Integrin_alpha2	480..916	CDD:285619	101/494 (20%)
		GFFKR motif	1017..1021		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832073
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740