DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS4 and Itga2

DIOPT Version :9

Sequence 1:	NP_611025.2	Gene:	ItgaPS4 / 36693	FlyBaseID:	FBgn0034005	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	NP_032422.2	Gene:	Itga2 / 16398	MGIID:	96600	Length:	1178	Species:	Mus musculus

Alignment Length:	905	Identity:	226/905 - (24%)
Similarity:	391/905 - (43%)	Gaps:	197/905 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 MGELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGMNTNRKCNECNPEPK 259
            |.::|.||..:..|..|::||.|...|.|::                         ..|.:.:|.
Mouse   375 MAQVGFSADYAPQNDILMLGAVGAFDWSGTL-------------------------VQETSHKPV 414

  Fly   260 NFGQEEF----------SYFGYAVSSGYFDSSNLST---VLYVATAPRGNNQFGEAYIFDIYED- 310
            .|.::.|          |:.||:|::       :||   |.:||.|||. |..|:..::.:.:.
Mouse   415 IFPKQAFDQVLQDRNHSSFLGYSVAA-------ISTEDGVHFVAGAPRA-NYTGQIVLYSVNKQG 471

  Fly   311 --SIYKYHEFRGNHFGEYFGYSVLAEDLNGDGKTDV-IISAPLYALRNSYDDGAIYVF-INKGSF 371
              ::.:.|  ||:..|.|||..:.:.|::.|..||| ::.||.|......::|.:|:| |.||..
Mouse   472 NVTVIQSH--RGDQIGSYFGSVLCSVDVDKDTITDVLLVGAPTYMNDLKKEEGKVYLFTITKGIL 534

  Fly   372 TFEERIIRSPAGSG-GRFGTTLSRIGDINKDGYNDVAVGAPF--AGNGSVFIYLGSENGLRDPPS 433
            . :.:.:..|.|:| .|||:.::.:.|||.||:|||.||:|.  ..:|:|:||.|.:..:|...|
Mouse   535 N-QHQFLEGPEGTGNARFGSAIAALSDINMDGFNDVIVGSPVENENSGAVYIYNGHQGTIRTKYS 598

  Fly   434 QCLDAPSQQPSKYGSY-----MFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLY-RAYPVVKIHA 492
            |.:...:      |::     .||..|....|::|:...|.:||| ..:.:.|: ::...|.|.|
Mouse   599 QKILGSN------GAFRRHLQFFGRSLDGYGDLNGDSITDVSIGA-LGQVIQLWSQSIADVAIEA 656

  Fly   493 IIKPKLQNVNPEEERVNITVCYRLSSK---SDSKAKALMEQELVIRIDIDTKSK--IKLAVFDEE 552
            :..|....:..::.::.:.:|:|...:   .:::...|....|    |.|..|.  ....|| .|
Mouse   657 LFTPDKITLLNKDAKITLKLCFRAEFRPAGQNNQVAILFNMTL----DADGHSSRVTSRGVF-RE 716

  Fly   553 HGSQMSFKAKAFHE-EICSEFQIEMDKRAKFTPIALEMQYELSKKIPNSGDFCEDCAVVDPAEPK 616
            :..:...|....:| :.|||..|.:.|.:.... .|:::.::|.:.|.:....|       |..:
Mouse   717 NSERFLQKNMVVNEVQKCSEHHISIQKPSDVVN-PLDLRVDISLENPGTSPALE-------AYSE 773

  Fly   617 FVTEY-ITFNTGCATD-VCVADL-----KISCINASSTLVLGTTAVLRLTYNI--TNNGEFAYHP 672
            .|..: |.|...|.:| :|::||     ::..|...|.:|.....  |||:::  .|.||.||:.
Mouse   774 TVKVFSIPFYKECGSDGICISDLILDVQQLPAIQTQSFIVSNQNK--RLTFSVILKNRGESAYNT 836

  Fly   673 KFSVTNSAGLSLAQ----VPG---NCKV--NEAVMVCDLNHGQRMAKGDTD-SLTISFD--VRQL 725
            ......|..|..|.    |.|   .|:|  ::..:.||:  |....|.:.. :.||:||  ::.|
Mouse   837 VVLAEFSENLFFASFSMPVDGTEVTCEVGSSQKSVTCDV--GYPALKSEQQVTFTINFDFNLQNL 899

  Fly   726 RGRSLEIQAEVLSARDESNPENNKLTNVLSLREKADIYVSGVQTNDHVVLKESPYTAEVVNYYEI 790
            :.:: .|..:..|...|:|..:|.::..:.|...|:::::. .||              :|:|||
Mouse   900 QNQA-AINFQAFSESQETNKADNSVSLTIPLLYDAELHLTR-STN--------------INFYEI 948

  Fly   791 KSHGPSTLENLTVSLYIPVAYKTPDSTNVKHIVTSSPKIQSKYAHKIMPINFIDQNNALANNFAI 855
            .|.     ||      .|...|:.:....|.|.  |.|:.:..|    |::.     ||......
Mouse   949 SSD-----EN------APSVIKSVEDIGPKFIF--SLKVTAGSA----PVSM-----ALVTIHIP 991

  Fly   856 DH--DQSTLLFSATPQHENVGNLSGIVEQN--------PSISLLNEDLPVNNTLVLNCQDTNVTL 910
            .:  :::.||:....|.:..|::|...|.|        ||:|..||:.  .:|..|:|:.|:
Mouse   992 QYTKEKNPLLYLTGIQTDQAGDISCTAEINPLKLPHTAPSVSFKNENF--RHTKELDCRTTS--- 1051

  Fly   911 CVPVEIRLENGLQLKPEELMNMTVSF-----------TVNLKDADDI----WEYFVIQTDLKVHK 960
            |..:...|:: |.:|.|..:|:|...           ||.|..|.:|    .:.|||:.    :.
Mouse  1052 CSNITCWLKD-LHMKAEYFINVTTRVWNRTFAASTFQTVQLTAAAEIDTHNPQLFVIEE----NA 1111

  Fly   961 IGDPTLSSFTIEKKIESNVICKHAEIAIWKIIVSVIVGILVFSAATYALYKRGFFKRAIK 1020
            :..|.:.....||          ||:....||.|:|.|||:..|.|..|:|.|||||..|
Mouse  1112 VTIPLMIMKPTEK----------AEVPTGVIIGSIIAGILLLLAMTAGLWKLGFFKRQYK 1161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	28/75 (37%)
		Int_alpha	384..434	CDD:214549	21/52 (40%)
		Int_alpha	447..>492	CDD:214549	13/50 (26%)
		Integrin_alpha2	484..808	CDD:285619	77/350 (22%)
Itga2	NP_032422.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	31..89
		Int_alpha	44..92	CDD:214549
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	98..158
		vWA_integrins_alpha_subunit	170..350	CDD:238746
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	363..417		13/66 (20%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	420..472		15/59 (25%)
		Int_alpha	430..473	CDD:214549	14/50 (28%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	474..536		21/64 (33%)
		Cell attachment site. /evidence=ECO:0000255	480..482		1/1 (100%)
		Int_alpha	484..532	CDD:214549	16/47 (34%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	537..595		22/57 (39%)
		Int_alpha	548..601	CDD:214549	22/52 (42%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	601..661		14/66 (21%)
		Int_alpha	611..>637	CDD:214549	7/25 (28%)
		Integrin_alpha2	646..1057	CDD:285619	104/470 (22%)
		Integrin_alpha	1152..1166	CDD:278771	7/10 (70%)
		GFFKR motif	1154..1158		3/3 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832038
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840