DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ItgaPS4 and itga2.2

DIOPT Version :9

Sequence 1:	NP_611025.2	Gene:	ItgaPS4 / 36693	FlyBaseID:	FBgn0034005	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	XP_003199352.2	Gene:	itga2.2 / 100536533	ZFINID:	ZDB-GENE-091118-70	Length:	1197	Species:	Danio rerio

Alignment Length:	942	Identity:	230/942 - (24%)
Similarity:	399/942 - (42%)	Gaps:	213/942 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 MGELGLSAHVSDDNSKLLMGAPGIDQWKGS-VHLKQEVPSI--KTSSGRQRRGMNTNRKCNECNP 256
            |.::|.||:.:.:...:|:||.|...|.|: ||...:...|  ||:.   .:.:.....|
Zfish   380 MSQVGFSAYQTRNKDVILLGAAGAYNWIGTVVHQTAQKSDILPKTAF---EKVLEDKSHC----- 436

  Fly   257 EPKNFGQEEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDI-YEDSIYKYHEFRG 320
                      |..||:|||    .::.|:..|||.|||..:: |:..::.| .:.........||
Zfish   437 ----------SLLGYSVSS----VTDGSSEYYVAGAPRAVHR-GQVVVYSINSQKQAVVIDSQRG 486

  Fly   321 NHFGEYFGYSVLAEDLNGDGKTD-VIISAPLYALRNSYDDGAIYVF-INKGSFTFEERIIRSPAG 383
            :..|.|||..:...|::.||.|| :::.||:|......:.|.:|:| |.||        |.|..|
Zfish   487 DQIGSYFGSVLCPVDVDSDGVTDLLLVGAPMYMSEEKAETGRVYMFTITKG--------ILSNQG 543

  Fly   384 ------SGGRFGTTLSRIGDINKDGYNDVAVGAPFAGN--GSVFIYLGSENGLRDPPSQ-----C 435
                  ...||||.::.:.|:|.||::||.||||...|  |:::||.|....::...||     .
Zfish   544 FLEGSQKNARFGTAIAAVPDLNLDGFSDVVVGAPMEANDQGAIYIYYGHRKSIKKQSSQRIVGGK 608

  Fly   436 LDAPSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLY-RAYPVV---------KI 490
            ||:..:        .||..|....|::|:...|.|:|. ..:.|.|: |...||         ||
Zfish   609 LDSALK--------FFGRSLDGSGDMNGDSIPDVAVGG-FGKVVQLWSRGLAVVTAKVSFTPDKI 664

  Fly   491 HAIIKPKLQNVNPEEERVNITVCYRLSSKSDS--KAKA-------------LMEQELVIRIDIDT 540
            ..:.||                | |.|.:..|  ||||             |::.:..:.:|.|.
Zfish   665 SILSKP----------------C-RYSGRQVSCFKAKACFSATFKPTNSIRLIDVKYNLTLDADL 712

  Fly   541 K-SKIKLAVF--DEEHGSQMSFKAKAFHEEICSEFQIEMDKRAKFTP-----IALEMQYELSKKI 597
            : |::....:  :.|...|......|  :::|.|.::.:.:    ||     |||.:...|....
Zfish   713 QDSRVSPRGYFSNLERVIQKGITVSA--QDLCEEHEVYVQE----TPDLVNSIALRVDVFLGNPD 771

  Fly   598 PNSGDFCEDCAVVDPAEPKFVTEYITFNTGCA-TDVCVADLKISCINASSTLVLGTTAVL----- 656
            .|        .|:|...|.....:|.|:..|. .|||::||   .:...|...||.|.::
Zfish   772 AN--------PVLDVFSPNAWEFFIPFSKDCGQDDVCLSDL---VLTVESEEKLGKTPLVVSQNK 825

  Fly   657 -RLTYNIT--NNGEFAYHPKFSVTNSAGLSLAQVPGNCKVNEA---------VMVCDLNH-GQRM 708
             ||::.:|  |..|.||:.:.|.:.|:.|..:.|....:..|.         :::|.::: ..|.
Zfish   826 RRLSFTVTVMNRKENAYNTRVSASYSSNLFYSSVTPLVEGTEVKCTPIKESNILMCQVSYPALRT 890

  Fly   709 AKGDTDSLTISFDVRQLRGRSLEIQAEVLSARDESNPENNKLTNVLSLREKADIYVSGVQTND-H 772
            .:..|..:...|::.|:: :..::..|.||...|..|.:||::..:.::..::|.:|.....| :
Zfish   891 DQLATFVVNFDFNLNQIK-KEAKVDFEALSDSTEETPADNKISISIPVQYNSEIILSRESNIDVY 954

  Fly   773 VVLKESPYTAEVVNYYEIKSHGPSTLENLTVSL-YIPVA-----YKTPDSTNVKHIVTSSPKIQS 831
            ::.|::.:...|.||.:|   ||....||.||. .:||:     ...|::|...:.:..:.:|::
Zfish   955 LLEKDNNFLTTVQNYKDI---GPDFNFNLKVSTGTVPVSLVYLNISLPNNTRAGNPLLYTSRIKT 1016

  Fly   832 KYAHKIMPINFIDQNNALANNFAIDHDQSTLLFSATPQHENVGNLSGIVEQNPSISLLNEDLPVN 896
            ..|.||:          ..:|..||    .|..|..|.               |.....|..  .
Zfish  1017 SPADKIL----------CKDNDLID----PLKISVKPH---------------SARFTEESF--R 1050

  Fly   897 NTLVLNCQDTNVTLCVPVEIRLENGLQLKPEELMNMTV-----SFTVNLKDADDIWEYFVIQTDL 956
            .|..|||:..:   |..|:..|:: |..|.:..:|:|.     :|.:    ||.::....::.|:
Zfish  1051 GTDELNCRTAS---CRAVQCTLKD-LDQKSDYYINVTTNIWNGTFVM----ADFLYVVLSVRADI 1107

  Fly   957 KVHKIGDPTLSSFTIEKKIESNV-ICK---HAEIAIWKIIVSVIVGILVFSAATYALYKRGFFKR 1017
            :.   ..|.| .|..:|:::..| :.|   .|::.:..|:.|:|.|:|:.:.|...|||.|||||
Zfish  1108 ET---SQPDL-LFIEQKQLKVEVKVSKPGAKADVPVGAIVGSIIGGLLLLALAVAVLYKLGFFKR 1168

  Fly  1018 AIKDDLKQLIRDSFEDGIIRTEMEENAQSQGD 1049
            ..:..:|     ..|:|....|::||.::.|:
Zfish  1169 KYQPLMK-----GEENGAEVQELQENNEASGE 1195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	27/80 (34%)
		Int_alpha	384..434	CDD:214549	19/51 (37%)
		Int_alpha	447..>492	CDD:214549	15/54 (28%)
		Integrin_alpha2	484..808	CDD:285619	83/376 (22%)
itga2.2	XP_003199352.2	Int_alpha	47..95	CDD:214549
		vWFA	174..354	CDD:294047
		Int_alpha	437..475	CDD:214549	15/42 (36%)
		Int_alpha	489..537	CDD:214549	16/47 (34%)
		Int_alpha	551..604	CDD:214549	21/52 (40%)
		Int_alpha	615..>637	CDD:214549	7/21 (33%)
		Integrin_alpha2	647..1067	CDD:285619	106/491 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574911
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.840