Protein Alignment ItgaPS4 and itga4

DIOPT Version :10

• Sequence 1: NP_611025.2
• Gene: ItgaPS4 / 36693
• FlyBaseID: FBgn0034005
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: XP_002932062.3
• Gene: itga4 / 100487924
• XenbaseID: XB-GENE-960093
• Length: 1030
• Species: Xenopus tropicalis
• Alignment Length: 1136
• Identity: 297/1136 - (26%)
• Similarity: 476/1136 - (41%)
• Gaps: 238/1136 - (20%)

  Fly    18 AYNISPYPNSVLNFPELEGNRRSSYFGFSLVIREKS----IMVAAPRANSSLEAQRNISEPGVIF 78
            :|||.  .:|.:.|...:|    |.||||:|:....    |:|.||:::.:   .:|::.||.|.
 Frog    32 SYNID--ESSPVVFKGSQG----SLFGFSVVLHSNGDGNWIVVGAPQSSWT---TKNVTNPGAIL 87

  Fly    79 RCYFESGNN--CSPYNIDTKGNYKGMPNDGLLTAKNKDFRWLGGAMDGGTRDSDKFLVCAPRFYS 141
            :|..|...|  |....:   ||..| ...|....:.:|.:|||.::...:....:.|.|..|:.:
 Frog    88 KCRIEQNPNGSCDVLEL---GNLNG-AKCGKTCKEEQDNQWLGVSLSRQSTKDGQILACGHRWKN 148

  Fly   142 IN---NENDYNNGMCYWLSDTPKNIDSTEVMEKWPLRI---EKKQVLKLADTNLIPYYSMGELGL 200
            |:   :::....|:||.:   |.|. .||:.:    ||   .|..|.|..|:     |...:.|:
 Frog   149 IHFMLSDHKLPYGVCYGI---PANF-RTELSK----RICPCYKDHVRKFGDS-----YGSCQAGI 200

  Fly   201 SAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGMNTNRKCNECNPEPKNFGQEE 265
            |....:|  .::|||||...|.||:.:.....             ||.:...:.|...| ||
 Frog   201 STFYVED--VIVMGAPGSFYWTGSIFVYNTTE-------------NTIKSYVDLNNAVK-FG--- 246

  Fly   266 FSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYEDSIYKYHEFRGNHFGEYFGYS 330
             ||.||:|.:|:|.:.|...|  :..||: ..|.|:||||...|..:....|..|...|.|||.:
 Frog   247 -SYLGYSVGAGHFRTPNSYEV--IGGAPQ-QEQTGKAYIFTYEEKQLVILFEAGGKKLGSYFGAA 307

  Fly   331 VLAEDLNGDGKTDVIISAPLYA-LRNSYDDGAIYVFINKGSFTFEERIIRSPAGS---GGRFGTT 391
            |.|.||||||.:|:::.||:.: :|   ::|.::|::|.|....|| :....:||   ..|||.|
 Frog   308 VCAVDLNGDGLSDLLVGAPMQSTIR---EEGRVFVYMNTGGGAMEE-LQFELSGSDLYAARFGDT 368

  Fly   392 LSRIGDINKDGYNDVAVGAPFAGN--GSVFIYLGSENGLRDPPSQCLDAPSQQPSK--YGSYMFG 452
            ::.:|||:.||:.|||:.||..|:  |:|:||.|.|.|:....||.|     |.||  ||..|||
 Frog   369 IANLGDIDNDGFEDVAIAAPQEGDLEGAVYIYNGREKGITPSFSQRL-----QGSKFGYGLRMFG 428

  Fly   453 HGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHAIIK-PKLQNVNPEE--ER------V 508
            ..:|...||||||:||.||||..:::..|.|..||:.|.|.:| |...|....|  |.      :
 Frog   429 QSISNVLDIDGNGYNDVAIGAFLSDSAVLLRTRPVIVIDASLKLPMTVNKTRFECMENGAPAVCM 493

  Fly   509 NITVCYRLSSKSDSKAKALMEQELVIRIDIDTKSKIKLAVFDEEHGSQ------MSFKAKAFHEE 567
            |:|:|:.... .|.....:|...  |..|:..||......:...:|:.      |:...|:.:.:
 Frog   494 NVTICFAYKG-LDVPGYIVMYYN--ITSDVRRKSGTPARFYFVSNGTSDVMSGTMNIHQKSGNCK 555

  Fly   568 ICSEFQIEMDKRAKFTPIALEMQYELSKKIPNSGDFCEDCAVVDPAEP---------KFVTEYIT 623
            ....| :..|.|..||||.:|..|.|.|.|.:... .:|   :.|.:|         ..:|..:.
 Frog   556 THKAF-MRKDTRDIFTPIHMESSYYLGKHIVSKRS-ADD---LQPLQPVLQQKEGKGNVITNKVH 615

  Fly   624 FNTGCATDVCVADLKISCINA-----SSTLVLGTTAVLRLTYNIT--NNGEFAYHPKFSVTNSAG 681
            |...|....|.|||:|:...:     .|.|.|....:..|..|||  |.|:.|:.....:....|
 Frog   616 FARHCTLLNCSADLQITGKLSFPKPFESKLYLAVGGMKSLMINITLFNGGDDAFQTVLQLRLPKG 680

  Fly   682 LSLAQV------PGNCKVN-----EAVMVCDLNHGQRMAKG--------DTDSLTISFDVRQLRG 727
            |...:|      ..:|.||     :..:.|.:.|....|..        |:.:||.:.:
 Frog   681 LYFVKVFDMLEKEISCAVNKEENEQTRLDCSVGHFYVDAFSKQEFSFLLDSSALTRAEE------ 739

  Fly   728 RSLEIQAEVLSARD--ESNPENNKLTNVLSLREKADIYVSGVQTNDHVVLKESPYTAEVVNYYEI 790
             .|.|.|.|....:  |....||:::.::..|.:.|:.|.|.         .||::. |...:|.
 Frog   740 -DLVINATVACENEFTEDTIWNNEVSFIVPTRYEIDLNVLGT---------VSPFSF-VFGPHED 793

  Fly   791 KSHGPSTLENLTVSLYIPVAYKTPDSTNVKHIVTSSPKIQSKYAHKIMPINFIDQNNALANNFAI 855
            :..|...:|.:..:..:         .|....:..:.|:|..     :|..|......|.:..|:
 Frog   794 EPDGACIMEKIEFTFNV---------INAGSSLVPAAKLQIS-----LPNTFSPNGVKLLDILAV 844

  Fly   856 DHDQSTLLFS------ATPQH--ENVGNLSGI-----------VEQNPS---ISLLNEDLPVNNT 898
            ........|.      .||::  ..||:|...           ::.:||   |..|..|:.
 Frog   845 KTTVGECYFDNYTRGCETPKNTRSKVGDLFAFFSRPDKRWLYCMKDDPSCIQILCLFGDME---- 905

  Fly   899 LVLNCQDTNVTLCVPVEIRLE---NGLQLKPEELMNMTVSFTVNLKDADDIWEYFVIQTDLKVHK 960
                 :::..|    ||::||   :.|:.....|:....:.....:|:..|     |..:...|
 Frog   906 -----RESKAT----VEVQLEISHSYLETDEATLIQFFTTAQAGFEDSPKI-----INLNQDHH- 955

  Fly   961 IGDPTLSSFTIEKKIESNVICKHAEIAIWKII-VSVIVGILVFSAATYALYKRGFFKRAIKDDLK 1024
                   ::.:.:.:.::...||   .|:.|| :|:::|||:||..||.|:|.|||.|..:.
 Frog   956 -------AYVVLEALHNHKPKKH---VIYLIIGISLLLGILLFSLLTYILWKVGFFNRKYQP--- 1007

  Fly  1025 QLIRDSFEDGIIRTEMEENAQSQGDADLDEK 1055
                       |.||.....:|....:.|||
 Frog  1008 -----------IGTEETSRRESWNYVNKDEK 1027

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	FG-GAP_3	335..408	CDD:433275	29/76 (38%)
		Int_alpha	384..434	CDD:214549	23/54 (43%)
		Int_alpha	447..>492	CDD:214549	22/44 (50%)
		Integrin_alpha2	486..808	CDD:462478	83/373 (22%)
itga4	XP_002932062.3	Int_alpha	47..98	CDD:214549	18/57 (32%)
		Int_alpha	301..347	CDD:214549	20/48 (42%)
		Int_alpha	363..415	CDD:214549	24/51 (47%)
		Int_alpha	426..>464	CDD:214549	19/37 (51%)
		Integrin_alpha2	461..898	CDD:462478	98/475 (21%)