Protein Alignment ItgaPS4 and itgav

DIOPT Version :9

• Sequence 1: NP_611025.2
• Gene: ItgaPS4 / 36693
• FlyBaseID: FBgn0034005
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: NP_001028893.1
• Gene: itgav / 100151255
• ZFINID: ZDB-GENE-060616-382
• Length: 1045
• Species: Danio rerio
• Alignment Length: 1159
• Identity: 294/1159 - (25%)
• Similarity: 477/1159 - (41%)
• Gaps: 233/1159 - (20%)

  Fly     4 LLVIVLLALQSEINAYNISPYPNSVLNFPELEGNRRSSYFGFSLVI-----REKSIMVAAPRANS 63
            |..:|.|.......|:|:.....:|.:.|.      .||||||:..     .:.:|:|.|||||:
Zfish    10 LWALVALFTTKRAPAFNLDISKPTVFSGPP------GSYFGFSVAFFNPDNSQFNILVGAPRANT 68

  Fly    64 SLEAQRNISEPGVIFRCYFESGNNCSPYNIDTKGNYKGMPNDGLLTAKNKDFRWLGGAMDGGTRD 128
            |.:....::|.|.:|.|.::....|:....|:..:.|......:   :.|..:|.|..:    |.
Zfish    69 SDQTPSAVTERGAVFSCPWQKSGTCTQIQFDSTDDRKHSNGQQM---EFKSNQWFGATV----RS 126

  Fly   129 S-DKFLVCAPRF----YSINNENDYNNGMCYWLSDTPKNIDSTEVMEKWPLRIEKKQVLKLADTN 188
            | |:.|.|||.:    |..:.....  |.||...       ...::|..|.|         :.:|
Zfish   127 SGDQILACAPLYQWSTYGFSEREPV--GTCYLKK-------GNNIVEYSPCR---------SKSN 173

  Fly   189 LIPYYSMGELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGMNTNRK--- 250
            ........:.|.||.....| ::::|.||...|:|.: :..:|..:          :|...|
Zfish   174 SPEGQGFCQAGFSADFVKKN-RVVIGGPGSFYWQGQL-ISDDVTEV----------INRYNKDFL 226

  Fly   251 ---CNECNPEPKNFGQEEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYE-DS 311
               .|:.:.:|.. .|.:.||.||:|:.|.|:......  ||...|||....|...||:... :|
Zfish   227 TPYSNQLSTKPAG-AQYDDSYLGYSVAVGDFNEDGEDD--YVTGVPRGEKALGYVNIFNGRNMES 288

  Fly   312 IYKYHEFRGNHFGEYFGYSVLAEDLNGDGKTDVIISAPLYALRNS----YDDGAIYVFINKGSFT 372
            :|   .|.|.....|||:||.|.|:|.|||.|:.:.|||:..|.|    .:.|.:||::.||.||
Zfish   289 MY---NFTGTQMAAYFGHSVAAVDVNNDGKMDLFVGAPLFMDRGSDGKLREVGQVYVYLGKGGFT 350

  Fly   373 FEERIIRSPAGSGGRFGTTLSRIGDINKDGYNDVAVGAPFAG---NGSVFIYLGSENGLRDPPSQ 434
            |...|..:.:....|:|:::..:||:|.|||||||:.||:.|   .|.|:|:.|...|.....||
Zfish   351 FNSVIKLTGSEIYARYGSSVCSVGDLNMDGYNDVAIAAPYGGPFHRGLVYIHNGRSTGPNPVASQ 415

  Fly   435 CLD---APSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHAIIKP 496
            .|:   |....||.     ||:.::.|:|:|.||:.|..:||..|:...||||.||:.::..:..
Zfish   416 VLEGTWASVSMPSS-----FGYSMNGGTDVDQNGYPDLIVGAFGADKAILYRARPVISVNTTLDI 475

  Fly   497 KLQNVNPEEERVNI----------TVCYRLSSKSDSKAKALMEQELVIRIDIDT---KSKIKLAV 548
            ..|.:|||::...:          ||.|.|.:.......:|:.|   :.:.:|.   |..||..:
Zfish   476 SPQILNPEDKSCTLPGTATKVSCFTVKYCLKASGKGAPSSLLFQ---VDLTLDRLKHKGAIKRVL 537

  Fly   549 FDEEHGSQMSFKAKAFHEE--ICSEFQI----EMDKRAKFTPIALEMQYELSKKIPNSGDFCEDC 607
            |.....|..|......:.:  .|.|.|.    :.:.|.|.|||::.|:|.|..|  ::.|.....
Zfish   538 FLYNKMSHYSKNMTVNNNQGLACEELQAYLIDDSEFRDKITPISVFMEYSLDYK--SAADKTGLL 600

  Fly   608 AVVDPAEPKFVTEYITFNTGCATD-VCVADLKISCINASSTLVLGTTAVLRLTYNITNNGEFAYH 671
            .::|.:.|..||:.......|..| :|..|||:|.::..:.:.:|....|.|.....|.||.||.
Zfish   601 PILDQSAPTNVTKQAHILLDCGEDNICKPDLKLSVVSDQNEIYIGDDNPLTLEVTAENGGEGAYE 665

  Fly   672 PKFSVT------------NSAGLSLAQVPGNC---KVNEA-VMVCDLNHGQRMAKGDTDSLTISF 720
            ....||            ||..||..    :|   |.|:. |:||||  |..|..|......:.|
Zfish   666 ADLIVTLPSQADFTAVVRNSETLSRL----SCAFKKDNQTRVVVCDL--GNPMKGGTKIVAGLRF 724

  Fly   721 DVRQLRGRSLEIQAEV-LSARDESNPENNKLTNVLSLREKADIYVSGVQTNDHVVL-------KE 777
            .|.||..:..|::..: :.:.::.|..:|.::.|..|...|.:.:.||...:.|.|       ||
Zfish   725 SVHQLSEQDTEVKFGLQIQSTNQFNNTSNLVSVVTKLAVLAKVELRGVSAPEQVFLPIANWQPKE 789

  Fly   778 SPYTAE-----VVNYYEIKSHGPSTLENLTVSLYIPVAYKTPDSTNV-KHIVTSSPKIQSKYAHK 836
            :|...:     |.:.||:::.||||.....:.:..|..:.......: |..|..:....|.  .:
Zfish   790 NPVLEDDIGPLVQHIYELRNKGPSTFSKAILDVQWPYRFNNGSLLYITKFSVDGNMNCSSN--RE 852

  Fly   837 IMPIN-----FIDQNNALANNFAIDHDQSTLLFSATPQHENVGNLSGIVEQNPSISLLNEDLPVN 896
            :.|:|     |:|||:..|:                       ...|....|.....|.|.....
Zfish   853 LNPLNVTSPRFLDQNDTSAS-----------------------GAEGRNRHNVHRRDLEEKHGEE 894

  Fly   897 NTLVLNCQDTNVTLCVPVEI---RLENGLQ--------------LKPEE-----LMNMTVSFTVN 939
            |..:|:|.:..   |..::.   |||.|..              ||.|.     ::..:.||:
Zfish   895 NLEILDCGNAE---CQEIKCFVGRLEKGQSAILFIYSRLAVNTFLKAESQNKSYIVRSSASFS-- 954

  Fly   940 LKDADDIWEYFVIQTDLKVHKIGDPTLSSFTIEKKIESNVICKHAE----IAIWKIIVSVIVGIL 1000
                       ||:..   :|..:|.|.:.|....::   :..::|    :..|.:.::|:.|:|
Zfish   955 -----------VIEMP---YKNLNPELPTSTQSASLK---VIWNSENPQPVPGWVVALAVLAGLL 1002

  Fly  1001 VFSAATYALYKRGFFKRAIKDDLKQLIRDSFEDGIIRTEMEE-NAQSQGDADLD 1053
            :.:...:.:||.|||.|         :|...||   |||.|: ..|..||.:.:
Zfish  1003 LLALLIFVMYKLGFFNR---------VRPPQED---RTEKEQLQPQENGDRNTE 1044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	31/76 (41%)
		Int_alpha	384..434	CDD:214549	20/52 (38%)
		Int_alpha	447..>492	CDD:214549	17/44 (39%)
		Integrin_alpha2	484..808	CDD:285619	93/372 (25%)
itgav	NP_001028893.1	Int_alpha	39..99	CDD:214549	19/65 (29%)
		VCBS	255..320	CDD:290251	25/69 (36%)
		Int_alpha	297..>345	CDD:214549	20/47 (43%)
		Int_alpha	362..417	CDD:214549	22/54 (41%)
		Int_alpha	426..>470	CDD:214549	19/48 (40%)
		Integrin_alpha2	463..911	CDD:285619	112/486 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574888
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740