DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and ITGA8

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_003629.2	Gene:	ITGA8 / 8516	HGNCID:	6144	Length:	1063	Species:	Homo sapiens

Alignment Length:	1195	Identity:	290/1195 - (24%)
Similarity:	471/1195 - (39%)	Gaps:	259/1195 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVI-----RQTSIIVGAPRAQ 72
            |.:|......:|||.......|.:.||          .|||||.:..     |..|::||||:|.
Human    27 LGMLLWSPACQAFNLDVEKLTVYSGPK----------GSYFGYAVDFHIPDARTASVLVGAPKAN 81

  Fly    73 STLESQRTINETGAIYRC---SLTNGVCSPYVLDSRGNVDAPYSEYTFDSERKDFQWLGGSMDGG 134
            :   ||..|.|.||:|.|   :..:..|.....|:..|.....:......|.|..||.|.::..
Human    82 T---SQPDIVEGGAVYYCPWPAEGSAQCRQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATVKA- 142

  Fly   135 TKDTDKLLVCAPRFY----APSSRDNHLHGVCY-WVNNTVASTPQHVTRISPLRLKSEQVKEEDN 194
              ...|::.|||.::    .|:...:.: |.|| .:.|..|     ....||.|  :.....|..
Human   143 --HKGKVVACAPLYHWRTLKPTPEKDPV-GTCYVAIQNFSA-----YAEFSPCR--NSNADPEGQ 197

  Fly   195 GN-KASF---FYIMGELGLSAHVADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRDTSK 255
            |. :|.|   ||..|:|             ::|.||...|:|.||.....|.:.|      .:.|
Human   198 GYCQAGFSLDFYKNGDL-------------IVGGPGSFYWQGQVITASVADIIAN------YSFK 243

  Fly   256 ALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQANK 320
            .:.|........:..|..|             :|||.||:|::|.|...:..:|  ||..|:..:
Human   244 DILRKLAGEKQTEVAPASY-------------DDSYLGYSVAAGEFTGDSQQEL--VAGIPRGAQ 293

  Fly   321 QSGEAYIFDVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQHALEDSHDN--- 382
            ..|  |:..:....:.....|.|||...||||:|:..|:|.||..||:|.||.....:...|
Human   294 NFG--YVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNSDGLDDVLVGAPLFMEREFESNPRE 356

  Fly   383 -GAIYVFINKGFFNFERQILRSPVETMARFGTALSRLGDINHDGYNDVAVGAPFAG---NGTVFI 443
             |.||:::......|....:.:..||..|||:|::.|||:|.|||||:|:|.||||   .|.|.|
Human   357 VGQIYLYLQVSSLLFRDPQILTGTETFGRFGSAMAHLGDLNQDGYNDIAIGVPFAGKDQRGKVLI 421

  Fly   444 YLGSENGLRDQPSQRLDAPSQQPSKYGSHM----FGHGLSRGSDIDGNGFNDFAIGAPNAEAVYL 504
            |.|:::||..:|||.|.      ..:.||.    ||..|...||||.|.:.|..:||.....|.:
Human   422 YNGNKDGLNTKPSQVLQ------GVWASHAVPSGFGFTLRGDSDIDKNDYPDLIVGAFGTGKVAV 480

  Fly   505 YRAYPVVKVHATVKSESREIKPEQEKVKI------TACYRL---STTSTDKLVQEQELAIRIAMD 560
            |||.|||.|.|.:......|..|.:..::      .||:.|   ::.:...:.....|...:.:|
Human   481 YRARPVVTVDAQLLLHPMIINLENKTCQVPDSMTSAACFSLRVCASVTGQSIANTIVLMAEVQLD 545

  Fly   561 --KQLKRVKFTQTQTNEISFKV-----NANFGEQCRDF------ETQVRYSEKDIFTPIDLEMHY 612
              ||...:|.|....|..:.:|     ......||:||      ||:.|    |..:||::.::|
Human   546 SLKQKGAIKRTLFLDNHQAHRVFPLVIKRQKSHQCQDFIVYLRDETEFR----DKLSPINISLNY 606

  Fly   613 ELTKKVPDSEEFCETCAIVDPTEPKVSTQNIIFSTGCATD-VCTADLQLRSKDVSPTYILGSADT 676
            .|.:..  .:|..|...|::.....:.::.......|..| :|..||:|.::......|:|..:.
Human   607 SLDEST--FKEGLEVKPILNYYRENIVSEQAHILVDCGEDNLCVPDLKLSARPDKHQVIIGDENH 669

  Fly   677 LRLNYEITNIGETAYLPQFNVTSTSRLAFAQV--------PGNCKV----VDAVMVCDLNRGRPL 729
            |.|.....|.||.||..:..|.......:..:        |.:|:.    |..::||||  |.|:
Human   670 LMLIINARNEGEGAYEAELFVMIPEEADYVGIERNNKGFRPLSCEYKMENVTRMVVCDL--GNPM 732

  Fly   730 AKGDTDSVTISFDVSQLSGQSLIIHAEV-FSTGYEQNPTDNRQTNVIGLKEFTEIDASGGQTNSQ 793
            ..|...|:.:.|.|.:|...::.|:.:: ..:..:.||..|..:..|.:....:::..|.....|
Human   733 VSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSLQINITAVAQVEIRGVSHPPQ 797

  Fly   794 IDLEHYSNSAE------------IVNNYEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIINV 846
            |.|..::...|            :.:.||:.:.|||.|....:....|.:   |....::.|.::
Human   798 IVLPIHNWEPEEEPHKEEEVGPLVEHIYELHNIGPSTISDTILEVGWPFS---ARDEFLLYIFHI 859

  Fly   847 TSLKMQASYDSQLLSIDLYDQNNTMLVVDPVEVTTTLSGGLERTVITQNRQSYDIHTSGHVHQTM 911
            .:|                         .|::...           ..|....||..:.....|.
Human   860 QTL-------------------------GPLQCQP-----------NPNINPQDIKPAASPEDTP 888

  Fly   912 EVLDTSMVATASMSRKRRDLKALTANREQYARISNVKAHDLLSDDFKGKLPVNRTIVFNCRDPEM 976
            |:......:|.....::||:..:..:|:..|:|                        .||.:.|
Human   889 ELSAFLRNSTIPHLVRKRDVHVVEFHRQSPAKI------------------------LNCTNIE- 928

  Fly   977 TICVRAEMRV-HFRPEKSINLNMRYSVDLNEVNAILVDPWEYFVILTDLKLQKKGDP----TSTS 1036
              |::....| .....:|..|.:|..:            |.:..      ||:|.||    :..|
Human   929 --CLQISCAVGRLEGGESAVLKVRSRL------------WAHTF------LQRKNDPYALASLVS 973

  Fly  1037 FSINRR---------------IEPNII--SKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGF 1084
            |.:.:.               |:.::|  :.:....:|:|:||::::.|||:|:.::..|:|.||
Human   974 FEVKKMPYTDQPAKLPEGSIVIKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTLALWKCGF 1038

  Fly  1085 FNRTK---KDELDRLVQQNPVEPEA 1106
            |:|.:   :|..||....|...|||
Human  1039 FDRARPPQEDMTDREQLTNDKTPEA 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	21/59 (36%)
		FG-GAP	350..388	CDD:280083	17/41 (41%)
		Int_alpha	409..459	CDD:214549	29/52 (56%)
		Int_alpha	473..>515	CDD:214549	19/45 (42%)
		Integrin_alpha2	507..829	CDD:285619	80/369 (22%)
ITGA8	NP_003629.2	Int_alpha	54..112	CDD:214549	21/60 (35%)
		Int_alpha	263..311	CDD:214549	14/51 (27%)
		Int_alpha	317..>365	CDD:214549	18/47 (38%)
		Int_alpha	383..437	CDD:214549	29/53 (55%)
		Int_alpha	448..492	CDD:214549	19/43 (44%)
		Integrin_alpha2	483..934	CDD:285619	100/524 (19%)
		Integrin_alpha	1035..1049	CDD:278771	5/13 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142006
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740