DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and ITGA10

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	XP_016858111.1	Gene:	ITGA10 / 8515	HGNCID:	6135	Length:	1181	Species:	Homo sapiens

Alignment Length:	969	Identity:	222/969 - (22%)
Similarity:	363/969 - (37%)	Gaps:	241/969 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 NKASFFYIMGELGLSAHVADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRDTSKALRRT 260
            |::||...|.::|.|.|...|.  .|.|..|...|.|||:.......:..|..:..|
Human   378 NESSFGLEMSQIGFSTHRLKDG--ILFGMVGAYDWGGSVLWLEGGHRLFPPRMALED-------- 432

  Fly   261 YRDVDSNDYTPEHYAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGEA 325
                            |.| |.|  |...:|.||:|||......   :.|:::.||:. :..|:.
Human   433 ----------------EFP-PAL--QNHAAYLGYSVSSMLLRGG---RRLFLSGAPRF-RHRGKV 474

  Fly   326 YIFDV-RGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDV-IVSAPQHALEDSHDNGAIYVF 388
            ..|.: :..::......:|||.|.|||..:...|.:.||.||| :|:||......:.:.|.:||:
Human   475 IAFQLKKDGAVRVAQSLQGEQIGSYFGSELCPLDTDRDGTTDVLLVAAPMFLGPQNKETGRVYVY 539

  Fly   389 I--NKGFFNFERQILRSPVETMARFGTALSRLGDINHDGYNDVAVGAPF--AGNGTVFIYLGSEN 449
            :  .:.....:..:...|.:. ||||.|:..|.|:|.||:.|||||||.  ...|.:::|.|:::
Human   540 LVGQQSLLTLQGTLQPEPPQD-ARFGFAMGALPDLNQDGFADVAVGAPLEDGHQGALYLYHGTQS 603

  Fly   450 GLRDQPSQRLDAPSQQPSKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVH 514
            |:|..|:||:.|.|.   .:....||..:....|:||:...|.|:||..  |..|..:.|:  ||
Human   604 GVRPHPAQRIAAASM---PHALSYFGRSVDGRLDLDGDDLVDVAVGAQG--AAILLSSRPI--VH 661

  Fly   515 ATVKSESREIKPE-------------QEKVKITA--CYRLSTTSTDKLVQEQELAIRIAMDKQL- 563
            .|   .|.|:.|:             ||.|.:||  |:::::.:..:...:..:....::|:..
Human   662 LT---PSLEVTPQAISVVQRDCRRRGQEAVCLTAALCFQVTSRTPGRWDHQFYMRFTASLDEWTA 723

  Fly   564 -KRVKFTQTQTNEISFKVNANFGE-QCRDFETQVRYSEKDIFTPIDLEMHYEL---TKKVPDSEE 623
             .|..|..:.......::..:.|. .|......| ....|...|:.|.:.:.|   ||..|...|
Human   724 GARAAFDGSGQRLSPRRLRLSVGNVTCEQLHFHV-LDTSDYLRPVALTVTFALDNTTKPGPVLNE 787

  Fly   624 FCETCAIVDPTEPKVSTQNII-FSTGCATD-VCTADL------QLRSKDVSPTYILGSADTLRLN 680
            ...|           |.|.:: ||..|..| .|..||      .:|....:|..:.|....:.::
Human   788 GSPT-----------SIQKLVPFSKDCGPDNECVTDLVLQVNMDIRGSRKAPFVVRGGRRKVLVS 841

  Fly   681 YEITNIGETAYLPQFNVTSTSRLAFAQ--------VPGNCKVVDA-VMVCDLNRGRPLAKGD--- 733
            ..:.|..|.||....::..:..|..|.        :...|....| ..:|.:  |.|:.:..
Human   842 TTLENRKENAYNTSLSLIFSRNLHLASLTPQRESPIKVECAAPSAHARLCSV--GHPVFQTGAKV 904

  Fly   734 TDSVTISFDVSQLSGQSLIIHAEVFSTGYEQNPTDNRQTNVIGLKEFTEIDASGGQTNSQIDLE- 797
            |..:...|..|.|..| :.:.....|...|:|.|         |::.|      .||::.|..|
Human   905 TFLLEFEFSCSSLLSQ-VFVKLTASSDSLERNGT---------LQDNT------AQTSAYIQYEP 953

  Fly   798 HYSNSAE-IVNNYEIKSN-----GPSVIEQLTVSFYIPIAYKVAG--STAIIPIINVTSLKMQAS 854
            |...|:| .::.||:...     ||....:.|:.......|.|:|  .:|::|.:        |.
Human   954 HLLFSSESTLHRYEVHPYGTLPVGPGPEFKTTLRVQNLGCYVVSGLIISALLPAV--------AH 1010

  Fly   855 YDSQLLSIDLYDQNNTMLVVD-----------PVEV--TTTLSGGLERTVITQNRQSYDIHTSGH 906
            ..:..||:.....||...:|.           |.|:  |..|:|        .|.|...:..  |
Human  1011 GGNYFLSLSQVITNNASCIVQNLTEPPGPPVHPEELQHTNRLNG--------SNTQCQVVRC--H 1065

  Fly   907 VHQTMEVLDTSMVATASMSRKRRDLKALTANREQYARISNVKAHDLLSDDFKGKLPVNRTIVFNC 971
            :.|..:..:.|:           .|..|..|  ::.|.:..|:..::|             .|..
Human  1066 LGQLAKGTEVSV-----------GLLRLVHN--EFFRRAKFKSLTVVS-------------TFEL 1104

  Fly   972 RDPEMTICVRAEMRVHFRPEKSINLNMRYSVDLNEVNAILVDPWEYFVILTDLKLQKKGDPTSTS 1036
            ...|.::....|.             .|:|..|.||
Human  1105 GTEEGSVLQLTEA-------------SRWSESLLEV----------------------------- 1127

  Fly  1037 FSINRRIEPNIISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRTKKDELDR 1095
              :..|  |.:||        :||:|.||:||||||:.:.:.|:|.|||...|..|.::
Human  1128 --VQTR--PILIS--------LWILIGSVLGGLLLLALLVFCLWKLGFFAHKKIPEEEK 1174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549
		FG-GAP	350..388	CDD:280083	13/38 (34%)
		Int_alpha	409..459	CDD:214549	24/51 (47%)
		Int_alpha	473..>515	CDD:214549	13/41 (32%)
		Integrin_alpha2	507..829	CDD:285619	74/369 (20%)
ITGA10	XP_016858111.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141981
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840