DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and Itga7

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_110469.1	Gene:	Itga7 / 81008	RGDID:	71022	Length:	1135	Species:	Rattus norvegicus

Alignment Length:	1242	Identity:	280/1242 - (22%)
Similarity:	476/1242 - (38%)	Gaps:	356/1242 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LISHIEAFNFMPRPS----------RVINSPKHLKFHINQTRSSYFGYTLVIR-------QTSII 65
            |:|.:.|...:||.|          |....|           .|.||:::.:.       |:.::
  Rat    18 LLSFLLAGLLLPRASAFNLDVMGAIRKEGEP-----------GSLFGFSVALHRQLQPRPQSWLL 71

  Fly    66 VGAPRAQSTLESQRTINETGAIYRC--SLTNGVCSPYVLDSRGNVDAPYSEYTFDSERKDFQWLG 128
            ||||:|.: |..|:. |.||.::.|  ||....|....:|...||         ..|.|:.||||
  Rat    72 VGAPQALA-LPGQQA-NRTGGLFACPLSLEETDCYRVDIDRGANV---------QKESKENQWLG 125

  Fly   129 GSM----DGGTKDTDKLLVCAPRFYAPSSRDNHLH-----GVCYWVNNTVASTPQHVTRISPLRL 184
            .|:    .||     |::.||.|:.:....|..|.     |.|:.::..:|
  Rat   126 VSVRSQGAGG-----KVVTCAHRYESRQRVDQVLETRDVIGRCFVLSQDLA-------------- 171

  Fly   185 KSEQVKEEDNGNKASFF---------YIMGELGLSAHVADDNTKFLIGAPGINTWRGSV------ 234
                :::|.:|.:..|.         :...:.|.:|..:.|:...:.||||...|:|.:
  Rat   172 ----IRDELDGGEWKFCEGRPQGHEQFGFCQQGTAATFSPDSHYLIFGAPGTYNWKGLLFVTNID 232

  Fly   235 ------ILYRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEEDSYFG 293
                  ::|:.:||.|..|....|.:.                                 :||.|
  Rat   233 SSDPDQLVYKTLDPADRLTGPAGDLTL---------------------------------NSYLG 264

  Fly   294 YAVSSGFFDSSNPTKLLYVATAPQAN---------KQSGEAYIFDVRGKSIHKYHVFRGEQFGEY 349
            :::.|| .......:|.:||.||:||         |.|....|.:|         |..||:....
  Rat   265 FSIDSG-KGLMRSEELSFVAGAPRANHKGAVVILRKDSASRLIPEV---------VLSGERLTSG 319

  Fly   350 FGYSVLAEDLNGDGKTDVIVSAPQHALEDSHDNGAIYVFINKGFFNFERQILRSPVETMARFGTA 414
            ||||:...|||.||..|:||.||..........||:||::|:|....:...||......:.||.:
  Rat   320 FGYSLAVTDLNSDGWADLIVGAPYFFERQEELGGAVYVYMNQGGHWADISPLRLCGSPDSMFGIS 384

  Fly   415 LSRLGDINHDGYNDVAVGAPFAGNGTVFIYLGSENGLRDQPSQRLDAPSQQPSKYGSHMFGHGLS 479
            |:.|||:|.||:.|:||||||.|:|.||||.||..|:..:|||.|:..:     .|...||:.||
  Rat   385 LAVLGDLNQDGFPDIAVGAPFDGDGKVFIYHGSSLGVVTKPSQVLEGEA-----VGIKSFGYSLS 444

  Fly   480 RGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIKPEQEK--------VKITAC 536
            .|.|:|||.:.|..:|: .|:...|:||.||:.|...:..:.|.|..||..        |.:..|
  Rat   445 GGLDVDGNHYPDLLVGS-LADTAALFRARPVLHVSQEIFIDPRAIDLEQPNCADGRLVCVHVKVC 508

  Fly   537 YR-LSTTSTDKLVQEQELAIRIAMDKQLK----RVKFTQTQTNEISFKVNANFG------EQCRD 590
            :. ::..|:...:...:..:....|::|:    ||.|.....:::..:.:....      ..|.|
  Rat   509 FSYVAVPSSYSPIVVLDYVLDGDTDRRLRGQAPRVTFPGRGPDDLKHQSSGTVSLKHQHDRVCGD 573

  Fly   591 FETQVRYSEKDIFTPIDLEMHY-----ELTKKVPDSEEFCETCAIVDPTEPKVSTQNIIF-STGC 649
            ...|::.:.||....|.:.:.|     .|.::.|| :.......|::..:|......|.| ..||
  Rat   574 TVFQLQENVKDKLRAIVVTLSYGLQTPRLRRQAPD-QGLPLVAPILNAHQPSTQRTEIHFLKQGC 637

  Fly   650 ATD-VCTADLQLRSK------------------DVSPTYILGSADTLRLNYEITNI--------- 686
            ..| :|.::|||...                  |.:..:.|.....:.|...:||:
  Rat   638 GDDKICQSNLQLAQAQFCSRISDTEFQALPMDLDGTALFALSGQPFIGLELTVTNLPSDPARPQA 702

  Fly   687 -GETAYLPQFNVTSTSRLAFAQVPGNCKVVDAV-------------MVCDLNRGRPLAKG----- 732
             |:.|:..|...|..:.|.::.|    :.:|:|             :.|:|  |.|:.:|
  Rat   703 DGDDAHEAQLLATLPASLRYSGV----RTLDSVEKPLCLSNENASHVECEL--GNPMKRGTQVTF 761

  Fly   733 ----DTDSVTISFDVSQLSGQSLIIHAEVFSTGYEQNPTDNRQTNVIGLKEFTEIDASGGQTNSQ 793
                .|..:||  :.::|..:.|:                                    .|.|:
  Rat   762 YLILSTSGITI--ETTELKVELLL------------------------------------ATISE 788

  Fly   794 IDLEHYSNSAEIVNNYEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTS-LKMQASYDS 857
            .||...|..|.:.....:..:|.:..:||..|      .||.|.:|:....:|.| :|.:.:..:
  Rat   789 QDLHPVSVRAHVFIELPLSISGVATPQQLFFS------GKVKGESAMRSERDVGSKVKYEVTVSN 847

  Fly   858 QLLSIDL-----------YDQNNTMLVVDPVEVTTTLSGGLERTVITQNRQSYDIHTSGHVHQTM 911
            |..|::.           ::..|...::.|:.|......|.|:..|...|.:. :|
  Rat   848 QGQSLNTLGSAFLNIMWPHEIANGKWLLYPMRVELEGGQGPEKKGICSPRPNI-LH--------- 902

  Fly   912 EVLDTSMVATASMSRKRRDL--------KALTANREQYARISNVKAHDLLSDDFKGKLPVNRTIV 968
              ||..     |..|:||:|        .........:..:|:.:..::..|..:|   ..:.:|
  Rat   903 --LDVD-----SRDRRRRELGQPEPQEPPEKVEPSTSWWPVSSAEKRNVTLDCAQG---TAKCVV 957

  Fly   969 FNCRDPEMTICVRAEMRV-----------HFRPEKSINLNMRYSVDLNE--VNAILVDPWEYFVI 1020
            |:|  |..:....|.:.|           .:...||:.:.:|.::.:..  .|.:|.|......:
  Rat   958 FSC--PLYSFDRAAVLHVWGRLWNSTFLEEYMSVKSLEVIVRANITVKSSIKNLLLRDASTVIPV 1020

  Fly  1021 LTDLKLQKKGDPTSTSFSINRRIEPNIISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFF 1085
            :..|      ||.:            ::::    |:|.|:|:::|:.|||:|:.:..||:|.|||
  Rat  1021 MVYL------DPVA------------VVAE----GVPWWVILLAVLAGLLVLALLVLLLWKLGFF 1063

  Fly  1086 NRTKKDE 1092
            .|.|..|
  Rat  1064 KRAKHPE 1070

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	18/60 (30%)
		FG-GAP	350..388	CDD:280083	17/37 (46%)
		Int_alpha	409..459	CDD:214549	28/49 (57%)
		Int_alpha	473..>515	CDD:214549	18/41 (44%)
		Integrin_alpha2	507..829	CDD:285619	70/397 (18%)
Itga7	NP_110469.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	38..103		19/77 (25%)
		Int_alpha	48..109	CDD:214549	19/73 (26%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	110..165		19/68 (28%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	185..238		9/52 (17%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	248..305		17/90 (19%)
		Int_alpha	260..311	CDD:214549	16/60 (27%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	306..367		25/69 (36%)
		Int_alpha	318..371	CDD:214549	20/52 (38%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	368..423		27/54 (50%)
		Int_alpha	377..429	CDD:214549	28/51 (55%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	427..486		21/64 (33%)
		Int_alpha	439..>479	CDD:214549	18/40 (45%)
		Integrin_alpha2	471..960	CDD:285619	99/559 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	905..933		5/32 (16%)
		GFFKR motif	1061..1065		3/3 (100%)
		3 X 4 AA repeats of D-X-H-P	1111..1130
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335712
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740