DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and Itgad

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_113879.2	Gene:	Itgad / 64350	RGDID:	71075	Length:	1161	Species:	Rattus norvegicus

Alignment Length:	1283	Identity:	263/1283 - (20%)
Similarity:	440/1283 - (34%)	Gaps:	423/1283 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 FGYTLV-IRQTSIIVGAPRAQSTLESQRTINETGAIYRCSLTNGVCSPYVL-------------- 102
            ||.|:| ...:.::||||     ||:. .:|:||.:|.|:...|:|.|.||
  Rat    37 FGQTVVQFGGSRLVVGAP-----LEAV-AVNQTGRLYDCAPATGMCQPIVLRSPLEAVNMSLGLS 95

  Fly   103 --------------------------------------------------------------DSR 105
                                                                          |..
  Rat    96 LVTATNNAQLLACGPTAQRACVKNMYAKGSCLLLGSSLQFIQAVPASMPECPRQEMDIAFLIDGS 160

  Fly   106 GNVD---------------------------APYSE----------------------------- 114
            |:::                           ..||.
  Rat   161 GSINQRDFAQMKDFVKALMGEFASTSTLFSLMQYSNILKTHFTFTEFKNILDPQSLVDPIVQLQG 225

  Fly   115 --YTFDSERKDFQWLGGSMDGGTKDTDKLLVCA--------PRFYA---PSSRDNHLHGVCYWVN 166
              ||....|...:.|..|.:|..|...|:|:..        |..|:   |::....:  :.|.:.
  Rat   226 LTYTATGIRTVVEELFHSKNGSRKSAKKILLVITDGQKYRDPLEYSDVIPAADKAGI--IRYAIG 288

  Fly   167 --------------NTVASTP--QHVTRI---SPLRLKSEQVKEE-------DNGNKASFFYIMG 205
                          ||:.|.|  .||.::   :.||....|::|:       .:.:.:||.:.|.
  Rat   289 VGDAFQEPTALKELNTIGSAPPQDHVFKVGNFAALRSIQRQLQEKIFAIEGTQSRSSSSFQHEMS 353

  Fly   206 ELGLSAHVADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYT 270
            :.|.|:.:..|..  ::||.|..:|.|...||   .|...||        .:..:..:||.
  Rat   354 QEGFSSALTSDGP--VLGAVGSFSWSGGAFLY---PPNTRPT--------FINMSQENVDM---- 401

  Fly   271 PEHYAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGEAYIFDVRGKSI 335
                             .|||.||:.:..|:...:.    .:..||: ::.:|:..||....:..
  Rat   402 -----------------RDSYLGYSTAVAFWKGVHS----LILGAPR-HQHTGKVVIFTQEARHW 444

  Fly   336 HKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQHALEDSHDNGAIYVFI---NKGFFNFE 397
            ......||.|.|.|||.|:.:.|::.||.||:::....|..|.:. .|.:.|..   .:|.:..|
  Rat   445 RPKSEVRGTQIGSYFGASLCSVDVDRDGSTDLVLIGAPHYYEQTR-GGQVSVCPVPGVRGRWQCE 508

  Fly   398 RQILRSPVETMARFGTALSRLGDINHDGYNDVAVGAP--FAGNGTVFIYLGSENGLRDQPSQRLD 460
            ..:.........|||.||:.|||:|.|...|||:|||  ....|.|:|:.|:.. |...||
  Rat   509 ATLHGEQGHPWGRFGVALTVLGDVNGDNLADVAIGAPGEEESRGAVYIFHGASR-LEIMPS---- 568

  Fly   461 APSQQPSKYGSHM------FGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKS 519
             |||:.:  ||.:      ||..||.|.|:..:|..|.|:||..  .|.|.|:.|::||..:::.
  Rat   569 -PSQRVT--GSQLSLRLQYFGQSLSGGQDLTQDGLVDLAVGAQG--HVLLLRSLPLLKVELSIRF 628

  Fly   520 ESREIKPE-----------QEKVKITACYRLSTTSTDKLVQEQ-ELAIRIAMD--KQLKRVKFTQ 570
            ...|:...           .|..:.|.|..:...|.|.|...| .:...:|:|  :.:.|..|.:
  Rat   629 APMEVAKAVYQCWERTPTVLEAGEATVCLTVHKGSPDLLGNVQGSVRYDLALDPGRLISRAIFDE 693

  Fly   571 TQTNEISFKVNANFGEQCRDFETQVRYSEKDIFTPIDLEMHYELTKKVPDSEEFCETCAIVDPTE 635
            |:...::.:.....|:.|...:..:....:|..:||.|.:::.|.:               |...
  Rat   694 TKNCTLTGRKTLGLGDHCETVKLLLPDCVEDAVSPIILRLNFSLVR---------------DSAS 743

  Fly   636 PK-------VSTQNII-----FSTGCATD-VCTADLQLRSKDVSPTYIL--GSADTLRLNYEITN 685
            |:       |.:|:.|     |...|..: :|..||.: |.:.|...:|  |.:..|.:...:.|
  Rat   744 PRNLHPVLAVGSQDHITASLPFEKNCKQELLCEGDLGI-SFNFSGLQVLVVGGSPELTVTVTVWN 807

  Fly   686 IGETAYLPQFNVTSTSRLAFAQVPGN-----------CKVVDAVM------VCDLNRGRPL-AKG 732
            .||.:|.........:.|::.:|.|.           |:...|..      .|.:|  .|: .:|
  Rat   808 EGEDSYGTLVKFYYPAGLSYRRVTGTQQPHQYPLRLACEAEPAAQEDLRSSSCSIN--HPIFREG 870

  Fly   733 DTDSVTISFDVSQLS--GQSLIIHAEVFSTGYEQNPTDNRQTNV-----IGLKEFTEIDASGGQT 790
            ...:..|:||||..:  |..|::.|:..|   |.|..|..:|..     :....:|.|......|
  Rat   871 AKTTFMITFDVSYKAFLGDRLLLRAKASS---ENNKPDTNKTAFQLELPVKYTVYTLISRQEDST 932

  Fly   791 NS-QIDLEHYSNSAEIVNNYEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKMQAS 854
            |. .....|.....|..:.|.:.:..|..: .:.|:|::|:            ::|
  Rat   933 NHVNFSSSHGGRRQEAAHRYRVNNLSPLKL-AVRVNFWVPV------------LLN--------- 975

  Fly   855 YDSQLLSIDLYDQNNTMLVVDPVEVTTTLSGGLER-TVITQNR--QSYDIHTSGHVHQTMEVLDT 916
                  .:.::|              .|||...:. :.::|.:  |:.|..|.   .|...|||.
  Rat   976 ------GVAVWD--------------VTLSSPAQGVSCVSQMKPPQNPDFLTQ---IQRRSVLDC 1017

  Fly   917 SMVATASMSRKRRDLKALTANREQYARISNVKAHDLLSDDFKGKLPVNRTIVFNCRDPEMTICVR 981
            |:.                               |.|.              |.|..|.:.|  :
  Rat  1018 SIA-------------------------------DCLH--------------FRCDIPSLGI--Q 1035

  Fly   982 AEMRVHFRPEKSINLNMRYSVDLNEVNAILVDPWEYFVILTDLKLQKKGDPTSTSFSINRRIEPN 1046
            .|:....|.    ||:..:.....:...:||...| ....|.:..|..|........:...:|..
  Rat  1036 DELDFILRG----NLSFGWVSQTLQEKVLLVSEAE-ITFDTSVYSQLPGQEAFLRAQVETTLEEY 1095

  Fly  1047 IISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRTKKDELD 1094
            ::.:      ||:::..|.:||||||:.|:.:|||.|||.|..|:.||
  Rat  1096 VVYE------PIFLVAGSSVGGLLLLALITVVLYKLGFFKRQYKEMLD 1137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	20/126 (16%)
		FG-GAP	350..388	CDD:280083	11/37 (30%)
		Int_alpha	409..459	CDD:214549	23/51 (45%)
		Int_alpha	473..>515	CDD:214549	17/47 (36%)
		Integrin_alpha2	507..829	CDD:285619	74/376 (20%)
Itgad	NP_113879.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	21..78		17/46 (37%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	79..138		2/58 (3%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	341..392		16/63 (25%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	393..444		13/76 (17%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	445..505		18/60 (30%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	508..566		22/58 (38%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	571..631		20/63 (32%)
		GFFKR motif	1126..1130		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335737
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940