Protein Alignment scb and itga1

DIOPT Version :9

• Sequence 1: NP_523750.2
• Gene: scb / 36692
• FlyBaseID: FBgn0286785
• Length: 1115
• Species: Drosophila melanogaster
• Sequence 2: XP_021334930.1
• Gene: itga1 / 570868
• ZFINID: ZDB-GENE-091118-115
• Length: 1183
• Species: Danio rerio
• Alignment Length: 1372
• Identity: 266/1372 - (19%)
• Similarity: 480/1372 - (34%)
• Gaps: 480/1372 - (34%)

  Fly     5 STMFPHIFLALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIRQTS----II 65
            |.::.....|||||:..:..||...:.....:.|.          ...||||:...:.|    ::
Zfish     3 SGVYQFTLAALLALLPWLSCFNVDEKNRMSFSGPV----------EDMFGYTVQQFENSEGKWVL 57

  Fly    66 VGAPRAQSTLESQRTINETGAIYRC---SLTNGVCSPYVLDSRGNVDAPYSEYTFDSERKDFQWL 127
            :|:|     |..| ....||.:|||   |.::..|..::|..  |...|..     :|.|:...:
Zfish    58 IGSP-----LTGQ-PAKRTGDVYRCRVGSNSDSKCEKFLLSE--NTTIPNI-----NEVKENMTM 109

  Fly   128 GGSM----DGGTKDTDKLLVCAPRFYAPSSRDNHLHGVC------YWVNNTVASTPQ-------- 174
            |.::    ||     :..|.|.|::.....:..::.|:|      :.|.|::|.|.:
Zfish   110 GTTLVVNPDG-----NGFLACGPQYGYMCGKQQYITGICSNVSSSFKVLNSIAPTVRECSQDMDI 169

  Fly   175 --------------HVT----------RISPLRL--------------------KSEQVK----- 190
                          |:|          .|.|.|:                    ..|.||
Zfish   170 VIVLDGSNSIYPWDHITDFLVKFLQNIEIGPARVGIVSYGDDVGHVFNLSQFSNTKELVKNAADI 234

  Fly   191 ---------------------------------------------------------EEDN---- 194
                                                                     :||.
Zfish   235 RQRTGHKTMTALGIDTARKEAFTVERGARPGVKKVMVIVTDGESHDHHNLKSVIDQCQEDGIERF 299

  Fly   195 -----------------------------------------------------GNK--------- 197
                                                                 |:|
Zfish   300 AVAVLGDYNRQNKSIDEIKKFIEEIEYIASETKSDHFFNVSDERALVTIVDTLGSKIFALEATSG 364

  Fly   198 ---ASFFYIMGELGLSAHVADDNTKFLIGAPGINTWRGSVILYR-------QVDPVDNPTASRRD 252
               :||...|.:.|.|||.:  ....::||.|...|.|:|::..       :.:...||:..|.:
Zfish   365 KHTSSFEMEMSQAGFSAHTS--KAGVMLGAVGAFDWNGTVVMQAGNEFVVPKKNTFHNPSVQRYE 427

  Fly   253 TSKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQ 317
                                         |:.|     |.||.|.|.:    .|..:||:..||:
Zfish   428 -----------------------------GMAG-----YVGYDVQSAY----TPNGVLYITGAPR 454

  Fly   318 ANKQSGEAYIFDVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDV-IVSAPQHALEDSHD 381
            .| .||...::...|:::......:|||.|.|||..:...|::||..||: :|:||.....:..:
Zfish   455 FN-HSGRVTVYRFDGENVTIVQTLKGEQIGSYFGSVLQTHDIDGDNYTDILLVAAPMFMGPERDE 518

  Fly   382 NGAIYVF-INKGFFNFERQILRSPVETM--------------------ARFGTALSRLGDINHDG 425
            .|.:||: :|:... ||.::...||...                    ||||||::.:.|:|.|.
Zfish   519 QGQVYVYKLNESGL-FEHEMTLKPVNQTCCSGHSHNNCKIVSKNEPCGARFGTAIAAVPDLNLDK 582

  Fly   426 YNDVAVGAPFAGN--GTVFIYLGSENGLRDQPSQRLDAPSQQPSKYGSHMFGHGLSRGSDIDGNG 488
            ::|:.:|:|...:  |.|:||.||:..::::..||:.|.....|   ...||..:....|::.:|
Zfish   583 FSDIVIGSPLENDHRGAVYIYHGSQKSIKEKYVQRIAAGGDGES---MKFFGQSIHGIMDLNDDG 644

  Fly   489 FNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIKPEQE---------KVKITACYRLSTTST 544
            ..|..||.....|:|..|  .|.::.|.:..:..:|..:..         .||...|::....|.
Zfish   645 IIDVTIGGIGGAALYWSR--DVAELLAEMTFDPIKINLQHTCQVHGKTTVCVKTRVCFKYRIKSV 707

  Fly   545 DKLVQEQELAIRIAMD--KQLKRVKFTQTQTNEISFKVNANFGEQCRD--FETQVRYSEKDIFTP 605
            .::.....:...:.:|  :.:.|.:|.:|:...:. |..:...:.||:  |.|..:...:|   |
Zfish   708 KEMNTGTVIRYSLTLDSLRAVARGRFNETEDRRLQ-KNESIRNKFCREHTFYTSDKLDFRD---P 768

  Fly   606 IDLEMHYELTKK----VPDSE---EFCETCAIVDPTEPKVSTQNIIFSTGC-ATDVCTADLQLR- 661
            |.:.:.:.|..:    |.|.|   ...:|.|:||                | :.:.|.|:|.|:
Zfish   769 IMVTLEFGLADEDKGPVLDGELPTSLNKTIALVD----------------CGSNEKCVANLHLQA 817

  Fly   662 SKDVSPTYILGSADTLRLNYEITNIGETAYLPQFNVTSTSRLAFAQV---PGNCKVVDAVMVCDL 723
            |.::|...|..:.:...:|.:|.|.|:.||..:..::.|..:.:.:|   ..:|:.....:||.:
Zfish   818 SANISSLLIKSNQEKFYVNIDIKNTGDNAYNTKVTLSHTENINYVKVEPKDKDCETNHTRIVCAV 882

  Fly   724 NRGRPLAKGDTDSVTISFDVSQLSGQSLIIHAEVFSTGYEQNPTDNRQTNVIGLKEFTEIDASGG 788
              |.|..|..                    ..|.|...:|.||:..|:..||.:...|:.:.|
Zfish   883 --GYPFLKTK--------------------DRETFKIQFEPNPSLIRKDIVINVTATTDSEQS-- 923

  Fly   789 QTNSQIDLEHYSNSAEIVNNYEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKMQA 853
                         .:.:..|:|                           |.|||:.:..|::..|
Zfish   924 -------------DSALKRNFE---------------------------TIIIPVRHEASMRFTA 948

  Fly   854 SYDSQLLSIDLYDQ-------NNTMLVVDPVEVTTTL-------SGGLERTVITQNRQSYDIHTS 904
            :...:...|.|.::       |:|.::.|.|:::.|:       |..::.|::      :...||
Zfish   949 NKYMKEDHIILKEKETIPSVFNHTSVIGDEVKISYTIEKDPDMPSPPVKLTIM------FPYQTS 1007

  Fly   905 GHVHQTMEVLDTSMVATASMSRKRRDLKALTANREQYARISNVKAHDLLSDDFKGKLPVNRTIVF 969
            .. :..:.:.|.|..|....|          |:.....:|...|.|.|  :..|..|.:   .:.
Zfish  1008 AK-NFLLYLTDLSYTAGIRCS----------ADWINPLKIQPSKPHSL--NTKKETLSI---YLL 1056

  Fly   970 NCRDPEMTICVRAEMRVHFRPEKSINLNMRYSVDLNEVN--------AILVDPWEYFVILTDLKL 1026
            :|::.|             .|.:|.:..:. |.|.|::|        ..:...:....:..|.||
Zfish  1057 SCKEKE-------------NPCQSFSCFIP-SGDFNQINTTFRLWRPTFIKGEFSTIHMAVDAKL 1107

  Fly  1027 QKKGDPTSTSFSINRRI---EPNI-ISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNR 1087
            :.:   .:..|.:|..|   |..| ::|...||:|:||||:|::.|||:|:.:.:.|:|.|||.|
Zfish  1108 ETQ---NTDLFVLNENIKTREVRIQVTKDIRTGIPLWIIILSILIGLLILALVIFALWKAGFFKR 1169

  Fly  1088 TKKDELD 1094
            ...:|::
Zfish  1170 KSVEEMN 1176

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	16/58 (28%)
		FG-GAP	350..388	CDD:280083	12/38 (32%)
		Int_alpha	409..459	CDD:214549	19/51 (37%)
		Int_alpha	473..>515	CDD:214549	11/41 (27%)
		Integrin_alpha2	507..829	CDD:285619	61/346 (18%)
itga1	XP_021334930.1	vWFA	167..348	CDD:320736	10/180 (6%)
		Int_alpha	482..532	CDD:214549	16/49 (33%)
		Int_alpha	565..618	CDD:214549	19/52 (37%)
		Integrin_alpha2	661..1070	CDD:312071	94/529 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574929
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.840