DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and itga6b

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_001013466.1	Gene:	itga6b / 541320	ZFINID:	ZDB-GENE-050320-5	Length:	1085	Species:	Danio rerio

Alignment Length:	1225	Identity:	291/1225 - (23%)
Similarity:	499/1225 - (40%)	Gaps:	302/1225 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LALLALISHIEAFNFMPRPSRVINSPKHLKFHINQT--RSSYFGYTLVIR-------QTSIIVGA 68
            |:||.| :.|.|||.     ..:|.       |.:|  .:|.||:::.:.       :..::||:
Zfish    12 LSLLGL-TLISAFNL-----DTVNV-------IRKTGDANSLFGFSMAMHRQLRPADKRMLLVGS 63

  Fly    69 PRAQSTLESQRTINETGAIYRC--SLTNGVCSPYVLDSRGNVDAPYSEYTFDSERKDFQWLGGSM 131
            |:|:: |.:||: ..||.:|.|  ::....|...:.|:..|:         .:|.|:.||:|.::
Zfish    64 PKAKA-LPNQRS-KITGGLYNCDINIPGQSCQRVMFDNEENL---------QTENKENQWMGVTV 117

  Fly   132 D----GGTKDTDKLLVCAPRF----YAPSSRD-NHLHGVCYWVNNTVASTPQHVTRISPLRLKSE 187
            .    ||     |:||||.|:    :..|.:: ..|.|.||.::..|.               ..
Zfish   118 QSQGPGG-----KILVCAHRYQRRLFVGSVQELRDLTGRCYVLSEDVT---------------IN 162

  Fly   188 QVKEEDNG--------NKASFFYIMGELGLSAHVADDNTKFLIGAPGINTWRGSVILYRQVDPVD 244
            ::.:||.|        |:....:...:.|:||....|....:.||||...|:|.|.|
Zfish   163 EISDEDGGDWMFCNGRNRGHERFGSCQQGMSATFTKDYHYLVFGAPGAYNWKGIVRL-------- 219

  Fly   245 NPTASRRDTSKALRRTYRDVDSNDYTPEHYAPE-------IPTPGLWGQEEDSYFGYAVSSGFFD 302
                .:::||      ..|.|..|..|.....|       :|.|.      :||.|:::.||..
Zfish   220 ----EQKNTS------LFDKDIFDDGPYEVGDENRLDAELVPVPA------NSYLGFSLDSGKM- 267

  Fly   303 SSNPTKLLYVATAPQANKQSGEAYIF---DVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGK 364
            .:...:|..||.||:|| .||...:.   :.:...:...:...|......|||.:...|:||||.
Zfish   268 LTKRGQLTIVAGAPRAN-HSGAVVLLKKDEAKSSLLTAEYTLEGSGLASSFGYDLAVLDINGDGW 331

  Fly   365 TDVIVSAPQHALEDSHDNGAIYVFINK--GFFNFERQILRSPVETMARFGTALSRLGDINHDGYN 427
            .|::|.|||:.::|....|||||::|:  .:.....:.:..|..:|  ||.|:..:||:|.|||.
Zfish   332 QDIVVGAPQYFIKDGDIGGAIYVYLNEEGAWDKITPKRIDGPAYSM--FGLAVENMGDVNLDGYQ 394

  Fly   428 DVAVGAPFAGN--GTVFIYLGSENGLRDQPSQRLDAPSQQPSKYGSHMFGHGLSRGSDIDGNGFN 490
            ||||.||:..|  |.|.|:.||..||:  .||.|..     ..:...:||:.|:...|:|.|.:.
Zfish   395 DVAVSAPYDSNGAGNVIIFHGSPQGLK--KSQVLGG-----KDHNVKLFGYSLAGNMDLDRNNYP 452

  Fly   491 DFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIKPEQEK--------VKITACYRLST---TST 544
            |.|||: .:::|::||:..|:.:..||.:..:|:...::.        :.:.||::.|.   |..
Zfish   453 DLAIGS-LSDSVFVYRSRSVINIEKTVTTTPKELDLTKKNCNNGNNICLDVKACFKFSVKPKTYN 516

  Fly   545 DKLVQEQELAIRIAMDKQLK------RVKFTQTQTNEIS----FKVNANFGEQCRDFETQVRYSE 599
            ..|    ::|..|.::.:.|      ||.|.....|:..    .::.....|.|......::.:.
Zfish   517 PTL----KVAYTIRVESERKKLNLPSRVIFNPRSNNDYESTGIVELKGQGTESCIYRNLMLQETL 577

  Fly   600 KDIFTPIDLEMHYELTKK---------------VPDSEEFCETCAIVDPTEPKVSTQNIIFSTGC 649
            ||....|.:|:..|:..:               :.||.:...|.|:|.           ....||
Zfish   578 KDKLRGIPIEVSVEILNQNKRRRRQAALPNLLPILDSNQEATTVAMVQ-----------FIKEGC 631

  Fly   650 ATD-VCTADLQLRSK---------------DVSPTYILGSADTLRLNYEI--TNIGETAYLPQFN 696
            ..| :|.:||||:.|               :.....||..:|...:..||  .|:||.||..|..
Zfish   632 GADHLCQSDLQLQYKFHTREPNKDNFFPFDEEKGVPILSLSDQKEIALEIKAVNLGEDAYETQLT 696

  Fly   697 VTSTSRLAFAQVPG-------NCKVVDAVMVCDLNRGRPLAKGDTDSVTISFDVSQLSGQSLIIH 754
            .:....|:::.|..       :|.|.......|.:.|.|..|   |:.|..:.:....|.||
Zfish   697 ASFPKSLSYSAVRTQSGDKQISCLVNQNGSQADCDLGNPFKK---DAQTTFYIILSTGGISL--- 755

  Fly   755 AEVFSTGYE-----QNPTDNRQTNVIGLKEFTEIDASGGQTNSQIDLEHYSNSAEIVNNYEIKSN 814
               .:|..|     :..::.:|...:..|...:|..       .:.|...:..:::....|:|..
Zfish   756 ---DTTEIEIDLKLKTTSEQKQLQAVKAKAIVKIQL-------LLSLSGVAKPSQVFFTGEVKGE 810

  Fly   815 GPSVIEQLTVSFYIPIAYKVAGSTAIIPI---INVTSLKMQASYDSQLLSIDLYDQNNT----ML 872
            .               |.||||... .||   ..||:|........:...|..:.::|:    :|
Zfish   811 S---------------AMKVAGDVG-SPIDYEFRVTNLDKPLKSFGRASMIIQWPKHNSQGKWLL 859

  Fly   873 VVDPVEVTTTLSGGLERTVITQNRQSYDIHTSGHVHQTMEVLDTSMVATASMSRKRRDLKALTAN 937
            .:  :::|:|   ||:....|   .|.:::..|             :...|:||.:|::...:|.
Zfish   860 YL--MKMTST---GLDSLSCT---NSDEVNKLG-------------LKELSVSRTKREVGETSAA 903

  Fly   938 REQYARISNVKAHDLLSDDFKGKLPVNRTIVFNC----RDPEMTICVRAEMRVHFRPEKSINLNM 998
            ..:.|..::.:.:.|||.|...:     .|.|.|    .|....|.:||.:           .|.
Zfish   904 EGKTAFFTDKRKYTLLSCDDGAE-----CITFICPLTGMDSNAVISLRAYL-----------WNA 952

  Fly   999 RYSVD---LNEVNAILVDPWEYFVILTDLKLQKKGDPTSTSFSI--NRRIEPNIISKHQETGLPI 1058
            .:..|   ||.|:.|.....::....|:::|  |.:|:....::  .|::.       |..|:|.
Zfish   953 TFLEDYAKLNYVDIIAKASLDFKTTATNIQL--KNEPSQVRVTVFPERKVA-------QYGGMPW 1008

  Fly  1059 WIIIVSVIGGLLLLSAISYLLYKFGFFNRTKKDELDRLVQQNPV---EPEAENLN 1110
            |:|:|:::.|||||..:.:||:|.|||.|:|.|  |.:...|.|   ..|.:||:
Zfish  1009 WVILVAILLGLLLLGLLVFLLWKCGFFKRSKYD--DSVPSYNAVRIKREERDNLS 1061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	15/60 (25%)
		FG-GAP	350..388	CDD:280083	18/37 (49%)
		Int_alpha	409..459	CDD:214549	25/51 (49%)
		Int_alpha	473..>515	CDD:214549	14/41 (34%)
		Integrin_alpha2	507..829	CDD:285619	69/387 (18%)
itga6b	NP_001013466.1	Int_alpha	37..98	CDD:214549	15/62 (24%)
		Int_alpha	254..>292	CDD:214549	14/45 (31%)
		Int_alpha	315..365	CDD:214549	20/49 (41%)
		Int_alpha	374..425	CDD:214549	25/54 (46%)
		Integrin_alpha2	468..932	CDD:285619	101/536 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574963
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740