Protein Alignment scb and Itgax

DIOPT Version :10

• Sequence 1: NP_523750.2
• Gene: scb / 36692
• FlyBaseID: FBgn0286785
• Length: 1115
• Species: Drosophila melanogaster
• Sequence 2: NP_001406686.1
• Gene: Itgax / 499271
• RGDID: 1561123
• Length: 1182
• Species: Rattus norvegicus
• Alignment Length: 1374
• Identity: 285/1374 - (20%)
• Similarity: 459/1374 - (33%)
• Gaps: 478/1374 - (34%)

  Fly    15 LLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIRQTS-IIVGAPRAQSTLESQ 78
            ||.:.:....||        :::.|..:||::   .:.||:::|....| ::||||:     |.|
  Rat    10 LLKVFASCLGFN--------LDAEKPTRFHMD---GAEFGHSVVQYGGSWVVVGAPK-----EIQ 58

  Fly    79 RTINETGAIYRCSLTNGVCSP-------------------------------------------- 99
            .| |:.|.:|:|....|:|..
  Rat    59 AT-NQIGGLYKCGYHTGMCESISLQVPPEAVNMSLGLSLTATNPSWLLACGPTVHHICRENTYLT 122

  Fly   100 ---YVLDS--RGNVDAPYSE---------------------YTFDSER----------------- 121
               ::|||  |.|.:.|.::                     || |.|:
  Rat   123 GLCFLLDSSFRQNQNFPAAQQGCPRQDQDIVFLIDGSGSITYT-DFEKMLAFVKAVMSQLQQSST 186

  Fly   122 -----------------KDF-------------QWLGGS-----------------MDGGTKDTD 139
                             .||             ..|.||                 ..|..||..
  Rat   187 RFSLMQFSHTFRTHFTFNDFISTSSPLRLLDFVNQLRGSTRTASAIKHVITELFTTQKGARKDAT 251

  Fly   140 KLLV--------------------------------CAPRFYAPSSRDNHLHGVCYWVNNTVAST 172
            |:|:                                ....||...||..         ...:||:
  Rat   252 KILIVITDGRKEGDRLDYGDVIPMAEAAGIIRYAIGVGQAFYQAQSRQE---------LKDIASS 307

  Fly   173 PQH-----VTRISPLRLKSEQVKEE-------DNGNKASFFYIMGELGLSAHVADDNTKFLIGAP 225
            |..     |.....|:....|:||:       :..:.:||...|.:.|.||....|..  ::||.
  Rat   308 PSREYVFSVENFDALKDIQNQLKEKIFAIEGTETPSSSSFELEMSQEGFSAVFTPDGP--VLGAV 370

  Fly   226 GINTWRGSVILYRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEEDS 290
            |...|.|...||   .|...||        .:..:..:||.                     .||
  Rat   371 GSFGWSGGAFLY---PPNTRPT--------FINMSQENVDM---------------------RDS 403

  Fly   291 YFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGEAYIFDVRGKSIHKYHVFRGEQFGEYFGYSVL 355
            |.||:.:..|:...:.    .:..||: ::.:|:..||....:........||.|.|.|||.|:.
  Rat   404 YLGYSTAVAFWKGVHS----LILGAPR-HQHTGKVVIFTQEARHWRPKSEVRGTQIGSYFGASLC 463

  Fly   356 AEDLNGDGKTDVIVSAPQHALEDSHDNGAIYVFINKGF---FNFERQILRSPVETMARFGTALSR 417
            :.|::.|..||:::....|..|.:. .|.:.|....|.   :..|..:.........|||.||:.
  Rat   464 SVDMDRDDSTDLVLIGAPHYYEQTR-GGQVSVCPVPGVGSRWQCEATLHGEQGHPWGRFGAALTV 527

  Fly   418 LGDINHDGYNDVAVGAP--FAGNGTVFIYLG-SENGLRDQPSQRLDAPSQQPS-KYGSHMFGHGL 478
            |||:|.|...|||:|||  ....|.|:|:.| |...:...||||:.|....|. :|    ||..|
  Rat   528 LGDVNGDDLADVAIGAPGEEESRGAVYIFHGASRLEISPSPSQRISASRIFPRLQY----FGQSL 588

  Fly   479 SRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIK-----------PEQEKVK 532
            |.|.|:.|:|..|.|:|:..  .:.|.|..|::::.:|::....||.           .||....
  Rat   589 SGGQDLTGDGLVDLAVGSKG--HLLLLRTRPILRMSSTIQFTPTEISRSVFECQGQVTREQTLGT 651

  Fly   533 ITACYRLSTTSTDKLVQEQELAIRIAMDKQL------KRVKFTQTQTNEISFKVNANFGEQCRDF 591
            .|.|.|   |......|..:|...:..|..|      .|..|.:|:|..::..........|...
  Rat   652 ATVCLR---TYESSKTQRGDLQSIVTFDLALDPGRLSPRAIFKETKTQALTKVRTLGLSSHCEPV 713

  Fly   592 ETQVRYSEKDIFTPIDLEMHYELT-KKVPDSEEFCETCAIVDPTEPKVSTQNIIFSTGCATD-VC 654
            ...:....:|..|||.|.:::.|. ..:|..:......|:.:.|   ..|.::.|...|..| :|
  Rat   714 TLLLPACVEDSVTPITLRLNFSLVGVPIPSLQNLQPMLAVDEQT---YFTASLPFEKNCGADHIC 775

  Fly   655 TADLQL--RSKDVSPTYILGSADTLRLNYEITNIGETAYLPQFNV-----TSTSRLAFAQVPGNC 712
            ..||.:  ...|:. |.::||...|.:...:||.||.:|.....:     .|..|:|.|||  ..
  Rat   776 QDDLGIIFGFPDLK-TLVVGSNLELSVAVTVTNDGEDSYGTTITLFYPVGLSFRRVAEAQV--FL 837

  Fly   713 KVVDAV-----------MVCDLNRGRP--------------LAKGDTDSVTISFDVSQLS--GQS 750
            :..|..           ::||....|.              ...|...:..::||||..:  |..
  Rat   838 RTEDTQQWQQQGRHSLHLMCDSTPDRSQGIWSTSCSSRHVIFRGGSQMTFLVTFDVSPKAELGDR 902

  Fly   751 LIIHAEVFSTGYEQNPTDNRQTN--------------VIGLKEFTE-IDASGGQTNSQIDLEHYS 800
            |::.|.|.|   |....:.|:|.              :....:||: ::.|..:.:....:||
  Rat   903 LLLRARVSS---ENGVPETRKTTFQLELPVKYAVYTVISSHDQFTKYLNFSASEKSRVSVVEH-- 962

  Fly   801 NSAEIVNNYEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLLSIDLY 865
                   .:::.:.|...: .::::|.:|                 |.||.:..:
  Rat   963 -------RFQVNNLGQRDL-PVSINFRVP-----------------TELKGETVW---------- 992

  Fly   866 DQNNTMLVVDPVEVTTTLSGGLERTVITQNR---QSYDIHTSGHVHQTMEVLDTSMVATASMSRK 927
                |::|..|...:|.         ..|||   ..:|:.|  |: |...|||.|:   |.....
  Rat   993 ----TVMVSHPQNPSTQ---------CYQNRLKPTQFDLLT--HM-QKSPVLDCSI---ADCLHF 1038

  Fly   928 RRDLKALTANREQYARISNVKAHDLLSDDF--KGKLP---VNRTIVFNCRDPEMTICVRAEMRVH 987
            |.|:.:|....|.               ||  ||.|.   :::|:       :..:.:.:|..:.
  Rat  1039 RCDIPSLGIQDEL---------------DFILKGNLSFGWISQTL-------QKKVLLVSEAEIS 1081

  Fly   988 FRPEKSINLNMRYSVDLNEVNAILVDPWEYFVILTDLKLQKKGDPTSTSFSINRRIEPNIISKHQ 1052
            |  :.|:     || .|....|.|                              |.:.....:..
  Rat  1082 F--DTSV-----YS-QLPGQEAFL------------------------------RAQAKTTLEMY 1108

  Fly  1053 ETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRTKKDEL---------------DRLVQQNPV 1102
            |...|:.:|:.|.:||||||:.|:.:|||.|||.|..|:.|               .::.||...
  Rat  1109 EVHNPVPLIVGSSVGGLLLLALITAVLYKAGFFKRQYKEMLAEANGQFASGNGNPNPQVTQQELP 1173

  Fly  1103 EPEAENLNS 1111
            .|.:.||.|
  Rat  1174 SPSSLNLPS 1182

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	17/99 (17%)
		FG-GAP	350..388	CDD:460357	10/37 (27%)
		Int_alpha	409..459	CDD:214549	24/52 (46%)
		Int_alpha	473..>515	CDD:214549	14/41 (34%)
		Integrin_alpha2	509..829	CDD:462478	75/387 (19%)
Itgax	NP_001406686.1	vWA_integrins_alpha_subunit	150..325	CDD:238746	23/184 (13%)
		Int_alpha	454..510	CDD:214549	15/56 (27%)
		Int_alpha	517..572	CDD:214549	24/54 (44%)
		Int_alpha	582..>606	CDD:214549	11/27 (41%)
		Integrin_alpha2	616..1040	CDD:462478	95/491 (19%)