DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and itga2b

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_001003857.1	Gene:	itga2b / 445380	ZFINID:	ZDB-GENE-051031-1	Length:	1037	Species:	Danio rerio

Alignment Length:	1198	Identity:	304/1198 - (25%)
Similarity:	490/1198 - (40%)	Gaps:	277/1198 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FPHIFLALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIRQT-----SIIVG 67
            |..:||::|...:||..||.......|.:.|:          .||||:::...|:     |::||
Zfish     7 FSLLFLSILIFTNHIRGFNLDLNQYTVFSGPE----------DSYFGFSVDFYQSSSKSVSVVVG 61

  Fly    68 APRAQSTLESQRTINETGAIYRCS-LTNG-VCSPYVLDSRGNVDAPYSEYTFDSERKDFQWLGGS 130
            ||||.:   :|..::..|:::.|. .|.| .|.....|.:|:.:..:......:.:.: ||||.|
Zfish    62 APRANT---NQSGVSHGGSVFMCPWATRGQSCQTLNFDQKGDENITFGNMLLMAHKSN-QWLGAS 122

  Fly   131 MDGGTKDTDKLLVCAPRFYAPSSRDNHLHGVCYW---VNNTVA-STPQHVTRISPLRLKSEQVKE 191
            :   ....:.:|.|||.|              :|   |:...| :||  |.....|.:|:
Zfish   123 V---RTYNNYILACAPLF--------------HWNVLVDQEEAMNTP--VGNCQLLNMKT----- 163

  Fly   192 EDNGNKASF----------FYIMG-------ELGLSAHVADDNTKFLIGAPGINTWRGSVILYRQ 239
               |..|::          .|..|       |.|.:..:. .|.:.::||||...::|.:|
Zfish   164 ---GELANYAPCREEYVYAIYTRGYPDRRYCEAGFTTDIT-KNGRVVLGAPGGYYFQGQII---- 220

  Fly   240 VDPVDNPTASRRDTSKALRRTYRDVDSNDYTPEH-YAPEIPTPGLWGQEE---DSYFGYAVSSGF 300
                   |||..:...:         .:.:||:| ...|..||    |..   |.|.||:|::|.
Zfish   221 -------TASLVNIMSS---------GSSFTPKHSMNGETKTP----QRRDYYDLYLGYSVAAGK 265

  Fly   301 FDSSN-PTKLLYVATAPQANKQSGEAYIFDVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGK 364
            |::.| |.   ||...|.....:|...|.:.....:.......|.|...|||:||...|:|.||.
Zfish   266 FNNDNIPD---YVVGVPNDLHTAGSVKIINGATVPLQIMKAISGTQIASYFGHSVAVTDINRDGW 327

  Fly   365 TDVIVSAP----QHALEDSHDNGAIYVFINKGFFNF---ERQILRSPVETMARFGTALSRLGDIN 422
            .|:::.||    |.:.:...:.|.:||::.:..|:|   ..||| :......|||:|::.|||::
Zfish   328 DDILIGAPLFMEQLSTQKFREVGQVYVYLQRNDFSFASRPNQIL-AGTYAYGRFGSAIAPLGDLD 391

  Fly   423 HDGYNDVAVGAP-FAGNGTVFIYLGSENGLRDQPSQRLDAPSQQPSKYGSHMFGHGLSRGSDIDG 486
            |||:|||||||| ....|.||||||...||..|..|.:::|.:  |.....|||..:..|:|||.
Zfish   392 HDGFNDVAVGAPGSVDGGKVFIYLGKSGGLSTQYVQVIESPFR--SLIDPPMFGFSIRGGTDIDD 454

  Fly   487 NGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIKPEQEKVK------------ITACYRL 539
            ||:.|..|||..|..|..|||..||:..|.:......:.||.:..:            |.||.|:
Zfish   455 NGYPDLIIGAWGASKVVTYRAQAVVRTQARLSFFPDLLNPEDKFCQLQQSGTYITCFTIMACIRV 519

  Fly   540 S-TTSTDKLVQEQELAI---RIAMDKQLKRVKFTQTQTNEISFKVNANFGEQCRDFETQVRYSEK 600
            | .....::|...||.:   :.:|.::...:...|..|| ....|:.|..:.||:|...:....|
Zfish   520 SGHRIPQQIVFNTELQLDRMKQSMARRTLLLDSNQPYTN-FQISVDRNSRDVCRNFTAYLLPEFK 583

  Fly   601 DIFTPIDLEMHYELTKKVPDSEEFCETCAIVDPTEPKVSTQNIIFSTGCATDVCTADLQLRSKDV 665
            |..:||.:.::|.|.    ||:.     |::......|....||.:.| ..:||..||||::...
Zfish   584 DKLSPIFISVNYSLA----DSQN-----AVLHGQSVAVGQTRIILNCG-PDNVCIPDLQLKAVTS 638

  Fly   666 SPTYILGSADTLRLNYEITNIGETAYLPQFNVTSTSRLAFAQVPGNCKVVDA------------V 718
            :...::|..:...|..|..|.||.||..:..::..:...:..|..|.:...|            :
Zfish   639 TEPILIGDENPALLIIEAENQGEGAYETELYISPPANTHYQGVLSNHEDFSALVCGQKKENGSVI 703

  Fly   719 MVCDLNRGRPLAKGDTDSVTISFDVSQLSGQSLIIHAEVFSTGYEQNPTDNRQTNVIGLK----E 779
            :||||  |.||..|......:.|.:..|  :.:..|. .|........:.|..:|::.|:    .
Zfish   704 VVCDL--GNPLEAGQQLKAGLYFSMGDL--EQVENHI-TFQMQIRSKNSQNSDSNLVQLQVNVTA 763

  Fly   780 FTEIDASGGQTNSQIDL---------EHYSNSAE-----IVNNYEIKSNGPSVIE-QLTVSFYIP 829
            ...::..|  .:|.:|.         :.|....:     |.:.||:::.|||.:. :||:.|
Zfish   764 VASLEMRG--VSSPVDCVLPISKWESKDYPEDLDEVGPLIEHVYELRNRGPSPVNVKLTLEF--- 823

  Fly   830 IAYKVAGSTAIIPIINVTS--LKMQASYDSQLLSIDLYDQNNTMLVVDPVEVTTTLSGGLERTVI 892
                        |:....|  |.:.|:...:|:|... |..|    :||            |.::
Zfish   824 ------------PVSQNESYLLYVFANASEELISCQT-DYAN----IDP------------RRLV 859

  Fly   893 TQNRQSYDIHTSGHVHQTMEVLDTSMVATASMSRKRRDLKALTANREQYARISNVKAHDLLSDDF 957
            .|  :|.:| |...||..                .:|||...|.|.:|:
Zfish   860 KQ--ESTNI-TVAEVHHF----------------NKRDLSQKTENEQQW---------------- 889

  Fly   958 KGKLPVNRTIVFNCRDPEMTI---CVRAEMRVHFRPEKSI-----NLNMRYSVDLNEVNAILVDP 1014
                  ..|:..||...|..:   ||.|.::   |.|::|     .|.::..:....||.:|...
Zfish   890 ------QHTVHVNCSSSEQCVVFDCVAAGLQ---RDERAIVRVMSRLWVQTFLKRPYVNYVLHST 945

  Fly  1015 WEYFVILTDLKLQKKGDPTSTSFSINRRIEPNII--SKHQETGLPIWIIIVSVIGGLLLLSAISY 1077
            ..|.|:....|:|....||..:     .....||  |...:..:|:|.|:||::.|||||:|:|.
Zfish   946 AHYEVMNVPSKIQPDVLPTGKA-----ETHTKIIWRSPDGQEEVPLWWIVVSIVAGLLLLAALST 1005

  Fly  1078 LLYKFGFFNRTK------KDELDRLVQQ 1099
            :.:|.|||.|.:      .|:.|.:.||
Zfish  1006 IFWKMGFFKRNRPPSDNDDDDDDDVTQQ 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	18/58 (31%)
		FG-GAP	350..388	CDD:280083	14/41 (34%)
		Int_alpha	409..459	CDD:214549	29/50 (58%)
		Int_alpha	473..>515	CDD:214549	20/41 (49%)
		Integrin_alpha2	507..829	CDD:285619	81/368 (22%)
itga2b	NP_001003857.1	Int_alpha	256..>293	CDD:214549	13/39 (33%)
		Int_alpha	309..>358	CDD:214549	16/48 (33%)
		Int_alpha	376..429	CDD:214549	29/52 (56%)
		Int_alpha	441..>480	CDD:214549	19/38 (50%)
		Integrin_alpha2	475..908	CDD:285619	108/523 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574941
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740