DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and itga3a

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	XP_017210291.1	Gene:	itga3a / 407685	ZFINID:	ZDB-GENE-090805-3	Length:	1073	Species:	Danio rerio

Alignment Length:	1120	Identity:	263/1120 - (23%)
Similarity:	447/1120 - (39%)	Gaps:	214/1120 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 QTRSSYFGYTLVI-------RQTSIIVGAPRAQSTLESQRTINETGAIYRC--SLTNGVCSPYVL 102
            :|..|.||.::.:       ::..::||||:.::  ||..:.||||.:|.|  |..:..|:...|
Zfish    39 KTAGSLFGLSVALHEQVVNEKRHMLLVGAPKEKA--ESGLSANETGDVYACPISADSKDCARLNL 101

  Fly   103 DSRGNVDAP-YSEYTFDSERKDFQWLGGSMDGGTKDTDKLLVCAPRFYAPSSRDNHLHGVCYWVN 166
            .|....|.| ...|..|.     .|||.|:...::...:::.|..|:....:.:..:.|.||...
Zfish   102 ISSNPEDKPDLKNYVIDG-----MWLGVSIVSQSQPGGRVVACGHRYIRNFTSNFRMIGRCYVRG 161

  Fly   167 NTVASTPQHVTRISPLRLKSEQVKEED---NGNKASFFYIMGELGLSAHVADDNTKFLIGAPGIN 228
            |.:           .|.|...|.:..|   :..:|.....|..||:||.|.  .::...||||..
Zfish   162 NDL-----------QLNLSDYQWQSYDEICDPREAQNSEGMCLLGMSAAVT--FSEIFFGAPGCF 213

  Fly   229 TWRGSVILYRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEEDSYFG 293
            .|:|::.     ....||.    |....|:....|                     .::.:.|.|
Zfish   214 NWQGNIF-----SKWHNPA----DEFHLLKSKLPD---------------------SRKGNIYIG 248

  Fly   294 YA--VSSGFFDSSNPTKLLYVATAPQANKQSGEAYIFDV---RGKSIHKYHV-FRGEQFGEYFGY 352
            |:  |..........|    |.|....::..|...:.:|   .|....|..| ..|||.|.|||.
Zfish   249 YSTIVDQDVLVKGKDT----VVTGAPRDEAKGSVMMAEVLKSGGSGEVKIKVTVTGEQVGSYFGN 309

  Fly   353 SVLAEDLNGDGKTDVIVSAPQHALEDSHDNGAIYVFINK--GFFNFERQILRSPVETMARFGTAL 415
            ||...|||.||..|:||.||.:........||:||::|:  .|.|....:|..|.:  :.||.::
Zfish   310 SVAVVDLNNDGWKDLIVGAPFYFDRKMDKGGAVYVYMNQNGSFRNKSDVVLTGPKD--SGFGMSV 372

  Fly   416 SRLGDINHDGYNDVAVGAPFAGNGTVFIYLGSENGLRDQPSQRLDAPSQQPSKYGSHMFGHGLSR 480
            ..:||:|.||:.|.|||||:...|.|.|:.||:.|:..:|||.:|.......  |...||:.:||
Zfish   373 VAIGDVNQDGFQDFAVGAPYHSTGRVSIWTGSKTGISQEPSQVIDGKDIPGG--GFQTFGYSISR 435

  Fly   481 GSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIKPE------QEKVKITACYRL 539
            |.|:|.||:.|.|:|:.: :.|.|.|:.||:.:..|.......|..|      :.||..:..|..
Zfish   436 GLDVDRNGYPDIAVGSLD-DRVVLLRSRPVIHLKNTFTVTPMVINLEDCVACIEAKVCFSYTYST 499

  Fly   540 STTSTDKLVQEQELAIRIAMDKQLK---RVKFTQTQTNEISFKVNANFGEQCRDFETQVRYSE-K 600
            .|.|:.|.|   .|...:..|:|..   ||.|......:.:.|::.|....|...:.::.... :
Zfish   500 GTASSQKAV---TLQYTVEADQQSSRSPRVSFLDNNKGKYTGKMSVNPSGDCHSLKLELASKTIQ 561

  Fly   601 DIFTPIDLEMHYELTKKVPDSEEFCETCA---IVDPTEPKVSTQNIIFSTGCATD-VCTADLQLR 661
            |..:.|..::...:....|...:..|..:   ::...:.......|.....|..| .|.::||:.
Zfish   562 DKVSAIIFQLSVSVVDPPPSGGKMLEDLSAFPVISQRDALTGRAEIHIQKACGLDNKCESNLQMT 626

  Fly   662 S--KDVSPTYILGSADTLRLNY-----------EITNI------GETAYLPQFNVTSTSRLAFA- 706
            :  .|...|..|...|....||           .::|:      .|.||....|:|..|.|:|:
Zfish   627 AAFTDEKNTPFLMQEDHQIFNYTTDIKKLKLLVNVSNVPSEGRKAEDAYNAILNITIPSSLSFSS 691

  Fly   707 ---QVP----GNCKVVDAVMVCDLNRGRPLAKGDTDSVTISFDVSQLSGQSLIIHAEV-FSTGYE 763
               ::|    |:.....:.::|.|  |.|........:.|:|:.|.:|.....|..|: .||..:
Zfish   692 LNPKLPSTLNGDPSSGGSYLLCTL--GDPFKSNQRVEIEITFETSGISIDMQEIETELQLSTLSD 754

  Fly   764 QNPTDNRQTNVIGLKEFTEIDASGGQTNSQIDLEHYSN---SAEIVNNYEIKSNGPSVIEQLTVS 825
            ||  |.|..:.:.|.|:.        .....:|..|..   |..:|....:||         |..
Zfish   755 QN--DLRPLSRVLLVEYI--------LQPLFNLIPYFRAEFSGNVVGESAMKS---------TSD 800

  Fly   826 FYIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLLSIDLYDQNNTMLVVDPVEVTTTLSGGLERT 890
            ...|:.:.::...:..|:.|:..|::...:.|.:.:      ...:|.:..:::|.|
Zfish   801 IGSPVEFNISVDISGKPLGNLGFLEVVFQWPSAVAN------EKWLLYLSEIQMTGT-------- 851

  Fly   891 VITQNRQSYDIHTSGHVHQTMEVLDTSMVATASMSRKRRDLKALTANR---EQYARISNVKAHDL 952
                 .:|:.: ..|.|:      ..::..:...||:|:..:.|:.::   .|..|....|..::
Zfish   852 -----SESFCV-AKGIVN------PLNLTVSERKSRRRKRDEVLSESKLAMSQKTRQGQNKPREV 904

  Fly   953 LSDDFKGKLPVNRTIVFNCRDPEMTICVRAEMRVHFRPEKSINLNMRYSVDLNEVNAILVDPW-- 1015
            |:.. ||   ..|...|:|                  |..::..:...:|.....|:.:::.:
Zfish   905 LNCT-KG---TARCQTFSC------------------PLSAMKTSAMLTVRARVWNSTMLEDYRA 947

  Fly  1016 -----EYFVILTDLKLQKKGDPTSTS---FSINRRIEPNIISKHQETGLPIWIIIVSVIGGLLLL 1072
                 :..|:|| ||..||....:.:   |::  .|:| .:::......|:|||||||:.|:::|
Zfish   948 KGVSVQGSVMLT-LKTDKKNIKMNNNIREFTV--EIDP-AVAEELPYEAPLWIIIVSVLSGVVML 1008

  Fly  1073 SAISYLLYKFGFFNR 1087
            ..|..||:|.|||.|
Zfish  1009 GVIVILLWKSGFFTR 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	17/60 (28%)
		FG-GAP	350..388	CDD:280083	17/37 (46%)
		Int_alpha	409..459	CDD:214549	22/49 (45%)
		Int_alpha	473..>515	CDD:214549	17/41 (41%)
		Integrin_alpha2	507..829	CDD:285619	73/366 (20%)
itga3a	XP_017210291.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574936
Domainoid	1	1.000	61	1.000	Domainoid score	I10420
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.740