DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and itga9

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_001311427.1	Gene:	itga9 / 394012	ZFINID:	ZDB-GENE-040426-1129	Length:	1032	Species:	Danio rerio

Alignment Length:	1175	Identity:	290/1175 - (24%)
Similarity:	481/1175 - (40%)	Gaps:	270/1175 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IFLALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLV--IRQTS--IIVGAPRA 71
            :|:.|.: :|...:||...:...|...|.          :::|||:::  :...:  |:||||||
Zfish    18 VFVCLCS-VSLAYSFNIDLQYPVVFRGPD----------ATFFGYSVLEHVHDNTRWIVVGAPRA 71

  Fly    72 QSTLESQRTINETGAIYRCSLTNGV---CSPYVLDSRGNVDAPYSEYTFDSERKDFQWLGGSMDG 133
            .|:..|  ::...||:|:|.:.|..   |:...| .|||........|...:|.| :|:|.|:..
Zfish    72 NSSFSS--SVQSPGAVYKCRIRNNPEQRCTEMDL-GRGNKQRESCGKTCQGDRND-EWMGVSLAR 132

  Fly   134 GTKDTDKLLVCAPRFYAPSSRDNHL--HGVCYWVNNTVASTPQHVTRISPLRLKSEQVKE---ED 193
            ..|...|:|.||.|:........::  ||.|..:...:....|      ||....|..|:   |:
Zfish   133 QNKPNGKILACAHRWKNVYYESEYILPHGYCSIIPANLQGKSQ------PLIPCYEDHKKTYGEE 191

  Fly   194 NGNKASFFYIMGELGLSAHVADDNTKFLI--GAPGINTWRGSVILYRQVDPVDNPTASRRDTSKA 256
            :|:            ..|.:|...|:.|:  ||||...|.|:|.::       |.|::
Zfish   192 HGS------------CQAGIAGVFTEELVVMGAPGSYYWTGTVKVF-------NMTSN------- 230

  Fly   257 LRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQANKQ 321
               |:.:::.:|.:|..|               ||.||||::|.|  |:|..:...|.||| :..
Zfish   231 ---THYNLNQDDLSPHRY---------------SYLGYAVTAGHF--SSPNTIDVAAGAPQ-DSG 274

  Fly   322 SGEAYIFDVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQHALEDSHDNGAIY 386
            .|:.|:|.:.|.::.|.....|:..|.|||.|:.|.|||.||.:|::|.||.|:  :..|.|.:.
Zfish   275 GGKVYVFRIEGTALVKIFQASGKMMGSYFGSSLCAVDLNADGLSDLLVGAPMHS--EIRDEGQVS 337

  Fly   387 VFINKGFFNFER-QILRSPVETMARFGTALSRLGDINHDGYNDVAVGAPFAGN--GTVFIYLGSE 448
            |:::.|....|. .||.......|.||..::.||||:.|||.|||:|||...:  |.|:||.|..
Zfish   338 VYLSSGNGVMEEVAILNGDNAYNAHFGECITSLGDIDDDGYQDVAIGAPEEDDYGGAVYIYHGDA 402

  Fly   449 NGLRDQPSQRLDAPSQQPSKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKV 513
            .|:.::.|.||...|..|:   ..|||..:|...|:||||:.|..|||..|::|.|.|:.||:.|
Zfish   403 RGIVNKYSMRLSGRSINPT---LQMFGQSISGNVDMDGNGYPDVTIGAFMADSVVLLRSRPVISV 464

  Fly   514 HATV---------KSESREIKPEQEKVKITAC---------------YRLSTTSTDKLVQEQELA 554
            ..::         ..:..|.........:|.|               |.|:..|
Zfish   465 DVSIFLPVSINITVPQCHEGPQHLNCFNVTVCMSFRGKHVPGHIELLYNLTADS----------- 518

  Fly   555 IRIAMDKQLK----RVKFTQ--TQTNEISFKVNANF-GEQCRDFETQVRYSEKDIFTPIDLEMHY 612
                 ||:.|    |..|..  .||..:|.:.|... .:||..:...||...||:|..|..|..|
Zfish   519 -----DKRHKGLPPRAYFGNGGEQTGVVSQRFNLEIHRQQCHQYTAFVRKEVKDVFAAIVFEAAY 578

  Fly   613 ELTKKVPDSEEFCETCAIVDPTEP--------KVSTQN-IIFSTGCATDVCTADLQLRSK-DVSP 667
            .|.|.:.|..:..:    :.|..|        |::.:| ..|...|.:|.|.|||||..| .:|.
Zfish   579 SLGKHIVDEHQDRD----LPPLSPILRWKKGEKIAAKNETWFEKNCLSDDCAADLQLHGKLLLSG 639

  Fly   668 TYI-----LGSADTLRLNYEITNIGETAYLPQ--FNVT-STSRLAFAQVPG---NCKVVDA-VMV 720
            .||     ||....:.||..|:|.|:.||...  ||.: ....:.|.|...   :|.:|:. .:.
Zfish   640 RYISSHLALGGVKNVSLNLTISNAGDDAYDTNIYFNFSKEVHYINFLQREEKGISCMLVELDFLK 704

  Fly   721 CDLNRGRPLAKGDTD-SVTISFDVSQLSGQS----LIIHAEVFSTGYEQNPTDNR---------- 770
            |.:  |.|..:..|. .::..||.|:|||::    .::||...:..::....||.
Zfish   705 CSV--GFPFMRAQTKYHISALFDTSRLSGENETLLFLVHARSANPEHDNTLHDNTLELSIPLVHE 767

  Fly   771 -QTNVIGLKEFTEIDASGGQTNSQ-IDLEHYSNSAEIVN-NYEIKSNGPSVIEQLTVSFYIPIAY 832
             .|.:.|:...|..........|: :.||....|.:.:| .:::.:||||.:....|...||  :
Zfish   768 VDTTITGVVNPTSFVYGNSVDRSRFVQLEDMECSFQPLNFTFQVINNGPSRLPGSRVDIRIP--H 830

  Fly   833 KVAGSTAIIPIINVTSLKMQASYDSQLLSIDLYDQNNTMLVVDPVEVTTTLSGGLERTVITQNRQ 897
            ::|||          ..:|....|:|:...    :.|.....:|...|           |.|:::
Zfish   831 RLAGS----------GPEMFHIIDTQVSDA----RGNCTWHRNPKPCT-----------IPQDKE 870

  Fly   898 SYDIHTSGHVHQTMEVLDTSMVATASMSRKRRDLKALTANREQYARISNVKAHDLLSDDFKGKLP 962
            |. .||                ..|..::..|  |.|..:|                       |
Zfish   871 SI-FHT----------------IFAFFTKSGR--KVLDCDR-----------------------P 893

  Fly   963 VNRTIVFNCRDPEMTICVRAEMRVHFRPEKSINLNMRYSVDL--NEVNAILVDPWEYFVILTDLK 1025
            ....:..:|     ::..:|:     ....||::.|..:.::  .:.::::     .||....::
Zfish   894 GRACLTISC-----SLGSQAK-----EEATSIDVQMLLNTEILQRDSSSVI-----QFVTRGHVQ 943

  Fly  1026 LQKKGDPTSTSFSINRRIEPNIISKHQETGLPI-WIIIVSVIGGLLLLSAISYLLYKFGFFNRTK 1089
            |..:....|:....:..:....:...:..|..: |||.:|::.|:|:...::.||:|.|||.|..
Zfish   944 LDDRTVEVSSGLPDDISLVMEALHSQEPRGYVVGWIIAISLLVGILIFLLLAVLLWKMGFFRRHY 1008

  Fly  1090 KDELD 1094
            ::.::
Zfish  1009 REIIE 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	18/58 (31%)
		FG-GAP	350..388	CDD:280083	16/37 (43%)
		Int_alpha	409..459	CDD:214549	23/51 (45%)
		Int_alpha	473..>515	CDD:214549	20/41 (49%)
		Integrin_alpha2	507..829	CDD:285619	90/392 (23%)
itga9	NP_001311427.1	Int_alpha	45..93	CDD:214549	16/59 (27%)
		Int_alpha	245..293	CDD:214549	20/65 (31%)
		Int_alpha	299..345	CDD:214549	20/47 (43%)
		Int_alpha	360..413	CDD:214549	23/52 (44%)
		Int_alpha	423..>465	CDD:214549	19/41 (46%)
		Integrin_alpha2	458..902	CDD:285619	112/534 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574944
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D105280at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850