DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and ItgaPS5

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_611808.2	Gene:	ItgaPS5 / 37732	FlyBaseID:	FBgn0034880	Length:	1018	Species:	Drosophila melanogaster

Alignment Length:	1108	Identity:	587/1108 - (52%)
Similarity:	761/1108 - (68%)	Gaps:	112/1108 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IFLALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIRQTSIIVGAPRAQSTL 75
            :||..|||.....|.||.|.|:|||::|||||..:.|.|||||||:||||.|||.||||||||||
  Fly     5 LFLIFLALKYQSNAMNFSPLPNRVIDAPKHLKTRMIQVRSSYFGYSLVIRPTSIFVGAPRAQSTL 69

  Fly    76 ESQRTINETGAIYRCSLTNGVCSPYVLDSRGNVDAPYSEYTFDSERKDFQWLGGSMDGGTKDTDK 140
            |||.:||||||:|||.|.:|.||.|||:.:.|              |.|||||||||||||||||
  Fly    70 ESQGSINETGAVYRCPLASGSCSHYVLNDKLN--------------KQFQWLGGSMDGGTKDTDK 120

  Fly   141 LLVCAPRFYAPSSRD-NHLHGVCYWVNNTVASTPQHVTRISPLRLKSEQVKEEDNGNKASFFYIM 204
            ||||||||:.|.::: ..:.|:||||.:|||.||. ::.:..:.|...|.:|          :.|
  Fly   121 LLVCAPRFFVPKNKNYGQMRGICYWVRDTVADTPP-LSDVRTISLIPSQAEE----------HFM 174

  Fly   205 GELGLSAHVADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRDTSKALRRTY--RDVDSN 267
            .||||||||.|||:.|||||||:.:|:|||:::|..|             .|.:.:|  :.:||.
  Fly   175 LELGLSAHVTDDNSGFLIGAPGVRSWKGSVLVHRGED-------------LAAQGSYAVKMLDSW 226

  Fly   268 DYTPEHYAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGEAYIFDVRG 332
            |:...|:               :|.|||:|||:|.|:|.|.||||.|||.:...:|:||||||.|
  Fly   227 DWVKNHF---------------TYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFDVVG 276

  Fly   333 KSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQHALEDSHDNGAIYVFINKGFFNFE 397
            :.:.|.|||.|||.||||||||:||||||||.|||:||||.:||.||:|.||||||||||.|.||
  Fly   277 EIVRKLHVFHGEQLGEYFGYSVVAEDLNGDGLTDVVVSAPLNALGDSYDVGAIYVFINKGLFKFE 341

  Fly   398 RQILRSPVETMARFGTALSRLGDINHDGYNDVAVGAPFAGNGTVFIYLGSENGLRDQPSQRLDAP 462
            ::|:|.|:.:.||||::||::||||||||||:||||||||||.|||:||||:||||:||||||||
  Fly   342 KKIIRLPLSSGARFGSSLSKVGDINHDGYNDLAVGAPFAGNGAVFIFLGSEHGLRDEPSQRLDAP 406

  Fly   463 SQQPSKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIKPE 527
            |::|..||:||||.|||||||||||||||.|||||.||||||||||||||:||||:||||.|:||
  Fly   407 SREPGPYGAHMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVVKIHATVRSESRAIRPE 471

  Fly   528 QEKVKITACYRLSTTSTDKLVQEQELAIRIAMDKQLKRVKFTQTQTNEISFKVNANFGEQCRDFE 592
            ||.:.:||||||.|||..:.:|:|||..|:.:|:.|:||.|...:|||:||:..|.....||:|.
  Fly   472 QETITVTACYRLETTSKARQMQQQELTFRMTIDELLQRVSFAPMRTNEVSFQAQAGLSGSCRNFS 536

  Fly   593 TQVRYSEKDIFTPIDLEMHYELTKKVPDSEE-FCETCAIVDPTEPKVSTQNIIFSTGCATDVCTA 656
            ..|.|: ..||||||||:||||.||:|.|.| |||:||:|||.|||.:|..:.|.||||..||.:
  Fly   537 VGVHYT-GGIFTPIDLELHYELAKKIPHSHEAFCESCAVVDPLEPKYATGTLSFMTGCAAHVCVS 600

  Fly   657 DLQLRSKDVSPTYILGSADTLRLNYEITNIGETAYLPQFNVTSTSRLAFAQVPGNCKVVDAVMVC 721
            ||||.||||:.::|.||.:.|..:|||||.||.||:.||||||::||.||:|||||:|...||:|
  Fly   601 DLQLSSKDVNSSFIFGSLEVLSFSYEITNSGEPAYVAQFNVTSSARLPFAKVPGNCRVRHEVMLC 665

  Fly   722 DLNRGRPLAKGDTDSVTISFDVSQLSGQSLIIHAEVFSTGYEQNPTDNRQTNVIGLKEFTEIDAS 786
            |||.||.||:||::|:||.|||:|||||||.|.|.|.|.|.:|||.||..:..|.|:|:.|||||
  Fly   666 DLNGGRALARGDSESLTIIFDVTQLSGQSLTIEAAVSSAGMDQNPKDNTMSTTISLREYAEIDAS 730

  Fly   787 GGQTNSQIDLEHYSNSAEIVNNYEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKM 851
            ||..:..|.|:.|..|||:.|:||.||:|||:|::|||...:||||.|.||..|..|.|::||:|
  Fly   731 GGPIDGHIALKEYPYSAEVNNSYEFKSHGPSIIDELTVYVDVPIAYTVTGSAGIKSIFNISSLQM 795

  Fly   852 QASYDSQLLSIDLYDQNNTMLVVDPVEVTTTLSGGLERTVITQNRQSYDIHTSGHVHQTMEVLDT 916
            ||::.|:|:.|.||||.||:....|:|                                    |:
  Fly   796 QATHGSELVPIKLYDQTNTLAKEYPLE------------------------------------DS 824

  Fly   917 SMVATASMSRKRRDLKALTANREQYARISNVKAHDLLSDDFKGKLPVNRTIVFNCRDPEMTICVR 981
            |..|    :||||:|:     ::|||.:.:|...|:|:   |..||.|||:|.:|.....|||||
  Fly   825 SRRA----NRKRRELQ-----QDQYAIMPDVNISDILT---KENLPANRTLVLDCLRGNWTICVR 877

  Fly   982 AEMRVHFRPEKSINLNMRYSVDLNEVNAILVDPWEYFVILTDLKLQKKGDPTSTSFSINRRIEPN 1046
            ::|||..:||:.|:|.:.:.||||:    .|:.::|.||.|::::.|:||  |||.::.|.::||
  Fly   878 SQMRVQLKPEQPIDLRISFKVDLND----FVNTFDYLVIFTNVEMFKEGD--STSIALKRNLKPN 936

  Fly  1047 IISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRTKKDELDRLVQQNPVEPEAENLNS 1111
            :|..:.||.||||.||:|:|.|.|||.|::|:|||..||.|.||:||.||::::..|.:....:.
  Fly   937 VIFNYSETPLPIWYIILSLIAGHLLLGAMTYILYKLRFFKRGKKEELKRLLEEHRSETKEPATDC 1001

  Fly  1112 GGN 1114
            .||
  Fly  1002 EGN 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	40/51 (78%)
		FG-GAP	350..388	CDD:280083	29/37 (78%)
		Int_alpha	409..459	CDD:214549	40/49 (82%)
		Int_alpha	473..>515	CDD:214549	37/41 (90%)
		Integrin_alpha2	507..829	CDD:285619	185/322 (57%)
ItgaPS5	NP_611808.2	VCBS	302..375	CDD:338792	50/72 (69%)
		Int_alpha	351..403	CDD:214549	40/51 (78%)
		Int_alpha	417..463	CDD:214549	41/45 (91%)
		Integrin_alpha2	451..836	CDD:337057	218/425 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470092
Domainoid	1	1.000	61	1.000	Domainoid score	I10420
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	724	1.000	Inparanoid score	I1731
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG27051
OrthoDB	1	1.010	-	-		D10102at7147
OrthoFinder	1	1.000	-	-		FOG0012678
OrthoInspector	1	1.000	-	-		mtm9718
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X10533
	10	10.010