DRSC/TRiP Functional Genomics Resources

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Protein Alignment scb and ITGAV

DIOPT Version :9

Sequence 1:NP_523750.2 Gene:scb / 36692 FlyBaseID:FBgn0286785 Length:1115 Species:Drosophila melanogaster
Sequence 2:NP_002201.2 Gene:ITGAV / 3685 HGNCID:6150 Length:1048 Species:Homo sapiens


Alignment Length:1199 Identity:291/1199 - (24%)
Similarity:480/1199 - (40%) Gaps:277/1199 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 LISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTL------VIRQTSIIVGAPRAQSTLE 76
            |:....|||.      .::||.    ..:....||||:.:      ...:..::||||:|.:|  
Human    24 LLPLCRAFNL------DVDSPA----EYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTT-- 76

  Fly    77 SQRTINETGAIYRCSLTN-GVCSPYVLDSRGNVDAPYSEYTFDS--ERKDFQWLGGSMDGGTKDT 138
             |..|.|.|.:.:|..:: ..|.|...|:.||.|     |..|.  |.|..||.|.|:   ....
Human    77 -QPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRD-----YAKDDPLEFKSHQWFGASV---RSKQ 132

  Fly   139 DKLLVCAPRFY--APSSRDNHLHGVCYWVNNTVASTPQHVTRISPLRLKSEQVKEEDNGNKASFF 201
            ||:|.|||.::  ....::....|.|:..:.|      .....:|.|  |:.:..:..|      
Human   133 DKILACAPLYHWRTEMKQEREPVGTCFLQDGT------KTVEYAPCR--SQDIDADGQG------ 183

  Fly   202 YIMGELGLSAHVADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRDTSKALRRTYRDVDS 266
            :..|...:....||   :.|:|.||...|:|.:|                  |..:.......|.
Human   184 FCQGGFSIDFTKAD---RVLLGGPGSFYWQGQLI------------------SDQVAEIVSKYDP 227

  Fly   267 NDYTPEHYAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGEAYIFDVR 331
            |.|:.: |..::.|.......:|||.||:|:.|.|:......  :|:..|:|.:..|..||:|  
Human   228 NVYSIK-YNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDD--FVSGVPRAARTLGMVYIYD-- 287

  Fly   332 GKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQHALEDS----HDNGAIYVFINKG 392
            ||::...:.|.|||...|||:||.|.|:|||...||.:.||......|    .:.|.:.|.:.:.
Human   288 GKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRA 352

  Fly   393 FFNFERQILRSPVETMARFGTALSRLGDINHDGYNDVAVGAPFAG---NGTVFIYLGSENGLRDQ 454
            ..:|:...|.. .|..||||:|::.|||::.||:||:|:.||:.|   .|.|:|:.|...||...
Human   353 SGDFQTTKLNG-FEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAV 416

  Fly   455 PSQRLD----APSQQPSKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHA 515
            |||.|:    |.|..||      ||:.:...:|||.||:.|..:||...:...||||.||:.|:|
Human   417 PSQILEGQWAARSMPPS------FGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNA 475

  Fly   516 TVKSESREIKPEQEKVKI------TACYR----LSTTSTDKLVQEQELAIRIAMDK-----QLKR 565
            .::.....:..:.:...:      .:|:.    |.......|.::....:.:.:||     .::|
Human   476 GLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRR 540

  Fly   566 VKFTQTQTNEISFKVNANFG--EQCRDFETQVR-YSE-KDIFTPIDLEMHYELTKKVPDSEEFCE 626
            ..|..:::...|..:..:.|  .||.:....:| .|| :|..|||.:.|.|.|     |.....:
Human   541 ALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRL-----DYRTAAD 600

  Fly   627 TCAIVDP-----TEPKVSTQ-NIIFSTGCATDVCTADLQLR-SKDVSPTYILGSADTLRLNYEIT 684
            |..: .|     |...:|.| :|:...| ..:||...|::. ..|....|| |..:.|.|..:..
Human   601 TTGL-QPILNQFTPANISRQAHILLDCG-EDNVCKPKLEVSVDSDQKKIYI-GDDNPLTLIVKAQ 662

  Fly   685 NIGETAYLPQFNVTSTSRLAFAQVPGNCKVVDAV------------MVCDLNRGRPLAKGDTDSV 737
            |.||.||..:..|:...:..|..|..|.:.:..:            :||||  |.|:..|.....
Human   663 NQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDL--GNPMKAGTQLLA 725

  Fly   738 TISFDVSQLSGQSLIIHAEVFSTGYEQNPTDNRQTNV-------IGLKEFTEIDASGGQTNSQID 795
            .:.|.|.|.|.....:..::      |..:.|....|       :.|.....::..|..:...:.
Human   726 GLRFSVHQQSEMDTSVKFDL------QIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVF 784

  Fly   796 L-----EHYSNS------AEIVNN-YEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTS 848
            |     ||..|.      ..:|.: ||:::||||...:..:....|..|.               
Human   785 LPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYN--------------- 834

  Fly   849 LKMQASYDSQLLSIDLYDQNNTM-----LVVDPVEV------TT----TLSGGLERTVITQNR-- 896
                   ::.||.|..||.:..|     :.::|:.:      ||    |::|..||..:...|  
Human   835 -------NNTLLYILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDL 892

  Fly   897 --QSYDIHTSG-HVHQTMEVLDTSMVATASMSRKRRDLKALTANREQYARISNVKAHDLLSDDFK 958
              ...||||.| .|.|.::::       ..:.|..|...|          |..||:. |.::.|.
Human   893 ALSEGDIHTLGCGVAQCLKIV-------CQVGRLDRGKSA----------ILYVKSL-LWTETFM 939

  Fly   959 GKLPVNRTIVFNCRDPEMTICVRAEMRVHFRPEKSINLNMRYSVDLNEVNAILVDPWEYFVILTD 1023
            .|                                 .|.|..||:..:....::..|::      :
Human   940 NK---------------------------------ENQNHSYSLKSSASFNVIEFPYK------N 965

  Fly  1024 LKLQKKGDPTSTSFSINRRIEPNIISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRT 1088
            |.::...:.|..:.::...|:|      ....:|:|:||::|:.|||||:.:.:::|:.|||.|.
Human   966 LPIEDITNSTLVTTNVTWGIQP------APMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRV 1024

  Fly  1089 K--KDELDRLVQQNPVEPEAENLNSGGNN 1115
            :  ::|.:| .|..|.|      |..||:
Human  1025 RPPQEEQER-EQLQPHE------NGEGNS 1046

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scbNP_523750.2 Int_alpha 51..103 CDD:214549 17/58 (29%)
FG-GAP 350..388 CDD:280083 15/41 (37%)
Int_alpha 409..459 CDD:214549 25/52 (48%)
Int_alpha 473..>515 CDD:214549 17/41 (41%)
Integrin_alpha2 507..829 CDD:285619 79/378 (21%)
ITGAVNP_002201.2 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 32..98 18/78 (23%)
Int_alpha 46..103 CDD:214549 17/59 (29%)
WD40 repeat 51..120 CDD:293791 20/76 (26%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 109..170 18/74 (24%)
WD40 repeat 126..183 CDD:293791 13/67 (19%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 173..225 14/80 (18%)
WD40 repeat 188..248 CDD:293791 15/81 (19%)
VCBS 221..271 CDD:316075 13/52 (25%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 237..291 18/57 (32%)
Int_alpha 248..>288 CDD:214549 15/43 (35%)
WD40 repeat 254..298 CDD:293791 13/47 (28%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 292..357 21/64 (33%)
Int_alpha 302..355 CDD:214549 17/52 (33%)
WD40 repeat 307..362 CDD:293791 16/54 (30%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 358..415 24/57 (42%)
Int_alpha 367..421 CDD:214549 25/53 (47%)
WD40 repeat 371..422 CDD:293791 22/50 (44%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 419..482 24/68 (35%)
Int_alpha 434..476 CDD:214549 17/41 (41%)
Integrin_alpha2 467..914 CDD:312071 102/491 (21%)
GFFKR motif 1019..1023 3/3 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1027..1048 8/27 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141976
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3637
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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