DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and ITGAL

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_002200.2	Gene:	ITGAL / 3683	HGNCID:	6148	Length:	1170	Species:	Homo sapiens

Alignment Length:	1327	Identity:	268/1327 - (20%)
Similarity:	460/1327 - (34%)	Gaps:	411/1327 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IFLALLALISHI------EAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIRQTSIIVGAP 69
            |.:..:||:|..      .::|...|.:|..:.|:         ...:|||.::.....:|||||
Human     6 ITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPR---------AGRHFGYRVLQVGNGVIVGAP 61

  Fly    70 RAQSTLESQRTINETGAIYRCSLTNGVCSPYVLDSRGNVDAPYSEYTFDSERKDFQWLGGSMDGG 134
            ...         |.||::|:|....|.|.|..|  ||      |.||       .::||  |...
Human    62 GEG---------NSTGSLYQCQSGTGHCLPVTL--RG------SNYT-------SKYLG--MTLA 100

  Fly   135 TKDTD-KLLVCAPRFYAPSSRDNHLHGVCY-----------------------------WVNNTV 169
            |..|| .:|.|.|.......::.:|.|:||                             ..:.::
Human   101 TDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSM 165

  Fly   170 ASTPQHVTRISPL------RLK---------------------SEQVKEED-------------- 193
            :..|....:|...      :|.                     |:.||.:|
Human   166 SLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLL 230

  Fly   194 -----------------------NGNKASFFYIMGELGLSAHV--ADDNTKFLIG-APGINTWRG 232
                                   :..|.......||...|.::  |.|..:::|| .....|...
Human   231 TNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKES 295

  Fly   233 SVILYRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYTPE--------HYAPEIPTPGL------ 283
            ...|::......:......||.:.|:..:.::....|..|        .:..|:.:.|:
Human   296 QETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSR 360

  Fly   284 ------------W-----------------GQE------EDSYFGYAVSSGFFDSSNPTKLLYVA 313
                        |                 |.|      ...|.||.|:  :..|...|.||  |
Human   361 GHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVT--WLPSRQKTSLL--A 421

  Fly   314 TAPQANKQSGEAYIFDVRGKSIH--KYHVFRGEQFGEYFGYSVLAEDLNGDGKTD-VIVSAPQHA 375
            :.....:..|...:|.......|  :.....|.|.|.|||..:...|::.||:|: :::.||...
Human   422 SGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFY 486

  Fly   376 LEDSHDNGAIYVFINKGFFNFER--QILRSPVETMARFGTALSRLGDINHDGYNDVAVGAPFAGN 438
            .|..  .|.:::: .:....||.  ::...|...:.|||.|::.|.|||.||..|||||||....
Human   487 GEQR--GGRVFIY-QRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQ 548

  Fly   439 GTVFIYLGSENGLRDQPSQRLDAPSQQPSKYGSHMFGHGLSRGSDIDGNGFNDFAIGA------- 496
            |.|:|:.|...||..|||||::. :|..|  |...||..:....|::|:|..|.|:||
Human   549 GAVYIFNGRHGGLSPQPSQRIEG-TQVLS--GIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVL 610

  Fly   497 ---PNAEAVYLYRAYPV-VKVHATVKSESREIKPEQEKVKITACYRLSTTSTD---KLVQEQELA 554
               |..:.|.|....|. :.||....|.|...| .:|.|.||.|:::.:....   :||......
Human   611 SSRPVVDMVTLMSFSPAEIPVHEVECSYSTSNK-MKEGVNITICFQIKSLIPQFQGRLVANLTYT 674

  Fly   555 IRIAMDKQLKRVKFTQTQTNEISFKVNANFGEQCRDFETQVRYSEKDIFTPIDLEMHYEL----- 614
            :::...:..:|..|...: :|:...:.......|.||........:|:.:||::.:::.|
Human   675 LQLDGHRTRRRGLFPGGR-HELRRNIAVTTSMSCTDFSFHFPVCVQDLISPINVSLNFSLWEEEG 738

  Fly   615 --------TKKVPDSEEFCETCAIVDPTEPKVSTQNIIFSTGCATD-VCTADLQL-----RSKDV 665
                    .|.:|         .|:.|:... .|..|.|...|..| .|.|:|::     ||:.:
Human   739 TPRDQRAQGKDIP---------PILRPSLHS-ETWEIPFEKNCGEDKKCEANLRVSFSPARSRAL 793

  Fly   666 SPTYILGSADTLRLNYEITNIGETAYLPQFNVTSTSRLAF---------AQVPGNC-------KV 714
            .    |.:..:|.:...::|:.|.||..|.::.....|:|         :|:|.:|       ::
Human   794 R----LTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQIPVSCEELPEESRL 854

  Fly   715 VDAVMVCDLNRGRPLAK-GDTDSVTISFD--VSQLSGQSLIIHAEVFSTGYEQN-PTDNRQTNVI 775
            :...:.|  |...|:.| |.:.::.:.|:  |:...|.|:.:||.|.....:.: ..||..|.:|
Human   855 LSRALSC--NVSSPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTCNNEDSDLLEDNSATTII 917

  Fly   776 GL----------KEFTEIDASGGQTNSQIDLEHYSNSAEIVNNYEIKSNGPSVIEQLTVSFYIPI 830
            .:          :|.:.:..|......:|.        ::.:.|:::.. ||:.:.     .||.
Human   918 PILYPINILIQDQEDSTLYVSFTPKGPKIH--------QVKHMYQVRIQ-PSIHDH-----NIPT 968

  Fly   831 AYKVAG---STAIIPIINVTSLKMQASYDSQLLSIDLYDQNNTMLVVDPVEVTTTLSGGLERTVI 892
            ...|.|   ..:..||.:..|::|:......      |:....:    |......|.|.|.|..:
Human   969 LEAVVGVPQPPSEGPITHQWSVQMEPPVPCH------YEDLERL----PDAAEPCLPGALFRCPV 1023

  Fly   893 TQNRQSYDIHTSGHVHQTMEVLDTSMVATASMSRKRRDLKALTANREQYARISNVKAHDLLSDDF 957
            . .||...:...|    |:|:                              :..::|..:.|
Human  1024 V-FRQEILVQVIG----TLEL------------------------------VGEIEASSMFS--- 1050

  Fly   958 KGKLPVNRTIVFNCRDPEMTICVRAEMRVHFRPEKSINLNMRYSVDLNEVNAILVDPWEYFVILT 1022
                                :|  :.:.:.|...|..:|   |.     .||.|..    .|:..
Human  1051 --------------------LC--SSLSISFNSSKHFHL---YG-----SNASLAQ----VVMKV 1081

  Fly  1023 DLKLQKKGDPTSTSFSINRRIEPNIISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNR 1087
            |:..:|:                           .:::.::|.|||||||..|..:|||.|||.|
Human  1082 DVVYEKQ---------------------------MLYLYVLSGIGGLLLLLLIFIVLYKVGFFKR 1119

  Fly  1088 TKKDELD--RLVQQNPVEPEAENLNSG 1112
            ..|::::  |.|.......::|.|.||
Human  1120 NLKEKMEAGRGVPNGIPAEDSEQLASG 1146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	16/51 (31%)
		FG-GAP	350..388	CDD:280083	10/38 (26%)
		Int_alpha	409..459	CDD:214549	27/49 (55%)
		Int_alpha	473..>515	CDD:214549	14/52 (27%)
		Integrin_alpha2	507..829	CDD:285619	71/374 (19%)
ITGAL	NP_002200.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	31..82		18/68 (26%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	83..141		19/74 (26%)
		vWA_integrins_alpha_subunit	155..323	CDD:238746	20/167 (12%)
		I-domain (insertion domain)	170..349		21/178 (12%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	390..445		13/58 (22%)
		Int_alpha	402..451	CDD:214549	12/52 (23%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	446..506		15/62 (24%)
		Int_alpha	456..503	CDD:214549	12/49 (24%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	507..563		24/55 (44%)
		Int_alpha	517..569	CDD:214549	27/51 (53%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	567..627		17/62 (27%)
		Int_alpha	579..>603	CDD:214549	7/23 (30%)
		Integrin_alpha2	612..983	CDD:285619	78/402 (19%)
		GFFKR motif	1115..1119		3/3 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1128..1170		6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141995
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840