DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment scb and ITGAE

DIOPT Version :9

Sequence 1:NP_523750.2 Gene:scb / 36692 FlyBaseID:FBgn0286785 Length:1115 Species:Drosophila melanogaster
Sequence 2:XP_024306508.1 Gene:ITGAE / 3682 HGNCID:6147 Length:1217 Species:Homo sapiens


Alignment Length:1022 Identity:234/1022 - (22%)
Similarity:394/1022 - (38%) Gaps:260/1022 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   167 NTVASTPQH-----VTRISPL-----RLKSEQVKEEDNGNKASFFYIMGELGLSAHVADDNTKFL 221
            |.:||.|..     ||....|     :|:...:..|.....| ..|.:.::|.||.:.|:. :.|
Human   372 NLIASDPDETHAFKVTNYMALDGLLSKLRYNIISMEGTVGDA-LHYQLAQIGFSAQILDER-QVL 434

  Fly   222 IGAPGINTWRGSVILYRQVDPVDNPTASRRDTSKALRRT---YRDVDSNDYTPEHYAPEIPTPGL 283
            :||.|...|.|..:||        .|.|||  .:.|.:|   ..|.::..|              
Human   435 LGAVGAFDWSGGALLY--------DTRSRR--GRFLNQTAAAAADAEAAQY-------------- 475

  Fly   284 WGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGEAYIFDVRGKSIHKYHVFRGEQFGE 348
                  ||.||||:.    ......|.|:|.||: .|..|..:.....|:......|..|||.|.
Human   476 ------SYLGYAVAV----LHKTCSLSYIAGAPR-YKHHGAVFELQKEGREASFLPVLEGEQMGS 529

  Fly   349 YFGYSVLAEDLNGDGKTD-VIVSAPQHALEDSHDNGAIYVF---INKGFFNFERQILRSPVETMA 409
            |||..:...|::.||.|| ::|:||.:.:..  :.|.:||:   ...|.|:..|.:...|..|.|
Human   530 YFGSELCPVDIDMDGSTDFLLVAAPFYHVHG--EEGRVYVYRLSEQDGSFSLARILSGHPGFTNA 592

  Fly   410 RFGTALSRLGDINHDGYNDVAVGAPFAG--------NGTVFIYLGSENGLRDQPSQRLDAPSQQP 466
            |||.|::.:||::.|...|||:|||..|        .|:|:||.|..:||...||||:.|.:..|
Human   593 RFGFAMAAMGDLSQDKLTDVAIGAPLEGFGADDGASFGSVYIYNGHWDGLSASPSQRIRASTVAP 657

  Fly   467 SKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIKPE---- 527
               |...||..::.|.||.|:|..|..:|......|  :|:.|||::..     |....|.    
Human   658 ---GLQYFGMSMAGGFDISGDGLADITVGTLGQAVV--FRSRPVVRLKV-----SMAFTPSALPI 712

  Fly   528 --QEKVKITACYRLS--TTSTDKLVQEQELAIRIAMD--KQLKRVKFTQTQTNEISFKVNANFGE 586
              ...|.:..|:.:|  ||:::..::|..|...:.:|  ||.:|::.:..::.....:..::..:
Human   713 GFNGVVNVRLCFEISSVTTASESGLREALLNFTLDVDVGKQRRRLQCSDVRSCLGCLREWSSGSQ 777

  Fly   587 QCRD---FETQVRYSEKDIFTPIDLEMHYELTKKVPDSEEFCETCAIVDPTEPKVSTQNIIFSTG 648
            .|.|   ..|:....|:|.|:...:::.|:|  :.|:.:.......:...|||....| :.:...
Human   778 LCEDLLLMPTEGELCEEDCFSNASVKVSYQL--QTPEGQTDHPQPILDRYTEPFAIFQ-LPYEKA 839

  Fly   649 CATDV-CTADLQLRSKDVSPTYILGSADTLRLNYEITNIGETAYLPQ--FNVTSTSRLAFAQVPG 710
            |...: |.|:|||.:.......::|....|.||..:||.||.:|:..  .|.....:|...|.|.
Human   840 CKNKLFCVAELQLATTVSQQELVVGLTKELTLNINLTNSGEDSYMTSMALNYPRNLQLKRMQKPP 904

  Fly   711 NCKV-------VDAVMVCDLNRGRPLAKGDTDSVTISFDVSQLSGQ------SLIIHAEVFSTGY 762
            :..:       |.:|::.:...|.|:.|..:.|   .|.:.:.|..      .::.|..|. ...
Human   905 SPNIQCDDPQPVASVLIMNCRIGHPVLKRSSVS---RFGLIRSSHHPAVGVFCILAHVSVV-WQL 965

  Fly   763 EQNPTDNRQTNVIGLKEFTEIDASGGQTNSQIDLEHYSNSAEIVNNYEIKSNGPSVIEQLT---V 824
            |:|...||.         .:|..:...:|.:..|.:.:::.:..:.:....:.||::...|   :
Human   966 EENAFPNRT---------ADITVTVTNSNERRSLANETHTLQFRHGFVAVLSKPSIMYVNTGQGL 1021

  Fly   825 SFYIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLLSIDLYDQNNTMLVVDPVEVTTTLSG---- 885
            |.:....:.|.|...           ..|.|..|:.                  |.|.|.|    
Human  1022 SHHKEFLFHVHGENL-----------FGAEYQLQIC------------------VPTKLRGLQVV 1057

  Fly   886 GLERTVITQNRQSYDIHTSGHVHQTMEVLDTSMVATASMSRKRRDLKALTANREQYARISNVKAH 950
            .:::...||                     .|.|.|  .|::|....:...:.|::..:|.|.|.
Human  1058 AVKKLTRTQ---------------------ASTVCT--WSQERACAYSSVQHVEEWHSVSCVIAS 1099

  Fly   951 DLLSDDFKGKLPVNRTIVFNCRDPEMTICVRAEMRVHFRPEKSINLNMRYSVDLNEVNAILVDPW 1015
            |                       :..:.|.||:                             .|
Human  1100 D-----------------------KENVTVAAEI-----------------------------SW 1112

  Fly  1016 EYF-VILTDL-KLQKKGDPTSTSFSINRRIEPNIISKHQET-------------GLPIWIIIVSV 1065
            ::. .:|.|: :||..|:     .|.|:.:...:.:::..|             .||  |||...
Human  1113 DHSEELLKDVTELQILGE-----ISFNKSLYEGLNAENHRTKITVVFLKDEKYHSLP--IIIKGS 1170

  Fly  1066 IGGLLLLSAISYLLYKFGFFNRTKKDELD-------RLVQQNPVEPE 1105
            :||||:|..|..:|:|.|||.| |..:|:       :|..:|.:|.|
Human  1171 VGGLLVLIVILVILFKCGFFKR-KYQQLNLESIRKAQLKSENLLEEE 1216

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scbNP_523750.2 Int_alpha 51..103 CDD:214549
FG-GAP 350..388 CDD:280083 12/38 (32%)
Int_alpha 409..459 CDD:214549 25/57 (44%)
Int_alpha 473..>515 CDD:214549 14/41 (34%)
Integrin_alpha2 507..829 CDD:285619 69/353 (20%)
ITGAEXP_024306508.1 vWA_integrins_alpha_subunit 218..395 CDD:238746 7/22 (32%)
Int_alpha 527..578 CDD:214549 16/52 (31%)
Int_alpha 591..650 CDD:214549 25/58 (43%)
Int_alpha 660..>695 CDD:214549 11/36 (31%)
Integrin_alpha2 693..>942 CDD:312071 55/259 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141986
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3637
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23220
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.840

Return to query results.
Submit another query.