Protein Alignment scb and ITGAD

DIOPT Version :10

• Sequence 1: NP_523750.2
• Gene: scb / 36692
• FlyBaseID: FBgn0286785
• Length: 1115
• Species: Drosophila melanogaster
• Sequence 2: XP_011544137.1
• Gene: ITGAD / 3681
• HGNCID: 6146
• Length: 1190
• Species: Homo sapiens
• Alignment Length: 1344
• Identity: 265/1344 - (19%)
• Similarity: 446/1344 - (33%)
• Gaps: 449/1344 - (33%)

  Fly    15 LLALISHIEAFNF-MPRPSRVINSPKHLKFHINQTRSSYFGYTLV-IRQTSIIVGAPRAQSTLES 77
            ||::::....||. :..|:            |.|..:..||.::| ...:.::||||     ||.
Human     8 LLSVLASYHGFNLDVEEPT------------IFQEDAGGFGQSVVQFGGSRLVVGAP-----LEV 55

  Fly    78 QRTINETGAIYRCSLTNGVCSP------------------------------------------- 99
            . ..|:||.:|.|:...|:|.|
Human    56 V-AANQTGRLYDCAAATGMCQPIPLHIRPEAVNMSLGLTLAASTNGSRLLACGPTLHRVCGENSY 119

  Fly   100 -----YVLDSRGNV---------DAPYSE----YTFDS----ERKDFQWLGGSM----------- 131
                 .:|.||..:         :.|:.|    :..|.    ::.||..:.|.:
Human   120 SKGSCLLLGSRWEIIQTVPDATPECPHQEMDIVFLIDGSGSIDQNDFNQMKGFVQAVMGQFEGTD 184

  Fly   132 ----------------------------------------------------------DGGTKDT 138
                                                                      :|..|..
Human   185 TLFALMQYSNLLKIHFTFTQFRTSPSQQSLVDPIVQLKGLTFTATGILTVVTQLFHHKNGARKSA 249

  Fly   139 DKLLV----------------CAPR----------------FYAPSSRDNHLHGVCYWVNNTVAS 171
            .|:|:                ..|:                |..|::|..         .||::|
Human   250 KKILIVITDGQKYKDPLEYSDVIPQAEKAGIIRYAIGVGHAFQGPTARQE---------LNTISS 305

  Fly   172 TP--QHVTRI----------SPLRLKSEQVKEEDNGNKASFFYIMGELGLSA---------HVAD 215
            .|  .||.::          ..|:.|...|:...:...:||.:.|.:.|.|.         .:..
Human   306 APPQDHVFKVDNFAALGSIQKQLQEKIYAVEGTQSRASSSFQHEMSQEGFSTALTMSLPSPGILS 370

  Fly   216 DNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYTPEHYAPEIPT 280
            ......:||.|..:|.|...||   .|..:||        .:..:..:||.
Human   371 SQDGLFLGAVGSFSWSGGAFLY---PPNMSPT--------FINMSQENVDM-------------- 410

  Fly   281 PGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGEAYIFDVRGKSIHKYHVFRGEQ 345
                   .|||.||:.....:.....    .|..||: .:.:|:|.||....:...|.....|.|
Human   411 -------RDSYLGYSTELALWKGVQN----LVLGAPR-YQHTGKAVIFTQVSRQWRKKAEVTGTQ 463

  Fly   346 FGEYFGYSVLAEDLNGDGKTDVIVSAPQHALEDSHDNGAIYVFINKGFFNFER------QILRSP 404
            .|.|||.|:.:.|::.||.||:|:....|..|.:.........:.:|    :|      .:||..
Human   464 IGSYFGASLCSVDVDSDGSTDLILIGAPHYYEQTRGGQVSVCPLPRG----QRVQWQCDAVLRGE 524

  Fly   405 V-ETMARFGTALSRLGDINHDGYNDVAVGAP--FAGNGTVFIYLG-SENGLRDQPSQRLDAPSQQ 465
            . ....|||.||:.|||:|.|...|||:|||  ....|.|:::.| ||:|:....|||:.:....
Human   525 QGHPWGRFGAALTVLGDVNEDKLIDVAIGAPGEQENRGAVYLFHGASESGISPSHSQRIASSQLS 589

  Fly   466 PS-KYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESREI----- 524
            |. :|    ||..||.|.|:..:|..|.|:||..  .|.|.|:.||:||...::....|:
Human   590 PRLQY----FGQALSGGQDLTQDGLMDLAVGARG--QVLLLRSLPVLKVGVAMRFSPVEVAKAVY 648

  Fly   525 -----KPEQ-EKVKITACYRLSTTSTDKLVQEQELAIR--IAMD--KQLKRVKFTQTQTNEISFK 579
                 ||.. |....|.|..:..:|.|:|...|. ::|  :|:|  :...|..|.:|:...::.:
Human   649 RCWEEKPSALEAGDATVCLTIQKSSLDQLGDIQS-SVRFDLALDPGRLTSRAIFNETKNPTLTRR 712

  Fly   580 VNANFGEQCRDFETQVRYSEKDIFTPIDLEMHYELTKK-VPDSEEFCETCAIVDPTEPKVSTQNI 643
            .....|..|...:..:....:|:.:||.|.:::.|.:: :|..:......|:   ....:.|.::
Human   713 KTLGLGIHCETLKLLLPDCVEDVVSPIILHLNFSLVREPIPSPQNLRPVLAV---GSQDLFTASL 774

  Fly   644 IFSTGCATD-VCTADLQLR-SKDVSPTYILGSADTLRLNYEIT--NIGETAY-----------LP 693
            .|...|..| :|..||.:. |.....|..:||  :|.||..:|  |.||.:|           |.
Human   775 PFEKNCGQDGLCEGDLGVTLSFSGLQTLTVGS--SLELNVIVTVWNAGEDSYGTVVSLYYPAGLS 837

  Fly   694 QFNVT--------STSRLAFAQVPGNCKVVDAVMVCDLNRGRPL-AKGDTDSVTISFDVSQLS-- 747
            ...|:        |..|||...||...:.:.:.. |.:|  .|: .:|...:..::||||..:
Human   838 HRRVSGAQKQPHQSALRLACETVPTEDEGLRSSR-CSVN--HPIFHEGSNGTFIVTFDVSYKATL 899

  Fly   748 GQSLIIHAEVFSTGYEQNPTDNRQTNVIGLKEFTEIDASGGQTNSQIDLEHYSNSAEIVNNYEIK 812
            |..:::.|   |...|.|                  .||..:...|::|
Human   900 GDRMLMRA---SASSENN------------------KASSSKATFQLEL---------------- 927

  Fly   813 SNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLLSIDLYDQNNTMLVVDPV 877
                            |:.|.|....:..|:..:                             |:
Human   928 ----------------PVKYAVYTMISRCPVPGL-----------------------------PL 947

  Fly   878 EVTTTLSGGLERTVITQNRQSYDIHTSGHVHQTMEVLDTSMVATASMSRKRRDLKALTANREQYA 942
            .....|....|.:....|..:.|............|.:.|          :||| |::.|.....
Human   948 GPLAFLYAWQEESTKYFNFATSDEKKMKEAEHRYRVNNLS----------QRDL-AISINFWVPV 1001

  Fly   943 RISNVKAHDLLSDDFKGKLP----------------VNRTIVFNCRDPEMTICVRAEMRV-HFRP 990
            .::.|...|::.:.....||                ::|:.:.:|   .:..|::....| .|..
Human  1002 LLNGVAVWDVVMEAPSQSLPCVSERKPPQHSDFLTQISRSPMLDC---SIADCLQFRCDVPSFSV 1063

  Fly   991 EKSINLNMRYSVDLNEV-----NAILVDPWEYFVILTDLKLQKKGDPTSTSFSINRRIEPNIISK 1050
            ::.::..::.::....|     ..:||.........|.:..|..|....      .|.:..::.:
Human  1064 QEELDFTLKGNLSFGWVRETLQKKVLVVSVAEITFDTSVYSQLPGQEAF------MRAQMEMVLE 1122

  Fly  1051 HQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRTKKDELD 1094
            ..|....|.||:.|.:|.||||:.|:..|||.|||.|..|:.|:
Human  1123 EDEVYNAIPIIMGSSVGALLLLALITATLYKLGFFKRHYKEMLE 1166

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	17/100 (17%)
		FG-GAP	350..388	CDD:460357	11/37 (30%)
		Int_alpha	409..459	CDD:214549	24/52 (46%)
		Int_alpha	473..>515	CDD:214549	18/41 (44%)
		Integrin_alpha2	509..829	CDD:462478	73/361 (20%)
ITGAD	XP_011544137.1	vWA_integrins_alpha_subunit	149..324	CDD:238746	18/183 (10%)
		Int_alpha	464..>506	CDD:214549	13/41 (32%)
		Int_alpha	528..583	CDD:214549	24/54 (44%)
		Int_alpha	593..>625	CDD:214549	14/37 (38%)
		Integrin_alpha2	628..>933	CDD:462478	75/366 (20%)
		Integrin_alpha	1153..1167	CDD:459778	7/14 (50%)