Protein Alignment scb and ITGA9

DIOPT Version :10

• Sequence 1: NP_523750.2
• Gene: scb / 36692
• FlyBaseID: FBgn0286785
• Length: 1115
• Species: Drosophila melanogaster
• Sequence 2: NP_002198.2
• Gene: ITGA9 / 3680
• HGNCID: 6145
• Length: 1035
• Species: Homo sapiens
• Alignment Length: 1209
• Identity: 296/1209 - (24%)
• Similarity: 487/1209 - (40%)
• Gaps: 313/1209 - (25%)

  Fly    11 IFLALLALISHIEAFNFMP-RPSRVINSPKHLKFHINQTRSSYFGYTLV----IRQTSIIVGAPR 70
            :.|||:.......|:|..| ||           .|......|:|||.::    .....::||||:
Human    16 LLLALVVAGIPAGAYNLDPQRP-----------VHFQGPADSFFGYAVLEHFHDNTRWVLVGAPK 69

  Fly    71 AQSTLESQRTINETGAIYRCSL-TNGVCSPYVLD-SRGNVDAPYSEYTFDSERKDFQWLGGSMDG 133
            |.|  :...::...||:::|.: ||.......|| :||.........|...:|.| :|:|.|:..
Human    70 ADS--KYSPSVKSPGAVFKCRVHTNPDRRCTELDMARGKNRGTSCGKTCREDRDD-EWMGVSLAR 131

  Fly   134 GTKDTDKLLVCAPRFYAPSSRDNHL--HGVCYWVNNTVASTPQHVTRISPLRLKS---------E 187
            ..|...::|.||.|:.......:|:  ||.||               |.|..|::         |
Human   132 QPKADGRVLACAHRWKNIYYEADHILPHGFCY---------------IIPSNLQAKGRTLIPCYE 181

  Fly   188 QVKE---EDNGNKASFFYIMGELGLSAHVADDNTKFLI--GAPGINTWRGSVILYRQVDPVDNPT 247
            :.|:   |::|:            ..|.:|...|:.|:  ||||...|.|::   :.::..||
Human   182 EYKKKYGEEHGS------------CQAGIAGFFTEELVVMGAPGSFYWAGTI---KVLNLTDN-- 229

  Fly   248 ASRRDTSKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYV 312
                        ||..::........|               :|.||||::|.|  |:|:.:..|
Human   230 ------------TYLKLNDEVIMNRRY---------------TYLGYAVTAGHF--SHPSTIDVV 265

  Fly   313 ATAPQANKQSGEAYIF--DVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQHA 375
            ..||| :|..|:.|||  |.|..::.|.....|::.|.|||.|:.|.||||||.:|::|.||.
Human   266 GGAPQ-DKGIGKVYIFRADRRSGTLIKIFQASGKKMGSYFGSSLCAVDLNGDGLSDLLVGAPM-- 327

  Fly   376 LEDSHDNGAIYVFINKGFFNFERQI-LRSPVETMARFGTALSRLGDINHDGYNDVAVGAP----F 435
            ..:..|.|.:.|:||:|....|.|: |.......|.||.:::.|.|:::||:.|||:|||    |
Human   328 FSEIRDEGQVTVYINRGNGALEEQLALTGDGAYNAHFGESIASLDDLDNDGFPDVAIGAPKEDDF 392

  Fly   436 AGNGTVFIYLGSENGLRDQPSQRLDAPSQQPSKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAE 500
            |  |.|:||.|...|:..|.|.:|......|.   ..|||..:|.|.|:||||:.|..:||..::
Human   393 A--GAVYIYHGDAGGIVPQYSMKLSGQKINPV---LRMFGQSISGGIDMDGNGYPDVTVGAFMSD 452

  Fly   501 AVYLYRAYPVVKVH------ATVKSESREIKPEQEKV---KITACYRLSTTST-DKLVQEQELAI 555
            :|.|.||.||:.|.      .::...:.:....|:.|   .:|.|:....... .::.....|..
Human   453 SVVLLRARPVITVDVSIFLPGSINITAPQCHDGQQPVNCLNVTTCFSFHGKHVPGEIGLNYVLMA 517

  Fly   556 RIAMDK--QLKRVKF-----TQTQTNEISFKVNANFGEQ-CRDFETQVRYSEKDIFTPIDLEMHY 612
            .:|..:  |:.||.|     |..|..|   |:...:.|: ||.:...|:...:|:.:||..|..|
Human   518 DVAKKEKGQMPRVYFVLLGETMGQVTE---KLQLTYMEETCRHYVAHVKRRVQDVISPIVFEAAY 579

  Fly   613 ELTKKVPDSEEFCETCAIVDPTEP--------KVSTQN-IIFSTGCATDVCTADLQLRSK----- 663
            .|::.|...||     ..:.|..|        |::.:| .:|...|.::.|.|||||:.|
Human   580 SLSEHVTGEEE-----RELPPLTPVLRWKKGQKIAQKNQTVFERNCRSEDCAADLQLQGKLLLSS 639

  Fly   664 -DVSPTYI-LGSADTLRLNYEITNIGETAYLPQFNVTSTSRLAF------AQVPGNCKVVDA-VM 719
             |....|: ||:...:.||..|:|:|:.||....:...:..|.|      .::..:|::::: .:
Human   640 MDEKTLYLALGAVKNISLNISISNLGDDAYDANVSFNVSRELFFINMWQKEEMGISCELLESDFL 704

  Fly   720 VCDLNRGRPLAKGDTD-SVTISFDVSQLSGQ----SLIIHAEVFSTGYEQNPTDNR--------- 770
            .|.:  |.|..:..:. ..::.||.|.|||:    |.|:.|:..:|...::..||.
Human   705 KCSV--GFPFMRSKSKYEFSVIFDTSHLSGEEEVLSFIVTAQSGNTERSESLHDNTLVLMVPLMH 767

  Fly   771 --QTNVIGLKEFT------EIDASGGQTNSQIDLEHYSNSAEIVN-NYEIKSNGPSVIEQLTVSF 826
              .|::.|:...|      .:||:     :.|.|:......:.:| ..::.:.|||.:...:||.
Human   768 EVDTSITGIMSPTSFVYGESVDAA-----NFIQLDDLECHFQPINITLQVYNTGPSTLPGSSVSI 827

  Fly   827 YIPIAYKVAGSTAI-IPIINVTSLKMQASYDSQLLSIDLYDQNNTMLVVDPVEVTTTLSGGLERT 890
            ..|......|:... :..:.|...|...|:           |.|....:.|.|
Human   828 SFPNRLSSGGAEMFHVQEMVVGQEKGNCSF-----------QKNPTPCIIPQE------------ 869

  Fly   891 VITQNRQSYDIHT-------SGHVHQTMEVLDTSMVATASMSRKRRDLKALTAN------REQYA 942
                  |....||       ||.     :|||.          ::..:..|||:      .::.:
Human   870 ------QENIFHTIFAFFTKSGR-----KVLDC----------EKPGISCLTAHCNFSALAKEES 913

  Fly   943 RISNVKAHDLLSDDFKGKLPVNRTIVFNCR-----DPEMTICVRAEMRVHFRPEKSINLNMRYSV 1002
            |  .:..:.||:.:.. |...:..|.|..|     ||.:.:...|    |..||
Human   914 R--TIDIYMLLNTEIL-KKDSSSVIQFMSRAKVKVDPALRVVEIA----HGNPE----------- 960

  Fly  1003 DLNEVNAILVDPWEYFVILTDLKLQKKGDPTSTSFSINRRIEPNIISKHQETGLPI-WIIIVSVI 1066
               ||..:                          |.....:||.        |..: |||.:|::
Human   961 ---EVTVV--------------------------FEALHNLEPR--------GYVVGWIIAISLL 988

  Fly  1067 GGLLLLSAISYLLYKFGFFNRTKKDELDRLVQQNPVEPE 1105
            .|:|:...::.||:|.|||.|..|:.::  .::|..|.|
Human   989 VGILIFLLLAVLLWKMGFFRRRYKEIIE--AEKNRKENE 1025

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	15/56 (27%)
		FG-GAP	350..388	CDD:460357	16/37 (43%)
		Int_alpha	409..459	CDD:214549	23/53 (43%)
		Int_alpha	473..>515	CDD:214549	20/47 (43%)
		Integrin_alpha2	509..829	CDD:462478	85/383 (22%)
ITGA9	NP_002198.2	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	35..96		18/73 (25%)
		Int_alpha	44..101	CDD:214549	15/58 (26%)
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	111..174		19/78 (24%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	182..232		16/78 (21%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	233..289		21/73 (29%)
		Int_alpha	244..294	CDD:214549	22/67 (33%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	290..349		24/60 (40%)
		Int_alpha	300..347	CDD:214549	22/48 (46%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	351..408		23/58 (40%)
		Int_alpha	361..414	CDD:214549	23/54 (43%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	411..474		23/65 (35%)
		Int_alpha	425..>466	CDD:214549	19/40 (48%)
		Integrin_alpha2	460..903	CDD:462478	105/501 (21%)
		GFFKR motif	1005..1009		3/3 (100%)