DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment scb and ITGA5

DIOPT Version :9

Sequence 1:NP_523750.2 Gene:scb / 36692 FlyBaseID:FBgn0286785 Length:1115 Species:Drosophila melanogaster
Sequence 2:NP_002196.4 Gene:ITGA5 / 3678 HGNCID:6141 Length:1049 Species:Homo sapiens


Alignment Length:1215 Identity:289/1215 - (23%)
Similarity:449/1215 - (36%) Gaps:350/1215 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 IFLALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIRQ-----TSIIVGAPR 70
            :.|.||.....:..||.......|::.|.          .|:||:::...:     .|::||||:
Human    28 LLLLLLPPPPRVGGFNLDAEAPAVLSGPP----------GSFFGFSVEFYRPGTDGVSVLVGAPK 82

  Fly    71 AQSTLESQRTINETGAIYRC----SLTNGVCSPYVLDSRGN----VDAPYSEYTFDSERKDFQWL 127
            |.:   ||..:.:.||:|.|    |.|.  |:|...||:|:    .....||.....|.|..||.
Human    83 ANT---SQPGVLQGGAVYLCPWGASPTQ--CTPIEFDSKGSRLLESSLSSSEGEEPVEYKSLQWF 142

  Fly   128 GGSMDGGTKDTDKLLVCAPRFYAPSSRDNHLH---GVCYWVNNTVASTPQHVTRI---SPLRLKS 186
            |.::   ......:|.||| .|:..:....|.   |.||      .|| .:.|||   :|.|   
Human   143 GATV---RAHGSSILACAP-LYSWRTEKEPLSDPVGTCY------LST-DNFTRILEYAPCR--- 193

  Fly   187 EQVKEEDNGNKASFFYIMGELGLSAHVADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRR 251
                 .|....|...|..|  |.||...... :.::|.||...|:|.::...|            
Human   194 -----SDFSWAAGQGYCQG--GFSAEFTKTG-RVVLGGPGSYFWQGQILSATQ------------ 238

  Fly   252 DTSKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQ---------EEDSYFGYAVSSGFFDSSNPT 307
                            :...|.|.||.....:.||         .:|||.||:|:.|.|...:..
Human   239 ----------------EQIAESYYPEYLINLVQGQLQTRQASSIYDDSYLGYSVAVGEFSGDDTE 287

  Fly   308 KLLYVATAPQANKQSGEAYIFDVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAP 372
            .  :||..|:.|...|  |:..:.|..|...:.|.|||...||||:|.|.|:||||..|::|.||
Human   288 D--FVAGVPKGNLTYG--YVTILNGSDIRSLYNFSGEQMASYFGYAVAATDVNGDGLDDLLVGAP 348

  Fly   373 QHALED------SHDNGAIYVFINKGFFNFERQILRSPVETM------ARFGTALSRLGDINHDG 425
              .|.|      ..:.|.:||::     .....|..:|..|:      .|||::|:.|||::.||
Human   349 --LLMDRTPDGRPQEVGRVYVYL-----QHPAGIEPTPTLTLTGHDEFGRFGSSLTPLGDLDQDG 406

  Fly   426 YNDVAVGAPFAG---NGTVFIYLGSENGLRDQPSQRLDAPSQQPSKYGSH---MFGHGLSRGSDI 484
            |||||:||||.|   .|.||::.|...||..:|||.|     ||....||   .||..|..|.|:
Human   407 YNDVAIGAPFGGETQQGVVFVFPGGPGGLGSKPSQVL-----QPLWAASHTPDFFGSALRGGRDL 466

  Fly   485 DGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIKPEQEKVKI----TACYRLS--TTS 543
            ||||:.|..:|:...:...:||..|:|...|::........||:....:    .||..||  ..:
Human   467 DGNGYPDLIVGSFGVDKAVVYRGRPIVSASASLTIFPAMFNPEERSCSLEGNPVACINLSFCLNA 531

  Fly   544 TDKLV--------------QEQELAIRIAMDKQLKRVKFTQTQTNEISFKVNANFGEQCRDFETQ 594
            :.|.|              |:|:..:|.|:....::...|||      ..:.....|.||:.:..
Human   532 SGKHVADSIGFTVELQLDWQKQKGGVRRALFLASRQATLTQT------LLIQNGAREDCREMKIY 590

  Fly   595 VRYSE--KDIFTPIDLEMHYELTKKVP-DSEEFCETCAIVDPTEPKVSTQNIIFSTGCATD-VCT 655
            :|...  :|..:||.:.:::.|..:.| ||............:..:...|.::   .|..| :|.
Human   591 LRNESEFRDKLSPIHIALNFSLDPQAPVDSHGLRPALHYQSKSRIEDKAQILL---DCGEDNICV 652

  Fly   656 ADLQLRSKDVSPTYILGSADTLRLNYEITNIGE-TAYLPQFNVTSTSRLAFAQV---PGNCKVVD 716
            .||||..........||..:.|.|.:...|:|| .||..:..||:.....::.:   |||...:.
Human   653 PDLQLEVFGEQNHVYLGDKNALNLTFHAQNVGEGGAYEAELRVTAPPEAEYSGLVRHPGNFSSLS 717

  Fly   717 A---------VMVCDLNRGRPLAKG---------------DTDSVTISFDVSQLSGQSLIIHAEV 757
            .         ::||||  |.|:..|               ||.. ||.||...||          
Human   718 CDYFAVNQSRLLVCDL--GNPMKAGASLWGGLRFTVPHLRDTKK-TIQFDFQILS---------- 769

  Fly   758 FSTGYEQNPTDNRQTNVIGLKEFTEIDASGGQTNSQIDLEHYSNSAEIV---------------- 806
                   ...:|.|::|:..:...|..|       |:.|...|....::                
Human   770 -------KNLNNSQSDVVSFRLSVEAQA-------QVTLNGVSKPEAVLFPVSDWHPRDQPQKEE 820

  Fly   807 -------NNYEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLLSIDL 864
                   :.||:.:.|||.|.|..:....|.|.:   ...::.:..||.|....::         
Human   821 DLGPAVHHVYELINQGPSSISQGVLELSCPQALE---GQQLLYVTRVTGLNCTTNH--------- 873

  Fly   865 YDQNNTMLVVDPVEVTTTLSGGLERTVITQNRQSYDIHTSGHVHQTMEVLDTSMVATASMSRKRR 929
                       |:                 |.:..::...|.:|...:                 
Human   874 -----------PI-----------------NPKGLELDPEGSLHHQQK----------------- 893

  Fly   930 DLKALTANREQYARISNVKAHDLLSDDFKGKLPVNRTIVFNCRDPEMTICVRAEMR---VHFRPE 991
                    ||..:|.|......:|                .|.:.|   |.|....   :|.:..
Human   894 --------REAPSRSSASSGPQIL----------------KCPEAE---CFRLRCELGPLHQQES 931

  Fly   992 KSINLNMR-------------YSVDLNEVNAILVDPWEYFVILTDLKLQKKGDPTSTSFSINRRI 1043
            :|:.|:.|             :|:....|...|..|  |.::...|..:::...|:..::     
Human   932 QSLQLHFRVWAKTFLQREHQPFSLQCEAVYKALKMP--YRILPRQLPQKERQVATAVQWT----- 989

  Fly  1044 EPNIISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRT 1088
                 ......|:|:||||::::.|||||..:.|:|||.|||.|:
Human   990 -----KAEGSYGVPLWIIILAILFGLLLLGLLIYILYKLGFFKRS 1029

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scbNP_523750.2 Int_alpha 51..103 CDD:214549 19/60 (32%)
FG-GAP 350..388 CDD:280083 18/43 (42%)
Int_alpha 409..459 CDD:214549 28/52 (54%)
Int_alpha 473..>515 CDD:214549 15/41 (37%)
Integrin_alpha2 507..829 CDD:285619 81/396 (20%)
ITGA5NP_002196.4 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 43..108 20/79 (25%)
Int_alpha 56..114 CDD:214549 19/72 (26%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 128..188 21/70 (30%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 192..245 15/91 (16%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 259..311 15/55 (27%)
Int_alpha 268..>310 CDD:214549 15/45 (33%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 312..377 25/71 (35%)
Int_alpha 322..379 CDD:214549 21/63 (33%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 378..437 27/58 (47%)
Int_alpha 389..443 CDD:214549 28/53 (53%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 441..504 22/67 (33%)
Int_alpha 455..498 CDD:214549 15/42 (36%)
Integrin_alpha2 490..921 CDD:312071 99/550 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 877..907 6/54 (11%)
Interaction with HPS5 1021..1028 5/6 (83%)
GFFKR motif 1024..1028 3/3 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3637
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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