DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and ITGA4

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_000876.3	Gene:	ITGA4 / 3676	HGNCID:	6140	Length:	1032	Species:	Homo sapiens

Alignment Length:	1170	Identity:	293/1170 - (25%)
Similarity:	475/1170 - (40%)	Gaps:	291/1170 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 SSYFGYTLVIRQTS----IIVGAPRAQSTLESQRTINETGAIYRCSLTNG---VCSPYVLDSRGN 107
            ::.|||::|:....    ::||||.| :.|.:...|| .||||||.:...   .|....|.|
Human    49 NTLFGYSVVLHSHGANRWLLVGAPTA-NWLANASVIN-PGAIYRCRIGKNPGQTCEQLQLGS--- 108

  Fly   108 VDAPYSEYTFDS--ERKDFQWLGGSMDGGTKDTDKLLVCAPR----FYAPSSRDNHL-HGVCYWV 165
               |..|....:  |.:|.||||.::.....:...::.|..|    ||.  ..:|.| .|.||.|
Human   109 ---PNGEPCGKTCLEERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYI--KNENKLPTGGCYGV 168

  Fly   166 NNTVASTPQHVTRISPLRLKSEQVKE-----EDNGNKASFFYIMGELGLSAHVADDNTKFLIGAP 225
                           |..|::|..|.     :|...|....:...:.|:|:....|  ..::|||
Human   169 ---------------PPDLRTELSKRIAPCYQDYVKKFGENFASCQAGISSFYTKD--LIVMGAP 216

  Fly   226 GINTWRGSVILYRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEEDS 290
            |.:.|.||:.:|       |.|.::   .||.......|                      :..|
Human   217 GSSYWTGSLFVY-------NITTNK---YKAFLDKQNQV----------------------KFGS 249

  Fly   291 YFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGEAYIFDVRGKSIHKYHVFRGEQFGEYFGYSVL 355
            |.||:|.:|.|.|.:.|::  |..||| ::|.|:||||.:..|.::..|..:|::.|.|||.||.
Human   250 YLGYSVGAGHFRSQHTTEV--VGGAPQ-HEQIGKAYIFSIDEKELNILHEMKGKKLGSYFGASVC 311

  Fly   356 AEDLNGDGKTDVIVSAPQHALEDSHDNGAIYVFINKG---FFNFERQILRSPVETMARFGTALSR 417
            |.|||.||.:|::|.||..:  ...:.|.::|:||.|   ..|.....|....:..||||.::..
Human   312 AVDLNADGFSDLLVGAPMQS--TIREEGRVFVYINSGSGAVMNAMETNLVGSDKYAARFGESIVN 374

  Fly   418 LGDINHDGYNDVAVGAPFAGN--GTVFIYLGSENGLRDQPSQRLDAPSQQPSKYGSHMFGHGLSR 480
            ||||::||:.|||:|||...:  |.::||.|..:|:....|||::  ..|.||..| |||..:|.
Human   375 LGDIDNDGFEDVAIGAPQEDDLQGAIYIYNGRADGISSTFSQRIE--GLQISKSLS-MFGQSISG 436

  Fly   481 GSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIKPEQEK--------------- 530
            ..|.|.||:.|.|:||..:::..|.|..|||.|.|::.      .||...
Human   437 QIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLS------HPESVNRTKFDCVENGWPSVC 495

  Fly   531 VKITACYRLSTTSTDKLVQEQELAIRIAMDKQLK-----RVKFTQTQTNEI---SFKVNANFGEQ 587
            :.:|.|:..........:   .|...:::|...|     |..|:...|:::   |.:|::. ...
Human   496 IDLTLCFSYKGKEVPGYI---VLFYNMSLDVNRKAESPPRFYFSSNGTSDVITGSIQVSSR-EAN 556

  Fly   588 CRDFETQVRYSEKDIFTPIDLEMHYELTKKV---PDSEEFCETCAIVDPTEPK-VSTQNIIFSTG 648
            ||..:..:|...:||.|||.:|..|.|...|   ..:|||.....|:...:.| :..:.|.|:..
Human   557 CRTHQAFMRKDVRDILTPIQIEAAYHLGPHVISKRSTEEFPPLQPILQQKKEKDIMKKTINFARF 621

  Fly   649 CATDVCTADLQLRSK------DVSPTYI-LGSADTLRLNYEITNIGETAYLPQFNVTSTSRLAFA 706
            ||.:.|:||||:.:|      ..:.||: :||..||.||..:.|.|:.||....:|.....|.|.
Human   622 CAHENCSADLQVSAKIGFLKPHENKTYLAVGSMKTLMLNVSLFNAGDDAYETTLHVKLPVGLYFI 686

  Fly   707 QV------PGNCKVVD--AVMVCDLNRGRPLAKGDTDSVTISF--DVSQLS----GQSLIIHAEV 757
            ::      ..||:|.|  .|:..|.:.|. :.......:.|||  |||.||    ..|:.:||..
Human   687 KILELEEKQINCEVTDNSGVVQLDCSIGY-IYVDHLSRIDISFLLDVSSLSRAEEDLSITVHATC 750

  Fly   758 FSTGYEQNPTDNRQTNVIGLKEFTEIDASGGQTNSQIDLEHYSNSAEIV--NNYEIKSNGPS--V 818
            .:.....|...:|.|..|.||...::...|           :.|....|  :|.|   |.|.  :
Human   751 ENEEEMDNLKHSRVTVAIPLKYEVKLTVHG-----------FVNPTSFVYGSNDE---NEPETCM 801

  Fly   819 IEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLLSIDLYDQNNTMLVVDPVEVTTTL 883
            :|::.::|::     :....::.|.::| .:.:..|:..|           |..:.:.::|.|
Human   802 VEKMNLTFHV-----INTGNSMAPNVSV-EIMVPNSFSPQ-----------TDKLFNILDVQT-- 847

  Fly   884 SGGLERTVITQNRQSYDIHTSGHVHQTMEVLDTSMVATASMSRKRRDLKALTANREQYARISNVK 948
                               |:|..|                             .|.|.|:..::
Human   848 -------------------TTGECH-----------------------------FENYQRVCALE 864

  Fly   949 AHDLLSDDFKGKLP-VNRTIVFNCRDPEMTICVRA------------------EMRVHFRPEKSI 994
            .........||.:. :::|      |..:..|::|                  |..||      |
Human   865 QQKSAMQTLKGIVRFLSKT------DKRLLYCIKADPHCLNFLCNFGKMESGKEASVH------I 917

  Fly   995 NLNMRYSV-DLNEVNAILVDPWEYFVILTDLKLQKKGDPTSTSFSINRRIEPNIIS------KHQ 1052
            .|..|.|: :::|.:|:            ..:::..|.|......|....:.|:..      .||
Human   918 QLEGRPSILEMDETSAL------------KFEIRATGFPEPNPRVIELNKDENVAHVLLEGLHHQ 970

  Fly  1053 ETGLPIWIIIV--SVIGGLLLLSAISYLLYKFGFFNRTKKDELDRLVQQNPVEPEAENLNSGGNN 1115
            .......|:|:  |::.||::|..|||:::|.|||.|..|.    ::|:.........:||..|:
Human   971 RPKRYFTIVIISSSLLLGLIVLLLISYVMWKAGFFKRQYKS----ILQEENRRDSWSYINSKSND 1031

Fly 1116 1115
Human 1032 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	19/58 (33%)
		FG-GAP	350..388	CDD:280083	15/37 (41%)
		Int_alpha	409..459	CDD:214549	23/51 (45%)
		Int_alpha	473..>515	CDD:214549	18/41 (44%)
		Integrin_alpha2	507..829	CDD:285619	92/373 (25%)
ITGA4	NP_000876.3	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	35..100		18/52 (35%)
		Int_alpha	48..105	CDD:214549	19/57 (33%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	110..177		20/83 (24%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	185..237		15/63 (24%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	238..291		21/77 (27%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	292..351		23/60 (38%)
		Int_alpha	303..352	CDD:214549	21/50 (42%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	355..412		22/56 (39%)
		Int_alpha	366..418	CDD:214549	23/51 (45%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	416..478		26/70 (37%)
		Int_alpha	428..479	CDD:214549	22/57 (39%)
		Integrin_alpha2	463..902	CDD:285619	111/536 (21%)
		SG1	606..616		1/9 (11%)
		GFFKR motif	1003..1007		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142024
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7035
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D105280at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.760