Protein Alignment scb and ITGA3

DIOPT Version :10

• Sequence 1: NP_523750.2
• Gene: scb / 36692
• FlyBaseID: FBgn0286785
• Length: 1115
• Species: Drosophila melanogaster
• Sequence 2: NP_002195.1
• Gene: ITGA3 / 3675
• HGNCID: 6139
• Length: 1051
• Species: Homo sapiens
• Alignment Length: 1206
• Identity: 267/1206 - (22%)
• Similarity: 462/1206 - (38%)
• Gaps: 281/1206 - (23%)

  Fly     9 PHIFLALLALI-----SHIEAFNFMPR--PSRVINSPKHLKFHINQTRSSYFGYTLVI-RQTS-- 63
            |.:.|..|||:     ..:.|||...|  ..:...:|           .|.|||::.: |||.
Human    12 PRLMLCALALMVAAGGCVVSAFNLDTRFLVVKEAGNP-----------GSLFGYSVALHRQTERQ 65

  Fly    64 ----IIVGAPRAQSTLESQRTINETGAIYRCSLTNGVCSPYVLDSRGNVDAPYSEYTFDSERKDF 124
                ::.||||..:..:..  .|.|||:|.|.||                    .:..|.||.:.
Human    66 QRYLLLAGAPRELAVPDGY--TNRTGAVYLCPLT--------------------AHKDDCERMNI 108

  Fly   125 -------------QWLGGSMDGGTKDTDKLLVCAPRF----YAPSSRDNHLHGVCYWVNNTVAST 172
                         .|||.:: .......::||||.|:    ::.|.....:.|.||
Human   109 TVKNDPGHHIIEDMWLGVTV-ASQGPAGRVLVCAHRYTQVLWSGSEDQRRMVGKCY--------- 163

  Fly   173 PQHVTRISPLRLKSEQ-----VKEEDNGNKASFFYIMGELGLSAHVADDNTKFLIGAPGINTWRG 232
                .|.:.|.|.|..     ..|..|.|.......|.:||.|.....:...|  ||||...|:|
Human   164 ----VRGNDLELDSSDDWQTYHNEMCNSNTDYLETGMCQLGTSGGFTQNTVYF--GAPGAYNWKG 222

  Fly   233 SVILYRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEEDSYFGYAVS 297
            :..:.::                      ::.|.::|:  :..||        .:.:.|.||.:.
Human   223 NSYMIQR----------------------KEWDLSEYS--YKDPE--------DQGNLYIGYTMQ 255

  Fly   298 SGFFDSSNPTKLLYVATAPQANKQSGEAYIFDVR-GKSIHKYHVFRGEQFGEYFGYSVLAEDLNG 361
            .|.| ..:|..:..|..||: ::..|..::.... |..:.:..|..|.|.|.|||.::...|||.
Human   256 VGSF-ILHPKNITIVTGAPR-HRHMGAVFLLSQEAGGDLRRRQVLEGSQVGAYFGSAIALADLNN 318

  Fly   362 DGKTDVIVSAPQHALEDSHDNGAIYVFINKGFFNFERQ---ILRSPVETMARFGTALSRLGDINH 423
            ||..|::|.||.:........||||||:|:...:|...   :|..|  :.:.||.:::.:||||.
Human   319 DGWQDLLVGAPYYFERKEEVGGAIYVFMNQAGTSFPAHPSLLLHGP--SGSAFGLSVASIGDINQ 381

  Fly   424 DGYNDVAVGAPFAGNGTVFIYLGSENGLRDQPSQ-----RLDAPSQQPSKYGSHMFGHGLSRGSD 483
            ||:.|:||||||.|.|.|:||..|..||..||.|     :|..|       |...||:.||...|
Human   382 DGFQDIAVGAPFEGLGKVYIYHSSSKGLLRQPQQVIHGEKLGLP-------GLATFGYSLSGQMD 439

  Fly   484 IDGNGFNDFAIGAPNAEAVYLYRAYPVVK-VHATVKSESREIKP----EQEKVKITACYRLSTTS 543
            :|.|.:.|..:|: .::.:.|.||.||:. ||.|:......:.|    ....|::..|:..:.::
Human   440 VDENFYPDLLVGS-LSDHIVLLRARPVINIVHKTLVPRPAVLDPALCTATSCVQVELCFAYNQSA 503

  Fly   544 TDKLVQEQ-ELAIRIAMDKQLK--RVKFTQTQTNEISFKVNANFG---EQCRDFETQVRYSEKDI 602
            .:...:.. .||..:..|:..:  |::|..::    |...:..|.   .:|:..|..:..:.:|.
Human   504 GNPNYRRNITLAYTLEADRDRRPPRLRFAGSE----SAVFHGFFSMPEMRCQKLELLLMDNLRDK 564

  Fly   603 FTPIDLEMHYELTKKVPDSEEF----CETCAIVDPTEPKVSTQNIIFSTGCATD-VCTADLQLRS 662
            ..||.:.|:|.|..::||....    .:...|::..:...:...:.|...|..| .|.::||:|:
Human   565 LRPIIISMNYSLPLRMPDRPRLGLRSLDAYPILNQAQALENHTEVQFQKECGPDNKCESNLQMRA 629

  Fly   663 KDVSP-----TYILGSADT--LRLNYEITNI------GETAYLPQFNVTSTSRLAFAQV--PGNC 712
            ..||.     :.:..|.|.  |.|:..:||.      ||.|:.....:.....|..:.|  ||.|
Human   630 AFVSEQQQKLSRLQYSRDVRKLLLSINVTNTRTSERSGEDAHEALLTLVVPPALLLSSVRPPGAC 694

  Fly   713 KVVDAVMVCDLNRGRPLAKGDTDSVTISFDV--SQLSGQSLIIHAEVFSTGYEQNPTDNRQTNVI 775
            :..:.:. |:|  |.|..:.....:.|:|:|  ..|..:.|.:..::.::.::    ||....::
Human   695 QANETIF-CEL--GNPFKRNQRMELLIAFEVIGVTLHTRDLQVQLQLSTSSHQ----DNLWPMIL 752

  Fly   776 GLKEFTEIDASGGQTNSQIDLEHYSNSAEIVNNYEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAI 840
            .|.....:..|....|.::.        .......:..:|...:|.:.    .|:.|:.......
Human   753 TLLVDYTLQTSLSMVNHRLQ--------SFFGGTVMGESGMKTVEDVG----SPLKYEFQVGPMG 805

  Fly   841 IPIINVTSLKMQASYDSQLLSIDLYDQNNTMLVVDPVEVTTTLSGGLERTVITQNRQSYDIHTSG 905
            ..::.:.:|.:...:.        |:.:|...::.|.|:|...:|            |:.....|
Human   806 EGLVGLGTLVLGLEWP--------YEVSNGKWLLYPTEITVHGNG------------SWPCRPPG 850

  Fly   906 HVHQTMEV-LDTSMVATASMSRKRRDL--------------KALTANREQYARISNVKAHDLLSD 955
            .:...:.: |.......:|..|:||.|              .|..|..|.....:..:||
Human   851 DLINPLNLTLSDPGDRPSSPQRRRRQLDPGGGQGPPPVTLAAAKKAKSETVLTCATGRAH----- 910

  Fly   956 DFKGKLPVNRTIVFNCRDPEMTICVRAEMRVHFRPEKSINLNMRYSVDLNEVNAILVDPWEYFVI 1020
                      .:...|..|:..:.....::...       .|..:..|..:.:.:.|:.|....:
Human   911 ----------CVWLECPIPDAPVVTNVTVKARV-------WNSTFIEDYRDFDRVRVNGWATLFL 958

  Fly  1021 LTDLKLQKKGDPT------STSFSINRRIEPNIISKHQETGLP----IWIIIVSVIGGLLLLSAI 1075
            .|.:       ||      :|.||::  |:..::.:     ||    :|:::|:|..|||||..|
Human   959 RTSI-------PTINMENKTTWFSVD--IDSELVEE-----LPAEIELWLVLVAVGAGLLLLGLI 1009

  Fly  1076 SYLLYKFGFFNRTKKDELDRLVQQ------NPVEPE 1105
            ..||:|.|||.|.:...|....:|      .|.|.|
Human  1010 ILLLWKCGFFKRARTRALYEAKRQKAEMKSQPSETE 1045

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	19/58 (33%)
		FG-GAP	350..388	CDD:460357	15/37 (41%)
		Int_alpha	409..459	CDD:214549	26/54 (48%)
		Int_alpha	473..>515	CDD:214549	15/42 (36%)
		Integrin_alpha2	509..829	CDD:462478	65/352 (18%)
ITGA3	NP_002195.1	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	38..103		21/97 (22%)
		Int_alpha	48..108	CDD:214549	23/92 (25%)
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	110..171		14/74 (19%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	185..235		14/73 (19%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	236..292		14/67 (21%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	293..354		23/60 (38%)
		Int_alpha	304..352	CDD:214549	20/47 (43%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	356..411		25/56 (45%)
		Int_alpha	365..417	CDD:214549	26/51 (51%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	415..477		21/69 (30%)
		Int_alpha	430..481	CDD:214549	17/51 (33%)
		Integrin_alpha2	463..916	CDD:462478	87/510 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	855..889		6/33 (18%)
		Interaction with HPS5	1015..1021		4/5 (80%)
		GFFKR motif	1017..1021		3/3 (100%)