DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment scb and ITGA2B

DIOPT Version :9

Sequence 1:NP_523750.2 Gene:scb / 36692 FlyBaseID:FBgn0286785 Length:1115 Species:Drosophila melanogaster
Sequence 2:NP_000410.2 Gene:ITGA2B / 3674 HGNCID:6138 Length:1039 Species:Homo sapiens


Alignment Length:1211 Identity:285/1211 - (23%)
Similarity:462/1211 - (38%) Gaps:336/1211 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 PSRVIN-SPKHLKFHINQTRSSYFGYTLVIRQTS-----IIVGAPRAQSTLESQRTINETGAIYR 89
            |:..:| .|..|.|:.. ...|.||::|...:.|     |:|||||   ||...:  .|||.::.
Human    28 PAWALNLDPVQLTFYAG-PNGSQFGFSLDFHKDSHGRVAIVVGAPR---TLGPSQ--EETGGVFL 86

  Fly    90 C--SLTNGVCSPYVLDSRG---NVDAPYSEYTFDSERKDFQWLGGSMDGGTKDTDKLLVCAPRFY 149
            |  ....|.|...:.|.|.   ||.:...: ||    |..|.||.|:   ...:|.::.|||   
Human    87 CPWRAEGGQCPSLLFDLRDETRNVGSQTLQ-TF----KARQGLGASV---VSWSDVIVACAP--- 140

  Fly   150 APSSRDNHLHGVCYW----------------VNNTVASTPQHVTR--ISPLRLKSEQVKEEDNGN 196
                          |                |.:...:.|:...|  .||.|           ||
Human   141 --------------WQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCR-----------GN 180

  Fly   197 KASFFYIMG---------ELGLSAHVADDNTKFLIGAPG----------------INTWRGSVIL 236
            ..|..|:..         |.|.|: |.....:.::||||                .:::|..::|
Human   181 TLSRIYVENDFSWDKRYCEAGFSS-VVTQAGELVLGAPGGYYFLGLLAQAPVADIFSSYRPGILL 244

  Fly   237 YRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEEDSYFGYAVSSGFF 301
            :..             :|::|     ..||::  ||::              |.|:||:|:.|.|
Human   245 WHV-------------SSQSL-----SFDSSN--PEYF--------------DGYWGYSVAVGEF 275

  Fly   302 DSS-NPTKLLYVATAPQANKQSGEAYIFDVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKT 365
            |.. |.|:  ||..||..:...|...|.|...:.:|:   .||||...|||:||...|:||||:.
Human   276 DGDLNTTE--YVVGAPTWSWTLGAVEILDSYYQRLHR---LRGEQMASYFGHSVAVTDVNGDGRH 335

  Fly   366 DVIVSAPQHALEDSHDN-----GAIYVFINK------GFFNFERQILRSPVETMARFGTALSRLG 419
            |::|.||.: :|...|.     |.:|:|:..      |    ...:|.:..:...|||:|::.||
Human   336 DLLVGAPLY-MESRADRKLAEVGRVYLFLQPRGPHALG----APSLLLTGTQLYGRFGSAIAPLG 395

  Fly   420 DINHDGYNDVAVGAPF---AGNGTVFIYLGSENGLRDQPSQRLDAPSQQPSKYGSHMFGHGLSRG 481
            |::.|||||:||.||:   :|.|.|.::||...|||.:|||.||:|....|     .||..|...
Human   396 DLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLRSRPSQVLDSPFPTGS-----AFGFSLRGA 455

  Fly   482 SDIDGNGFNDFAIGAPNAEAVYLYRAYPVVK------VHATVKSESREIKPEQEKVKITACYRLS 540
            .|||.||:.|..:||..|..|.:|||.||||      |..::....:.....|.|..: :|:.:.
Human   456 VDIDDNGYPDLIVGAYGANQVAVYRAQPVVKASVQLLVQDSLNPAVKSCVLPQTKTPV-SCFNIQ 519

  Fly   541 T---TSTDKLVQEQELAIRIAMDKQL----KRVKFTQTQTNEISFKVNANFGEQ----CR----- 589
            .   .:...:.|:..|...:.:|:|.    :||....:|  :....:|.:.|.:    |.     
Human   520 MCVGATGHNIPQKLSLNAELQLDRQKPRQGRRVLLLGSQ--QAGTTLNLDLGGKHSPICHTTMAF 582

  Fly   590 -----DFETQVRYSEKDIFTPIDLEMHYELTKKVPDSEEFCETCAIVDPTEPKVSTQNIIFSTGC 649
                 ||        :|..:||.|.::..|    |.:|.......::...........|:...| 
Human   583 LRDEADF--------RDKLSPIVLSLNVSL----PPTEAGMAPAVVLHGDTHVQEQTRIVLDCG- 634

  Fly   650 ATDVCTADLQLRSKDVSPTYILGSADTLRLNYEITNIGETAY-------LPQ--------FNVTS 699
            ..|||...|||.:.......::|:.:.|.|..:..|.||.||       |||        .||..
Human   635 EDDVCVPQLQLTASVTGSPLLVGADNVLELQMDAANEGEGAYEAELAVHLPQGAHYMRALSNVEG 699

  Fly   700 TSRLAFAQVPGNCKVVDAVMVCDLNRGRPLAKGDTDSVTISFDVSQL--SGQSLIIHAEVFSTGY 762
            ..||...|...|   ...|::|:|  |.|:.|.....:.:...|..|  :|:|:....::.|.. 
Human   700 FERLICNQKKEN---ETRVVLCEL--GNPMKKNAQIGIAMLVSVGNLEEAGESVSFQLQIRSKN- 758

  Fly   763 EQNPTDNRQTNVIGLKEFTEIDASGGQTNSQI-----DLEHYSNSAE-----IVNNYEIKSNGPS 817
            .|||........:.::...:::..|....:.:     :.|...||.:     :.:.||:.:|||.
Human   759 SQNPNSKIVLLDVPVRAEAQVELRGNSFPASLVVAAEEGEREQNSLDSWGPKVEHTYELHNNGPG 823

  Fly   818 VIEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLLSI-DLYDQNNTMLVVDPVEVTT 881
            .:..|.:|.::|                      ..|..|.||.| |:..|........|.....
Human   824 TVNGLHLSIHLP----------------------GQSQPSDLLYILDIQPQGGLQCFPQPPVNPL 866

  Fly   882 TLSGGLERTVITQNRQSYDIHTSGHVHQTMEVLDTSMVATASMSRKRRDLKALTANREQYARISN 946
            .:..||                        .:...|.:..|...|.||.:  .....||.:|:.:
Human   867 KVDWGL------------------------PIPSPSPIHPAHHKRDRRQI--FLPEPEQPSRLQD 905

  Fly   947 VKAHDLLSDDFKGKLPVNRTIVFNCRDPEMTICVRAEMRVHFRPEKSINLNMRYSVDLNEVNAIL 1011
                               .::.:|.....|: |:.:::...|.:::          :..|.|.|
Human   906 -------------------PVLVSCDSAPCTV-VQCDLQEMARGQRA----------MVTVLAFL 940

  Fly  1012 VDPWEYFVILTDLKLQKKG--DPTSTSFSI--------NRRIEPNIISKHQETGLPIWIIIVSVI 1066
            ..|..|...|....||...  :.:|..:::        ..::...::...:|..:|||.::|.|:
Human   941 WLPSLYQRPLDQFVLQSHAWFNVSSLPYAVPPLSLPRGEAQVWTQLLRALEERAIPIWWVLVGVL 1005

  Fly  1067 GGLLLLSAISYLLYKFGFFNRTKKDELDRLVQQNPVEPEAE 1107
            ||||||:.:...::|.|||.|.:.          |:|.:.|
Human  1006 GGLLLLTILVLAMWKVGFFKRNRP----------PLEEDDE 1036

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scbNP_523750.2 Int_alpha 51..103 CDD:214549 19/58 (33%)
FG-GAP 350..388 CDD:280083 17/42 (40%)
Int_alpha 409..459 CDD:214549 27/52 (52%)
Int_alpha 473..>515 CDD:214549 21/47 (45%)
Integrin_alpha2 507..829 CDD:285619 78/375 (21%)
ITGA2BNP_000410.2 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 35..96 21/66 (32%)
Int_alpha 46..102 CDD:214549 19/60 (32%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 110..173 16/87 (18%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 187..238 8/51 (16%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 251..305 22/76 (29%)
Int_alpha 262..>302 CDD:214549 16/55 (29%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 306..371 24/68 (35%)
Int_alpha 316..367 CDD:214549 19/51 (37%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 373..432 24/58 (41%)
Int_alpha 384..438 CDD:214549 27/53 (51%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 435..496 27/65 (42%)
Int_alpha 445..>485 CDD:214549 18/44 (41%)
Integrin_alpha2 481..921 CDD:285619 100/529 (19%)
Integrin_alpha 1020..1034 CDD:278771 7/23 (30%)
GFFKR motif 1022..1026 3/3 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142018
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3637
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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