DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment scb and ITGA1

DIOPT Version :9

Sequence 1:NP_523750.2 Gene:scb / 36692 FlyBaseID:FBgn0286785 Length:1115 Species:Drosophila melanogaster
Sequence 2:NP_852478.1 Gene:ITGA1 / 3672 HGNCID:6134 Length:1179 Species:Homo sapiens


Alignment Length:1357 Identity:274/1357 - (20%)
Similarity:461/1357 - (33%) Gaps:490/1357 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 AFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIRQTS----IIVGAPRAQSTLESQRTINET 84
            :||...:.|...:.|.          ...||||:...:..    :::|:|     |..|.. |.|
Human    28 SFNVDVKNSMTFSGPV----------EDMFGYTVQQYENEEGKWVLIGSP-----LVGQPK-NRT 76

  Fly    85 GAIYRCSLTNGVCSPYV-LDSRGNVDAPYSEYTFDSERKDFQWLGGSM----DGGTKDTDKLLVC 144
            |.:|:|.:..|...|.| ||...|...|..     :|.|:....|.::    :||      .|.|
Human    77 GDVYKCPVGRGESLPCVKLDLPVNTSIPNV-----TEVKENMTFGSTLVTNPNGG------FLAC 130

  Fly   145 APRFYAPSSRDNHLH---GVCYWVNNTVASTPQHVTRISPLRLKS-------------------- 186
            .|.:   :.|..|||   |:|    :.|:.|.|.|..|:|::..|                    
Human   131 GPLY---AYRCGHLHYTTGIC----SDVSPTFQVVNSIAPVQECSTQLDIVIVLDGSNSIYPWDS 188

  Fly   187 ---------------------------EQVKEEDNGNK--------------------------- 197
                                       |.|..|.|.||                           
Human   189 VTAFLNDLLERMDIGPKQTQVGIVQYGENVTHEFNLNKYSSTEEVLVAAKKIVQRGGRQTMTALG 253

  Fly   198 ----------------------------------------------------------------- 197
                                                                             
Human   254 IDTARKEAFTEARGARRGVKKVMVIVTDGESHDNHRLKKVIQDCEDENIQRFSIAILGSYNRGNL 318

  Fly   198 ----------------------------------------------------ASFFYIMGELGLS 210
                                                                |||...|.:.|.|
Human   319 STEKFVEEIKSIASEPTEKHFFNVSDELALVTIVKTLGERIFALEATADQSAASFEMEMSQTGFS 383

  Fly   211 AHVADDNTKFLIGAPGINTWRGSVILYR--QVDPVDNPTASRRDTSKALRRTYRDVDSNDYTPEH 273
            ||.:.|  ..::||.|...|.|:|::.:  |:....|.|.:...|.|                  
Human   384 AHYSQD--WVMLGAVGAYDWNGTVVMQKASQIIIPRNTTFNVESTKK------------------ 428

  Fly   274 YAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGEAYIFDVRGKSIHKY 338
                       .:...||.||.|:|....|.:   :||:|..|:.| .:|:..|:.:...:|...
Human   429 -----------NEPLASYLGYTVNSATASSGD---VLYIAGQPRYN-HTGQVIIYRMEDGNIKIL 478

  Fly   339 HVFRGEQFGEYFGYSVLAEDLNGDGKTDV-IVSAPQHALEDSHDNGAIYVF-INKGFFNFERQIL 401
            ....|||.|.|||..:...|::.|..||: :|.||.:...:..:.|.:||: :|:  ..||.|:.
Human   479 QTLSGEQIGSYFGSILTTTDIDKDSNTDILLVGAPMYMGTEKEEQGKVYVYALNQ--TRFEYQMS 541

  Fly   402 RSPVETM--------------------ARFGTALSRLGDINHDGYNDVAVGAPFAGN--GTVFIY 444
            ..|::..                    ||||||::.:.|:|.||:||:.:|||...:  |.|:||
Human   542 LEPIKQTCCSSRQHNSCTTENKNEPCGARFGTAIAAVKDLNLDGFNDIVIGAPLEDDHGGAVYIY 606

  Fly   445 LGSENGLRDQPSQRLDAPSQQPSKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYP 509
            .||...:|.:.:||:  ||....| ....||..:....|::|:|..|..||.....|::..|...
Human   607 HGSGKTIRKEYAQRI--PSGGDGK-TLKFFGQSIHGEMDLNGDGLTDVTIGGLGGAALFWSRDVA 668

  Fly   510 VVKVHATVKSESREIKPEQEK----------VKITACYRLSTTSTDKLVQEQELAIRIAMD--KQ 562
            ||||  |:..|..::..:::.          :..|.|:.:...|.:..:.|.:|..|:.:|  :|
Human   669 VVKV--TMNFEPNKVNIQKKNCHMEGKETVCINATVCFDVKLKSKEDTIYEADLQYRVTLDSLRQ 731

  Fly   563 LKRVKFTQTQTNEISFKVNANFGEQC----------RDFETQVRYSEKDIFTPIDLEMHYELTKK 617
            :.|..|:.||..::...:.....| |          .||:..||           :.:.:.||..
Human   732 ISRSFFSGTQERKVQRNITVRKSE-CTKHSFYMLDKHDFQDSVR-----------ITLDFNLTDP 784

  Fly   618 VPDSEEFCETCAIVDPTEPKVSTQNIIFSTGCAT-DVCTADLQLR----SKDVSPTYILGSADTL 677
                    |...::|.:.|....:.|.|:..|.. :.|.:||.|.    .||:  ..:....|..
Human   785 --------ENGPVLDDSLPNSVHEYIPFAKDCGNKEKCISDLSLHVATTEKDL--LIVRSQNDKF 839

  Fly   678 RLNYEITNIGETAYLPQFNVTSTSRLAFAQVPG------------NCKVVDAVMVCDLNRGRP-L 729
            .::..:.|..::||..:..|..:..|.|:.:..            .|||           |.| |
Human   840 NVSLTVKNTKDSAYNTRTIVHYSPNLVFSGIEAIQKDSCESNHNITCKV-----------GYPFL 893

  Fly   730 AKGD--TDSVTISFDVSQLSGQSLIIHAEVFSTGYEQNPTDNRQTNVIGLKEFTEIDASGGQTNS 792
            .:|:  |..:...|:.|.|. :::.|:  :.:|...:.|.:....||:.:..         ....
Human   894 RRGEMVTFKILFQFNTSYLM-ENVTIY--LSATSDSEEPPETLSDNVVNISI---------PVKY 946

  Fly   793 QIDLEHYSNSAEIVNNYEIKSNGPSVIEQL-TVSFYIPIAYKVAGSTAIIPIINVTSLKMQASYD 856
            ::.|:.||:::|...:.......|.||... .:...|.|.|.:..|.:    ..:..||:..|:.
Human   947 EVGLQFYSSASEYHISIAANETVPEVINSTEDIGNEINIFYLIRKSGS----FPMPELKLSISFP 1007

  Fly   857 SQLLSIDLYDQNNTMLVVDPVEVTTTLSGGLERTVITQNRQSYDIHTSGHVHQTMEVLDTSMVAT 921
            :  ::.:.|          ||...|.||            .|.:.:...|:.:....:::....|
Human  1008 N--MTSNGY----------PVLYPTGLS------------SSENANCRPHIFEDPFSINSGKKMT 1048

  Fly   922 ASMSRKRRDLKALTANREQYARISNVKAHDLLSDDFKGKLPVNRTIVFNCRDPEMTICVRAEMRV 986
            .|....:|. ..|..|..::|.|:                                 |       
Human  1049 TSTDHLKRG-TILDCNTCKFATIT---------------------------------C------- 1072

  Fly   987 HFRPEKSINLNMRYSVDLNEVNAILVDPWE------YFVILTDLKLQKKGDPTSTSFSI-----N 1040
                    ||.   |.|:::||..|: .|:      ||   :.|.|..:|:..|.:.|:     |
Human  1073 --------NLT---SSDISQVNVSLI-LWKPTFIKSYF---SSLNLTIRGELRSENASLVLSSSN 1122

  Fly  1041 RRIEPNI-ISKHQETG-LPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRTKKDELDR 1095
            ::.|..| |||....| :|:|:|::|...|||||..:...|:|.|||.|..|.::::
Human  1123 QKRELAIQISKDGLPGRVPLWVILLSAFAGLLLLMLLILALWKIGFFKRPLKKKMEK 1179

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scbNP_523750.2 Int_alpha 51..103 CDD:214549 16/56 (29%)
FG-GAP 350..388 CDD:280083 11/38 (29%)
Int_alpha 409..459 CDD:214549 23/51 (45%)
Int_alpha 473..>515 CDD:214549 14/41 (34%)
Integrin_alpha2 507..829 CDD:285619 68/364 (19%)
ITGA1NP_852478.1 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 30..91 17/76 (22%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 101..160 19/76 (25%)
vWA_integrins_alpha_subunit 171..351 CDD:238746 6/179 (3%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 365..417 16/53 (30%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 422..475 16/85 (19%)
Int_alpha 434..474 CDD:214549 14/43 (33%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 476..538 19/63 (30%)
Int_alpha 486..>529 CDD:214549 13/42 (31%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 557..615 21/57 (37%)
Int_alpha 568..621 CDD:214549 23/52 (44%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 619..679 21/64 (33%)
Integrin_alpha2 664..1056 CDD:285619 86/466 (18%)
GFFKR motif 1167..1171 3/3 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142003
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3637
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23220
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.840

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