DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and ITGA6

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_001381857.1	Gene:	ITGA6 / 3655	HGNCID:	6142	Length:	1130	Species:	Homo sapiens

Alignment Length:	1253	Identity:	292/1253 - (23%)
Similarity:	499/1253 - (39%)	Gaps:	344/1253 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LALL----ALISHI-EAFNFMPRPSRVI---NSPKHLKFHINQTRSSYFGYTLVIR-------QT 62
            |.||    .|:|.: .|||...|...||   ..|           .|.||::|.:.       :.
Human     7 LCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDP-----------GSLFGFSLAMHWQLQPEDKR 60

  Fly    63 SIIVGAPRAQSTLESQRTINETGAIYRCSLTNGVCSPYVLDSRGNVDAPYSEYTFD------SER 121
            .::||||||:: |..||. |.||.:|.|.:|          :||    |.:...||      ||.
Human    61 LLLVGAPRAEA-LPLQRA-NRTGGLYSCDIT----------ARG----PCTRIEFDNDADPTSES 109

  Fly   122 KDFQWLGGSMD----GGTKDTDKLLVCAPRF-------YAPSSRDNHLHGVCYWVNNTVASTPQH 175
            |:.||:|.::.    ||     |::.||.|:       ....|||  :.|.||
Human   110 KEDQWMGVTVQSQGPGG-----KVVTCAHRYEKRQHVNTKQESRD--IFGRCY------------ 155

  Fly   176 VTRISPLRLKSEQVKEEDNGNKASFFYIMGEL-----------GLSAHVADDNTKFLIGAPGINT 229
                    :.|:.::.||:.:...:.:..|.|           |::|....|....:.||||...
Human   156 --------VLSQNLRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYN 212

  Fly   230 WRGSVILYRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYTP-------EHYAPEIPTP-----G 282
            |:|.|    :|:..:|              |:.|::..:..|       ||....:|.|     |
Human   213 WKGIV----RVEQKNN--------------TFFDMNIFEDGPYEVGGETEHDESLVPVPANSYLG 259

  Fly   283 LW-------------------GQEE---------DSYFGYAVSSGFFDSSNPTKLLYVATAPQAN 319
            |.                   .:|:         :||.|:::.||....|. .::.:|:.||:||
Human   260 LLFLTSVSYTDPDQFVYKTRPPREQPDTFPDVMMNSYLGFSLDSGKGIVSK-DEITFVSGAPRAN 323

  Fly   320 KQSGEAYIFDVRGKSIH--KYHVFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQHALEDSHDN 382
             .||...:.....||.|  ..|:|.||.....|||.|...|||.||..|:::.|||:...|....
Human   324 -HSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVG 387

  Fly   383 GAIYVFIN-KGFFNFERQI-LRSPVETMARFGTALSRLGDINHDGYNDVAVGAPFAGNGTVFIYL 445
            ||:||::| :|.:|..:.| |....::|  ||.|:..:||||.|||.|:|||||:...|.||||.
Human   388 GAVYVYMNQQGRWNNVKPIRLNGTKDSM--FGIAVKNIGDINQDGYPDIAVGAPYDDLGKVFIYH 450

  Fly   446 GSENGLRDQPSQRLDAPSQQPSKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPV 510
            ||.||:..:|:|.|        |..|..||:.::...|:|.|.:.|.|:|: .:::|.::|:.||
Human   451 GSANGINTKPTQVL--------KGISPYFGYSIAGNMDLDRNSYPDVAVGS-LSDSVTIFRSRPV 506

  Fly   511 VKVHATVKSESREIKPEQEK---------VKITACYR--------------LSTTSTDKLVQEQE 552
            :.:..|:......|...|:.         :::.:|:.              :.|...:|..::..
Human   507 INIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSG 571

  Fly   553 LAIRIAMDKQLKRVKFTQTQTNEISFKVNANFGEQCRDFETQVRYSEKDIFTPIDLEMHYELTKK 617
            |:.|:....|....|:||    |::.|....  :.|.:....::.:.:|...||.:....|:.:
Human   572 LSSRVQFRNQGSEPKYTQ----ELTLKRQKQ--KVCMEETLWLQDNIRDKLRPIPITASVEIQE- 629

  Fly   618 VPDS----EEFCETCAIVDPTEPKVSTQNIIF-STGCATD-VCTADLQLRSKDVS---------- 666
             |.|    ....|...|::..|||.:..::.| ..||..| ||.::|:|..|..:
Human   630 -PSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKEGCGDDNVCNSNLKLEYKFCTREGNQDKFSY 693

  Fly   667 -------PTYILGSADTLRLNYEITNI----------GETAYLPQFNVTSTSRL---------AF 705
                   |..:|.....:.|...:||.          |:.|:..:...|....|         ||
Human   694 LPIQKGVPELVLKDQKDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAF 758

  Fly   706 AQVPGNCKVVDAVMVCDLNRGRPLAKGDT-------DSVTISFDVSQLSGQSLIIHAEVFSTGYE 763
            .:...:|.........|...|.|..:...       .:..::||...|.     |:.::.:|..:
Human   759 PEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLD-----INLKLETTSNQ 818

  Fly   764 QN--PTDNRQTNVIGLKEFTEIDASGGQTNSQIDLEHYSNSAEIVNNYEIKSNGP--SVIEQLTV 824
            .|  |...:...||.|.    :..||....||:   ::..:  :|....:||...  |:||
Human   819 DNLAPITAKAKVVIELL----LSVSGVAKPSQV---YFGGT--VVGEQAMKSEDEVGSLIE---- 870

  Fly   825 SFYIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLLSIDLYDQNNTMLVVDPVEVTTTLSGGLER 889
                   |:........|:.|:.:..:...:..::      .....:|.:..||     |.|||:
Human   871 -------YEFRVINLGKPLTNLGTATLNIQWPKEI------SNGKWLLYLVKVE-----SKGLEK 917

  Fly   890 TVITQNRQSYDIH-TSGHVHQTMEVLDTSMVATASMSRKRRDL--KALTANREQYARISNVKAHD 951
            ......::...:: |..|                 .|||:|::  |.:..|| :::..:..|...
Human   918 VTCEPQKEINSLNLTESH-----------------NSRKKREITEKQIDDNR-KFSLFAERKYQT 964

  Fly   952 LLSDDFKGKLPVNRTIVFNC---RDPEMTICVRAEMRVHFRPEKSINLNMRYSVDLNEVNAILVD 1013
            |           |.::..||   |.|...:..:|.:.:..|...|..|. .|| .||.::.::
Human   965 L-----------NCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLE-EYS-KLNYLDILM-- 1014

  Fly  1014 PWEYFVILT----DLKLQKKGDPTSTSFSINRRIEPNIISKHQETGLPIWIIIVSVIGGLLLLSA 1074
              ..|:.:|    :::|...|.....:...::.:.       |.:|:|.|||:|:::.|:|:|:.
Human  1015 --RAFIDVTAAAENIRLPNAGTQVRVTVFPSKTVA-------QYSGVPWWIILVAILAGILMLAL 1070

  Fly  1075 ISYLLYKFGFFNRTKKDE 1092
            :.::|:|.|||.|::.|:
Human  1071 LVFILWKCGFFKRSRYDD 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	19/58 (33%)
		FG-GAP	350..388	CDD:280083	17/37 (46%)
		Int_alpha	409..459	CDD:214549	27/49 (55%)
		Int_alpha	473..>515	CDD:214549	12/41 (29%)
		Integrin_alpha2	507..829	CDD:285619	72/397 (18%)
ITGA6	NP_001381857.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	30..95		25/91 (27%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	101..166		20/91 (22%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	176..229		15/70 (21%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	283..339		16/57 (28%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	340..402		24/61 (39%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	403..458		28/56 (50%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	459..518		18/67 (27%)
		Interaction with HPS5	1077..1083		4/5 (80%)
		GFFKR motif	1079..1083		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142030
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740