Protein Alignment scb and Itga3

DIOPT Version :10

• Sequence 1: NP_523750.2
• Gene: scb / 36692
• FlyBaseID: FBgn0286785
• Length: 1115
• Species: Drosophila melanogaster
• Sequence 2: NP_001359143.1
• Gene: Itga3 / 360606
• RGDID: 1310333
• Length: 1067
• Species: Rattus norvegicus
• Alignment Length: 1207
• Identity: 281/1207 - (23%)
• Similarity: 481/1207 - (39%)
• Gaps: 285/1207 - (23%)

  Fly    13 LALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVI-RQTS------IIVGAPR 70
            |||:...|...||.|......::     :|..:|.  .|.|||::.: |||.      ::.||||
  Rat    19 LALMVAASGRVAFAFNLDTKFLV-----VKEAVNP--GSLFGYSVALHRQTERQQRYLLLAGAPR 76

  Fly    71 AQSTLESQRTINETGAIYRCSLT--NGVCSPYVLDSRGNVDAPYSEYTFDSERKDFQWLGGSMDG 133
             ...::...| |.|||:|.|.||  ...|....:..:.:.|....|         ..|||.:: .
  Rat    77 -DLAVDDDYT-NRTGAVYLCPLTALKNDCERMDISEKSDPDHHIIE---------DMWLGVTV-A 129

  Fly   134 GTKDTDKLLVCAPRF----YAPSSRDNHLHGVCYWVNNTVASTP------QHVTRISPLRLKSEQ 188
            ......::||||.|:    ::.......:.|.||...|.:...|      .|
  Rat   130 SQGPAGRVLVCAHRYTKVLWSGLEDQRRMVGKCYVRGNDLQLDPGDDWQTYH------------- 181

  Fly   189 VKEEDNGNKASFFYIMGELGLSAHVADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRDT 253
             .|..|.|.......|.:||.|.....:...|  ||||...|:|:..:.::
  Rat   182 -NEMCNSNTDYLQTGMCQLGTSGGFTQNTVYF--GAPGAYNWKGNSYMIQR-------------- 229

  Fly   254 SKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEEDS--YFGYAVSSGFFDSS--NPTKLLYVAT 314
                    :|.|.::|:..            |.|:..  |.||.:..|   |:  :|:::..|..
  Rat   230 --------KDWDLSEYSYR------------GSEDQGNLYIGYTMQVG---SAILHPSEITLVTG 271

  Fly   315 APQANKQSGEAYIFDVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQHALEDS 379
            ||:.........:....|..:.:..|.:|.|.|.|||.::...|||.||..|::|.||.:.....
  Rat   272 APRHQHMGAVFLLKQESGGDLQRRQVLKGTQVGAYFGSAIALADLNNDGWQDLLVGAPYYFERKE 336

  Fly   380 HDNGAIYVFINKGFFNFERQ---ILRSPVETMARFGTALSRLGDINHDGYNDVAVGAPFAGNGTV 441
            ...||:|||:|:...:|..|   :|..|  :.:.||.:::.:||||.||:.|:||||||.|.|.|
  Rat   337 EVGGAVYVFMNQAGTSFPDQPSLLLHGP--SRSAFGISVASIGDINQDGFQDIAVGAPFEGLGKV 399

  Fly   442 FIYLGSENGLRDQPSQ-----RLDAPSQQPSKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEA 501
            :||..|..||..||.|     .|..|       |...||:.||...|:|.|.:.|..:|: .::.
  Rat   400 YIYHSSSGGLLKQPQQIIHGETLGLP-------GLATFGYSLSGKMDVDENLYPDLLVGS-LSDH 456

  Fly   502 VYLYRAYPVVKV-HATVKSESREIKPE----QEKVKITACYRLSTTSTDKLVQEQ-ELAIRIAMD 560
            :.|.||.||:.: |.|:.:....:.|.    ...|::..|:..:.::.:...:.. .||..:..|
  Rat   457 IVLLRARPVINILHRTLVARPAVLDPSLCTVTSCVQVELCFAYNQSAGNPNYRRNITLAYTVEAD 521

  Fly   561 KQLK--RVKFTQTQTNEIS--FKVNANFGEQCRDFETQVRYSEKDIFTPIDLEMHYELTKKVPDS 621
            :..:  |::|.::|::...  |.:...   .|:..|..:..:.:|...||.:.|:|.|..::||.
  Rat   522 RDRRPPRLRFARSQSSVFHGFFSMPET---HCQTLELLLMDNVRDKLRPIVITMNYSLPLRMPDR 583

  Fly   622 EEF----CETCAIVDPTEPKVSTQNIIFSTGCATD-VCTADLQLRSKDVSP-----TYILGSADT 676
            .:.    .:...:::..:...:...:.|...|..| .|.::||:|:..||.     :.:..|.||
  Rat   584 LKLGLRSLDAYPVLNQAQAMENHTEVHFQKECGPDNKCDSNLQMRAAFVSEQLQPLSRLQYSRDT 648

  Fly   677 --LRLNYEITN------IGETAY--LPQFNVTSTSRLAFAQVPGNCKVVDAVMVCDLNRGRPLAK 731
              |.|:..:||      .||.|:  |....|:|...|:..:..|.|:..:...||:|  |.|..:
  Rat   649 KKLFLSINVTNSPSRQRAGEDAHEALLTLEVSSALLLSSVRPAGTCQANETNTVCEL--GNPFKR 711

  Fly   732 GDTDSVTISFDVS--QLSGQSLIIHAEVFSTGYEQNPTDNRQTNVIGLKEFTEIDASGGQTNSQI 794
            .....:.|:|:|:  .|..:.|..|.::.::.::    ||.|...:.|               |:
  Rat   712 NQRMELLIAFEVTGVTLHTRDLRAHLQLSTSSHQ----DNLQPMFLTL---------------QV 757

  Fly   795 DLEHYSNSAEIVNNYEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTS-LKMQ------ 852
            |   |:..|.:           |::.....||:   :..|.|..|:..:.:|.| ||.:
  Rat   758 D---YTLQASL-----------SLMNHRLQSFF---SGTVMGEAAMKTVKDVGSPLKYEFQVSPV 805

  Fly   853 ----ASYDSQLLSIDL-YDQNNTMLVVDPVEVTTTLSGGLERTVITQNRQSYDIHTSGHVHQTME 912
                |:..:.:|.::. |:..|...::.|.|:|...:|            |:.....|::...:.
  Rat   806 GDGLAALGTLVLGLEWPYEVTNGKWLLYPTEITIHSNG------------SWPCQPHGNLVNPLN 858

  Fly   913 V-LDTSMVATASMSRKRRDL--------------KALTANREQYARISNVKAHDLLSDDFKGKLP 962
            : |....|...|..|:||.|              .|..|..|.....||.:|
  Rat   859 LTLSDPGVKPLSPQRRRRQLDPGGDQGPPPVTLAAAKKAKSETVLTCSNGRA------------- 910

  Fly   963 VNRTIVFNCRDPEMT----ICVRAEMRVHFRPEKSINLNMRYSVDLNEVNAILVDPWEYFVILTD 1023
              |.:...|..|:.:    :.|:|.:           .|..:..|..:.:.:.||.|....:.|.
  Rat   911 --RCVWLECPLPDASNITNVTVKARV-----------WNSTFIEDYKDFDRVRVDGWATLFLRTS 962

  Fly  1024 LKLQKKGDPT------STSFSINRRIEPNIISKHQETGLP----IWIIIVSVIGGLLLLSAISYL 1078
            :       ||      :|.||::  |:..::.:     ||    :|:::|:|..|||||..|..|
  Rat   963 I-------PTINMENKTTWFSVD--IDSELVEE-----LPAEIELWLVLVAVGAGLLLLGLIIIL 1013

  Fly  1079 LYKFGFFNRTK------KDELDRLVQQNPVEPEAENL 1109
            |:|..||..|:      |....|:.:::...|....|
  Rat  1014 LWKCDFFKPTRYYRIMPKYHAVRIREEDRYPPPGSTL 1050

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	21/60 (35%)
		FG-GAP	350..388	CDD:460357	14/37 (38%)
		Int_alpha	409..459	CDD:214549	26/54 (48%)
		Int_alpha	473..>515	CDD:214549	14/42 (33%)
		Integrin_alpha2	509..829	CDD:462478	71/351 (20%)
Itga3	NP_001359143.1	Int_alpha	48..108	CDD:214549	21/63 (33%)
		Int_alpha	304..352	CDD:214549	19/47 (40%)
		Int_alpha	367..417	CDD:214549	26/49 (53%)
		Integrin_alpha2	463..917	CDD:462478	102/521 (20%)