DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and if

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster

Alignment Length:	1071	Identity:	267/1071 - (24%)
Similarity:	450/1071 - (42%)	Gaps:	249/1071 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IFLALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIRQ-----------TSI 64
            :.|.|:|:.:|  .:|        |:.|.:::|  .|:.:|.||:::.:.:           .|:
  Fly    20 LILLLIAMSAH--GYN--------IDLPSYVRF--RQSSNSMFGFSIAMHKGRSGFYGNQNNVSL 72

  Fly    65 IVGAPRAQSTLESQRTINETGAIYRCSLTNGVCSPYVLDSRGNVDAPYSEYTFDSE---RKDFQW 126
            |||||:. .|...|:.:.|.|.:::|||.:..|.....||:||      ....|.|   ||.:||
  Fly    73 IVGAPKF-DTSRYQQGVTEAGGVFKCSLNDDDCKLVPFDSKGN------NRNVDKEVVDRKSYQW 130

  Fly   127 LGGSMDGGTKDTDKLLVCAPRFYAPSSRDNHLHGVCYWVNNTVASTPQHVTRISPLR--LKSEQV 189
            ||.::..| :|:|.::.||||:                |.:|:  ||....||.|:.  ..|...
  Fly   131 LGATVATG-RDSDLVVACAPRY----------------VFHTM--TPSRAFRIDPVGTCFTSHNF 176

  Fly   190 KEEDNGNKASFFYIMG---------------ELGLSAHVADDNTKFLIGAPGINTWRGSV----- 234
            :|         ||.:.               :.|.||.:..:.::..|||||...|:|..
  Fly   177 EE---------FYEVSPCRTNNWGYHRQGSCQAGFSAAINGNGSRLFIGAPGSWYWQGQTYSIPP 232

  Fly   235 -ILYRQVDPVDNP-----TASRRDTSKALRRTYRDVDS---NDYTPEHYAPEIPTPGLWGQEEDS 290
             ..:....|:..|     .||..|.::...:.:...:|   ||                    ||
  Fly   233 DAKFPFKPPLYQPFGTGGMASSHDVTRPENQVFSTSESASVND--------------------DS 277

  Fly   291 YFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGE--------AYIFDVRGKSIHKYHVFRGEQFG 347
            |.||::.:|.||......:  ....|:.....|.        |.||::.|:           |.|
  Fly   278 YLGYSMVTGDFDGDRSEDV--AIGMPRGGNLVGRIVVNRWNMANIFNITGR-----------QIG 329

  Fly   348 EYFGYSVLAEDLNGDGKTDVIVSAPQHA----LEDSHDNGAIYVFINKGFFNFER---QILRSPV 405
            ||||||:...|::|||..|:::.||.:.    :|..:|.|.:|:.:..|....:|   :.:|...
  Fly   330 EYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKYDVGRVYILLQGGPTEEKRWTTEHIRDGY 394

  Fly   406 ETMARFGTALSRLGDINHDGYNDVAVGAPF---AGNGTVFIYLGSENGLRDQPSQRLDAPSQQPS 467
            .:..|||.||:.|||:|.|||.|.|||||:   .|.|.|:|:.||..|...:|||.:.:......
  Fly   395 HSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQLVEG 459

  Fly   468 KYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHA-----------TVKSES 521
            ......||..||.|.|:|||.:.|.|:||.:::.|:::::.||..|:|           ::...|
  Fly   460 APYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKLISLDDRS 524

  Fly   522 REIKPEQEKVK---ITACYRLSTTSTDKLVQEQ-ELAIRIAMD-KQL--KRVKFTQTQTNEI-SF 578
            .::..:.:||.   :|.|:    :.|.:.:.|| :..:...:| |:|  .|:.|.:.:...| :.
  Fly   525 CQLVRDHKKVPCMLLTTCW----SYTGRYLPEQLDFDVSWLLDAKKLLNPRMFFLRDEGKNIRNQ 585

  Fly   579 KVNANFGEQ-CRDFETQVRYSEKDIFTPIDLEMHYELTKKVPDSEEFCETCAIVDPTEPKVSTQN 642
            .:..|:|:: |.:....:....:|..||:::|..|.|....|.........:|::|    |..||
  Fly   586 TIRLNYGQKYCLNETVYLLDKVQDKLTPLEVEARYNLRSSRPLDPMVRHRRSILEP----VIDQN 646

  Fly   643 --------IIFSTGCATD-VCTADLQLRSKDVSPTYILGSADTLRLNYEITNIGETAYLPQFNVT 698
                    |.....|..| :|..||:|:...|. .|:.||.:.|.:...|:|..|.|:...|.:.
  Fly   647 REIVLRDAINIQKNCGPDNICEPDLKLKVSTVD-KYLFGSPEPLVIEVFISNTNEDAFEAAFYMV 710

  Fly   699 STSRLAFAQV---------PGNCKVV----DAVMVCDLNRGRPLAKGDTDSVTISF--DVSQLSG 748
            :...|.|.::         |..|...    :..:.||:  |.||..|......||.  :....|.
  Fly   711 TPPDLQFRKLQQLGEKKDTPITCSPPTPENNHTLKCDI--GNPLESGKIAHFKISLVPEEKYGSS 773

  Fly   749 QSLIIHAEVFSTGYEQ--NPTDNRQTNVIGLKEFTEIDASGG-----QTNSQIDLEHYSNSA--- 803
            .|...:.|..||..|:  :..||:....:|:...|::|..|.     |.....|.:...|:.
  Fly   774 SSYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGTSLPDYQLYKADDYKELENATKED 838

  Fly   804 ----EIVNNYEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIIN--VTSLKMQASYDSQLLSI 862
                ::|:.|||::|.||:||:..|..::|  |:......::.::|  .|..|:|.
  Fly   839 DIGPQVVHIYEIRNNRPSIIEEAEVFIHLP--YETIVGDPLMYLLNQPETGGKIQC--------- 892

  Fly   863 DLYDQNNTMLVVDPVEVTTTLSGGLERTVITQNRQSYDIHTSGHVHQTMEVLDTSMVATASMSRK 927
            |....|...|::|            |:.|    ::|| :...|.:..:.:|   |..:::|.|..
  Fly   893 DDVAFNEYNLLLD------------EKLV----KKSY-LQAQGAIWNSAQV---SGQSSSSSSSG 937

  Fly   928 RRDLKALTANREQYAR---ISN-VKAHDLLS 954
            ...:....|..|.:.|   :|| ..|.|.||
  Fly   938 GASVHIEKARGEGFVRGVLVSNSTDAGDKLS 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	17/62 (27%)
		FG-GAP	350..388	CDD:280083	15/41 (37%)
		Int_alpha	409..459	CDD:214549	28/52 (54%)
		Int_alpha	473..>515	CDD:214549	17/41 (41%)
		Integrin_alpha2	507..829	CDD:285619	87/379 (23%)
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	17/64 (27%)
		Int_alpha	275..>316	CDD:214549	11/62 (18%)
		Int_alpha	398..451	CDD:214549	28/52 (54%)
		Int_alpha	466..>497	CDD:214549	14/30 (47%)
		Integrin_alpha2	499..893	CDD:285619	93/415 (22%)
		DUF2756	<1120..1178	CDD:298627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439843
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12256at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850