DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and Itga11

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_795896.4	Gene:	Itga11 / 319480	MGIID:	2442114	Length:	1188	Species:	Mus musculus

Alignment Length:	1349	Identity:	293/1349 - (21%)
Similarity:	466/1349 - (34%)	Gaps:	476/1349 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 EAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIRQTS----IIVGAPRAQSTLESQRTINE 83
            :.||...|..|||..|.          :::||||:.....|    ::||||  ..|...|:
Mouse    21 DTFNMDTRNPRVIAGPS----------AAFFGYTVQQHDISGKKWLVVGAP--METNGHQK---- 69

  Fly    84 TGAIYRCSLTNGVCSPYVLD--SRGNVDAPYSEYTFDSERKDFQWLGGSMDGGTKDTDKLLVCAP 146
            ||.:|:|.:|.|.|:...|.  :..||          |||||...||.|:....|| :..|.|:|
Mouse    70 TGDVYKCPVTQGNCTKLNLGRVTLSNV----------SERKDNMRLGLSLATNPKD-NSFLACSP 123

  Fly   147 RFYAPSSRDNHLHGVCYWVNN------TVA----------------------------------- 170
            .:........:..|:|..||:      |||
Mouse   124 LWSHECGSSYYTTGMCSRVNSNFRFSKTVAPALQRCQTYMDIVIVLDGSNSIYPWVEVQHFLINI 188

  Fly   171 ----------------------------------------------------------------- 170

Mouse   189 LKKFYIGPGQIQVGIVQYGEDAVHEFHLNDYRSVKDVVEAASHIEQRGGTETRTAFGIEFARSEA 253

  Fly   171 ---------------------------------STPQHVTR-------------ISPLRLKSEQV 189
                                             |...:|||             |:|....:| :
Mouse   254 FQKGGRKGAKKVMIVITDGESHDSPDLEKVIRQSEKDNVTRYAVAVLGYYNRRGINPETFLNE-I 317

  Fly   190 K----------------------------------EEDNGNKASFFYIMGELGLSAHVADDNTKF 220
            |                                  |..|.|:.||...|.:.|.|:||.:|.  .
Mouse   318 KYIASDPDDKHFFNVTDEAALKDIVDALGDRIFSLEGTNKNETSFGLEMSQTGFSSHVVEDG--I 380

  Fly   221 LIGAPGINTWRGSVILYRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYTPEHYAPEIPTPGLWG 285
            |:||.|...|.|:|:               ::||......:|         |.|..|.|
Mouse   381 LLGAVGAYDWNGAVL---------------KETSAGKVIPHR---------ESYLKEFP------ 415

  Fly   286 QEE----DSYFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGEAYIFDV---RGKSIHKYHVFRG 343
             ||    .:|.||.|:|..   |:....:|||.||:.| .:|:..:|.:   |..:||:  ..||
Mouse   416 -EELKNHAAYLGYTVTSVV---SSRQGRVYVAGAPRFN-HTGKVILFSMHNNRSLTIHQ--ALRG 473

  Fly   344 EQFGEYFGYSVLAEDLNGDGKTDV-IVSAPQHALEDSHDNGAIYVF-INKGFFNFERQILRSPVE 406
            ||.|.|||..:.:.|:|.|..||| :|.||.: ..:..:.|.:||: :.:..|.:...:..|...
Mouse   474 EQIGSYFGSEITSVDVNDDRVTDVLLVGAPMY-FSEGRERGKVYVYNLRQNRFVYNGTLKDSHSY 537

  Fly   407 TMARFGTALSRLGDINHDGYNDVAVGAPF--AGNGTVFIYLGSENGLRDQPSQRLDAPSQQPSKY 469
            ..||||:.::.:.|:|.|.||||.||||.  :..|.::|:.|.:..:..:|.||:.|....|
Mouse   538 QNARFGSCIASVQDLNQDSYNDVVVGAPLEDSHRGAIYIFHGFQTNILKKPMQRITASELAP--- 599

  Fly   470 GSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIKPEQEKVKIT 534
            |...||..:....|::.:|..|.|:|| ...||.|: |.|||:::|::..|     |.:..:...
Mouse   600 GLQHFGCSIHGQLDLNEDGLVDLAVGA-LGNAVVLW-ARPVVQINASLHFE-----PSKINIFHK 657

  Fly   535 ACYRLSTTSTDKLV-------------QEQELAIR--IAMDKQ--LKRVKFTQTQTNEISFKVNA 582
            .|.|....:|....             |...:.||  ..||::  :.|....:......:..|..
Mouse   658 DCKRNGRDATCLAAFLCFIPIFLAPHFQTATVGIRYNATMDERRYMPRAHLDEGGDQFTNRAVLL 722

  Fly   583 NFG-EQCRDFETQVRYSEKDIFTPIDLEMHYELTKKVPDSEEFCETCAIVD---PTEPKVSTQNI 643
            :.| |.|:.....| ....|...|:...:.|.|  :.||:.      .::|   ||..:||   :
Mouse   723 SSGQEHCQRINFHV-LDTADYVKPVAFSVEYSL--EDPDNG------PMLDNGWPTTLRVS---V 775

  Fly   644 IFSTGCATDV-CTADLQLRSKDVSPT------YILG-----------SADTL---------RLNY 681
            .|..||..|. |..||.|.::...||      .:||           |.||.         |:..
Mouse   776 PFWNGCNEDEHCVPDLVLDARSDLPTAMEYCQRVLGRPAQDCSSYTLSFDTTVFIIESTRRRVAV 840

  Fly   682 EIT--NIGETAYLPQFNVTSTSRLAFA---QVPGNCKVVDAV--------MVCDLNRGRPLAKGD 733
            |.|  |.||.||....|::.:..|.||   |...:...::.|        .||:::.....||..
Mouse   841 EATLENRGENAYSAVLNISQSENLQFASLIQKDDSDNSIECVNEERRLHKKVCNVSYPFFRAKAK 905

  Fly   734 TDSVTISFDVSQ-LSGQSLIIHAEVFSTGYEQNPTDNRQTNVIGLKEFTEIDASGGQTNSQIDLE 797
            . :..:.|:.|: :....|.||....|..:||:.|.:..|.::......|.|....:::|....|
Mouse   906 V-AFRLDFEFSKSVFLHHLQIHLGAGSDSHEQDSTADDNTALLRFHLKYEADVLFTRSSSLSHFE 969

  Fly   798 HYSNSAEIVNNYE-----------IKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKM 851
            ..:||:  :.:|:           :::.|...|..:.:...:|||.:  |...:
Mouse   970 VKANSS--LESYDGIGPPFNCVFKVQNLGFFPIHGVMMKITVPIATR--GGNRL----------- 1019

  Fly   852 QASYDSQLLSIDLY-DQNNTMLVVDPVEVTTTLSGGLE--RTVITQNRQSYDIHTSGHVHQTMEV 913
                   |:..|.: ||.||         :..:.|...  |:..|:...|   |.....|...:|
Mouse  1020 -------LMLRDFFTDQGNT---------SCNIWGNSTEYRSTPTEEDLS---HAPQRNHSNSDV 1065

  Fly   914 LDTSMVATASMSRKRRDLKALTANREQYARISNVKAHDLLSDDFKG-KLPVNRTIVFNCRDPEMT 977
            :  |::.         :|:...:....:..:.|:....|.:..::. |:.||..:......|.:
Mouse  1066 V--SIIC---------NLRLAPSQETSFYLVGNLWLTSLKALKYRSLKITVNAALQRQFHSPFI- 1118

  Fly   978 ICVRAEMRVHFRPEKSINLNMRYSVDLNEVNAILVDPWEYFVILTDLKLQKKGDPT-STSFSINR 1041
                      ||.|                                       ||: ..:|.
Mouse  1119 ----------FREE---------------------------------------DPSRQVTFE--- 1131

  Fly  1042 RIEPNIISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRTKK 1090
                  |||.::..:|||||:.|.:||||||:.:...|:|.|||...|:
Mouse  1132 ------ISKQEDWQVPIWIIVGSTLGGLLLLALLVLALWKLGFFKSAKR 1174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	18/55 (33%)
		FG-GAP	350..388	CDD:280083	13/38 (34%)
		Int_alpha	409..459	CDD:214549	20/51 (39%)
		Int_alpha	473..>515	CDD:214549	15/41 (37%)
		Integrin_alpha2	507..829	CDD:285619	84/394 (21%)
Itga11	NP_795896.4	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	24..85		24/76 (32%)
		Int_alpha	37..86	CDD:214549	18/64 (28%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	91..151		19/70 (27%)
		vWA_integrins_alpha_subunit	163..341	CDD:238746	8/178 (4%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	355..406		19/67 (28%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	411..461		18/60 (30%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	462..527		24/67 (36%)
		Int_alpha	476..523	CDD:214549	16/47 (34%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	528..586		19/57 (33%)
		Int_alpha	538..592	CDD:214549	20/53 (38%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	590..650		22/69 (32%)
		Integrin_alpha2	635..1034	CDD:285619	94/447 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832050
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840