Protein Alignment scb and Itga11

DIOPT Version :10

• Sequence 1: NP_523750.2
• Gene: scb / 36692
• FlyBaseID: FBgn0286785
• Length: 1115
• Species: Drosophila melanogaster
• Sequence 2: NP_001400722.1
• Gene: Itga11 / 315744
• RGDID: 1311711
• Length: 1188
• Species: Rattus norvegicus
• Alignment Length: 1371
• Identity: 298/1371 - (21%)
• Similarity: 472/1371 - (34%)
• Gaps: 489/1371 - (35%)

  Fly    23 EAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIRQTS----IIVGAPRAQSTLESQRTINE 83
            :.||...|..|||..|.          :::||||:.....|    ::||||     ||:... .:
  Rat    21 DTFNMDTRNPRVIAGPS----------AAFFGYTVQQHDISGKKWLVVGAP-----LETNGH-QK 69

  Fly    84 TGAIYRCSLTNGVCSPYVLD--SRGNVDAPYSEYTFDSERKDFQWLGGSMDGGTKDTDKLLVCAP 146
            ||.:|:|.:|.|.|:...|.  :..||          |||||...||.|:....||: ..|.|:|
  Rat    70 TGDVYKCPVTQGNCTKLNLGRVTLSNV----------SERKDNMRLGLSLATNPKDS-SFLACSP 123

  Fly   147 RFYAPSSRDNHLHGVCYWVNN------TVA----------------------------------- 170
            .:........:..|:|..||:      |||
  Rat   124 LWSHECGSSYYTTGMCSRVNSNFRFSKTVAPALQRCQTYMDIVIVLDGSNSIYPWVEVQHFLIEI 188

  Fly   171 ----------------------------------------------------------------- 170
                                                                             
  Rat   189 LTKFYIGPGQIQVGIVQYGEDAVHEFHLNDYKSVKDVVEAASHIEQRGGTETRTAFGIEFARSEA 253

  Fly   171 ---------------------------------STPQHVTR-------------ISPLRLKSEQV 189
                                             |...:|||             |:|....:| :
  Rat   254 FQKGGRKGAKKVMIVITDGESHDSPDLEKVIRQSEKDNVTRYAVAVLGYYNRRGINPETFLNE-I 317

  Fly   190 K----------------------------------EEDNGNKASFFYIMGELGLSAHVADDNTKF 220
            |                                  |..|.|:.||...|.:.|.|:||.:|..
  Rat   318 KYIASDPDDKHFFNVTDEAALKDIVDALGDRIFSLEGTNKNETSFGLEMSQTGFSSHVVEDGV-- 380

  Fly   221 LIGAPGINTWRGSVILYRQVDPVDNPTASRRDTSKA----LRRTYRDVDSNDYTPEHYAPEIPTP 281
            |:||.|...|.|:|:               ::||..    ||             |.|..|.|
  Rat   381 LLGAVGAYDWNGAVL---------------KETSAGKVIPLR-------------ESYLKEFP-- 415

  Fly   282 GLWGQEE----DSYFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGEAYIFDV---RGKSIHKYH 339
                 ||    .:|.||.|:|..   |:....:|||.||:.| .:|:..:|.:   |..:||:
  Rat   416 -----EELKNHAAYLGYTVTSVV---SSKQGRVYVAGAPRFN-HTGKVILFSIHTNRSLTIHQ-- 469

  Fly   340 VFRGEQFGEYFGYSVLAEDLNGDGKTDV-IVSAPQHALEDSHDNGAIYVF-INKGFFNFERQILR 402
            ..||||.|.|||..:.:.|:|.|..||| :|.||.: ..:..:.|.:||: :.:..|.|...:..
  Rat   470 ALRGEQIGSYFGSEITSVDINNDRVTDVLLVGAPMY-FSEGRERGKVYVYNLRQNRFVFNGTLKD 533

  Fly   403 SPVETMARFGTALSRLGDINHDGYNDVAVGAPF--AGNGTVFIYLGSENGLRDQPSQRLDAPSQQ 465
            |.....||||:.::.:.|:|.|.||||.||||.  :..|.::|:.|.:..:..:|.||:.|....
  Rat   534 SHSYQNARFGSCIASVQDLNQDSYNDVVVGAPLEDSHRGAIYIFHGFQTNILKKPVQRISASELA 598

  Fly   466 PSKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIKPEQEK 530
            |   |...||..:....|::.:|..|.|:|| ...||.|: |.|||:::|::..|     |.:..
  Rat   599 P---GLQHFGCSIHGQLDLNEDGLVDLAVGA-LGNAVVLW-ARPVVQINASLHFE-----PSKIN 653

  Fly   531 VKITACYRLSTTST--------------------------DKLVQEQELAIRIAMDKQLKRVKFT 569
            :....|.|....:|                          :..:.|:....|..:|:...  :||
  Rat   654 IFHKDCKRNGRDATCLAAFLCFGPIFLAPHFHTATVGIRYNATMDERRYMPRAHLDEGAD--QFT 716

  Fly   570 QTQTNEISFKVNANFGEQCRDFETQVRYSEKDIFTPIDLEMHYELTKKVPDSEEFCETCAIVD-- 632
            ....      :.::..|.|:.....| ....|...|:...:.|.|  :.||..      .::|
  Rat   717 NRAV------LLSSGQEHCQRINFHV-LDTADYVKPVAFSVEYSL--EDPDHG------PMLDNG 766

  Fly   633 -PTEPKVSTQNIIFSTGCATDV-CTADLQLRSKDVSPT------------------YILGSADTL 677
             ||..:||   :.|..||..|. |..||.|.::...||                  |.| |.||.
  Rat   767 WPTTLRVS---VPFWNGCNEDEHCVPDLVLDARSDLPTAMEYCQQVLRRPAQDCSSYTL-SFDTT 827

  Fly   678 ---------RLNYEIT--NIGETAYLPQFNVTSTSRLAFA---QVPGNCKVVDAV--------MV 720
                     |:..|.|  |.||.||....|::.:..|.||   |...:...::.|        .|
  Rat   828 VFIIESTRRRVAVEATLENRGENAYSAVLNISQSENLQFASLIQKDDSDNSIECVNEERRLHKKV 892

  Fly   721 CDLNRGRPLAKGDTDSVTISFDVSQ-LSGQSLIIHAEVFSTGYEQNPTDNRQTNVIGLKEFTEID 784
            |:::.....||... :..:.|:.|: :....|.||....|..:||:.|.:..|.::......|.|
  Rat   893 CNVSYPFFRAKAKV-AFRLDFEFSKSVFLHHLQIHLGAGSDSHEQDSTADDNTALLRFHLKYEAD 956

  Fly   785 ASGGQTNSQIDLEHYSNSAEIVNNYEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTSL 849
            ....:::|             ::::|:|:|  |.:|          :|...|     |..|.. .
  Rat   957 VLFTRSSS-------------LSHFEVKAN--SSLE----------SYDGIG-----PPFNCV-F 990

  Fly   850 KMQASYDSQLLSIDLYDQNNTMLVVDPVEVTTTLSGGLERTVITQNRQSYDIHTSGHV-HQTMEV 913
            |:|        ::..:..:..|:   .:.|.....|| .|.::.::..:..::||.:: ..:.|.
  Rat   991 KVQ--------NLGFFPIHGVMM---KITVPIATRGG-NRLLMLKDFFTDQVNTSCNIWGNSTEY 1043

  Fly   914 LDTSMVATASMSRKRRDLKALTANREQYARISNVKAHDLLSDDF--KGKLPVNRTIVFNCRDPEM 976
            ..|......|.:.:|..     :|.:..:.|.||:........|  .|.|.:........|..::
  Rat  1044 RSTPTEEDLSHAPQRNH-----SNSDVVSIICNVRLAPNQETSFYLVGNLWLMSLKALKYRSMKI 1103

  Fly   977 TICVRAEMRVH----FRPEKSINLNMRYSVDLNEVNAILVDPWEYFVILTDLKLQKKGDPT-STS 1036
            |:....:.:.|    ||.|                                       ||: ..:
  Rat  1104 TVNAALQRQFHSPFIFREE---------------------------------------DPSRQVT 1129

  Fly  1037 FSINRRIEPNIISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRTKKDELDRLVQQNP 1101
            |.         |||.::..:|||||:.|.:||||||:.:...|:|.|||...|:.....|   .|
  Rat  1130 FE---------ISKQEDWQVPIWIIVGSSLGGLLLLALLVLALWKLGFFKSAKRKREPSL---GP 1182

  Fly  1102 VEPEAE 1107
            |..|.|
  Rat  1183 VPKELE 1188

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	18/55 (33%)
		FG-GAP	350..388	CDD:460357	13/38 (34%)
		Int_alpha	409..459	CDD:214549	20/51 (39%)
		Int_alpha	473..>515	CDD:214549	15/41 (37%)
		Integrin_alpha2	509..829	CDD:462478	79/390 (20%)
Itga11	NP_001400722.1	Int_alpha	37..86	CDD:214549	18/64 (28%)
		vWA_integrins_alpha_subunit	163..341	CDD:238746	8/178 (4%)
		Int_alpha	476..523	CDD:214549	16/47 (34%)
		Int_alpha	538..592	CDD:214549	20/53 (38%)
		Integrin_alpha2	636..1064	CDD:462478	97/502 (19%)