DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and Itga5

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_001101588.1	Gene:	Itga5 / 315346	RGDID:	2925	Length:	1099	Species:	Rattus norvegicus

Alignment Length:	1197	Identity:	296/1197 - (24%)
Similarity:	452/1197 - (37%)	Gaps:	316/1197 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LALLALI----SHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIRQ-----TSIIVGA 68
            |.||.|:    ..:..||.......|::.|.          .|.||:::...:     .|::|||
  Rat    78 LPLLLLLWPPPLQVGGFNLDAEAPAVLSGPP----------GSLFGFSVEFYRPGRDGVSVLVGA 132

  Fly    69 PRAQSTLESQRTINETGAIYRCSL-TNGV-CSPYVLDSRGNVDAPYSEYTFDS-ERKDFQWLGGS 130
            |:|.:   ||..:.:.||:|.|.. |:.: ||....||:|:.....|.|:.:. |.|..||.|.:
  Rat   133 PKANT---SQPGVLQGGAVYVCPWGTSPIQCSTIQFDSKGSRILESSLYSEEPVEYKSLQWFGAT 194

  Fly   131 MDGGTKDTDKLLVCAPRFYAPSSRD--NHLHGVCYWVNNTVASTPQHVTRI---SPLRLKSEQVK 190
            :   ......:|.|||.:...:.:|  |...|.||      .|| ::.|||   :|.|
  Rat   195 V---RAHGSSILACAPLYSWRTEKDPQNDPVGTCY------LST-ENFTRILEYAPCR------- 242

  Fly   191 EEDNGNKASFFYIMGELGLSAHVADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRDTSK 255
             .|.|:.|...|..|  |.||...... :.::|.||...|:|.::           :|::...|
  Rat   243 -SDFGSAAGQGYCQG--GFSAEFTKTG-RVVLGGPGSYFWQGQIL-----------SATQEQIS- 291

  Fly   256 ALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQ---------EEDSYFGYAVSSGFFDSSNPTKLLY 311
                            |.|.|:.....:.||         .:|||.||:|:.|.|...:...  :
  Rat   292 ----------------ESYYPQYLINPVQGQLQTRQASSVYDDSYLGYSVAVGEFSGDDTED--F 338

  Fly   312 VATAPQANKQSGEAYIFDVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQHAL 376
            ||..|:.|...|  |:..:.|..||..:...|||...||||:|.|.|.||||..|::|.||. .:
  Rat   339 VAGVPKGNLTYG--YVTVLNGSDIHSLYNVSGEQMASYFGYAVAATDTNGDGLDDLLVGAPL-LM 400

  Fly   377 EDSHDN-----GAIYVFINKGFFNFERQILRSPVETM------ARFGTALSRLGDINHDGYNDVA 430
            |.:.|.     |.:|:::     .....|..:|..|:      .|||::|:.|||::.|||||||
  Rat   401 ERTADGRPQEVGRVYIYL-----QHPEGIEPTPSLTLTGQDEFGRFGSSLTPLGDLDQDGYNDVA 460

  Fly   431 VGAPFAG---NGTVFIYLGSENGLRDQPSQRLDAPSQQPSKYGSH---MFGHGLSRGSDIDGNGF 489
            :||||.|   .|.|||:.|...||..:|||.|     ||.....|   .||..|..|.|:||||:
  Rat   461 IGAPFGGEAQQGVVFIFPGGPGGLNTKPSQVL-----QPLWAAGHTPDFFGSALRGGRDLDGNGY 520

  Fly   490 NDFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIKPEQEKVKI----TACYRLS--TTSTDKLV 548
            .|..:|:...:...:||..|::...|::........||:....:    .:|..||  ..::.|.|
  Rat   521 PDLIVGSFGVDKALVYRGRPIISASASLTIFPSMFNPEERSCSLEGNPVSCINLSFCLNASGKHV 585

  Fly   549 --------------QEQELAIRIAMDKQLKRVKFTQTQTNEISFKVNANFGEQCRDFETQVRYSE 599
                          |:|:..:|.|:....|:...|||      ..:.....|.||:.:..:|...
  Rat   586 PNSIGFEVELQLDWQKQKGGVRRALFLASKQATLTQT------LLIQNGAREDCREMKIYLRNES 644

  Fly   600 --KDIFTPIDLEMHYELTKKVP-DSEEFCETCAIVDPTEPKVSTQNIIFSTGCATD-VCTADLQL 660
              :|..:||.:.:::.|..|.| ||............:..:...|.::   .|..| :|..||||
  Rat   645 EFRDKLSPIHIALNFSLDPKAPMDSHGLRPVLHYQSKSRIEDKAQILL---DCGEDNICVPDLQL 706

  Fly   661 RSKDVSPTYILGSADTLRLNYEITNIGE-TAYLPQFNVTSTSRLAFAQV---PGNCKVVD----A 717
            ..........||..:.|.|.:...|:|| .||..:..||:.....::.:   |||...:.    |
  Rat   707 AVYGEKKHVYLGDKNALNLTFLAQNLGEGGAYEAELRVTAPLEAEYSGLVRHPGNFSSLSCDYFA 771

  Fly   718 V-----MVCDLNRGRPLAKG---------------DTDSVTISFDVSQLSGQSLIIHAEVFSTGY 762
            |     :||||  |.|:..|               ||.. ||.||...||
  Rat   772 VNQSRQLVCDL--GNPMKAGTSIWGGLRFTVPHLQDTKK-TIQFDFQILS--------------- 818

  Fly   763 EQNPTDNRQTNVIGLKEFTEIDASGGQTNSQIDLEHYSNSAEIV--------------------- 806
              ...:|.|:|::......|..|       |:.|...|....::
  Rat   819 --KNLNNSQSNMVSFPLSVEAQA-------QVSLNGVSKPEAVIFPVSDWNPQDQPQKEGDLGPA 874

  Fly   807 --NNYEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLLSIDLYDQNN 869
              :.||:.:.|||.|.|..:....|.|.:   ...::.:..||.|....|.         |..|:
  Rat   875 VHHVYELINQGPSSISQGVLEISCPQALE---GQQLLYVTKVTGLNNCTSN---------YTPNS 927

  Fly   870 TMLVVDPVEVTTTLSGGLERTVITQNRQSYDIHTSGHVHQTMEVLDTSMVATASMSRKRRDLKAL 934
            ..|.:||                         ..|.|..|
  Rat   928 QGLELDP-------------------------EVSPHHLQ------------------------- 942

  Fly   935 TANREQYARISNVKAHDLLSDDFKGKLPVNRTIVFNCRDPEMTICVRAEMRVHFRPEKSINLNMR 999
              .||...|.|......:|      |.|..:.....|....:.......:::|||......|...
  Rat   943 --RREAPGRSSTTSGTQVL------KCPEAKCFRLRCEFGPLHRQESRSLQLHFRVWAKTFLQQE 999

  Fly  1000 Y---SVDLNEVNAILVDPWEYFVILTDLKLQKKGDPTSTSFSINRRIEPNIISKHQETGLPIWII 1061
            |   |:....:...|..|  |.::...|..:|....|:..::          ......|:|:|||
  Rat  1000 YQPFSLQCEALYEALKMP--YQILPRQLPQKKLQVATAVQWT----------KAEGSNGVPLWII 1052

  Fly  1062 IVSVIGGLLLLSAISYLLYKFGFFNRT 1088
            |::::.|||||..:.|:|||.|||.|:
  Rat  1053 ILAILFGLLLLGLLIYVLYKLGFFKRS 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	18/58 (31%)
		FG-GAP	350..388	CDD:280083	18/42 (43%)
		Int_alpha	409..459	CDD:214549	29/52 (56%)
		Int_alpha	473..>515	CDD:214549	14/41 (34%)
		Integrin_alpha2	507..829	CDD:285619	83/396 (21%)
Itga5	NP_001101588.1	Int_alpha	108..166	CDD:214549	18/70 (26%)
		Int_alpha	317..>359	CDD:214549	15/45 (33%)
		Int_alpha	371..432	CDD:214549	21/66 (32%)
		Int_alpha	438..492	CDD:214549	29/53 (55%)
		Int_alpha	504..556	CDD:214549	15/51 (29%)
		Integrin_alpha2	539..971	CDD:285619	104/537 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335749
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840