DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment scb and Itga10

DIOPT Version :9

Sequence 1:NP_523750.2 Gene:scb / 36692 FlyBaseID:FBgn0286785 Length:1115 Species:Drosophila melanogaster
Sequence 2:NP_001101169.2 Gene:Itga10 / 310683 RGDID:1305152 Length:1167 Species:Rattus norvegicus


Alignment Length:1395 Identity:274/1395 - (19%)
Similarity:460/1395 - (32%) Gaps:543/1395 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 ESTMFPHIFLALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIR----QTSI 64
            |....||:||.|..|......||......|:...|...:          |||:::..    |..:
  Rat     2 ELPSIPHLFLPLALLTGLCSPFNLDEHHPRLFTGPPEAE----------FGYSVLQHVGGGQRWM 56

  Fly    65 IVGAPRAQSTLESQRTINETGAIYRCSL--------TNGVCSPYVLDSRGNVDAPYSEYTFDSER 121
            :||||....:.:.:      |.:||||:        |.|....|.|   ||...|...       
  Rat    57 LVGAPWDGPSGDRK------GDVYRCSIGGFHSAPCTKGHLGDYQL---GNSSQPAVN------- 105

  Fly   122 KDFQWLGGSM-----DGGTKDTDKLLVCAPRFYAPSSRDNHLHGVCYWV---------------- 165
               ..||.|:     |||      .:.|||.:...........|:|..|                
  Rat   106 ---MHLGMSLLETDADGG------FMACAPLWSRACGSSVFSSGICAHVDASFRLQGSLAPTAQR 161

  Fly   166 -------------NNTV-------------------------------ASTPQHVTRISPLRLKS 186
                         :|::                               ...|.|...:...|.|.
  Rat   162 CPTYMDVVIVLDGSNSIYPWSEVQTFLRRLVGRLFIDPEQIQVGLVQYGENPVHEWSLGDFRTKE 226

  Fly   187 EQVK-----------------------------------------------EEDNG--------- 195
            |.|:                                               |..:|         
  Rat   227 EVVRAARNLSRREGRETRTAQAIMVACTEGFSESRGGRPEAARLLVVVTDGESHDGEELPAALKA 291

  Fly   196 ----------------------------------------------------------------- 195
                                                                             
  Rat   292 CEAGRVTRYGIAVLGHYLRRQRDPSSFLREIRAIASDPDERFFFNVTDEAALTDIVDALGDRIFG 356

  Fly   196 -------NKASFFYIMGELGLSAHVADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRDT 253
                   |::||...|.|:|.|.|...|.  .|.|..|...|.|||:...:...:..|..:..| 
  Rat   357 LEGSRGENESSFGLEMSEIGFSIHRLQDG--ILFGMVGAYDWGGSVLWLEEGRRLFPPRTALED- 418

  Fly   254 SKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQA 318
                                   |.| |.|  |...:|.||:|||......   :.|:::.||:.
  Rat   419 -----------------------EFP-PAL--QNHAAYLGYSVSSMLLPGG---RRLFLSGAPRF 454

  Fly   319 NKQSGEAYIFDVRGKSIHKY-HVFRGEQFGEYFGYSVLAEDLNGDGKTDV-IVSAPQHALEDSHD 381
             :..|:...|.::...:.|. ...:|:|.|.|||..:...|.:.||.|:: :|:||......:.:
  Rat   455 -RHRGKVIAFQLKKDGVVKVTQSLQGDQIGSYFGSELCPLDTDMDGITNILLVAAPMFLGPQNKE 518

  Fly   382 NGAIYVFINKGFFNFERQILRSPVETM-------ARFGTALSRLGDINHDGYNDVAVGAPF--AG 437
            .|.|||::      ..:|.|.....|:       :|||.|::.|.|:||||::|||||||.  ..
  Rat   519 TGRIYVYV------VGQQNLLMLQGTLQPDRSQDSRFGFAMAALPDLNHDGFSDVAVGAPLEDGH 577

  Fly   438 NGTVFIYLGSENGLRDQPSQRLDAPSQ-QPSKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEA 501
            .|.:::|.|::.|:|..|:||:.|.|. |..:|    ||..:....|:||:...|.|:||..  |
  Rat   578 QGALYLYHGTQTGIRPHPTQRIAAGSMPQALRY----FGRSVDGRLDLDGDDLVDVAVGAHG--A 636

  Fly   502 VYLYRAYPVVKVHATVKSESREIKPE-------------QEKVKITA--CYRLSTTSTDKLVQEQ 551
            ..|:.:.|::.:..|:     ::.|.             ||...:||  |:::.:.:..:     
  Rat   637 AILFSSQPIIHLIPTL-----DVMPPHISVVQKDCKRRGQEAACLTASLCFQVKSQTPGR----- 691

  Fly   552 ELAIRIAMDKQLKRVKFTQTQTNEISFKVNANF-GEQCRDFETQVRYSEKDIFTPIDLEMHYELT 615
                   .|::. .::|: ...:|.:....|.| |...|....|:|.|..::...   ::|:...
  Rat   692 -------WDRRF-HIRFS-ASLDEWTAGARAAFDGSGQRLSPGQLRLSVGNVTCE---QLHFHAL 744

  Fly   616 KKVPDSEEFCE------TCAIVDPTEP--------KVSTQNII-FSTGCATD-------VCTADL 658
                |:.::..      |.|:.:.|:|        ..|.:.:| ||..|..|       |..||:
  Rat   745 ----DTSDYLRPVALTVTFALDNTTKPGPVLAEGSSTSIRKLIPFSKDCGPDNECITDLVLQADM 805

  Fly   659 QLRSKDVSPTYILGSADTLRLNYEITNIGETAYLPQFNVTSTSRLAFAQV-PGNCKVVDA----- 717
            .:|....||..:.|....:.::..:.|..|.||....:::.:..|..|.: |...|.|..     
  Rat   806 DIRGSRKSPFVVQGGRQKVLVSVTLENKKENAYNTSLSLSFSRNLHLASLTPQRAKSVKVECAVP 870

  Fly   718 ---VMVCDLNRGRPLAK-GDTDSVTISFD------VSQLSGQSLIIHAEVFSTGYEQNPTDNRQT 772
               ..:|.:  |.|:.: |...|..:.|:      :||:|     :.....|:..|:|.|     
  Rat   871 SPHARLCIV--GHPVFQAGAKVSFLLEFEFSCTFLLSQVS-----VRLTASSSSLERNET----- 923

  Fly   773 NVIGLKEFTEIDASGGQTNSQIDLE-HYSNSAE-IVNNYE--------------------IKSNG 815
                |::.|      .||::.|..| |...|:| .::.||                    :::.|
  Rat   924 ----LQDNT------AQTSAYIRYEPHLMFSSESTLHRYEVHPYRALPVGPGPEFKTTLRVQNLG 978

  Fly   816 PSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLLSIDLYDQNNTMLVVDPVEVT 880
            ..|:..|.||             |::|.:        |...:..||:                 :
  Rat   979 CHVVSGLVVS-------------ALLPAV--------AHGGNYFLSL-----------------S 1005

  Fly   881 TTLSGGLERTVITQN---RQSYDIHTSGHVHQTMEVLDTSMVATASMSRKRRDLKALTANREQYA 942
            ..:||....||  ||   ...:.:|..       |:..||.:..::                  .
  Rat  1006 QVISGNASCTV--QNLTDPPGFPVHPE-------ELQHTSRLNGSN------------------T 1043

  Fly   943 RISNVKAHDLLSDDFKGKLPVNRTIVFNCRDPEMTI-CVRAEMRVHFRPE--KSINLNMRYSVDL 1004
            |...|:.|       .|.||         :..|::: .:|......||..  ||:.:...:.:..
  Rat  1044 RCQAVRCH-------LGLLP---------KGTEISVGLLRLVHNEFFRRAKFKSVTVVSTFKLGT 1092

  Fly  1005 NEVNAILVD---PW--EYFVILTDLKLQKKGDPTSTSFSINRRIEPNIISKHQETGLPIWIIIVS 1064
            .:.:.:|::   .|  .:..::..|                    |.:||        :||::.|
  Rat  1093 EKGSVLLLNEASQWRESHLEVIQTL--------------------PTLIS--------LWILVGS 1129

  Fly  1065 VIGGLLLLSAISYLLYKFGFFNRTK--KDE 1092
            |:||||||:.:.:.|:|.|||.|.|  |:|
  Rat  1130 VLGGLLLLALLVFCLWKLGFFTRKKIPKEE 1159

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scbNP_523750.2 Int_alpha 51..103 CDD:214549 16/63 (25%)
FG-GAP 350..388 CDD:280083 12/38 (32%)
Int_alpha 409..459 CDD:214549 24/51 (47%)
Int_alpha 473..>515 CDD:214549 12/41 (29%)
Integrin_alpha2 507..829 CDD:285619 75/397 (19%)
Itga10NP_001101169.2 Int_alpha 41..81 CDD:214549 13/45 (29%)
vWA_integrins_alpha_subunit 166..346 CDD:238746 9/179 (5%)
Int_alpha 482..>525 CDD:214549 14/42 (33%)
Int_alpha 545..599 CDD:214549 24/53 (45%)
Integrin_alpha2 642..1050 CDD:285619 92/520 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166335698
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3637
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23220
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.840

Return to query results.
Submit another query.