Protein Alignment scb and Itga10

DIOPT Version :10

• Sequence 1: NP_523750.2
• Gene: scb / 36692
• FlyBaseID: FBgn0286785
• Length: 1115
• Species: Drosophila melanogaster
• Sequence 2: NP_001101169.2
• Gene: Itga10 / 310683
• RGDID: 1305152
• Length: 1167
• Species: Rattus norvegicus
• Alignment Length: 1395
• Identity: 274/1395 - (19%)
• Similarity: 460/1395 - (32%)
• Gaps: 543/1395 - (38%)

  Fly     4 ESTMFPHIFLALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIR----QTSI 64
            |....||:||.|..|......||......|:...|...:          |||:::..    |..:
  Rat     2 ELPSIPHLFLPLALLTGLCSPFNLDEHHPRLFTGPPEAE----------FGYSVLQHVGGGQRWM 56

  Fly    65 IVGAPRAQSTLESQRTINETGAIYRCSL--------TNGVCSPYVLDSRGNVDAPYSEYTFDSER 121
            :||||....:.:.:      |.:||||:        |.|....|.|   ||...|...
  Rat    57 LVGAPWDGPSGDRK------GDVYRCSIGGFHSAPCTKGHLGDYQL---GNSSQPAVN------- 105

  Fly   122 KDFQWLGGSM-----DGGTKDTDKLLVCAPRFYAPSSRDNHLHGVCYWV---------------- 165
               ..||.|:     |||      .:.|||.:...........|:|..|
  Rat   106 ---MHLGMSLLETDADGG------FMACAPLWSRACGSSVFSSGICAHVDASFRLQGSLAPTAQR 161

  Fly   166 -------------NNTV-------------------------------ASTPQHVTRISPLRLKS 186
                         :|::                               ...|.|...:...|.|.
  Rat   162 CPTYMDVVIVLDGSNSIYPWSEVQTFLRRLVGRLFIDPEQIQVGLVQYGENPVHEWSLGDFRTKE 226

  Fly   187 EQVK-----------------------------------------------EEDNG--------- 195
            |.|:                                               |..:|
  Rat   227 EVVRAARNLSRREGRETRTAQAIMVACTEGFSESRGGRPEAARLLVVVTDGESHDGEELPAALKA 291

  Fly   196 ----------------------------------------------------------------- 195
                                                                             
  Rat   292 CEAGRVTRYGIAVLGHYLRRQRDPSSFLREIRAIASDPDERFFFNVTDEAALTDIVDALGDRIFG 356

  Fly   196 -------NKASFFYIMGELGLSAHVADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRDT 253
                   |::||...|.|:|.|.|...|.  .|.|..|...|.|||:...:...:..|..:..|
  Rat   357 LEGSRGENESSFGLEMSEIGFSIHRLQDG--ILFGMVGAYDWGGSVLWLEEGRRLFPPRTALED- 418

  Fly   254 SKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQA 318
                                   |.| |.|  |...:|.||:|||......   :.|:::.||:.
  Rat   419 -----------------------EFP-PAL--QNHAAYLGYSVSSMLLPGG---RRLFLSGAPRF 454

  Fly   319 NKQSGEAYIFDVRGKSIHKY-HVFRGEQFGEYFGYSVLAEDLNGDGKTDV-IVSAPQHALEDSHD 381
             :..|:...|.::...:.|. ...:|:|.|.|||..:...|.:.||.|:: :|:||......:.:
  Rat   455 -RHRGKVIAFQLKKDGVVKVTQSLQGDQIGSYFGSELCPLDTDMDGITNILLVAAPMFLGPQNKE 518

  Fly   382 NGAIYVFINKGFFNFERQILRSPVETM-------ARFGTALSRLGDINHDGYNDVAVGAPF--AG 437
            .|.|||::      ..:|.|.....|:       :|||.|::.|.|:||||::|||||||.  ..
  Rat   519 TGRIYVYV------VGQQNLLMLQGTLQPDRSQDSRFGFAMAALPDLNHDGFSDVAVGAPLEDGH 577

  Fly   438 NGTVFIYLGSENGLRDQPSQRLDAPSQ-QPSKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEA 501
            .|.:::|.|::.|:|..|:||:.|.|. |..:|    ||..:....|:||:...|.|:||..  |
  Rat   578 QGALYLYHGTQTGIRPHPTQRIAAGSMPQALRY----FGRSVDGRLDLDGDDLVDVAVGAHG--A 636

  Fly   502 VYLYRAYPVVKVHATVKSESREIKPE-------------QEKVKITA--CYRLSTTSTDKLVQEQ 551
            ..|:.:.|::.:..|:     ::.|.             ||...:||  |:::.:.:..:
  Rat   637 AILFSSQPIIHLIPTL-----DVMPPHISVVQKDCKRRGQEAACLTASLCFQVKSQTPGR----- 691

  Fly   552 ELAIRIAMDKQLKRVKFTQTQTNEISFKVNANF-GEQCRDFETQVRYSEKDIFTPIDLEMHYELT 615
                   .|::. .::|: ...:|.:....|.| |...|....|:|.|..::...   ::|:...
  Rat   692 -------WDRRF-HIRFS-ASLDEWTAGARAAFDGSGQRLSPGQLRLSVGNVTCE---QLHFHAL 744

  Fly   616 KKVPDSEEFCE------TCAIVDPTEP--------KVSTQNII-FSTGCATD-------VCTADL 658
                |:.::..      |.|:.:.|:|        ..|.:.:| ||..|..|       |..||:
  Rat   745 ----DTSDYLRPVALTVTFALDNTTKPGPVLAEGSSTSIRKLIPFSKDCGPDNECITDLVLQADM 805

  Fly   659 QLRSKDVSPTYILGSADTLRLNYEITNIGETAYLPQFNVTSTSRLAFAQV-PGNCKVVDA----- 717
            .:|....||..:.|....:.::..:.|..|.||....:::.:..|..|.: |...|.|..
  Rat   806 DIRGSRKSPFVVQGGRQKVLVSVTLENKKENAYNTSLSLSFSRNLHLASLTPQRAKSVKVECAVP 870

  Fly   718 ---VMVCDLNRGRPLAK-GDTDSVTISFD------VSQLSGQSLIIHAEVFSTGYEQNPTDNRQT 772
               ..:|.:  |.|:.: |...|..:.|:      :||:|     :.....|:..|:|.|
  Rat   871 SPHARLCIV--GHPVFQAGAKVSFLLEFEFSCTFLLSQVS-----VRLTASSSSLERNET----- 923

  Fly   773 NVIGLKEFTEIDASGGQTNSQIDLE-HYSNSAE-IVNNYE--------------------IKSNG 815
                |::.|      .||::.|..| |...|:| .::.||                    :::.|
  Rat   924 ----LQDNT------AQTSAYIRYEPHLMFSSESTLHRYEVHPYRALPVGPGPEFKTTLRVQNLG 978

  Fly   816 PSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLLSIDLYDQNNTMLVVDPVEVT 880
            ..|:..|.||             |::|.:        |...:..||:                 :
  Rat   979 CHVVSGLVVS-------------ALLPAV--------AHGGNYFLSL-----------------S 1005

  Fly   881 TTLSGGLERTVITQN---RQSYDIHTSGHVHQTMEVLDTSMVATASMSRKRRDLKALTANREQYA 942
            ..:||....||  ||   ...:.:|..       |:..||.:..::                  .
  Rat  1006 QVISGNASCTV--QNLTDPPGFPVHPE-------ELQHTSRLNGSN------------------T 1043

  Fly   943 RISNVKAHDLLSDDFKGKLPVNRTIVFNCRDPEMTI-CVRAEMRVHFRPE--KSINLNMRYSVDL 1004
            |...|:.|       .|.||         :..|::: .:|......||..  ||:.:...:.:..
  Rat  1044 RCQAVRCH-------LGLLP---------KGTEISVGLLRLVHNEFFRRAKFKSVTVVSTFKLGT 1092

  Fly  1005 NEVNAILVD---PW--EYFVILTDLKLQKKGDPTSTSFSINRRIEPNIISKHQETGLPIWIIIVS 1064
            .:.:.:|::   .|  .:..::..|                    |.:||        :||::.|
  Rat  1093 EKGSVLLLNEASQWRESHLEVIQTL--------------------PTLIS--------LWILVGS 1129

  Fly  1065 VIGGLLLLSAISYLLYKFGFFNRTK--KDE 1092
            |:||||||:.:.:.|:|.|||.|.|  |:|
  Rat  1130 VLGGLLLLALLVFCLWKLGFFTRKKIPKEE 1159

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	16/63 (25%)
		FG-GAP	350..388	CDD:460357	12/38 (32%)
		Int_alpha	409..459	CDD:214549	24/51 (47%)
		Int_alpha	473..>515	CDD:214549	12/41 (29%)
		Integrin_alpha2	509..829	CDD:462478	75/395 (19%)
Itga10	NP_001101169.2	Int_alpha	41..81	CDD:214549	13/45 (29%)
		vWA_integrins_alpha_subunit	166..346	CDD:238746	9/179 (5%)
		Int_alpha	482..>525	CDD:214549	14/42 (33%)
		Int_alpha	545..599	CDD:214549	24/53 (45%)
		Integrin_alpha2	643..1050	CDD:462478	92/519 (18%)