Protein Alignment scb and Itgal

DIOPT Version :10

• Sequence 1: NP_523750.2
• Gene: scb / 36692
• FlyBaseID: FBgn0286785
• Length: 1115
• Species: Drosophila melanogaster
• Sequence 2: XP_006230331.1
• Gene: Itgal / 308995
• RGDID: 631424
• Length: 1161
• Species: Rattus norvegicus
• Alignment Length: 1300
• Identity: 254/1300 - (19%)
• Similarity: 442/1300 - (34%)
• Gaps: 399/1300 - (30%)

  Fly     9 PHIFLALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIRQTSIIVGAPRAQS 73
            |.:.|..|.|..:..::|.         ..:|.:..:.|. ..:|||.::.....::||||...
  Rat     8 PRLLLLGLQLFVNAWSYNL---------DTRHAQSFLTQA-GRHFGYQVLQFGDGVVVGAPGEG- 61

  Fly    74 TLESQRTINETGAIYRCSLTNGVCSPYVLDSRGNVDAPYSEYTFDSERKDFQWLGGSMDGGTKDT 138
                    |.||::|.|..::|.|.|..|.|...     |:|.                |.|..|
  Rat    62 --------NSTGSLYHCHPSSGSCQPVHLGSNHT-----SKYL----------------GMTMVT 97

  Fly   139 D----KLLVCAPRFYAPSSRDNHLHGVCYWVNNTVA-----STPQH------------------- 175
            |    .||.|.|.......::.:|.|:||..:.::.     :.|.:
  Rat    98 DAAKGSLLACDPGLSRTCDQNPYLSGLCYLFSQSLGKPILQNRPAYQECMKGNVDLVFLFDGSQS 162

  Fly   176 -------------------------------------------------------VTRISPLRLK 185
                                                                   :..::|:.|.
  Rat   163 LDKKDFEKIVDFMKDVMRKLSNTSYQFAAVQFSTECKTEFTFLDYIKLNKNPDVLLGNVTPMFLL 227

  Fly   186 SE----------QVKEEDNGNKASFFYIM-----GELGLSAHV--ADDNTKFLIG-APGINTWRG 232
            :.          .|.:|::|.:.....::     ||...:.::  |.|.|:::|| ....:|.:.
  Rat   228 TNTFRAINYVVTHVFKEESGARPDATKVLVIITDGEASDNGNIDAAQDITRYIIGIGKHFSTTQK 292

  Fly   233 SVILYRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYTPE--------HYAPEIPTPGL------ 283
            ...|:..............||.:.|:..:.|:....|..|        .:..|:.:.|:
  Rat   293 QEKLHIFASKPVEEFVKILDTFEKLKDLFTDLQRKIYAIEGTSKQDLASFNMELSSSGISADLSK 357

  Fly   284 ------------W-----------------GQ------EEDSYFGYAVSSGFFDSSNPTKLLYVA 313
                        |                 ||      |...|.||.|:.....||.|   |..|
  Rat   358 GHAVVGAVGAKDWAGGFLDLHEDLEGATFVGQEPLTSDERGGYLGYTVAWLTSRSSRP---LLAA 419

  Fly   314 TAPQANKQSGEAYIFDV--RGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTD-VIVSAPQHA 375
            .||: .:..|:..:|..  .|...::.....|.|.|.|||..:.:.||:.||:|| :::.||...
  Rat   420 GAPR-YQHVGQVLLFQAPEAGGHWNQTQKIEGTQIGSYFGGELCSVDLHQDGETDLLLIGAPLFY 483

  Fly   376 LEDSHDNGAIYVFINKGFFNFERQILRSPVETMARFGTALSRLGDINHDGYNDVAVGAPFAGNGT 440
            .|......::|. ..:..|....::...|...:.|||.|:|.|.|||.||..|||||||....|.
  Rat   484 GEQRGGRVSVYQ-RRRSLFEMVSELQGDPGYPLGRFGAAISALTDINGDGLTDVAVGAPLEEQGA 547

  Fly   441 VFIYLGSENGLRDQPSQRLDAPSQQPSKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLY 505
            |:|:.|...|...|.|||:......|   |...||..:....|:.|:...|..:||..  .|.:.
  Rat   548 VYIFNGKPGGFSSQSSQRIPGTQVSP---GVRWFGRSIHGVKDLGGDRLADVVVGAEG--QVIVL 607

  Fly   506 RAYPVVKVHATVKSESREI------------KPEQEKVKITACYR---LSTTSTDKLVQEQELAI 555
            .:.|||.:...:.....||            :.::|.||:..|::   |::....:|:......:
  Rat   608 SSRPVVDIVTELSFSPDEIPVHEVECSYSASQEQKEGVKLKVCFQIRPLTSQFQGRLLANLSYTL 672

  Fly   556 RIAMDKQLKRVKFTQTQTNEISFKVNANFGEQCRDFETQVRYSEKDIFTPIDLEMHYELTKK--- 617
            ::...:...|..| ...:.|:....:....:.|.||........:|:.:||::.:::.|.::
  Rat   673 QLDGHRTRSRGLF-PGGSRELGGNTSVTPDKSCMDFHFHFPICIQDLISPINVSLNFSLLEEEGS 736

  Fly   618 VPDSEEFCETCAIVDPTEPKVSTQNIIFSTGCATD-VCTADLQLRSKDVSPTYILGSADTLRLNY 681
            ..|.:...:...|:.|:...| |:.|.|...|..| .|.|||.|.....|....|.|:.:|.:.:
  Rat   737 PRDQKGGRDMQPILRPSIHAV-TKEIPFEKNCGEDKKCEADLALSPPARSGVLRLMSSASLAVEW 800

  Fly   682 EITNIGETAYLPQFNVTSTSRLAF---------AQVPGNCKVVDAVMVCDLNRGRPLAKGDTDSV 737
            .:.|:||.||..:.::.....|:|         :|:|.:|:
  Rat   801 TLRNLGEDAYWVRLDLDFPRGLSFRKVEMLQPHSQIPVSCE------------------------ 841

  Fly   738 TISFDVSQLSGQSLIIHAEVFSTGYEQNPTDNRQTNVIGLKEFTEIDASGGQTNSQIDLEHYSNS 802
                   :|:.:|.::             |...:.||     .:.|..:|.|...|:......||
  Rat   842 -------ELTEESSLL-------------TKTLKCNV-----SSPIFKAGKQMTLQVMFNTLLNS 881

  Fly   803 A-----EIVNNYEIKSNGPSVIEQLTVSFYIPIAYKV-------AGSTAII----------PIIN 845
            :     |:......::...|:.:..:.:..||:.|.|       ..||..|          .:.:
  Rat   882 SWGDFVELNGTVHCENENSSLGKDNSATTRIPVLYPVNILTEDQENSTLYISFTPKGPKTQQVQH 946

  Fly   846 VTSLKMQASYDSQLLSIDLYDQNNTMLVVDPVEVTTTLSGGLERTVITQNRQSYDIHTSGHVHQT 910
            :..:::|.|         .||.|...|.. .|||...                   |:.|.:..|
  Rat   947 IYKVRIQPS---------AYDHNMPALEA-LVEVPQP-------------------HSEGPIAHT 982

  Fly   911 MEVLDTSMVATASMSRKRRDLKALTANREQYARISNVKAHDLLSDDFKGKLPVNRTIVFNC---- 971
            ..|....:|..     .|.|||..|...||                     |....:.|.|
  Rat   983 WTVHTDPLVTC-----HREDLKKPTREAEQ---------------------PCLPGVQFRCPIVF 1021

  Fly   972 -RDPEMTICVRAEMRVHFRPEKSINLNMRYSVDLNEVNAILVDPWEYFVILTDLKLQKKGDPTST 1035
             ::..:.:....|:....:...:::|....||..|                           :|.
  Rat  1022 RQETFIRVAGTVELSEKIKASSTLSLCSSLSVSFN---------------------------SSK 1059

  Fly  1036 SFSI--NRRIEPNIISK----HQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRTKKDELD 1094
            .|.:  ::..:..::.|    :::..|.::::  |.||||||||.|...|||.|||.|..|::::
  Rat  1060 HFHLYGSKASKAQVLMKVDMIYEKEMLHLYVL--SGIGGLLLLSLIFLALYKVGFFKRKLKEKME 1122

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	15/51 (29%)
		FG-GAP	350..388	CDD:460357	12/38 (32%)
		Int_alpha	409..459	CDD:214549	26/49 (53%)
		Int_alpha	473..>515	CDD:214549	11/41 (27%)
		Integrin_alpha2	509..829	CDD:462478	62/352 (18%)
Itgal	XP_006230331.1	Int_alpha	38..81	CDD:214549	15/52 (29%)
		vWFA	151..320	CDD:469594	17/168 (10%)
		Int_alpha	398..448	CDD:214549	14/53 (26%)
		Int_alpha	453..499	CDD:214549	14/46 (30%)
		Int_alpha	514..566	CDD:214549	26/51 (51%)
		Int_alpha	577..621	CDD:214549	11/45 (24%)
		Integrin_alpha2	610..978	CDD:462478	79/447 (18%)
		Integrin_alpha	1109..1123	CDD:459778	6/13 (46%)