DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and Itga1

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_112256.1	Gene:	Itga1 / 25118	RGDID:	2923	Length:	1180	Species:	Rattus norvegicus

Alignment Length:	1011	Identity:	235/1011 - (23%)
Similarity:	394/1011 - (38%)	Gaps:	281/1011 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 RISPLRLKSEQVKEEDNGNKASFFYIMGELGLSAHVADDNTKFLIGAPGINTWRGSVILYRQVDP 242
            ||..|...::|       :.|||...|.:.|.|||.:.|  ..::||.|...|.|:|::.:
  Rat   358 RIFALEATADQ-------SAASFEMEMSQTGFSAHYSQD--WVMLGAVGAYDWNGTVVMQK---- 409

  Fly   243 VDNPTASRRDTSKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPT 307
                                   :|.....|.......|....:...||.||.|:|    ::.|.
  Rat   410 -----------------------ANQMVIPHNTTFQTEPAKMNEPLASYLGYTVNS----ATIPG 447

  Fly   308 KLLYVATAPQANKQSGEAYIFDVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTD-VIVSA 371
            .:||:|..|:.| .:|:..|:.:...:|:......|||.|.|||..:...|::.|..|| ::|.|
  Rat   448 DVLYIAGQPRYN-HTGQVVIYKMEDGNINILQTLGGEQIGSYFGSVLTTIDIDKDSYTDLLLVGA 511

  Fly   372 PQHALEDSHDNGAIYVF-INKGFFNFERQILRSPVETM--------------------ARFGTAL 415
            |.:...:..:.|.:||: :|:  ..||.|:...|:...                    ||||||:
  Rat   512 PMYMGTEKEEQGKVYVYAVNQ--TRFEYQMSLEPIRQTCCSSLKDNSCTKENKNEPCGARFGTAI 574

  Fly   416 SRLGDINHDGYNDVAVGAPFAGN--GTVFIYLGSENGLRDQPSQRLDAPSQQPSKYGSHMFGHGL 478
            :.:.|:|.||:|||.:|||...:  |.|:||.||...:|:..:||:  ||....| ....||..:
  Rat   575 AAVKDLNVDGFNDVVIGAPLEDDHAGAVYIYHGSGKTIREAYAQRI--PSGGDGK-TLKFFGQSI 636

  Fly   479 SRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIKPEQEKVKI---------- 533
            ....|::|:|..|..||.....|::..|...||||  |:..|..::..:::..::
  Rat   637 HGEMDLNGDGLTDVTIGGLGGAALFWARDVAVVKV--TMNFEPNKVNIQKKNCRVEGKETVCINA 699

  Fly   534 TACYRLSTTSTDKLVQEQELAIRIAMD--KQLKRVKFTQTQTNEISFKVNANFGEQCR------- 589
            |.|:.:...|.:..:.|.:|..|:.:|  :|:.|..|:.||..:|...:.....|..|
  Rat   700 TMCFHVKLKSKEDSIYEADLQYRVTLDSLRQISRSFFSGTQERKIQRNITVRESECIRHSFYMLD 764

  Fly   590 --DFETQVRYSEKDIFTPIDLEMHYELTKKVPDSEEFCETCAIVDPTEPKVSTQNIIFSTGCAT- 651
              ||:..||           :.:.:.||..        |...::|...|....::|.|:..|..
  Rat   765 KHDFQDSVR-----------VTLDFNLTDP--------ENGPVLDDALPNSVHEHIPFAKDCGNK 810

  Fly   652 DVCTADLQLRSKDVSPTYILGSADTLRLNYEIT--NIGETAYLPQFNVTSTSRLAFAQVPGNCKV 714
            :.|.:||.|.......:.::..:...:.|..:|  |.|::||..:..|..:..|.|:.:....|
  Rat   811 ERCISDLTLNVSTTEKSLLIVKSQHDKFNVSLTVKNKGDSAYNTRTVVQHSPNLIFSGIEEIQK- 874

  Fly   715 VDAVMVCDLNR------GRP-LAKGDTDS--VTISFDVSQLSGQSLIIHAEVFSTGYE--QNPTD 768
             |:   |:.|:      |.| |..|:|.:  :...|:.|.|| ::.|||....|...|  ::..|
  Rat   875 -DS---CESNQNITCRVGYPFLRAGETVTFKIIFQFNTSHLS-ENAIIHLSATSDSEEPLESLND 934

  Fly   769 NRQTNV-------IGLKEFT-----EIDASGGQTNSQIDLEHYSNSAEIVNN-----YEIKSNG- 815
            | :.|:       :||:.::     .|..:..:|     :..:.||.|.:.|     |.|:..|
  Rat   935 N-EVNISIPVKYEVGLQFYSSASEHHISVAANET-----IPEFINSTEDIGNEINVFYTIRKRGH 993

  Fly   816 -PSVIEQLTVSF-------YIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLLSIDLYDQNNTML 872
             |....||::||       | |:.|.:..|::  ..:|.....::
  Rat   994 FPMPELQLSISFPNLTADGY-PVLYPIGWSSS--DNVNCRPRSLE-------------------- 1035

  Fly   873 VVDPV------EVTTTLSGGLERTVITQNRQSYDIHTSGHVHQTMEVLDTSMVATASMSRKRRDL 931
              ||.      ::|.:.|..|:|..|                  .:...|..|||.:.|....||
  Rat  1036 --DPFGINSGKKMTISKSEVLKRGTI------------------QDCSSTCGVATITCSLLPSDL 1080

  Fly   932 KALTANREQYARISNVKAHDLLSDDFKGKLPVNRTIVFNCRDPEMTICVRAEMRVHFRPEKSINL 996
            ..:..:                                      :.:.....:|.||   .|:||
  Rat  1081 SQVNVS--------------------------------------LLLWKPTFIRAHF---SSLNL 1104

  Fly   997 NMRYSVDLNEVNAILVDPWEYFVILTDLKLQKKGDPTSTSFSINRRIEPNI-ISKHQETG-LPIW 1059
            .:|  .:|...|:.|                       |..|.||:.|..| |||....| :|:|
  Rat  1105 TLR--GELKSENSSL-----------------------TLSSSNRKRELAIQISKDGLPGRVPLW 1144

  Fly  1060 IIIVSVIGGLLLLSAISYLLYKFGFFNRTKKDELDR 1095
            :|::|...|||||..:...|:|.|||.|..|.::::
  Rat  1145 VILLSAFAGLLLLMLLILALWKIGFFKRPLKKKMEK 1180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549
		FG-GAP	350..388	CDD:280083	11/38 (29%)
		Int_alpha	409..459	CDD:214549	24/51 (47%)
		Int_alpha	473..>515	CDD:214549	14/41 (34%)
		Integrin_alpha2	507..829	CDD:285619	84/382 (22%)
Itga1	NP_112256.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	30..91
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	101..160
		vWA_integrins_alpha_subunit	171..351	CDD:238746
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	365..417		17/87 (20%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	422..474		15/56 (27%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	475..537		19/63 (30%)
		Int_alpha	485..>528	CDD:214549	13/42 (31%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	556..614		22/57 (39%)
		Int_alpha	567..620	CDD:214549	24/52 (46%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	618..678		21/64 (33%)
		Integrin_alpha2	663..1073	CDD:285619	100/485 (21%)
		GFFKR motif	1168..1172		3/3 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335725
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940